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Wyniki wyszukiwania dla: IN VITRO DISSOLUTION
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Preparation, characterization, and manufacturing of new polymeric materials for 3D printing for medical applications
PublikacjaThis work concerns the synthesis, formation, and characteristics of new filaments for 3D printing in FDM™/FFF technology for medical purposes. Two types of filaments were developed, i.e. degradable polyurethane and biodegradable polylactide-starch. The influence of the 3D printing process on selected filament properties was investigated. A detailed analysis of the filament formation process by the extrusion method was carried out,...
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Influence of Ultrasound on the Characteristics of CaP Coatings Generated Via the Micro-arc Oxidation Process in Relation to Biomedical Engineering
PublikacjaOver the past decade, bone tissue engineering has been at the core of attention because of an increasing number of implant surgeries. The purpose of this study was to obtain coatings on titanium (Ti) implants with improved properties in terms of biomedical applications and to investigate the effect of ultrasound (US) on these properties during the micro-arc oxidation (MAO) process. The influence of various process parameters, such...
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Biochemical, Structural Analysis, and Docking Studies of Spiropyrazoline Derivatives
PublikacjaIn this study, we evaluated the antiproliferative potential, DNA damage, crystal struc‐ tures, and docking calculation of two spiropyrazoline derivatives. The main focus of the research was to evaluate the antiproliferative potential of synthesized compounds towards eight cancer cell lines. Compound I demonstrated promising antiproliferative properties, especially toward the HL60 cell line, for which IC50 was equal to 9.4 μM/L....
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Aktywność biologiczna koniugatów nanonośników molekularnych z inhibitorami enzymatycznymi
PublikacjaPrzedmiotem badań były cztery grupy koniugatów nanonośników molekularnych z inhibitorami enzymatycznymi o potencjalnym działaniu przeciwgrzybowym. Pierwszą z tych grup tworzyły koniugaty peptydów penetrujących z inhibitorem gyrazy ciprofloksacyną lub z cząsteczką kwasu N3-(4-metoksyfumaroilo)-L-2,3-diaminopropanowego (FMDP), inhibitorem syntazy GlcN-6-P. W dwóch kolejnych grupach, cząsteczki FMDP oraz cispentacyny, inhibitora syntetazy...
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The Impact of the Antigenic Composition of Chimeric Proteins on Their Immunoprotective Activity against Chronic Toxoplasmosis in Mice
PublikacjaToxoplasmosis may pose a serious threat for individuals with weakened or undeveloped immune systems. However, to date, there is no specific immunoprophylaxis for humans. Thus, the aim of this study was to evaluate the immunogenicity of three trivalent—SAG2-GRA1-ROP1L (SGR), SAG1L-MIC1-MAG1 (SMM), and GRA1-GRA2-GRA6 (GGG)—and two tetravalent—SAG2-GRA1-ROP1-GRA2 (SGRG) and SAG1-MIC1-MAG1-GRA2 (SMMG)—chimeric T. gondii proteins, as...
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Application of micellar electrokinetic chromatography for detection of silver nanoparticles released from wound dressing
PublikacjaThe recent emergence of nanotechnology has provided a new therapeutic modality in case of silver nanoparticles. Dressings containing silver form the basis for the treatment of burns and wounds, either acute or chronic ones. The aim of the study was to examine silver release from the different wound dressings: commercially available (Atrauman Ag, Aqua- cel Ag) and experimental (FKDP-AgNPs) using MEKC. In order to characterize prepared keratin...
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Medical-Grade PCL Based Polyurethane System for FDM 3D Printing—Characterization and Fabrication
PublikacjaThe widespread use of three-dimensional (3D) printing technologies in medicine has contributed to the increased demand for 3D printing materials. In addition, new printing materials that are appearing in the industry do not provide a detailed material characterization. In this paper, we present the synthesis and characterization of polycaprolactone (PCL) based medical-grade thermoplastic polyurethanes, which are suitable for forming...
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Elicitation strategies for the improvement of essential oil content in Rhododendron tomentosum (Ledum palustre) bioreactor-grown microshoots
PublikacjaRhododendron tomentosum Harmaja, previously Ledum palustre L., is a fragrant plant growing in swampy areas, which is characterized by well-known repellent properties and the anti-arthritic potential. In the present study, R. tomentosum microshoots cultivated in RITA® bioreactor, providing the alternative, environment-independent source of the valuable essential oil, were treated for 7 days with copper and nickel salts, methyl jasmonate,...
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Synthesis of 3-(2-Alkylthio-4-chloro-5-methylbenzenesulfonyl)-2-(1-phenyl-3-arylprop-2-enylideneamino)guanidine Derivatives with Pro-Apoptotic Activity against Cancer Cells
PublikacjaThe untypical course of reaction between chalcones and benzenesulfonylaminoguanidines led to the new 3-(2-alkylthio-4-chloro-5-methylbenzenesulfonyl)-2-(1-phenyl-3-arylprop-2- enylideneamino)guanidine derivatives 8–33. The new compounds were tested in vitro for their impact on the growth of breast cancer cells MCF-7, cervical cancer cells HeLa and colon cancer cells HCT-116 by MTT assay. The results revealed that the activity of...
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N-doped carbon nanospheres as selective fluorescent probes for mercury detection in contaminated aqueous media: chemistry, fluorescence probing, cell line patterning, and liver tissue interaction
PublikacjaA precise nano-scale biosensor was developed here to detect Hg2+ in aqueous media. Nitrogen-doped carbon nanospheres (NCS) created from the pyrolysis of melamine–formaldehyde resin were characterized by FESEM, XRD, Raman spectra, EDS, PL, UV–vis spectra, and N2 adsorption–desorption, and were used as a highly selective and sensitive probe for detecting Hg2+ in aqueous media. The sensitivity of NCS to Hg2+ was evaluated by photoluminescence...
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Nanodiamonds Doped with Manganese for Applications in Magnetic Resonance Imaging
PublikacjaNanodiamonds (NDs) are emerging with great potential in biomedical applications like biomarking through fluorescence and magnetic resonance imaging (MRI), targeted drug delivery, and cancer therapy. The magnetic and optical properties of NDs could be tuned by selective doping. Therefore, we report multifunctional manganese-incorporated NDs (Mn-NDs) fabricated by Mn ion implantation. The fluorescent properties of Mn-NDs were tuned...
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Evaluation of the yield, chemical composition and biological properties of essential oil from bioreactor-grown cultures of Salvia apiana microshoots
PublikacjaMicroshoot cultures of the North American endemic Salvia apiana were established for the first time and evaluated for essential oil production. Stationary cultures, grown on Schenk-Hildebrandt (SH) medium, supplemented with 0.22 mg/L thidiazuron (TDZ), 2.0 mg/L 6-benzylaminopurine and 3.0% (w/v) sucrose, accumulated 1.27% (v/m dry weight) essential oil, consisting mostly of 1,8-cineole, β-pinene, α-pinene, β-myrcene and camphor....
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Essentials of computer science for Bachelor in Management students
Kursy OnlineVarious resources accompanying "Essentials of computer science" classes for Bachelor in Management 1st year students.
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[ITiT] Transmission Channel in Radio Communication Systems - 2023/2024
Kursy Online{mlang pl} Dyscyplina: informatyka techniczna i telekomunikacja Zajęcia fakultatywne dla doktorantów II roku Prowadzący: dr hab. inż. Sławomir Ambroziak, prof. PG Liczba godzin: 15 Forma zajęć: wykład {mlang} {mlang en} Discipline: technical informatics and telecommunications Elective course for 2nd-year PhD students Academic teachers: dr hab. inż. Sławomir Ambroziak, prof. PG Total hours of training: 15 teaching hours Course...
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[soft skills] Didactic methods in the modern teaching process
Kursy Online{mlang pl} Dyscyplina: wszystkie dyscypliny Zajęcia obowiązkowe dla doktorantów II roku Prowadzący: dr hab. Joanna Mytnik, prof. PG, mgr Alina Guzik, Centrum Nowoczesnej Edukacji Liczba godzin: 15 Forma zajęć: wykład Kurs realizowany w zakładce Centrum Nowoczesnej Edukacji: https://enauczanie.pg.edu.pl/moodle/course/view.php?id=10875 Na kurs należy zapisać się samodzielnie: https://enauczanie.pg.edu.pl/moodle/enrol/index.php?id=10875 Hasło...
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[NCh-bio] Advances in Biotechnology: Protein Folding and Assembly
Kursy Online{mlang pl} Dyscyplina: nauki chemiczne Zajęcia obowiązkowe dla doktorantów I i II roku z obszaru biotechnologii Prowadzący: dr hab. Gracjana Klein-Raina, prof. PG Liczba godzin: 15 Forma zajęć: wykład {mlang} {mlang en} Discipline: chemical sciences Obligatory course for 1st and 2nd-year PhD students from biotechnology area Academic teachers: dr hab. Gracjana Klein-Raina, prof. PG Total hours of training: 15 teaching...
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Application of Mathematics in Technology for Dezhou University, 2022
Kursy OnlineApplication of Mathematics
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[Soft Skills] Didactic methods in the modern teaching process
Kursy Online{mlang pl} Dyscyplina: wszystkie dyscypliny Zajęcia obowiązkowe dla doktorantów II roku ProwadzącA: mgr Olga Ludyga Liczba godzin: 15 Forma zajęć: warsztaty {mlang} {mlang en} Discipline: all disciplines Obligatory course for 1st-year PhD students Academic teacher: mgr Olga Ludyga Total hours of training: 15 teaching hours Course type: workshop {mlang} Soft skills, area II - didactic skills
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Communication and Visualisation in Building Automation - 2022/23 - Nowy
Kursy OnlineLecture "Communication and Visualisation in Building Automation", Wydział ETI, katedra KSA, II stopień studiów
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New and Fast Analytical Techniques in Food Quality Analysis
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[Soft Skills] - Didactic methods in the modern teaching process
Kursy Online{mlang pl} Dyscyplina: wszystkie dyscypliny Zajęcia obowiązkowe dla doktorantów I roku Prowadząca: dr hab. Joanna Mytnik, prof. uczelni Liczba godzin: 15 Forma zajęć: warsztaty {mlang} {mlang en} Discipline: all disciplines Obligatory course for 1st-year PhD students Academic teacher: Joanna Mytnik, Ph.D., ass. prof. Total hours of training: 15 teaching hours Course type: workshop {mlang} Soft skills, area I - didactic...
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Placement Test 2nd Degree (Studies in English) 1 sem
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Advances in materials engineering instrumentation: new trends and applications
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Contemporary directions of development in mechanical engineering kopia 1
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Architectural and Urban Theories in Revitalization Process 2023/24
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Numerical Modelling in flow systems design_W/S_Energetyka_sem6_lato 23/24_PG_00042087
Kursy OnlinePrzedstawienie podstaw modelowania komputerowego procesów mających zastosowanie w technice cieplnej tak aby słuchacz był w stanie zrozumieć i zinterpretować wyniki otrzymane przy pomocy kodów obliczeniowych
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Polymeric materials in medicine – structure and desing 2023/24
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[AiU]20232024_Challenges and Perspectives in Contemporary Architecture and Urbanism
Kursy OnlineThis course is compulsory for PhD students assigned to Architecture and Urbanism tracks at Doctoral School at Gdańsk University of Technology. The course is conducted by Prof. Marichela Sepe, DICEA / Sapienza University Rome Course type: workshops Total hours of training: 15 teaching hours Classes in online mode (classes conducted online)
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Topology and Dynamical Systems in Action - Summer school 2023
Kursy OnlineThe course is designed for participants in the Spinnaker summer school in mathematics.
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Space and Landscape in a Global Context - 2023/24
Kursy OnlineModule SPACE AND LANDSCAPE IN A GLOBAL CONTEXT (2022/2023, autumn semester) Objective The objective of the module is to debate different approaches to managing spatial development and contemporary issues in a global context. The course is founded on the students' knowledge about urban planning and instruments used to make them better places both for people and the environment. Course proceedings Lectures and classes run online...
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Application of Mathematics in Technology for Dezhou University, 2023
Kursy OnlineApplication of Mathematics MOODLE ENV localdevtestprod
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[Soft Skills] Workshop in research ethics gr.1 AIU_ILGIT_IŚGIE_EIF
Kursy Online{mlang pl} Dyscyplina: Wszystkie dyscypliny Zajęcia obowiązkowe dla doktorantów III roku Prowadzący: A. Karalus Liczba godzin: 5 {mlang} {mlang en} Discipline: All disciplines Obligatory course for 3rd year PhD students Academic teacher: A. Karalus Total hours of training: 5 teaching hours {mlang}
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Microbe Power and Diversity: in Health and Society - wykład
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Electrochemical detection of 4,4',5,5'-tetranitro-1H,1'H-2,2'-biimidazole on boron-doped diamond/graphene nanowall electrodes
PublikacjaWe present a promising approach to the electroanalytical detection of a specific nitroaromatic explosive in landfill leachates (LLs) that originated from a municipal solid waste plant. The paper is focused but not limited to the sensing of 4,4',5,5'-tetranitro-1H,1'H-2,2'-biimidazole (TNBI) using differential pulse voltammetry and cyclic voltammetry. Highly electroactive nanocarbon was applied to determine low concentrations of...
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ECOLOGY OR ECONOMICS? THE ASPECT DETERMINING THE USE OF DISPLACEMENT PILES FOR THE FOUNDATIONS OF BRIDGE STRUCTURES
PublikacjaW ostatnich latach rzadko wykonuje się pale wiercone o bardzo dużych średnicach ze względu na: wymagany sprzęt, transport wydobytego urobku gruntowego, duże ilości stali zbrojeniowej. Konstrukcje inżynierskie na autostradzie A-1, na drodze ekspresowej S-7 i Obwodnicy Południowej Gdańska posadowiono na palach prefabrykowanych. Fundamenty największych mostów na autostradzie A-1 zbudowano na palach Vibro i Franki. W artykule zwrócono...
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3. E-TECH: Online education in practice for teachers. Advanced
Kursy OnlineTo enroll to this course please write an e-mail at: alina.guzik@pg.edu.pl
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2 - E-TECH: Online education in practice for teachers. Intermediate
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[ILiT, IŚGiE] Process engineering in circular economy 20/21 Summer
Kursy OnlineKurs jest przeznaczony dla doktorantów szkoły doktorskiej w dyscyplnach: inżynieria lądowa i transport (SzD), III stopnia, stacjonarne inżynieria środowiska, górnictwo i energetyka (SzD), III stopnia, stacjonarne The course is addressed to PhD students of the doctoral school in disciplines: civil engineering and transport environmental engineering, mining and power engineering Course type: lecture Total hours of...
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1 - E-TECH: Online education in practice for teachers. Foundations
Kursy OnlineThis module has been designed to help teachers to get the very best out of online learning education. We've created it to support many aspects of your learning online. The aim is to provide skills to create and engage with your teaching materials online. After completion the course you can download your Certifacte.
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NEW AND FAST ANALYTICAL TECHNIQUES IN FOOD QUALITY ANALYSIS 2024
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[NCh, ICh] Physical Chemistry of Organic Compounds in Natural Waters
Kursy Online{mlang pl} Dyscyplina: Nauki chemiczne Zajęcia obieralne dla doktorantów Prowadzący: prof. dr hab. Tadeusz Górecki Liczba godzin: 15 {mlang} {mlang en} Discipline: Chemical science Elective course for PhD students Academic teacher: prof. dr hab. inż. Tadeusz Górecki Total hours of training: 15 teaching hours {mlang}
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Safety and risk in transportation systems - summer semester 2023/2024
Kursy OnlinePodstawy teorii bezpieczeństwa i ryzyka w kontekście aplikacji w systemach transportowych.
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Source and Channel Coding in Radio Communication Systems 2023/2024
Kursy OnlineKurs służy jako narzędzie pomocnicze do realizacji przedmiotu.
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Development and evaluation of thermosensitive hydrogels with binary mixture of Scutellariae baicalensis radix extract and chitosan for periodontal diseases treatment.
PublikacjaScutellaria baicalensis root displays anti-inflammatory and antibacterial properties due to the presence of flavonoids, particularly baicalin, baicalein, and wogonin. Our work aimed at developing thermosensitive hydrogels containing a binary mixture of S. baicalensis radix lyophilized extract and chitosan as a novel approach for periodontal diseases treatment....
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Bioactive and bioavailability of minerals in rats loaded with cholesterol and kiwi fruit
PublikacjaThe aim of this study was to compare the content of polyphenols (TP), minerals, ascorbic acid (AA) and total antioxidant capacities (TAC) of conventional and organic kiwifruit ‘Hayward’ treated with ethylene after harvest and to determine their influence on plasma TAC, mineral content in the liver and bioavailability (RBV — relative bioavailability value) in rats fed diet containing cholesterol. Organic and conventionally grown...
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Opracowanie optymalnych warunków rozdzielania i identyfikacji metabolitów ro lin z rodzaju droseraceae, z zastosowaniem wysokosprawnej kolumnowej chromatografii cieczowej= A research on the composition of eluent for separation of plant metabolites by column reversed phase liquid chromatography
PublikacjaOd kilku lat na świecie trwają badania składników roślin owadożernych wykazujących atrakcyjne właściwości biologicznie czynne, tj. działanie przeciwbakteryjne, przeciwgrzybowe, antyoksydacyjne, a być może, także, przeciwnowotworowe. Pozyskiwanie substancji biologicznieaktywnych z materiału naturalnego, na drodze hodowli in vitro a następnie ekstrakcji i rozdzielania jest bardziej korzystne pod względem ekonomicznym, niż ich wytwarzanie...
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O07 Filaggrin insufficiency renders keratinocyte-derived small extracellular vesicles capable of affecting CD1a-mediated T-cell responses and promoting allergic inflammation
PublikacjaThe association between FLG loss-of-function mutations and the development of atopic dermatitis (AD) indicates that filaggrin is critical to skin barrier function; the mutations are also linked to additional allergic manifestations, but it is unknown how the skin may influence inflammation in distant tissues. Here we investigated the impact of filaggrin insufficiency on keratinocyte-derived exosome-enriched small extracellular...
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PVA-Based Films with Strontium Titanate Nanoparticles Dedicated to Wound Dressing Application
PublikacjaBioactive materials may be applied in tissue regeneration, and an example of such materials are wound dressings, which are used to accelerate skin healing, especially after trauma. Here, we proposed a novel dressing enriched by a bioactive component. The aim of our study was to prepare and characterize poly(vinyl alcohol) films modified with strontium titanate nanoparticles. The physicochemical properties of films were studied,...
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Encapsulation of Amikacin into Microparticles Based on Low-Molecular-Weight Poly(lactic acid) and Poly(lactic acid-co-polyethylene glycol)
PublikacjaThe aim of this study was to fabricate novel microparticles (MPs) for efficient and long-term delivery of amikacin (AMI). The emulsification method proposed for encapsulating AMI employed low-molecular-weight poly(lactic acid) (PLA) and poly(lactic acid-co-polyethylene glycol) (PLA−PEG), both supplemented with poly(vinyl alcohol) (PVA). The diameters of the particles obtained were determined as less than 30 μm. Based on an in-vitro...
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Projektowanie, synteza oraz badanie aktywności biologicznej amidosiarczanowych inhibitorów sulfatazy steroidowej zawierających w swojej konstytucji ugrupowania fosforowe lub wiązania C-F
PublikacjaWedług Światowej Organizacji Zdrowia (WHO) estrogeny są jednymi z głównych czynników stymulujących wzrost nowotworów hormonozależnych. Dlatego też, projektowanie oraz synteza nowych, skuteczniejszych środków wpływających na biosyntezę estrogenów stanowi ogromne wyzwanie dla współczesnej medycyny. W ostatnich latach liczne ośrodki naukowe na całym świecie prowadzą intensywne badania związane z poszukiwaniem nowych, skutecznych inhibitorów...