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EFFECT OF SURFACE STATE AND STRESS ON AN OXIDATION OF THE ZIRCALOY-2 ALLOY
PublikacjaZr alloys are widely used as materials for nuclear fuel pellets in the nuclear industry. In the case of the LOCA or RIA happen, a temperature may locally reach high values. Even if the high temperature maintains shortly, the zirconium oxides may become permeable, absorb hydrogen appearing in cooling water from decomposition reaction and crack because of formation and brittle failure of hydrides. Such model cannot so far take into...
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Visualizing Carotid Bodies With Doppler Ultrasound Versus CT Angiography: Preliminary Study
PublikacjaOBJECTIVE. The purpose of this article is to evaluate the utility of ultrasound in identifying carotid bodies (CBs) in patients with drug-resistant arterial hypertension. SUBJECTS AND METHODS. We enrolled 13 patients with drug-resistant hypertension into a trial for surgical CB excision. CT angiography (CTA) and Doppler ultrasound (DUS) of the cervical arteries were performed before surgery. CBs were identified in a blind manner...
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Mechanism-based inactivation of human cytochrome P450 1A2 and 3A4 isoenzymes by antitumor triazoloacridinone C-1305.
Publikacja5-Dimethylaminopropylamino-8-hydroxytriazoloacridinone, C-1305, is a promising antitumor therapeutic agent with high activity against several experimental tumors. It was determined to be a potent and selective inhibitor of liver microsomal and human recombinant cytochrome P450 (CYP) 1A2 and 3A4 isoenzymes. Therefore, C-1305 might modulate the effectiveness of other drugs used in multidrug therapy. The objective of this study was...
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Thermodynamics and kinetics of amphotericin B self-association in aqueous solution characterized in molecular detail
PublikacjaAmphotericin B (AmB) is a potent but toxic drug commonly used to treat systemic mycoses. Its efficiency as a therapeutic agent depends on its ability to discriminate between mammalian and fungal cell membranes. The association of AmB monomers in an aqueous environment plays an important role in drug selectivity, as oligomers formed prior to membrane insertion – presumably dimers – are believed to act differently on fungal (ergosterol-rich)...
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Investigating the disease- modifying properties of sclerotiorin in Alzheimer's therapy using acetylcholinesterase inhibition
PublikacjaAlzheimer's disease (AD) is a progressive neurodegenerative disorder caused due to the damage and loss of neurons in specific brain regions. It is the most common form of dementia observed in older people. The symptoms start with memory loss and gradually cause the inability to speak and do day-to-day activities. The cost of caring for those affected individuals is huge and is probably beyond most developing countries capability....
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OTHER AND UNSPECIFIED PARTS OF BILIARY TRACT, Choledochal duct - Female, 60 - Tissue image [6140730016102481]
Dane BadawczeThis is the histopathological image of OTHER AND UNSPECIFIED PARTS OF BILIARY TRACT tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Urothelial carcinoma in situ - Male, 64 - Tissue image [11010630088568751]
Dane BadawczeThis is the histopathological image of BLADDER tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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OTHER AND UNSPECIFIED PARTS OF BILIARY TRACT, Common bile duct - Male, 70 - Tissue image [6110730021433501]
Dane BadawczeThis is the histopathological image of OTHER AND UNSPECIFIED PARTS OF BILIARY TRACT tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Carcinoma, NOS - Male, 85 - Tissue image [4260730006794051]
Dane BadawczeThis is the histopathological image of LIVER AND INTRAHEPATIC BILE DUCTS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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RID 4D Wpływ stosowania usług Inteligentnych Systemów Transportowych na poziom bezpieczeństwa ruchu drogowego
Projekty -
Characterization of Mesorhizobium huakuii lipid A containing bothD-galacturonic acid and phosphate residues.
PublikacjaLipid A jest mieszaniną co najmniej 6 związków, różniących się stopniem fosforylacji i strukturą kwasów tłuszczowych przyłączonych do szkieletu polisacharydowego. Szkielet cukrowy zawiera beta(1'->6)połączone dwie cząsteczki 2,3-diamino-2,3-dideoksyglucosy (DAG)oraz aglikon kwas alfa-D-galaktouronowy.
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Transport przybrzeżny i śródlądowy 2022
Kursy Online- kierunki wykorzystania rzek; - drogi wodne - budowa i zasady prowadzenia żeglugi; - nowoczesne systemy transportowe; - budowa podstawowych obiektów hydrotechnicznych; - sposoby podwyższenia parametrów żeglugowych dróg wodnych; Międzynarodowe Przepisy o Zapobieganiu Zderzeniom na Morzu (MPZZM) w kontekście żeglugi przybrzeżnej
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Molecular detection of Candida krusei
PublikacjaThe species identification of fungi belonging to genus Candida is an important issue as this genus becomes the emerging problem of nosocomial infections. As Candida krusei presents intrinsicresistance to the fluconazole that is the drug of the first choice in case of invasive candidiasis the PCR identifying the DNA of C. krusei was elaborated. The analytical sensitivity of the assay on spiked blood samples was estimated at 3-5...
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Ocena dynamiczna wybranych sposobów łączenia elementów trasy o zróżnicowanej krzywiźnie
PublikacjaArtykuł przedstawia porównanie właściwości dynamicznych kubicznych krzywych C-Bezier i PH krzywych Bezier piątego stopnia na tle krzywej typu K0 uzyskanej przy zastosowaniu uniwersalnej metody modelowania krzywizny. Właściwości dynamiczne i możliwości zastosowania wymienionych krzywych w projektowaniu dróg kolejowych omówiono na przykładach łączenia krzywą przejścia dwóch łuków kołowych odwrotnych oraz dwóch łuków zgodnych (bez...
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Free vibration analysis of thin-walled frames with use of node superelements
PublikacjaW pracy proponuje się model ramy cienkościennej zbudowany z prętów cienkościennych i superelementów węzłowych do analizy dragń swobodnych. Dzięki temu modelowi istnieje możliwość uwzględnienia wpływu deformacji węzłów na częstości i postacie drgań własnych. Porównanie wyników analizy numerycznej z rezultatami opatymi na modelu jednowymiarowym, belkowym i modelu podziału ramy na dwuwymiarowe elemnty skończone wskazuje na poprawność...
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Przyczyny i kierunki weryfikacji "Katalogu typowych konstrukcji nawierzchni podatnych i półsztywnych"
PublikacjaW artykule przedstawiono przegląd przyczyn i kierunków weryfikacji obecnego "Katalogu typowych konstrukcji nawierzchni podatnych i półsztywnych" z 1997 roku, której celem jest wyeliminowanie niedostatków obecnego Katalogu. Główne kierunki weryfikacji Katalogu, którą realizuję zespół Politechniki Gdańskiej to dostosowanie Katalogu do: (1) obecnych technologii i materiałów, (2) obecnych sposobów wzmacniania podłoży drogowych, (3)...
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Pathological brain network activity: memory impairment in epilepsy
PublikacjaOur thinking, memory and cognition in general, relies upon precisely timed interactions among neurons forming brain networks that support cognitive processes. The surgical evaluation of drug-resistant epilepsy using intracranial electrodes provides a unique opportunity to record directly from human brain and to investigate the coordinated activity of cognitive networks. In this issue of Neurology®, Kleen and colleagues1 implicate...
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Nadmierne osiadania nawierzchni drogowej w ujęciu geotechnicznym - przyczyny, monitoring, możliwe metody naprawy
PublikacjaNadmierne osiadania nawierzchni stanowią „wieczny” problem użytkowników dróg. Z odkształceniami nawierzchni łączy się obniżenie komfortu i bezpieczeństwa jazdy (BRD). Jedną z podstawowych przyczyn takiego zjawiska jest zachowanie się podłoża gruntowego. Najczęściej dotyczy to zjawiska osiadania podłoża gruntowego, stanowiącego efekt ściśliwości gruntów w wyniku przyłożenia obciążenia i jest przekroczeniem stanów granicznych użytkowalności...
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Ad hoc prayer spaces – a challenge of the architecture of the 21th century
PublikacjaThis article considers the problem of arranging places of prayer in the vicinity of universities and dormitories. A survey was conducted among students living in the dormitories of the Gdańsk University of Technology in order to determine if there was a real need to arrange such spaces. Subsequently, examples of temporary chapels designed in the last 20 years in Western European countries were presented. Analysis of the selected...
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Nadmierne osiadania nawierzchni drogowej w ujęciu geotechnicznym – przyczyny, monitoring, możliwe metody naprawy
PublikacjaNadmierne osiadania nawierzchni stanowią „wieczny” problem użytkowników dróg. Z odkształceniami nawierzchni łączy się obniżenie komfortu i bezpieczeństwa jazdy (BRD). Jedną z podstawowych przyczyn takiego zjawiska jest zachowanie się podłoża gruntowego. Najczęściej dotyczy to zjawiska osiadania podłoża gruntowego, stanowiącego efekt ściśliwości gruntów w wyniku przyłożenia obciążenia i jest przekroczeniem stanów granicznych użytkowalności...
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OTHER AN UNSPECIFIED FEMALE GENITAL ORGANS, Fallopian tube - Female, 49 - Tissue image [6110730021449171]
Dane BadawczeThis is the histopathological image of OTHER AN UNSPECIFIED FEMALE GENITAL ORGANS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Carcinoma, NOS - Male, 85 - Tissue image [4260730006796771]
Dane BadawczeThis is the histopathological image of LIVER AND INTRAHEPATIC BILE DUCTS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Urothelial carcinoma, NOS - Male, 67 - Tissue image [7100730013394401]
Dane BadawczeThis is the histopathological image of BLADDER tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Polyp of cervix uteri - Female, 39 - Tissue image [9270729565543271]
Dane BadawczeThis is the histopathological image of CERVIX UTERI tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Urothelial carcinoma in situ - Male, 64 - Tissue image [1101063008856331]
Dane BadawczeThis is the histopathological image of BLADDER tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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OTHER AN UNSPECIFIED FEMALE GENITAL ORGANS, Fallopian tube - Female, 49 - Tissue image [6110730021443131]
Dane BadawczeThis is the histopathological image of OTHER AN UNSPECIFIED FEMALE GENITAL ORGANS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Carcinoma, NOS - Male, 85 - Tissue image [4260730006799641]
Dane BadawczeThis is the histopathological image of LIVER AND INTRAHEPATIC BILE DUCTS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Carcinoma, NOS - Male, 85 - Tissue image [4260730006798421]
Dane BadawczeThis is the histopathological image of LIVER AND INTRAHEPATIC BILE DUCTS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Proces wytwarzania e-kursu. Studium przypadku.
PublikacjaArtykuł definiuje proces wytwarzania e-kursu i e-lekcji oraz kolejne jego etapy, zaczynając od okre - ślania celu i odbiorcy, a kończąc na udostępnieniu treści. Na podstawie opisanego procesu przedstawiane jest stu - dium przypadku dla e-kursu prowadzonego na studiach zaocznych na Wydziale ETI Politechniki Gdańskiej na przedmiocie Strategie informatyzacji. Artykuł pokazuje też ewaluację studium przypadku, zarówno na poziomie oceny...
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Nanoparticles: Taking a Unique Position in Medicine
PublikacjaThe human nature of curiosity, wonder, and ingenuity date back to the age of humankind. In parallel with our history of civilization, interest in scientific approaches to unravel mechanisms underlying natural phenomena has been developing. Recent years have witnessed unprecedented growth in research in the area of pharmaceuticals and medicine. The optimism that nanotechnology (NT) applied to medicine and drugs is taking serious...
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Natural Deep Eutectic Solvents as Agents for Improving Solubility, Stability and Delivery of Curcumin
PublikacjaPurpose Study on curcumin dissolved in natural deep eutectic solvents (NADES) was aimed at exploiting their beneficial properties as drug carriers. Methods The concentration of dissolved curcumin in NADES was measured. Simulated gastrointestinal fluids were used to determine the concentration of curcumin and quantum chemistry computations were performed for clarifying the origin of curcumin solubility enhancement in NADES. Results NADES...
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Międzynarodowa droga wodna E-70 jako potencjał rozwojowy Delty Wisły
PublikacjaTransport wodny jest najtańszy, najbezpieczniejszy i najmniej uciążliwy dla środowiska naturalnego. Przywrócenie regularnej żeglugi towarowej pociągnie za sobą rewitalizację istniejącej i budowę nowej infrastruktury przeładunkowo-logistycznej śródlądowych portów handlowych. Kreując politykę transportową, trzeba pamiętać, że transport wodny jest najbardziej ekologicznym rodzajem transportu. Wytwarza zaledwie 10% emisji gazów wydalanych...
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Phase I and phase II metabolism simulation of antitumor-active 2-hydroxyacridinone with electrochemistry coupled on-line with mass spectrometry.
PublikacjaHere, we report the metabolic profile and the results of associated metabolic studies of 2-hydroxyacridinone (2-OH-AC), the reference compound for antitumor-active imidazo- and triazoloacridinones. Electrochemistry coupled with mass spectrometry was applied to simulate the general oxidative metabolism of 2-OH-AC for the first time. The reactivity of 2-OH-AC products to biomolecules was also examined. The usefulness of the electrochemistry...
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Foliate-Targeting Quantum Dots-β-Cyclodextrin Nanocarrier for Efficient Delivery of Unsymmetrical Bisacridines to Lung and Prostate Cancer Cells
PublikacjaTargeted drug delivery by nanocarriers molecules can increase the efficiency of cancer treatment. One of the targeting ligands is folic acid (FA), which has a high affinity for the folic acid receptors, which are overexpressed in many cancers. Herein, we describe the preparation of the nanoconjugates containing quantum dots (QDs) and β-cyclodextrin (β-CD) with foliate-targeting properties for the delivery of anticancer compound...
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Antifungal Activity of Capridine β as a Consequence of Its Biotransformation into Metabolite Affecting Yeast Topoisomerase II Activity
PublikacjaIn the last few years,increasing importance is attached to problems caused by fungal pathogens. Current methods of preventing fungal infections remain unsatisfactory. There are several antifungal compounds whichare highly effective in some cases, however, they have limitations in usage: Nephrotoxicity and other adverse effects. In addition, the frequent use of available fungistatic drugs promotes drug resistance....
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The Substantial Improvement of Amphotericin B Selective Toxicity Upon Modification of Mycosamine with Bulky Substituents
PublikacjaAbstract: Background: It is assumed that the unfavorable selective toxicity of an antifungal drug Amphotericin B (AmB) can be improved upon chemical modification of the antibiotic molecule. Objective: The aim of this study was verification of the hypothesis that introduction of bulky substituents at the amino sugar moiety of the antibiotic may result in diminishment of mammalian vitro toxicity of thus prepared AmB derivatives. Methods:...
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Organic solvents aggregating and shaping structural folding of protein, a case study of the protease enzyme
PublikacjaLow solubility of reactants or products in aqueous solutions can result in the enzymatic catalytic reactions that can occur in non-aqueous solutions. In current study we investigated aqueous solutions containing different organic solvents / deep eutectic solvents (DESs) that can influence the protease enzyme's activity, structural, and thermal stabilities. Retroviral aspartic protease enzyme is responsible for the cleavage of the...
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Molecular mechanism of proton-coupled ligand translocation by the bacterial efflux pump EmrE
PublikacjaThe current surge in bacterial multi-drug resistance (MDR) is one of the largest challenges to public health, threatening to render ineffective many therapies we rely on for treatment of serious infections. Understanding different factors that contribute to MDR is hence crucial from the global “one health” perspective. In this contribution, we focus on the prototypical broad-selectivity proton-coupled antiporter EmrE, one of the...
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Imidazoacridinone-dependent lysosomal photodestruction: a pharmacological Trojan horse approach to eradicate multidrug-resistant cancers
PublikacjaMultidrug resistance (MDR) remains a primary hindrance to curative cancer therapy. Thus, introduction of novel strategies to overcome MDR is of paramount therapeutic significance. Sequestration of chemotherapeutics in lysosomes is an established mechanism of drug resistance. Here, we show that MDR cells display a marked increase in lysosome number. We further demonstrate that imidazoacridinones (IAs), which are cytotoxic fluorochromes,...
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Evaluation of possibilities in identification and susceptibility testing for Candida glabrata clinical isolates with the Integral System Yeast Plus (ISYP)
PublikacjaThe aim of this study was to evaluate possibilities of correct identification and susceptibility testing of C. glabrata clinical isolates with Integral System Yeast Plus (ISYP). For species identification, as the reference method, API Candida test and species-specific PCR reactions were used. The potential of antifungal susceptibility testing by the ISYP test was compared with the Sensititre Yeast One. Whilst the reference methods...
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CYP3A4-dependent cellular response does not relate to CYP3A4-catalysed metabolites of C-1748 and C-1305 acridine antitumor agents in HepG2 cells
PublikacjaHigh CYP3A4 expression sensitizes tumor cells to certain antitumor agents while for others it can lower their therapeutic ef fi cacy. We have elucidated the in fl uence of CYP3A4 overexpression on the cellular response induced by antitumor acridine derivatives, C-1305 and C-1748, in two hepatocellular carcinoma (HepG2) cell lines, Hep3A4 stably transfected with CYP3A4 isoenzyme, and HepC34 expressing empty vector. The compounds...
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obrona pracy doktorskiej na WILiŚ
Wydarzeniaobrona rozprawy doktorskiej mgr inż. Joanny Wachnickiej
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Neoplasm, malignant - Male, 65 - Tissue image [5150730018697771]
Dane BadawczeThis is the histopathological image of LIVER AND INTRAHEPATIC BILE DUCTS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Carcinoma, NOS - Male, 85 - Tissue image [4260730006792921]
Dane BadawczeThis is the histopathological image of LIVER AND INTRAHEPATIC BILE DUCTS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Papillary urothelial carcinoma, non-invasive - Male, 73 - Tissue image [6060730023686211]
Dane BadawczeThis is the histopathological image of BLADDER tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Carcinoma, NOS - Male, 85 - Tissue image [4260730006794491]
Dane BadawczeThis is the histopathological image of LIVER AND INTRAHEPATIC BILE DUCTS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Papillary urothelial carcinoma, non-invasive - Male, 73 - Tissue image [6060730023681501]
Dane BadawczeThis is the histopathological image of BLADDER tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Carcinoma, NOS - Male, 85 - Tissue image [4260730006792631]
Dane BadawczeThis is the histopathological image of LIVER AND INTRAHEPATIC BILE DUCTS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Neoplasm, malignant - Male, 65 - Tissue image [7040247104956061]
Dane BadawczeThis is the histopathological image of LIVER AND INTRAHEPATIC BILE DUCTS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Neoplasm, malignant - Male, 65 - Tissue image [5150730018694911]
Dane BadawczeThis is the histopathological image of LIVER AND INTRAHEPATIC BILE DUCTS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.