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Wyniki wyszukiwania dla: FLEXIBLE PEPTIDES
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On a method of modelling and simulation of vibration surveillance during ball end milling of flexible details
PublikacjaPraca dotyczy nadzorowania drgań podczas frezowania przedmiotów podatnych smukłym frezem kulistym, z uwzględnieniem zgodności parametrów modelu modalnego. Przeprowadzono analizę dynamiki procesu frezowania. Następnie przedstawiono analizę niestacjonarnego układu drgającego, w którym wyodrębniono podukłady: modalny, strukturalny i łączący. Do minimalizacji poziomu drgań zastosowano dopasowanie prędkości obrotowej wrzeciona do optymalnego...
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On a method of modelling and simulation of vibration surveillance during ball end milling of flexible details
PublikacjaPraca dotyczy nadzorowania drgań podczas frezowania przedmiotów podatnych smukłym frezem kulistym, z uwzględnieniem zgodności parametrów modelu modalnego. Przeprowadzono analizę dynamiki procesu frezowania. Następnie przedstawiono analizę niestacjonarnego układu drgającego, w którym wyodrębniono podukłady: modalny, strukturalny i łączący. Do minimalizacji poziomu drgań zastosowano dopasowanie prędkości obrotowej wrzeciona do optymalnego...
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Green TPUs from Prepolymer Mixtures Designed by Controlling the Chemical Structure of Flexible Segments
PublikacjaThis study concerns green thermoplastic polyurethanes (TPU) obtained by controlling the chemical structure of flexible segments. Two types of bio-based polyether polyols—poly(trimethylene glycol)s—with average molecular weights ca. 1000 and 2700 Da were used (PO3G1000 and PO3G2700, respectively). TPUs were prepared via a two-step method. Hard segments consisted of 4,4?- diphenylmethane diisocyanates and the bio-based 1,4-butanodiol...
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Numerically efficient algorithm for compact microwave device optimization with flexible sensitivity updating scheme
PublikacjaAn efficient trust-region algorithm with flexible sensitivity updating management scheme for electromagnetic (EM)-driven design optimization of compact microwave components is proposed. During the optimization process, updating of selected columns of the circuit response Jacobian is performed using a rank-one Broyden formula (BF) replacing finite differentiation (FD). The FD update is omitted for directions sufficiently well aligned...
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Application and evaluation of M-EPDG for performance analysis of Polish typical flexible and rigid pavements
PublikacjaThe main goal of the paper is to implement and evaluate the M-EPDG and the software AASHTOware to analyse the performance of new flexible and rigid pavements designed according to the Polish catalogues, which are comparable with analogous catalogues used in other European countries. For this purpose the site-specific inputs for Poland were determined and described in the paper as well as compared to the default input data used...
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High-Power Jamming Attack Mitigation Techniques in Spectrally-Spatially Flexible Optical Networks
PublikacjaThis work presents efficient connection provisioning techniques mitigating high-power jamming attacks in spectrally-spatially flexible optical networks (SS-FONs) utilizing multicore fibers. High-power jamming attacks are modeled based on their impact on the lightpaths’ quality of transmission (QoT) through inter-core crosstalk. Based on a desired threshold on a lightpath’s QoT, the modulation format used, the length of the path,...
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The biological role of prolyl oligopeptidase and the procognitive potential of its peptidic inhibitors from food proteins
PublikacjaProlyl oligopeptidase (POP) is a conserved serine protease belonging to proline-specific peptidases. It has both enzymatic and non-enzymatic activity and is involved in numerous biological processes in the human body, playing a role in e.g., cellular growth and differentiation, inflammation, as well as the development of some neurodegenerative and neuropsychiatric disorders. This article describes the physiological and pathological...
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Antifungal dipeptides incorporating an inhibitor of homoserine dehydrogenase
PublikacjaThe antifungal activity of 5‐hydroxy‐4‐oxo‐L‐norvaline (HONV), exhibited under conditions mimicking human serum, may be improved upon incorporation of this amino acid into a dipeptide structure. Several HONV‐containing dipeptides inhibited growth of human pathogenic yeasts of the Candida genus in the RPMI‐1640 medium, with minimal inhibitory concentration values in the 32 to 64 μg mL−1 range. This activity was not affected by multidrug...
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LETTERS IN PEPTIDE SCIENCE
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Synthesis and antimicrobial activity of amino acid and peptide derivatives of mycophenolic acid
PublikacjaThe series of 16 novel amino acid and peptide mycophenolic acid (MPA) derivatives was obtained as potential antibacterial agents. Coupling of MPA with respective amines was optimized with condensing reagents such as EDCI/DMAP and T3P/TEA. Amino acid analogs were received both as methyl esters and also with the free carboxylic group. The biological activity of the products was tested on five references bacterial strains: Klebsiella...
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Evaluation of Receptor Affinity, Analgesic Activity and Cytotoxicity of a Hybrid Peptide, AWL3020
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Double amino acid – A novel molecule enabling peptide interpenetrating structures
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Synthesis and conformational analysis of salivary proline-rich peptide P-B
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Antimicrobial and conformational studies of the active and inactive analogues of the protegrin-1 peptide
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Modified Peptide Molecules As Potential Modulators of Shelterin Protein Functions; TRF1
PublikacjaIn this work, we present studies on relatively new and still not well-explored potential anticancer targets which are shelterin proteins, in particular the TRF1 protein can be blocked by in silico designed "peptidomimetic" molecules. TRF1 interacts directly with the TIN2 protein, and this protein-protein interaction is crucial for the proper functioning of telomere, which could be blocked by our novel modified peptide molecules....
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Triple helical collagen-like peptide interactions with selected polyphenolic compounds
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Synthesis and Evaluation of Biological Activity of Antimicrobial – Pro-Proliferative Peptide Conjugates
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Increased Urinary C-Peptide and Albumin Excretion in Juvenile Borderline Hypertensives
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Interactions in aqueous solutions of K-peptide and DMSO – spectroscopic and calorimetric studies
PublikacjaIntroduction K-peptide (GILQINSRW) – short 9 amino acid fragment of the hen egg white lysozyme has the ability to form amyloid structures. Dimethyl sulfoxide (DMSO) is an osmolyte which can alter this ability. Our goal was to get an insight into the mechanism of Kpeptide-DMSO interactions in aqueous solutions. Such a knowledge can be helpful to understand processes leading to various neurodegenerative diseases. Methods ATR-FTIR...
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Non-ribosomal peptides produced by Planktothrix agardhii from Siemianówka Dam Reservoir SDR (northeast Poland)
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Multiple β-sheet molecular dynamics of amyloid formation from two ABl-SH3 domain peptides
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Chicken feather keratin as a source of bioactive peptides useful in prevention of metabolic disorders – in silico and in vitro hydrolysis
PublikacjaProtein derived bioactive peptides not only serve as nutrients but can also exert drug-like activity, e.g. antidiabetic, antihypertensive, or antimicrobial, to name a few. Most biopeptides have beneficial effects on health that make them attractive for nutraceutical applications. The majority of bioactive peptides have been obtained from food proteins, but protein-rich by-products generated by agriculture...
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Inhibitory and antimicrobial activities of OGTI and HV-BBI peptides, fragments and analogs derived from amphibian skin
PublikacjaA series of linear and cyclic fragments and analogs of two peptides (OGTI and HV-BBI) isolated from skin secretions of frogs were synthesized by the solid-phase method. Their inhibitory activity against several serine proteinases: bovine beta-trypsin, bovine alpha-chymotypsin, human leukocyte elastase and cathepsin G from human neutrophils, was investigated together with evaluation of their antimicrobial activities against Gram-negative...
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Fabrication and Characterization of Flexible Medical-Grade TPU Filament for Fused Deposition Modeling 3DP Technology
PublikacjaThe possibility of using additive manufacturing (AM) in the medicine area has created new opportunities in health care. This has contributed to a sharp increase in demand for 3D printers, their systems and materials that are adapted to strict medical requirements. We described herein a medical-grade thermoplastic polyurethane (S-TPU) which was developed and then formed into a filament for Fused Deposition Modeling (FDM) 3D printers...
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Ultra-stable sandwich shaped flexible MXene/CNT@Ni films for high performance supercapacitor
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On dynamics of flexible branched shell structures undergoing large overall motion using finite elements
PublikacjaZaprezentowano autorski algorytm do analizy dynamicznej powłok sprężystych oparty na niejawnym schemacie Newmarka. Rozważania dotyczą całkowania po czasie dynamicznych równań ruchu sformułowanych w ramach nieliniowej sześcioparametrowej teorii powłok. Opracowanie zawiera pewne elementy analizy statycznej, poprzedzającej badania dynamiczne. Przykłady numeryczne prezentują zastosowanie algorytmu stanowią podstawową część pracy.
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Vibration surveillance in the hybrid system on example of milling flexible details and considering assurance of modal subsystem.
PublikacjaPraca dotyczy nadzorowania drgań dużych mechanicznych układów niestacjonarnych modelowanych dyskretnie, za pomocą sterowania optymalnego przy energetycznym wskaźniku jakości. W układzie drgającym wyodrębniono podukład modalny, podukład strukturalny oraz podukład łączący. Dynamikę układu sterowanego opisano we współrzędnych hybrydowych, przez co uzyskano znacznie mniejszy rząd niż w przypadku modelu strukturalnego. Zdefiniowano...
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Optimal spindle speed determination for vibration reduction during ball-end milling of flexible details
PublikacjaIn the paper a method of optimal spindle speed determination for vibration reduction during ball-end milling of flexible details is proposed. In order to reduce vibration level, an original procedure of the spindle speed optimisation, based on the Liao–Young criterion, is suggested. As the result, an optimal, constant spindle speed value is determined. For this purpose, on-stationary computational model of machining process is...
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Study of the effect of thermally reduced graphene oxide on the physical and mechanical properties of flexible polyurethane foams
PublikacjaFlexible polyurethane foams were obtained from a two-component system via the one-step method. The foams were modified with thermally reduced graphene oxide added in the amount equal to 0.25, 0.5 and 0.75 wt%. The morphology, static and dynamic properties, and thermal stability of modified foams were determined. The application of carbon filler resulted in the visible increase in the cell size, apparent density and rigidity of...
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A novel method for vibration surveillance during high speed ball end milling of flexible details
PublikacjaPraca dotyczy nadzorowania drgań podczas obróbki zakrzywionych przedmiotów podatnych frezem kulistym, z uwzględnieniem zgodności parametrów modelu modalnego. Przedstawiono analizę dynamiki niestacjonarnego okładu drgającego, z którego wydzielono podukład modalny, strukturalny i łączący. Zastosowano minimalizację poziomu drgań z dopasowaniem prędkości obrotowej wrzeciona do optymalnego kąta przesunięcia fazowego. Eksperymenty doświadczalne...
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A novel method for vibration surveillance during high speed ball end milling of flexible details
PublikacjaPraca dotyczy nadzorowania drgań układów niestacjonarnych modelowanych metodą elementów skończonych. Obróbka frezem kulistym przedmiotów podatnych jest często stosowana w przypadku nowoczesnych centrów obróbkowych. Drgania względne narzędzie-przedmiot obrabiany mogą doprowadzić do utraty stabilności i powstania drgań samowzbudnych typu chatter. W pracy proponuje się metodę minimalizacji poziomu drgań poprzez dopasowanie prędkości...
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Non-linear behaviour of base-isolated building supported on flexible soil under damaging earthquakes
PublikacjaSeismic isolation is a strategy to reduce damage of structures exposed to devastating earthquake excitations. Isolation systems, applied at the base of buildings, lower the fundamental frequency of the structure below the range of dominant frequencies of the ground motion as well as allow to dissipate more energy during structural vibrations. The effectiveness of the base-isolated buildings in damage reduction has been confirmed...
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Creation of a map of optimal spindle speeds for a purpose of surveillance of high speed milling of flexible details
PublikacjaDrgania samowzbudne typu chatter często towarzyszą procesom frezowania szybkościowego. Ich skutkiem są nieodwracalne uszkodzenia powierzchni obrabianej. Mogą one również doprowadzić do intensywnego zużycia narzędzi skrawających, a nawet samej obrabiarki. W pracy przedstawiono metodę umożliwiającą tworzenie mapy optymalnych prędkości obrotowych wrzeciona. Stosowanie podczas procesu frezowania optymalnej prędkości obrotowej wrzeciona...
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Comparison of ZnO:Al, ITO and carbon nanotube transparent conductive layers in flexible solar cells applications
PublikacjaW artykule zostały przetestowane różne typy transparentnych elektrod z uwagi na właściwości mechaniczne, optyczne oraz elektryczne. Wszystkie przebadane materiały zostały nałożone w postaci warstw na podłoża elastyczne. Otrzymane wyniki zostały porównane z danymi dla podłoży sztywnych.
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Determination of Equivalent Axle Load Factors on the Basis of Fatigue Criteria for Flexible and Semi-Rigid Pavements
PublikacjaArtykuł przedstawia analizę współczynników równoważności obciążenia osi na podstawie kryteriów zmęczeniowych stosowanych w mechanistyczno-empirycznych metodach projektowania nawierzchni. Określono wzory służące do obliczania współczynnika w oparciu o szereg kryteriów zmęczeniowych. Podano wartości liczbowe współczynników.
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T-House. Shaping Ergonomic and Flexible Interiors in Modular Form Connected to Horticultural Therapy Zone
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Comparative analysis of the flow control over a circular cylinder with detached flexible and rigid splitter plates
PublikacjaA comparative study is performed on a circular cylinder with both flexible and rigid splitter plates (SPs). This study has the novelty of using single and dual detached SPs located downstream of the cylinder. The dimensionless gap distance between the first splitter plate and the cylinder as well as the distance between the SPs are varied. The strain of flexible SPs can be used for energy harvesting from the flow. Therefore, a...
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Insights into Stoichiometry Adjustments Governing the Performance of Flexible Foamed Polyurethane/Ground Tire Rubber Composites
PublikacjaPolyurethanes (PU) are widely applied in the industry due to their tunable performance adjusted by changes in the isocyanate index—stoichiometric balance between isocyanate and hydroxyl groups. This balance is affected by the incorporation of modifiers of fillers into the PU matrix and is especially crucial for PU foams due to the additional role of isocyanates—foaming of the material. Despite the awareness of the issue underlined...
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The Effect of Flexible Pavement Mechanics on the Accuracy of Axle Load Sensors in Vehicle Weigh-in-Motion Systems
PublikacjaWeigh-in-Motion systems are tools to prevent road pavements from the adverse phenomena of vehicle overloading. However, the effectiveness of these systems can be significantly increased by improving weighing accuracy, which is now insufficient for direct enforcement of overloaded vehicles. Field tests show that the accuracy of Weigh-in-Motion axle load sensors installed in the flexible (asphalt) pavements depends on pavement temperature...
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A comprehensive evaluation of flexible FDM/FFF 3D printing filament as a potential material in medical application
PublikacjaThe use of FDM/FFF in 3D printing for medical sciences is becoming common. This is due to the high availability and decent price of both 3D printers and filaments useful for FDM/FFF. Currently, researchers' attention is focused mainly on the study of medical filaments based on PLA, PCL or their modifications. This contributes to insufficient diversity of medical-grade filaments on the market. Moreover, due to the lack of specified...
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A Flexible Nafion Coated Enzyme‐free Glucose Sensor Based on Au‐dimpled Ti Structures
PublikacjaThe detection of glucose at low concentrations using electrochemical sensors is of great importance due to the possibility of using different human body fluids than blood, such as e.g. urine, saliva, sweat or tears. The interest behind those biofluids is related to their utility in non-invasive sugar determination. In this work, we present flexible, fully biocompatible electrode material based on Au nanoparticles immobilized onto...
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Reduction of vibration level by the spindle speed optimisation during ball end milling of flexible details
PublikacjaPraca dotyczy nadzorowania drgań podczas skrawania przedmiotów podatnych frezem kulistym. Przedsatwiono wspomaganą komputerowo procedurę nadzorowania z optymalizacją prędkości obrotowej narzędzia. Przy modelowaniu wykorzystano niestacjonarny model obliczeniowy. Rezultatem modelowania jest układ hybrydowy, w którym oddzielono podukłady: modalny, łączący i strukturalny. Metoda wymaga identyfikacji częstości własnych co może być wykonane...
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PTD4 Peptide Increases Neural Viability in an In Vitro Model of Acute Ischemic Stroke
PublikacjaIschemic stroke is a disturbance in cerebral blood flow caused by brain tissue ischemia and hypoxia. We optimized a multifactorial in vitro model of acute ischemic stroke using rat primary neural cultures. This model was exploited to investigate the pro-viable activity of cell-penetrating peptides: arginine-rich Tat(49–57)-NH2 (R49KKRRQRRR57-amide) and its less basic analogue, PTD4 (Y47ARAAARQARA57-amide). Our model included glucose...
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Release systems based on self-assembling RADA16-I hydrogels with a signal sequence which improves wound healing processes
PublikacjaSelf-assembling peptides can be used for the regeneration of severely damaged skin. They can act as scaffolds for skin cells and as a reservoir of active compounds, to accelerate scarless wound healing. To overcome repeated administration of peptides which accelerate healing, we report development of three new peptide biomaterials based on the RADA16-I hydrogel functionalized with a sequence (AAPV) cleaved by human neutrophil elastase...
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Tissue fixed with formalin and processed without paraffin embedding is suitable for imaging of both peptides and lipids by MALDI-IMS
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Taste-active peptides and amino acids of pork meat as components of dry-cured meat products: An in-silico study
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Hydrazone Linker as a Useful Tool for Preparing Chimeric Peptide/Nonpeptide Bifunctional Compounds
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Imunofan - RDKVYR peptide - stimulates skin cell proliferation and promotes tissue repair
PublikacjaRegeneration and wound healing are vital to tissue homeostasis and organism survival. One of the biggest challenges of today's science and medicine is finding methods and factors to stimulate these processes in the human body. Effective solutions to promote regenerative responses will accelerate advances in tissue engineering, regenerative medicine, transplantology, and a number of other clinical...
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Rapid PD-L1 detection in tumors with PET using a highly specific peptide
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A Novel Cryptic Clostridial Peptide That Kills Bacteria by a Cell Membrane Permeabilization Mechanism
PublikacjaThis work reports detailed characteristics of the antimicrobial peptide Intestinalin (P30), which is derived from the LysC enzyme of Clostridium intestinale strain URNW. The peptide shows a broader antibacterial spectrum than the parental enzyme, showing potent antimicrobial activity against clinical strains of Gram-positive staphylococci and Gram-negative pathogens and causing between 3.04 ± 0.12 log kill for Pseudomonas aeruginosa...