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Wyniki wyszukiwania dla: metabolity wtorne roslin
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Effect of GO-Fe3O4 and rotating magnetic field on cellular metabolic activity of mammalian cells
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Ability of Yeast Metabolic Activity to Reduce Sugars and Stabilize Betalains in Red Beet Juice
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Identification of the metabolic fingerprints in women with polycystic ovary syndrome using the multiplatform metabolomics technique
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Associations of ESR1 and ESR2 gene polymorphisms with metabolic syndrome and its components in postmenopausal women
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Metabolic transformations of antitumor imidazoacridinone, C-1311, with microsomal fractions of rat and human liver
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Metabolic transformations of antitumor imidazoacridinone, C-1311, with microsomal fractions of rat and human liver
PublikacjaWykazano, że enzymatyczna aktywacja jest konieczna dla aktywności biologicznej pochodnej C-1311 (Symadex R), która znajduje się w II fazie badań klinicznych. Zbadano przemiany enzymatyczne tego związku w obecności frakcji enzymatycznych mikrosomalnych komórek wątroby szczura i ludzkiej. Badania te wykazały, że związek C-1311 jest bardziej podatny na przemiany w obecności frakcji mikrosomalnej niż S9 i cytozolowej. Inkubacja związku...
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The influence of different expression of CYP3A4 izoenzymes on metabolic pathway derivatives in human hepatoma cells
PublikacjaCelem przeprowadzonych badań było określenie różnic w metabolizmie pochodnych C-857 i C-1748 w komórkach ludzkiego nowotworu wątroby HepG2 oraz określenie wpływu na ich biotransformację w podwyższonej ekspresji izoenzymu CYP3A4 w tejże linii. Uzyskane wyniki wskazały, że związek C-857, jak również C-1748 metabolizuje w komórkach HepG2 oraz Hep3A4 do wielu reaktywnych, niestabilnych metabolitów. Różnice w biotransformacji były bardzo...
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Pathogenesis of psoriasis in the “omic” era. Part III. Metabolic disorders, metabolomics, nutrigenomics in psoriasis
PublikacjaPsoriasis is a systemic disease that is strictly connected with metabolic disorders (insulin resistance, atherogenic dyslipidemia, arterial hypertension, and cardiovascular diseases). It occurs more often in patients with a more severe course of the disease. Obesity is specially an independent risk factor and it is associated with a worse treatment outcome because of the high inflammatory activity of visceral fatty tissue and...
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Electrochemical and in silico approaches for liver metabolic oxidation of antitumor-active triazoloacridinone C -1305
Publikacja5-Dimethylaminopropylamino-8-hydroxytriazoloacridinone (C-1305) is a promising antitumor compound developed in our laboratory. A better understanding of its metabolic transformations is still needed to explain the multidirectional mechanism of pharmacological action of triazoloacridinone derivatives at all. Thus, the aim of the current work was to predict oxidative pathways of C-1305 that would reflect its phase I metabolism. The...
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Multivariate Statistical Approach for Nephrines in Womenwith Obesity
PublikacjaCatecholamines are physiological regulators of carbohydrate and lipid metabolism during stress, but their chronic influence on metabolic changes in obese patients is still not clarified. The present study aimed to establish the associations between the catecholamine metabolites and metabolic syndrome (MS) components in obese women as well as to reveal the possible hidden subgroups of patients through hierarchical cluster analysis...
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Żywienie Człowieka i Metabolizm
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Mediterranean Journal of Nutrition and Metabolism
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Indian Journal of Endocrinology and Metabolism
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Therapeutic Advances in Endocrinology and Metabolism
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JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
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Journal of Nutrition and Intermediary Metabolism
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Turkish Journal of Endocrinology and Metabolism
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Drug Metabolism and Personalized Therapy
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DIABETES-METABOLISM RESEARCH AND REVIEWS
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International Journal of Endocrinology and Metabolism
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Journal of Drug Metabolism & Toxicology
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Expert Review of Endocrinology & Metabolism
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Iranian Journal of Endocrinology and Metabolism
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Annals of Pediatric Endocrinology and Metabolism
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Chinese Journal of Endocrinology and Metabolism
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JOURNAL OF BONE AND MINERAL METABOLISM
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JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
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International Journal of Diabetes and Metabolism
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Vibration Diagnostics of Rolling Mills Based on Nonlinear Effects in Dynamics
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The rolling contact fatigue of WC/C-coated spur gears
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Wpływ stresu pracy mundurowych na funkcjonowanie ich rodzin
PublikacjaW niniejszym artykule podjęto problem zagrożeń w funkcjonowaniu rodzin policjantów jako skutku stresu pracy . Głównie niestabilność oraz niedostępność emocjonalna funkcjonariuszy sprzyjają gorszemu funkcjonowaniu zarówno związku małżeńskiego, jak i całej rodziny. Ryzykowne zachowania wynikające ze stresu pracy wiązały się z agresją i spożywaniem alkoholu. Koszty stresu pracy męża ponoszą głównie ich żony, które równocześnie odgrywają...
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Reduction of Tire Rolling Resistance by Optimization of Road Surfaces and Tires
PublikacjaDuring interaction between tire and road surface three very important phenomena are always in effect. One of them (very desirable) is friction that is important for traction, braking and cornering. Two other phenomena are not desirable at all, that is rolling resistance and noise. This paper discusses relations between road surface and tire parameters versus tire rolling resistance. Road surface texture, porosity, impedance, strength...
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Comparison of Tire Rolling Resistance Measuring Methods for Different Surfaces
PublikacjaThe rolling resistance of car tires is one of the most important parameters characterizing tires today. This resistance has a very significant contribution to the energy consumption of wheeled vehicles. The climate crisis has forced tire and car manufacturers to place great emphasis on the environmental impact of their products. Paradoxically, the development of electric vehicles has led to an even greater importance of rolling...
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Reduction of noise and rolling resistance by horizontal grinding of asphalt pavements
PublikacjaGrinding of cement concrete pavements to reduce unevenness and noise is common since a long time. Grinding is then made with wheels equipped with diamond blades rotating in the vertical plane. This creates narrow vertical/longitudinal grooves in the pavement. It is not applied to asphalt pavements. In this paper an alternative type of grinding is studied. In this case plates with diamond heads rotate in the same plane as the pavement,...
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DESIGN AND CALIBRATION OF ROLLING RESISTANCE TEST TRAILER R2mk.2
PublikacjaThe paper describes construction nad calibration procedures of the rolling resistance test trailer R2 Mk2. The trailer is design to measure rolling resistance of passenger car tyres in various road conditions on trafficked road. The trailer utilizes so called angle method also known as vertical arm method. The paper presents also calibration procedures that are necessary to ascertain good precision of the measurements.
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Peculiarities associated with testing polyetheretherketone (PEEK) in a model rolling contact
PublikacjaPolyetheretherketone (PEEK) was investigated using a modified version of the four-ball tester in which the upper forth ball was replaced by a cone in such a way that kinematics of the four-ball configuration were fully preserved. Rotation of the cone enforced orbiting and rolling of the ceramic balls around the polymer cup. The results produced some unexpected peculiarities in the wear of ceramic balls which, in principle, should...
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Hardened Steel Surface Waviness Created by Rolling Burnishing Process
PublikacjaThe surface of the finishing machined parts is defined mainly by roughness parameters. Growing demands on the part, especially mating sliding or rolling, require the specification of additional parameters, such as waviness parameters, particularly when there is significant resistance to seizing or noise reduction. This paper presents surface waviness characteristics of hardened burnished steel.
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The Roughness of the Hardened Steel Surface Created by the Rolling-Burnishing Process
PublikacjaBurnishing hard materials can be used as an alternative finishing process. this paper presents the results of burnishing hardened steel. The article discusses surface deformation that occurs during this process and depends on the selected parameters of the geometric structure of the force applied for surface burnishing.
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Selected Aspects of Pavement Texture Influence on Tire Rolling Resistance
PublikacjaTire rolling resistance has a significant influence on fuel consumption in cars and trucks and on CO2 emissions. Rolling resistance depends on the tire construction, pavement texture and stiffness, as well as environmental and traffic conditions. This article presents a pilot study on the impact of pavement texture on the rolling resistance of passenger car tires. Reasons why Mean Profile Depth is not a good descriptor of pavement...
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Impact of the surface evenness and texture on tire/road rolling resistance
PublikacjaThis paper deals with the issue of a surface's roughness and texture impact on tire/road rolling resistance. It includes a brief description of research aims, measurements and an analysis of results. It also presents observations and conclusions regarding drum facility modernisation which allows studies concerning surface's roughness and texture impact on tire/road rolling resistance.
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Efficient recovery of electrophoretic profiles of nucleoside metabolites from urine samples by multivariate curve resolution
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Metabolism of 1α-hydroxyvitamin D3 by cytochrome P450scc to biologically active 1α,20-dihydroxyvitamin D3
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Absolute Configuration Determination by Quantum Mechanical Calculation of Chiroptical Spectra: Basics and Applications to Fungal Metabolites
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Photosynthesis and sucrose metabolism in leaves of Arabidopsis thaliana aos, ein4 and rcd1 mutants as affected by wounding
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Stability of texture, meltability and water mobility model of pizza-style cheeses from goat's milk
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COMPOSITION OF BIOACTIVE SECONDARY METABOLITES AND MUTAGENICITY OF SAMBUCUS NIGRA L. FRUIT AT DIFFERENT STAGES OF RIPENESS
PublikacjaThe relationship between the content of bioactive compounds and mutagenic activity of elderberry fruit at different stages of ripeness was investigated. Signifi cant differences in the antioxidant profi les (TLC, HPLC with post-column derivatization) and antioxidant activity (ABTS, DPPH, and FC tests) were observed for studied elderberry extracts. The more ripen the fruit at the time of harvest were, the higher the content of...
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Transcriptome profiling reveals distinctive traits of retinol metabolism and neonatal parallels in the MRL/MpJ mouse
PublikacjaBackground: The MRL/MpJ mouse is a laboratory inbred strain known for regenerative abilities which are manifested by scarless closure of ear pinna punch holes. Enhanced healing responses have been reported in other organs. A remarkable feature of the strain is that the adult MRL/MpJ mouse retains several embryonic biochemical characteristics, including increased expression of stem cell markers. Results: We explored the transcriptome...
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Integrating conventional nitrogen removal with anammox in wastewater treatment systems: Microbial metabolism, sustainability and challenges
PublikacjaThe various forms of nitrogen (N), including ammonium (NH4+), nitrite (NO2−), and nitrate (NO3−), present in wastewaters can create critical biotic stress and can lead to hazardous phenomena that cause imbalances in biological diversity. Thus, biological nitrogen removal (BNR) from wastewaters is considered to be imperatively urgent. Therefore, anammox-based systems, i.e. partial nitrification and anaerobic ammonium oxidation (PN/anammox)...
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Chemistry of human breast milk – a comprehensive review of the composition and role of milk metabolites in child development
PublikacjaEarly nutrition has an enormous influence on a child's physiological function, immune system maturation and cognitive development. Human breast milk (HBM) is recognized as the gold standard for human infant nutrition. Accordingly to WHO report breastfeeding is consider as an unequalled way of providing ideal food to the infant, which is required for his healthy growth and development. HBM contains various macronutrients (carbohydrates,...
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Lithuania inland waterways and its prospects
PublikacjaInland waterways have some traditions in Lithuania and in neighbor Countries, but during last 50 years other modes of transport move out inland waterway transport from real economical activity. In the same time inland waterways is the main green and sustainable transport system. In this article are presented analysis situation, methodology for the ships optimal using in inland waterways, forecasting of the possible cargo and passenger...