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Wyniki wyszukiwania dla: diminished toxicity
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Diminished toxicity of C-1748, 4-methyl-9-hydroxyethylamino-1-nitroacridine, compared with its demethyl analog, C-857, corresponds to its resistance to metabolism in HepG2 cells
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Diminshed toxicity of C-1748, 4-methyl-9-hydroxyethylamino-1-nitroacridine, compared with its demethyl analog, C-857, corresponds to its resistance to metabolism in HepG2 cells
PublikacjaThe narrow "therapeutic window" of anti-tumour therapy may be the result of drug metabolism leading to the activation or detoxification of antitumour agents. The aim of this work is to examine (i) whether the diminished toxicity of a potent antitumour drug, C-1748, 9-(2'-hydroxyethylamino)-4-methyl-1-nitroacridine, compared with its 4-demethyl analogue, C-857, results from the differences between the metabolic pathways for the...
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Prolonged Quercetin Administration Diminishes the Etoposide-Induced DNA Damage in Bone Marrow Cells of Rats
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Tea and Liver Antioxidant Capabilities in Ethanol Toxicity
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Chemoinformatic Approach to Assess Toxicity of Ionic Liquids
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Environmental risk, toxicity, and biodegradation of polyethylene: a review
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In vitro toxicity studies of biodegradable, polyelectrolyte nanocapsules
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Cadmium and lead toxicity and bioaccumulation in Microcystis aeruginosa
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Rapid test for ionic liquids toxicity evaluation
PublikacjaW literaturze przedmiotu dostępne są dane na temat toksyczności cieczy jonowych, szczególności tych mających zastosowanie przemysłowe, gdzie toksyczność wyrażana jest jako EC50 mierzone względem konkretnego organizmu np. Vibrio fischeri, Daphnia magna itp. Z uwagi na taksonomiczne zróżnicowanie osadu czynnego nie jest możliwe bezpośrednie wnioskowanie na temat toksyczności cieczy jonowych w stosunku do osadu czynnego na podstawie...
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Acute hypoxia diminishes the relationship between blood pressure and subarachnoid space width oscillations at the human cardiac frequency
PublikacjaAcute hypoxia exerts strong effects on the cardiovascular system. Heart-generated pulsatile cerebrospinal fluid motion is recognised as a key factor ensuring brain homeostasis. We aimed to assess changes in heart-generated coupling between blood pressure and subarachnoid space width oscillations during hypoxic exposure.
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Multi-Objective Genetic Algorithm (MOGA) As a Feature Selecting Strategy in the Development of Ionic Liquids’ Quantitative Toxicity–Toxicity Relationship Models
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Daphnia magna model in the toxicity assessment of pharmaceuticals: A review
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Influence of ozonation and biodegradation on toxicity of industrial textile wastewater
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Application of Fenton oxidation to reduce the toxicity of mixed parabens
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Problems in toxicity analysis - application of fuzzy neural networks
PublikacjaPraca dotyczy zastosowania sztucznych sieci neuronowych do przygotowywania danych do szacowania toksyczności (wody powierzchniowe). Przygotowanie to polega na sztucznym zagęszczaniu zbioru danych, które następnie mogą być wykorzystane do szacowania/modelowania wartości toksyczności na ich podstawie.
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Toxicity and chemical analyses of airport runoff waters in Poland
PublikacjaThe aim of this study was to assess the ecotoxicological effects of various compounds in complex airport effluents using a chemical and ecotoxicological integrated strategy. The present work deals with the determination of sum of PCBs, PAHs, pesticides, cations, anions, phenols, anionic, cationic, non-ionic detergents, formaldehyde and metals – as well as TOC and conductivity – in runoff water samples collected from 2009 to 2011...
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Biosurfactants - Biodegradability, toxicity, efficiency in comparison with synthetic surfactants
PublikacjaBiosurfactants are natural surface active agents produced by variety of bacteria yeast and fungi. A review of their biodegradability, toxicity and efficiency is presented in order to compare their properties with synthetic surfactants. Due to their high efficiency in many applications and environmentally friendly character we tried to apply them in oil refining process. The efficiency of biosurfactants in this application was very...
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Toxicity of the New Psychoactive Substance (NPS) Clephedrone (4-Chloromethcathinone, 4-CMC): Prediction of Toxicity Using In Silico Methods for Clinical and Forensic Purposes
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Preliminary study on toxicity of aquatic ecosystems in Bug river basin
PublikacjaW pracy zaprezentowano badania toksyczności wody, osadów i ścieków wykonane w dorzeczu rzeki Bug w 2001 r. Stosując standardowe mikrobiotesty, określono toksyczność wobec roślin, bakterii i skorupiaków. Wody powierzchniowe w dorzeczu rzeki Bug zakwalifikowano jako nietoksyczne, z wyjątkiem górnego dorzecza i punktu w Terespolu. Większość próbek ścieków wykazywała toksyczność wobec organizmów wskaźnikowych, przy czym różnice w odpowiedzi...
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Molecular Umbrellas Modulate the Selective Toxicity of Polyene Macrolide Antifungals
PublikacjaAntifungal polyene macrolide antibiotics Amphotericin B (AmB) and Nystatin (NYS) were conjugated through the ω-amino acid linkers with diwalled “molecular umbrellas” composed of spermidine-linked deoxycholic or cholic acids. The presence of “umbrella” substituents modulated biological properties of the antibiotics, especially their selective toxicity. Some of the AmB-umbrella conjugates demonstrated antifungal in vitro activity...
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Sensors for Rapid Detection of Environmental Toxicity in Blood of Poisoned People
PublikacjaRecently, the diagnosis and treatment of poisoned person can be done only in specialized centers. Furthermore, currently used clinical methods of intoxication diagnosis are not sufficient for early detection. Conventional laboratory tests based on urine and blood require professional, high skilled staff, high cost equipment as well as they are arduous and lasting analytical procedures. There is a need to elaborate relatively cheap...
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Analytical and bioanalytical problems associated with the toxicity of elemental sulfur in the environment
PublikacjaWe summarize the state of knowledge on the toxicity and the bioavailability of elemental sulfur. We also present: analytical methods used to determine the elemental sulfur content of samples with complex matrices; and, problems and difficulties encountered while using biotests for samples containing elemental sulfur.
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Mitigating metal-organic framework (MOF) toxicity for biomedical applications
PublikacjaMetal-organic frameworks (MOFs) are a novel class of crystalline porous materials, consisting of metal ions and organic linkers. These hybrid materials are highly porous and have a large specific surface area, making them of great interest for applications in gas separation, energy storage, biomedical imaging, and drug delivery. As MOFs are being explored for biomedical applications, it is essential to comprehensively assess their...
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The effect of processing on the nutritional value and toxicity of foods. Chapter 13
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Pregnane X receptor dependent up-regulation of CYP2C9 and CYP3A4 in tumor cells by antitumor acridine agents, C-1748 and C-1305, selectively diminished under hypoxia
PublikacjaInduction of proteins involved in drug metabolism and in drug delivery has a significant impact on drug-drug interactions and on the final therapeutic effects. Two antitumor acridine derivatives selected for present studies, C-1748 (9-(2’-hydroxyethylamino)-4-methyl-1-nitroacridine) and C-1305 (5-dimethylaminopropylamino-8-hydroxy-triazoloacridinone), expressed high and low susceptibility to metabolic transformations with liver...
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α-Lipoic Acid Reduces Ceramide Synthesis and Neuroinflammation in the Hypothalamus of Insulin-Resistant Rats, While in the Cerebral Cortex Diminishes the β-Amyloid Accumulation
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Gold Nanoparticles (AuNPs)—Toxicity, Safety and Green Synthesis: A Critical Review
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Azo dyes: Sources, occurrence, toxicity, sampling, analysis, and their removal methods
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Site environment type – The main factor of urban road dust toxicity?
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Cytotoxicity, acute and subchronic toxicity of ionic liquid, didecyldimethylammonium saccharinate, in rats
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Impact of Hydrogen Peroxide on the UVC Photolysis of Diclofenac and Toxicity of the Phototransformation Products
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Ozone-Based Technologies for Parabens Removal from Water: Toxicity Assessment
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The role of the enzymatic antioxidant system in cylindrospermopsin-induced toxicity in human lymphocytes
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Toxicity of cylindrospermopsin in human lymphocytes: Proliferation, viability and cell cycle studies
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Are Titania Photocatalysts and Titanium Implants Safe? Review on the Toxicity of Titanium Compounds
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Binary Mixtures of Selected Bisphenols in the Environment: Their Toxicity in Relationship to Individual Constituents
PublikacjaBisphenol A (BPA) is one of the most popular and commonly used plasticizer in the industry. Over the past decade, new chemicals that belong to the bisphenol group have increasingly been used in industrial applications as alternatives to BPA. Nevertheless, information on the combined effects of bisphenol (BP) analogues is insufficient. Therefore, our current study aimed to find the biological response modulations induced by the...
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Amygdalin: Toxicity, Anticancer Activity and Analytical Procedures for Its Determination in Plant Seeds
PublikacjaAmygdalin (D-Mandelonitrile 6-O--D-glucosido--D-glucoside) is a natural cyanogenic glycoside occurring in the seeds of some edible plants, such as bitter almonds and peaches. It is a medically interesting but controversial compound as it has anticancer activity on one hand and can be toxic via enzymatic degradation and production of hydrogen cyanide on the other hand. Despite numerous contributions on cancer cell lines, the clinical...
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Detrimental effects of chemotherapeutics and other drugs on the endothelium: A call for endothelial toxicity profiling
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Mitochondria dysfunction is one of the causes of diclofenac toxicity in the green alga Chlamydomonas reinhardtii
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Comparison of the Toxicity of Pristine Graphene and Graphene Oxide, Using Four Biological Models
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<p>Analysis of toxicity and anticancer activity of micelles of sodium alginate-curcumin</p>
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Zinc oxide nanoparticles toxicity toDaphnia magna: size-dependent effects and dissolution
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Organomercury Compounds in Environmental Samples: Emission Sources, Toxicity, Environmental Fate, and Determination
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A link between seasonality and radiation-related toxicity: The big time or time will tell?
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Effect of biochar activation by different methods on toxicity of soil contaminated by industrial activity
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Chemometric estimation of natural water and sediment using toxicity tests and physicochemical parameters
PublikacjaOceny jakości wód dokonano na podstawie analizy chemometrycznej bazy danych monitoringowych, składającej się z wyników testów toksyczności i wyników badań parametrów fizykochemicznych. Badaniom poddano próbki wód powierzchniowych pobrane z Jeziora Turawskiego oraz próbki wód podziemnych pobranych z otworów badawczych wykonanych w jego dnie, jak i wokół niego. Zastosowano następujące metody chemometryczne: analizę wiązkową i analizę...
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Organic micropollutants paracetamol and ibuprofen—toxicity, biodegradation, and genetic background of their utilization by bacteria
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Modeling of pharmaceuticals mixtures toxicity with deviation ratio and best-fit functions models
PublikacjaThe present study deals with assessment of ecotoxicological parameters of 9 drugs (diclofenac (sodium salt), oxytetracycline hydrochloride, fluoxetine hydrochloride, chloramphenicol, ketoprofen, progesterone, estrone, androstenedione and gemfibrozil), present in the environmental compartments at specific concentration levels, and theirmutual combinations by couples against Microtox® and XenoScreen YES/YAS® bioassays. As the quantitative...
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Assessing Acute Toxicity of Selected Packages Internal Layers Extracts using Microtox®
PublikacjaIn the scientific literature related to the widely understood issue of packaging materials designed to have contact with food (food contact materials), there is much information on raw materials used for their production, as well as their physiochemical properties, types and parameters. Unfortunately, not much attention is given to the issues concerning migration of toxic substances from packaging and its actual influence on the...
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Selected issues related to the toxicity of ionic liquids and deep eutectic solvents—a review
PublikacjaGreen Chemistry plays a more and more important role in implementing rules of sustainable development to prevent environmental pollution caused by technological processes, while simultaneously increasing the production yield. Ionic liquids (ILs) and deep eutectic solvents (DESs) constitute a very broad group of substances. Apart from many imperfections, ILs and DESs have been the most promising discoveries in the world of Green...