Filters
total: 3309
filtered: 3011
displaying 1000 best results Help
Search results for: EFFECTIVE DRUG CONCENTRATION
-
The influence of antiwear additive concentration on the tribological behaviour of a-C:H:W/steel tribosystem
Publication -
Determination of norflurazon concentration in wheat leaves using a modified QuEChERS method
Publication -
Effect of concentration boundary layers on mechanical pressure in a double-membrane system
Publication -
Control of mass concentration of reagents by sound in a gas with nonequilibrium chemical reactions
PublicationThe weakly nonlinear dynamics of a chemically reacting gas is studied. Nonlinear interaction of acoustic and nonacoustic types of motion are considered. We decompose the base equations using the relationships of the gas-dynamic perturbations specific for every type of motion. The governing equation for the mass fraction of a reagent influenced by dominating sound is derived and discussed. The conclusions concern the equilibrium...
-
Modeling sequencing batch reactor operational conditions depending on oxygen concentration
PublicationSequencing batch reactors (SBR) can be used as a fill-and draw activated sludge system for wastewater treatment with considerable operating flexibility and the possibility to conduct experiments under standard conditions and extreme case scenarios. Mathematical modeling and computer simulations provide an opportunity to implement existing wastewater processes in modeling software and evaluate different modifications at low costs...
-
Phosphorus concentration and availability in raw organic waste and post fermentation products
PublicationThe aim of the study was to determine the mobility of phosphorus forms in raw organic waste and from the solid and liquid fractions of digestate. To achieve the purpose of this study, the components (including livestock manure, agricultural waste, food waste, sewage sludge) and their post fermentation products were considered. Subsequently, the effect of the fermentation process on the mobility of phosphorus forms in post-fermentation fractions...
-
Concentration levels of selected analytes in the gas phase of an e-cigarette aerosol
PublicationThe aerosols generated from e-cigarettes are composed of liquid and gas phases resulting from vapourized e-liquid. The apportioning of substances from e-liquid into the liquid and gas phases during e-cigarette use has not been extensively studied. Partitioning of e-liquid components between the gas and the liquid phase of the aerosol influences the substances inhaled and exhaled by the users, leading to second-hand exposure. It...
-
LED Light Sources and Their Complex Set-Up for Visually and Biologically Effective Illumination for Ornamental Indoor Plants
PublicationOrnamental plants are often used in indoor environments as part of biophilic design to improve the health and wellbeing of occupants, and to support sustainable, green architecture. Unfortunately, many plants do not thrive and need to be continuously replaced, which is economically unsustainable. The wavelengths and spectrum ratio of commonly used light sources such as light emitting diode (LED), and the lack of an appropriate...
-
The interaction between bacterial abundance and selected pollutants concentration levels in an arctic catchment (southwest Spitsbergen, Svalbard)
PublicationPersistent organic pollutants (POPs) have been a topic of interest in environmental sciences for > 60 years. POPs in the Arctic have been investigated since the 1970s, when first atmospheric measurements revealed the presence of these pollutants in the polar regions. Major contaminant transport routes to the Arctic include atmospheric and oceanic transport, as well as inflow from rivers and sea ice. The sources of pollutants, such...
-
Determination of Heavy Metals Concentration in Water and Soil at Various Locations in Lahore and their Harmful Impacts on Human and Plants life
PublicationHeavy metals poisoning of soil and water has resulted from industrial expansion in Lahore, Pakistan, creating a significant environmental hazard. As a result, monitoring the contamination of soil and water around industrial sites is critical. The fact that higher concentrations of heavy metals have a negative influence on both plants and human life and this cannot be ignored. Higher heavy metal concentrations have a direct impact...
-
Antimicrobials Are a Photodynamic Inactivation Adjuvant for the Eradication of Extensively Drug-Resistant Acinetobacter baumannii
Publication -
Preparation and in vitro characterisation of bioactive mesoporous silica microparticles for drug delivery applications
Publication -
Batracylina (BAT) - potencjalny lek przeciwnowotworowy. Batracylin (BAT) - potential of anticancer drug
PublicationOpisano działanie potencjalnego leku przeciwnowotworowego - batracyliny(BAT). Batracylina została wyselekcjonowana przez National Cancer Institute (NCI, Bethesda, USA) w 1978 roku jako efekt programu poszukiwań nowych leków chemioterapii.Związek ten w badaniach in vivo u myszy okazał się bardzo aktywny przeciw nowotworowi okrężnicy 38 (colon 38), trudnemu do wyleczenia przez znane leki przeciwnowotworowe. Okazała się ona skuteczna...
-
Use of magnetic nanoparticles as a drug delivery system to improve chlorhexidine antimicrobial activity
Publication -
Molecular mechanism of the enzymatic oxidation investigated for imidazoacridinone antitumor drug C-1311.
PublicationPraca miala na celu określenie molekularnego mechanizmu enzymatycznej utleniającej aktywacji wymienionego związku przeciwnowotworowego w takim układzie modelowym, w którym wcześniej wykazano jego kowalencyjne wiązanie się do DNA. Badania struktur chemicznych produktów enzymatycznej aktywacji wykazały, że dwa z nich powstają w wyniku dealkilacji łańcucha bocznego cząsteczki, natomiast dwa inne w wyniku aktywacji pierścienia imidazoakrydonu....
-
Interactions of dissolved dsDNA with intercalating drug by anodic voltammetry and spectroscopy. Influence of pH
PublicationOddziaływanie związku przeciwnowotworowego C-1305 z DNA było badane przy pomocy impulsowej voltametrii różnicowej oraz spektroskopii UV/Vis. Triazoloakrydon C-1305 oddziałuje z DNA na dwóch drogach: przez interkalacje pomiedzy pary zasad oraz przez wiązanie sie w małym rowku helisy. W fizjologicznym pH (7,4) stałe wiązania wynoszą: K1=3,36E+5 i K2=0,18E+5 [1/M] a wielkość miejsca wiązania: n1=2,5 i n2=4,0, odpowiednio dla pierwszego...
-
Regenerative Drug Discovery Using Ear Pinna Punch Wound Model in Mice
PublicationThe ear pinna is a complex tissue consisting of the dermis, cartilage, muscles, vessels, and nerves. Ear pinna healing is a model of regeneration in mammals. In some mammals, including rabbits, punch wounds in the ear pinna close spontaneously; in common-use laboratory mice, they remain for life. Agents inducing ear pinna healing are potential regenerative drugs. We tested the effects of selected bioactive agents on 2 mm ear pinna...
-
The effective elastic properties of human trabecular bone may be approximated using micro-finite element analyses of embedded volume elements.
PublicationBoundary conditions (BCs) and sample size affect the measured elastic properties of cancellous bone. Samples too small to be representative appear stiffer under kinematic uniform BCs (KUBCs) than under periodicity-compatible mixed uniform BCs (PMUBCs). To avoid those effects, we propose to determine the effective properties of trabecular bone using an embedded configuration. Cubic samples of various sizes (2.63, 5.29, 7.96, 10.58...
-
Influence of hydrochloric acid concentration and type of nitrogen source on the electrochemical performance of TiO2/N-MoS2 for energy storage applications
PublicationIn this work, nitrogen-doped molybdenum sulfide was directly deposited on titanium dioxide nanotubes substrate (TiO2/N-MoS2) during hydrothermal synthesis. The study focuses on the influence of hydrochloric acid concentration used for the synthesis, with the results indicating its essential role in thioacetamide hydrolysis and thus in the effectiveness of the N-MoS2 deposition. The electrode material itself is characterized by...
-
Isothiocyanates as effective agents against enterohemorrhagic Escherichia coli: insight to the mode of action
Publication -
New Screening Protocol for Effective Green Solvents Selection of Benzamide, Salicylamide and Ethenzamide
PublicationNew protocol for screening efficient and environmentally friendly solvents was proposed and experimentally verified. The guidance for solvent selection comes from computed solubility via COSMO-RS approach. Furthermore, solute-solvent affinities computed using advanced quantum chemistry level were used as a rationale for observed solvents ranking. The screening protocol pointed out that 4-formylomorpholine (4FM) is an attractive...
-
Layered MoS2: effective and environment-friendly nanomaterial for photocatalytic degradation of methylene blue
Publication -
The Use of Effective Microorganisms as a Sustainable Alternative to Improve the Quality of Potatoes in Food Processing
Publication -
The Impact of Effective Microorganisms on Flesh Color and Chemical Composition of Raw Potato Tubers
Publication -
Specialization Integrated Strategy of Innovations: Effective Model for Emerging Regional Economy Development?
Publication -
Zeta potential, effective diameter and multimodal size distribution in oil/water emulsion
Publication -
Multivariate Features Extraction and Effective Decision Making Using Machine Learning Approaches
Publication -
Admission control method based on effective delay for flows using EF PHB.
Publication.
-
Effective one-band Hamiltonian for the copper-oxygen plane in the superconducting copper oxides
Publication -
Admission control method based on effective delay for flows using EF PHB.
Publication.
-
Effective rheological parameters of emulsion during their generation in the agitated draft - tube reactor
PublicationBadano właściwości reologiczne emulsji O/W i W/O w warunkach ich wytwarzania w pętlicowym reaktorze dwukolumnowym z mieszaniem w strefie wznoszenia. Obliczano lepkość pozorną emulsji, wykorzystując model potęgowy Ostwalda - de Waele, w którym szybkość ścinania obliczano jako stosunek prędkości pozornej dyspersji ciecz - ciecz w strefie opadania reaktora i szerokości strefy opadania. W celu identyfikacji typu emulsji mierzono przewodnictwo...
-
Silver Nanoparticles Combined With Naphthoquinones as an Effective Synergistic Strategy Against Staphylococcus aureus
Publication -
Effective mode volume of a natural mode of an open dielectric resonator with an active region
Publication -
Logical Interface for Soft Handover – an effective scheme of handovers in Proxy Mobile IPv6
PublicationMultimedia services are currently commonly available on mobile devices. Due to networks' convergence and migration to all-IP networks, mobility management at network layer is required. Moreover, nowadays it is popular to equip mobile devices with more than one wireless interface. Thus, soft handovers can be implemented, which means that an existing connection is removed after a new one is established. Usage of the Logical Interfaces...
-
CREATIVE PLACEMAKING IN POLAND. CAN ART BECOME AN EFFECTIVE TOOL OF URBAN REGENERATION?!
PublicationThe main aim of the paper is to examine the role of creative placemaking in shaping the urban environment in Polish cities. It also focuses on challenges and obstacles that creative placemaking projects encounter in Polish realities. Creative placemaking is a “micro-development” strategy (Johnson 2009) that focuses on cultural participation, com¬munity engagement and highlights the social role of arts and culture. Artistic interventions...
-
Effective dielectric constant of two phase systems: Application to mixed conducting systems
PublicationW pracy przedstawiono wyniki badań spektroskopii impedancyjnej systemów dwufazowych oraz ich porównanie z wynikami oczekiwanymi przez różne modele.
-
Musical Instrument Tagging Using Data Augmentation and Effective Noisy Data Processing
PublicationDeveloping signal processing methods to extract information automatically has potential in several applications, for example searching for multimedia based on its audio content, making context-aware mobile applications (e.g., tuning apps), or pre-processing for an automatic mixing system. However, the last-mentioned application needs a significant amount of research to reliably recognize real musical instruments in recordings....
-
Striking elements - A lifebelt or a fad? Searching for an effective way of adapting abandoned churches.
PublicationAre avant-garde elements added to historical objects as a temporary fashion to fulfill the aspirations of designers or an attempt to draw attention to themselves? It may be the exact opposite, and this type of controversial project is the best lifebelt for such monuments. This article explores issues related to external avant-garde elements added to adapted churches and their influence on the efficiency of such adaptation projects....
-
An interval estimator for chlorine monitoring in drinking water distribution systems under uncertain system dynamics, inputs and chlorine concentration measurement errors
PublicationThe design of an interval observer for estimation of unmeasured state variables with application to drinking water distribution systems is described. In particular, the design process of such an observer is considered for estimation of the water quality described by the concentration of free chlorine. The interval observer is derived to produce the robust interval bounds on the estimated water quality state variables. The stability...
-
The Occurrence of Cancer and of Adenomae in the Large Bowel and the Concentration of N -Nitrosamines in the Gastric Juice
Publication -
Determining ATP concentration in Candida albicans in process of forming germ tube forms
Publication -
Monitoring of Chlorine Concentration in Drinking Water Distribution Systems Using an Interval Estimator
PublicationThis paper describes the design of an interval observer for the estimation of unmeasured quality state variables in drinking water distribution systems. The estimator utilizes a set bounded model of uncertainty to produce robust interval bounds on the estimated state variables of the water quality. The bounds are generated by solving two differential equations. Hence the numerical efficiency is sufficient for on-line monitoring...
-
Response of the photosynthetic apparatus in the tropical fern Platycerium bifurcatum to increased ozone concentration
Publication -
Molecular Design Using Selected Concentration Effects in Optically Activated Fluorescent Matrices
PublicationMolecular physics plays a pivotal role in various fields, including medicine, pharmaceuticals, and broader industrial applications. This study aims to enhance the methods for producing specific optically active materials with distinct spectroscopic properties at the molecular level, which are crucial for these sectors, while prioritizing human safety in both production and application. Forensic science, a significant socio-economic...
-
Distribution and concentration of heavy metals in ash during thermal process sewage sludge
PublicationKażdego roku na świecie, obserwuje się znaczący wzrost produkcji osadów ściekowych. Przykładowo w 2006 roku, w Polsce ich ilość osiągnęła 1 mln ton w przeliczeniu na sucha masę, w tym ok. połowa pochodziła z oczyszczalni komunalnych. Problem ich zagospodarowania stanowi przedmiot zainteresowania wielu instytucji zajmujących się ochroną środowiska, zarówno w Polsce, jak i na całym świecie. Ich dotychczasowe wykorzystania polegało...
-
Electrochemical oxidation of sulphamerazine at boron-doped diamond electrodes: Influence of boron concentration
PublicationThe boron-doped diamond (BDD) electrodes with different boron concentrations have been tested as electrode material for sulphamerazine (SRM) oxidation in water solution. An investigation of the electrode morphology and molecular structure was carried out using high resolution scanning electron microscopy (SEM) and Raman spectroscopy. Electrochemical results showed clearly that the kinetics and efficiency of SRM oxidation were dependent...
-
Electrochemical oxidation of sulphamerazine at boron-doped diamond electrodes: Influence of boron concentration
Publication -
Thermodynamics and Intermolecular Interactions of Nicotinamide in Neat and Binary Solutions: Experimental Measurements and COSMO-RS Concentration Dependent Reactions Investigations
PublicationIn this study, the temperature-dependent solubility of nicotinamide (niacin) was measured in six neat solvents and five aqueous-organic binary mixtures (methanol, 1,4-dioxane, acetonitrile, DMSO and DMF). It was discovered that the selected set of organic solvents offer all sorts of solvent effects, including co-solvent, synergistic, and anti-solvent features, enabling flexible tuning of niacin solubility. In addition, differential...
-
Experimental and Theoretical Screening for Green Solvents Improving Sulfamethizole Solubility
PublicationSolubility enhancement of poorly soluble active pharmaceutical ingredients is of crucial importance for drug development and processing. Extensive experimental screening is limited due to the vast number of potential solvent combinations. Hence, theoretical models can offer valuable hints for guiding experiments aimed at providing solubility data. In this paper, we explore the possibility of applying quantum-chemistry-derived...
-
Antitumor Activity of Triazine Mimic Antibiotics for DNA-binding Implications (Impressive Activity in Vitro Against a Variety of Tumor Types in the NCI-60 Screen): NSC 710607 To Fight HCT-116 Human Colon Carcinoma Cell Lines in Vivo Using the Hollow Fiber Assay and Xenograft Mouse Models
PublicationPurpose Successful clinical applications of DNA-directed selective cytotoxic agents disrupt the vital replication/transcription processes and ultimately lead to cancer cell death. This study aimed to examine the growth screen of two lead triazine compounds in a number of cell lines and xenografts and to develop anticancer agents with noncovalent binding affinity bringing fewer side effects. Methods The NCI initial hollow...