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Inhibitors of glucosamine-6-phosphate synthase as potential antifungal drugs.
PublicationPrzedstawiono stan obecny i perspektywy zastosowania inhibitorów enzymu syntazy GlcN-6-P jako leków skutecznych w leczeniu grzybic układowych. Używając metod modelowania molekularnego zaprojektowano struktury inhibitorów enzymu należących do dwóch grup strukturalnych: analogów glutaminy oraz analogów stanu przejściowego reakcji katalizowanej przez enzym. Opracowano metody syntezy pochodnych zoptymalizowanych inhibitorów, wykazujących...
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Electrophoretic Deposition and Characterization of Chitosan/Eudragit E 100 Coatings on Titanium Substrate
PublicationCurrently, a significant problem is the production of coatings for titanium implants, which will be characterized by mechanical properties comparable to those of a human bone, high corrosion resistance, and low degradation rate in the body fluids. This paper aims to describe the properties of novel chitosan/Eudragit E 100 (chit/EE100) coatings deposited on titanium grade 2 substrate by the electrophoretic technique (EPD). The deposition...
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Electrophoretic Deposition and Characteristics of Chitosan–Nanosilver Composite Coatings on a Nanotubular TiO2 Layer
PublicationThe surface treatment of titanium implants has been applied mainly to increase surface bioactivity and, more recently, to introduce antibacterial properties. To this end, composite coatings have been investigated, particularly those based on hydroxyapatite. The present research was aimed at the development of another coating type, chitosan–nanosilver, deposited on a Ti13Zr13Nb alloy. The research comprised characterization of the...
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Electric chips for rapid detection and quantification of nucleic acids
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Partner profiles: Faculty of Architecture, Gdańsk University of Technology
PublicationPublikacja dotyczy uwarunkowań realizacji nowych zespołów mieszkaniowych na obrzeżach miast. Eskalacja procesów suburbanizacji dotyka wszystkich miast europejskich. Powstają struktury nie efektrywne energetycznie. Projekt hopus próbuje właczyć się w badania nad tym problemem. Opisane zostały prawne uwarunkowania planistyczne realizacji zabudowy w Polsce.
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The role of air masses on iron concentrations in wet atmospheric deposition over the urbanized coastal zone of the Gulf of Gdańsk
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Synthesis of Polycyclic δ-Lactams with Bridged Benzomorphan Skeleton: Selectivity and Diversity Driven by Substituents
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Functionalization of Graphite with Oxidative Plasma
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State tax policy and reform tools as a risk of running a business. Case study based on Polski Ład – Polish tax reform
PublicationThe aim of the article is to describe and present the Polish tax reform introduced at the beginning of 2022. Tax changes introduced in Poland had a strong impact on the risk of running a business in Poland because in their assumption they directly changed the rules of running a business. Due to the pace of the introduced changes, as well as the scope of the reform, the new tax law was subject to numerous criticisms of taxpayers...
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A Simple Replica Method as the Way to Obtain a Morphologically and Mechanically Bone-like Iron-Based Biodegradable Material
PublicationPorous iron-based scaffolds were prepared by the simple replica method using polyurethane foam as a template and applying the sintering process in a tube furnace. Their surface morphology was characterized using scanning electron microscopy (SEM) and phase homogeneity was confirmed using X-ray diffraction (XRD). Corrosion behavior was determined using immersion and potentiodynamic polarization methods in phosphate buffered saline...
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Mapping negative unintended consequences of disruptive technologies use in smart cities
PublicationSmart cities governance (SCG) consists of both to foster technology-enabled innovation, and to utilize disruptive technologies (DT) outcomes and impacts to increase public value of urban services. Despite widespread discussion of DT benefits, scientific literature identifies multiple determinants of unintended negative consequences (UC) of DT deployment in smart city initiatives. By considering UC as the negative aspects resulting...
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3D-Breast System for Determining the Volume of Tissue Needed for Breast Reconstruction
Publication3D imaging systems can be used to effectively determine breast volumes for surgical applications. This article presents methods for surface reconstruction and volume determination based on the point cloud created by 3D imaging. Such a system would be used to accurately estimate breast volume in patients classified for breast reconstruction surgery at plastic surgery centers. To develop such a system, various methods of determining...
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Urinary 5-hydroxymethyluracil and 8-oxo-7,8-dihydroguanine as potential biomarkers in patients with colorectal cancer
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Molecular factors involved in the development of diabetic foot syndrome.
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Nonsteroidal anti-inflammatory drugs modulate cellular glycosaminoglycan synthesis by affecting EGFR and PI3K signaling pathways
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The role of genetic factors and monocyte-to-osteoclast differentiation in the pathogenesis of Charcot neuroarthropathy
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Synthetic genistein derivatives as modulators of glycosaminoglycan storage
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The aberrant overexpression of vimentin is linked to a more aggressive status in tumours of the gastrointestinal tract
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The clinical and prognostic evaluation of GRP94 immunoexpression in Caucasian patients with colorectal adenocarcinoma
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Catalase immunoexpression in colorectal lesions
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The prognostic activity of transforming acidic coiled-coil 3 (TACC3) immunohistochemical expression in colon adenocarcinoma patients
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Vimentin immunoexpression and its prognostic activity in colon cancer among Caucasian patients
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Adjuvant, neoadjuvant, and experimental regimens in overcoming pancreatic ductal adenocarcinoma
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The effect of cigarette smoking on the clinical course of inflammatory bowel disease
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Human proteinase 3 resistance to inhibition extends to alpha‐2 macroglobulin
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Local anaesthetics upregulate nitric oxide generation in cord blood and adult human neutrophils
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Metody oceny zagrożeń pieszych
PublicationZarządzanie bezpieczeństwem pieszych uczestników ruchu drogowego. Identyfikacja najbardziej niebezpiecznych miejsc dla pieszych na podstawie analizy wypadków. Identyfikacja źródeł zagrożeń w miejscach najbardziej niebezpiecznych na podstawie wyników badań pośrednich miar brd.
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N-Substituted piperazine derivatives as potential multitarget agents acting on histamine H3 receptor and cancer resistance proteins
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The Effect of Conjugation with Octaarginine, a Cell-Penetrating Peptide on Antifungal Activity of Imidazoacridinone Derivative
PublicationAcridine cell-penetrating peptide conjugates are an extremely important family of compounds in antitumor chemotherapy. These conjugates are not so widely analysed in antimicrobial therapy, although bioactive peptides could be used as nanocarriers to smuggle antimicrobial compounds. An octaarginine conjugate of an imidazoacridinone derivative (Compound 1-R8) synthetized by us exhibited high antifungal activity against reference...
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Xanthone synthetic derivatives with high anticandidal activity and positive mycostatic selectivity index values
PublicationWith the current massive increases in drug-resistant microbial infection as well as the significant role of fungal infections in the death toll of COVID-19, discovering new antifungals is extremely important. Natural and synthetic xanthones are promising derivatives, although only few reports have demonstrated their antifungal mechanism of action in detail. Newly synthetized by us xanthone derivative 44 exhibited strong antifungal...
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Electrochemical study of lithium insertion into carbon-rich polymer-derived silicon carbonitride ceramics
PublicationW pracy przedstawiono materiał ceramiczny, bogaty w węgiel krzemo azotek węgla (SiCN), otrzymany na drodze pirolizy w zakresie temperatur od 1100 do 1700°C. Badania elektrochemiczne insercji litu wykazały, że materiał elektrodowy na bazie SiCN może być obiecujący jako anoda w bateriach litowych. Próbka otrzymana w 1300°C cechuje się pojemnością 392 mAh/g i jest stabilna aktywna elektrochemicznie w trakcie interkalacji i deinterkalacji...
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Organomercury Compounds in Environmental Samples: Emission Sources, Toxicity, Environmental Fate, and Determination
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Rip currents in the non-tidal surf zone with sandbars: numerical analysis versus field measurements
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Wyspa Spichrzów - nowy, dobry adres w Gdańsku w kontekście rewitalizacji historycznych struktur miejskich
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Organomercury compounds in environmental samples: emission sources, toxicity, environmental fate and determination.
PublicationIn view of the specific properties of mercury and its capability of forming compounds that can be bioaccumulated and biomagnified at successive levels of the trophic pyramid, it has become necessary to gather detailed information on the sources of emission of this element into the environment and its fate there. Moreover, the increasing awareness of the relationship between the toxicity of mercury and its chemical form has sharpened...
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Organotin Compounds: Environmental Fate and Analytics
PublicationFor more than 50 years, organotin compounds have been used in almost all sectors of industry. As a consequence, specific environmental compartments are affected by the emission of these xenobiotics. The emissions of organotin compounds into the environment from paints used in the shipbuilding industry for ship hull coating, and from the plant protection products are particularly significant.In 2001, the IMO introduced a global...
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Towards a Smart Sustainable City Roadmap
PublicationThis workshop of the CAP4CITY (Erasmus+ Strengthening Governance Capacity for Smart Sustainable Cities) project is to promote and stimulate the discussion and networking in the area of Digital Government. Smart Sustainable Cities and related concepts of Digital, Intelligent and Smart Cities represent a progression of how cities around the world apply digital technology to serve their populations, pursue sustainable socio-economic...
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Genetic variation in C-reactive protein (CRP) gene is associated with retinopathy and hypertension in adolescents with type 1 diabetes
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The relationship between 8-oxo-7,8-dihydro-2′-deoxyguanosine level and extent of cytosine methylation in leukocytes DNA of healthy subjects and in patients with colon adenomas and carcinomas
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Severe oxidatively damaged DNA after cisplatin treatment of cancer patients
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Effects of basal level of antioxidants on oxidative DNA damage in humans
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Oxidative stress and oxidative DNA damage is characteristic for mixed Alzheimer disease/vascular dementia
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DNA repair is responsible for the presence of oxidatively damaged DNA lesions in urine
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Deep Infiltrating Endometriosis in Adolescence: Early Diagnosis and Possible Prevention of Disease Progression
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Znajomość własnego ciśnienia tętniczego i rozpowszechnienie nadciśnienia tętniczego w populacji wiejskiej - Program Kiełpino = The cognizance of patient's own blood pressure values and the hypertension prevalence among rural population - Kiełpino program
PublicationNadciśnienie tętnicze jest jedną z najczęstszych chorób przewlekłych występujących w Polsce. Nieleczone nadciśnienie tętnicze prowadzi do licznych powikłań, jest przyczyna przedwczesnej umieralności, wpływa na pogorszenie komfortu życia pacjenta i zwiększa koszty leczenia. Ocena znajomości własnego ciśnienia tętniczego krwi oraz rozpowszechnienia nadciśnienia tętniczego u pacjentów w wiejskiej praktyce lekarza rodzinnego - jest...
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The Modifications of Haemoglobin, Erythropoietin Values and Running Performance While Training at Mountain vs. Hilltop vs. Seaside
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Monitoring of myocardium state during off-pump coronary artery by-pass grafting
PublicationW pracy przedstawiono technikę pomiarową do oceny procesów zachodzących podczas operacji przesłowania aortalno-wieńcowego wymagających zatrzymania przepływu krwi. Zaproponiwany system i metoda pomiarowa przewidziane są do wykorzystania podczas opercacji na tzw. bijącym sercu. Pokazano przykłady rejestrowanych sygnałów przydatnych do oceny stanu mieśnia serca oraz dokonano oceny właściwości pomiarowych zastosowanych technik.
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Phenotypic consequences of LYS4 gene disruption in Candida albicans
PublicationA BLAST search of the Candida Genome Database with the Saccharomyces cerevisiae LYS4 sequence known to encode homoaconitase (HA) revealed ORFs 19.3846 and 19.11327. Both alleles of the LYS4 gene were sequentially disrupted in Candida albicans BWP17 cells using PCR-based methodology. The null lys4Δ mutant exhibited lysine auxotrophy in minimal medium but was able to grow in the presence of L-Lys and α-aminoadipate, an intermediate...
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Soft-mode enhanced type-I superconductivity in LiPd2Ge
PublicationThe synthesis, crystal structure, and physical properties (magnetization, resistivity, heat capacity) in combination with theoretical calculations of the electronic structure and phonon properties are reported for intermetallic compounds LiPd2X (X = Si, Ge, and Sn). LeBail refinement of powder x-ray diffraction data confirms that all compounds belong to the Heusler family (space group Fm-3m, No. 225). The lattice parameter increases...
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Homoisocitrate dehydrogenase from Candida albicans: properties, inhibition, and targeting by an antifungal pro-drug
PublicationThe LYS12 gene from Candida albicans, coding for homoisocitrate dehydrogenase was cloned and expressed as a His-tagged protein in Escherichia coli. The purified gene product catalyzes the Mg2+- and K+-dependent oxidative decarboxylation of homoisocitrate to alpha-ketoadipate. The recombinant enzyme demonstrates strict specificity for homoisocitrate. SDS-PAGE of CaHIcDH revealed its molecular mass of 42.6±1 kDa, while in size-exclusion...