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Search results for: BIO-BASED 1,4-BUTANEDIOL
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Bio‑derived polyurethanes obtained by non‑isocyanate route using polyol‑based bis(cyclic carbonate)s—studies on thermal decomposition behavior
PublicationNon-isocyanate polyurethanes (NIPUs) constitute one of the most prospective groups of eco-friendly materials based on their phosgene-free synthesis pathway. Moreover, one of the steps of their obtaining includes the use of carbon dioxide (CO 2 ), which allows for the promotion of the development of carbon dioxide capture and storage technologies. In this work, non- isocyanate polyurethanes were obtained via three-step synthesis...
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Development of Sulfamoylated 4‑(1-Phenyl‑1H‑1,2,3-triazol-4-yl)phenol Derivatives as Potent Steroid Sulfatase Inhibitors for Efficient Treatment of Breast Cancer
PublicationWe present here the advances achieved in the development of new sulfamoylated 4-(1-phenyl-1H-1,2,3-triazol-4-yl)phenol derivatives as potent steroid sulfatase (STS) inhibitors for the treatment of breast cancer. Prompted by promising biological results and in silico analysis, the initial series of similar compounds were extended, appending a variety of m-substituents at the outer phenyl ring. The inhibition profiles of the newly...
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Sustainable synthesis of cyclic carbonates from bio‐based polyether polyol: the structure characterization, rheological behaviour and thermal properties
PublicationThe cycloaddition of CO2 to epoxides represents a green efficient method to form bis(cyclic carbonate)s. The main purpose of the work reported in this paper was to examine the effect of the gas flow rate (20, 40, 60 and 100 mL min–1) during carbonation on the conversion yield, chemical structure, rheological behaviour and thermal properties of the prepared compounds. A series of new bis(cyclic carbonate)s was obtained from bio‐based...
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Mechanical Properties of Bio-Composites Based on Epoxy Resin and Nanocellulose Fibres
PublicationThe aim of our research was to investigate the effect of a small nanocellulose (NC) addition on an improvement of the mechanical properties of epoxy composites. A procedure of chemical extraction from pressed lignin was used to obtain nanocellulose fibers. The presence of nanoparticles in the cellulose pulp was confirmed by FTIR/ATR spectra as well as measurement of nanocellulose particle size using a Zetasizer analyzer. Epoxy...
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Synthesis, molecular structure, and metabolic stability of new series of N' -(2-alkylthio-4-chloro-5-methylbenzenesulfonyl)-1-(5-phenyl-1 H -pyrazol-1-yl)amidine as potential anti-cancer agents
PublicationA series of new N'-(2-alkylthio-4-chloro-5-methylbenzenesulfonyl)-1-(5-phenyl-1H-pyrazol-1-yl)amidine derivatives have been synthesized and evaluated in vitro by MTT assays for their antiproliferative activity against cell lines of colon cancer HCT-116, cervical cancer HeLa and breast cancer MCF-7. The studied compounds display selective activity mainly against HCT-116 and HeLa cells. Thus, five compounds show selective cytotoxic...
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Diamine derivatives of dimerized fatty acids and bio-based polyether polyol as sustainable platforms for the synthesis of non-isocyanate polyurethanes
PublicationA series of environmentally friendly non-isocyanate polyurethanes (NIPUs) were successfully prepared via the polyaddition reaction of bio-based polyether polyol-based cyclic carbonate with diamine derivative of dimerized fatty acids. The syntheses of NIPUs were realized by the three-step method in the absence of toxic solvents and, importantly, the process of carbonation did not require the use of elevated pressure. The effect...
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A novel nucleotide found in human erythrocytes, 4-pyridone-3-carboxamide-1-beta-D-ribonucleoside triphosphate
PublicationZidentyfikowano nowy, nieznany nukleotyd, występujący w erytrocytach osób chorych na przewlekłą niewydolność nerek, w stężeniu porównywalnym do zawartości ATP. Nukleotyd ten wyizolowano chromatograficznie, a jego strukturę określono jako trójfosforan 4-piridono-3-karboksyamido-1-b-D-rybonukleozydu, na podstawie danych spektralnych UV, MS, IR i NMR.
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Physics-Based Coarse-Grained Modeling in Bio- and Nanochemistry
PublicationCoarse-grained approaches, in which groups of atoms are represented by single interaction sites, are very important in biological and materials sciences because they enable us to cover the size- and time-scales by several orders of magnitude larger than those available all-atom simulations, while largely keeping the details of the systems studied. The coarse-grained approaches differ by the scheme of reduction and by the origin...
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Algebraic periods and minimal number of periodic points for smooth self-maps of 1-connected 4-manifolds with definite intersection forms
PublicationLet M be a closed 1-connected smooth 4-manifolds, and let r be a non-negative integer. We study the problem of finding minimal number of r-periodic points in the smooth homotopy class of a given map f: M-->M. This task is related to determining a topological invariant D^4_r[f], defined in Graff and Jezierski (Forum Math 21(3):491–509, 2009), expressed in terms of Lefschetz numbers of iterations and local fixed point indices of...
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Solubility of Carbon Dioxide in Deep Eutectic Solvents Based on 3-Amino-1-Propanol and Tetraalkylammonium Salts at Low Pressure
PublicationDeep eutectic solvents (DESs) became an object of a great interest as an alternative to ionic liquids (ILs) and commonly used in CO2 capture amine solutions. In the present study, five different DESs based on 3-amino-1-propanol as physical-chemical CO2 absorbents were used. The composition was chosen in order to estimate the effects of hydrogen bond acceptor:hydrogen bond donor (HBA:HBD) molar ratio, anion type and length of alkyl...
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Lower Rim Substituted p-tert-Butyl-Calix[4]arene. Part 15. Pb(II)-Ion-Selective Electrodes Based on p-tert-Butyl-calix[4]arene Thioamides.
PublicationTetra podstawione tioamidowe pochodne para-tert-butylokaliks[4]arenu (1-5) zostały zastosowane jako jonofory w membranowych elektrodach jonoselektywnych (EJS) selektywne na kationy Pb(II). Wyznaczono współczynniki selektywności. Czwartorzędowe kaliks[4]aren-tioamidy (1,2) wykazują nadzwyczaj dobrą selektywność na kationy Pb(II) w porównaniu z kaliks[4]aren-amidami. Membrany z tymi ligandami wykazują dużą trwałość, a charakterystyki...
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Solid-State Modification of Poly(butylene terephthalate) with a Bio-Based Fatty Acid Dimer Diol Furnishing Copolyesters with Unique Morphologies
PublicationCopolyesters based on poly(butylene terephthalate) (PBT) and a bio-based fatty acid dimer diol (FADD) were prepared by solid-state modification (SSM). The chemical incorporation of the FADD into the backbone of the PBT was proven using various techniques. It was clear that the incorporation rate was diffusion-limited rather than reaction-limited. From quantitative 13C NMR a nonrandom chemical microstructure was obtained at all...
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The influence of 4-substituted and unsubstituted derivatives of 1-nitroacridine on the cell cycle and induction of apoptosis in human cancer HT29 and HeLa S3.
PublicationZbadano wpływ pochodnych 1-nitroakrydyny C-1748 i C-857, w stężeniach biologicznie istotnych, na cykl życiowy oraz indukcję apoptozy komórek raka jelita grubego HT29 oraz raka szyjki macicy HeLa S3. Metodą cytometrii przepływowej wykazano, że 4-metylo-1-nitroakrydyna C-1748 powoduje akumulację komórek HT29 w fazie S i komórek HeLa S3 w fazie G2 cyklu komórkowego zaś związek C-857 indukuje akumulację komórek HT29 i HeLa S3 w fazie...
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Numerical analyses of novel prefabricated structural wall panels in residential buildings based on laboratory tests in scale 1:1
PublicationThe paper presents experimental and numerical investigations on novel prefabricated composite building wall panels for residential building constructions. The wall panels were composed of reinforced concrete ribbed elements with the core from the EPS foam as the thermal insulation. The wall panels in the full-scale 1:1 were subjected to vertical loads. In the first step, the experiments were analysed with simple usual static methods....
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Progress in upscalingMiscanthusbiomass production for the European bio-economy with seed-based hybrids
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Electrically Conductive Carbon‐based (Bio)‐nanomaterials for Cardiac Tissue Engineering
PublicationA proper self-regenerating capability is lacking in human cardiac tissue which along with the alarming rate of deaths associated with cardiovascular disorders makes tissue engineering critical. Novel approaches are now being investigated in order to speedily overcome the challenges in this path. Tissue engineering has been revolutionized by the advent of nanomaterials, and later by the application of carbon-based nanomaterials...
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Modification of structured bio‑carbon derived from spongin-based scaffolds with nickel compounds to produce a functional catalyst for reduction and oxidation reactions: Potential for use in environmental protection
PublicationThree different 3D fibrous-like NiO/Ni(OH)2/Ni‑carbonized spongin-based materials were prepared via a simple sorption–reduction method. Depending on the support used, the catalysts were composed of carbon, nickel oxide, nickel hydroxide and zero-valent nickel, with the surface content of the nickel-containing phase in the range 15.2–26.0 wt%. Catalytic studies showed promising activity in the oxidation of phenolic compounds in water...
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Structure analysis and thermal degradation characteristics of bio-based poly(propylene succinate)s obtained by using different catalyst amounts
PublicationLinear bio-based polyester polyols were prepared with the use of succinic acid and 1.3-propanediol (both with natural origin). As a catalyst was used tetraisopropyl orthotitanate (TPT). In order to determine the effect of various catalyst content on the thermal degradation characteristics, three different TPT amounts, as a 1.3-propanediol equivalent, were used, namely 0.1 mass% (PPS-0.1), 0.2 mass% (PPS-0.2) and 0.25 mass% (PPS-0.25)....
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Influence of chemical structure on physicochemical properties and thermal decomposition of the fully bio-based poly(propylene succinate-co-butylene succinate)s
PublicationIn this work, two polyesters and four copolyesters were studied. All materials were synthesized to obtain the monomers dedicated for thermoplastic polyurethane elastomers. For this type of PUR, the monomers should characterize by appropriate selected physicochemical properties and macromolecular structure distribution, which depends on synthesis conditions. The study of chemical structure with extensive and knowledgeable analysis...
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Fabrication and Structural Properties of LaNb 1‐x As x O 4 Ceramics
PublicationLanthanum niobate substituted with arsenic was synthesized by three methods: solid state reaction from binary oxides and two different methods combining co-precipitation and solidstate reaction. In the first of the combined methods LaNb1- xAsxO4 was synthesized from LaAsO4, obtained from coprecipitation method, and lanthanum and niobium oxides. In the second LaNbO4 was first synthesized from binary oxides and then mixed with LaAsO4...
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Synthesis, Molecular Structure, Anticancer Activity, and QSAR Study of N-(aryl/heteroaryl)-4-(1H-pyrrol-1-yl)Benzenesulfonamide Derivatives
PublicationA series of N-(aryl/heteroaryl)-4-(1H-pyrrol-1-yl)benzenesulfonamides were synthesized from 4-amino-N-(aryl/heteroaryl)benzenesulfonamides and 2,5-dimethoxytetrahydrofuran. All the synthesized compounds were evaluated for their anticancer activity on HeLa, HCT-116, and MCF-7 human tumor cell lines. Compound 28, bearing 8-quinolinyl moiety, exhibited the most potent anticancer activity against the HCT-116, MCF-7, and HeLa cell lines,...
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The induction of autophagy in human colon wt p53 and p53-null HCT116 cells by 4-methyl-1-nitroacridine derivative C-1748
PublicationPrzeprowadzone badania miały na celu określenie zdolności pochodnej 4-metylo-1-nitroakrydyny C-1748 do uruchomienia autofagii komórek ludzkiego raka okrężnicy HCT116 posiadających dziki gen p53 oraz podlinii nie posiadającej tego genu. Wszystkie eksperymenty przeprowadzone zostały przy stężeniu hamującym proliferację komórek nowotworowych w 90%. Wykazano, że indukowana przez C-1748 autofagia w komórkach raka okrężnicy jest zależna...
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Coffee silverskin as a potential bio-based antioxidant for polymer materials: Brief review
PublicationCoffee silverskin is one of the by-products generated by the coffee industry. Although it is not the most burdensome one, because it stands only for ~4.2 wt % of coffee, it seems like an auspicious raw material for industrial processes. Coffee silverskin is characterized by a relatively low moisture content of ~5–7%, so it often does not require quite energy-consuming drying processes. The chemical composition of coffee silverskin,...
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Biopolymers based paper coating with promoted grease resistivity, bio-degradable and mechanical properties
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Morphology of bio-based polyurethane composites filled by mer-cerized or silanized natural fibres
PublicationBio-composites are materials which possess unique properties and undergo biodegra-dation under specific conditions. Bio-composites belong to the group of materials produced with the use of renewable raw materials. They contain reinforcement, mainly in the form of natural fiber, which has high stiffness and resistance; filler powders are less frequently used. Significant features of natural fibers are elongation, density, thermal...
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Diminshed toxicity of C-1748, 4-methyl-9-hydroxyethylamino-1-nitroacridine, compared with its demethyl analog, C-857, corresponds to its resistance to metabolism in HepG2 cells
PublicationThe narrow "therapeutic window" of anti-tumour therapy may be the result of drug metabolism leading to the activation or detoxification of antitumour agents. The aim of this work is to examine (i) whether the diminished toxicity of a potent antitumour drug, C-1748, 9-(2'-hydroxyethylamino)-4-methyl-1-nitroacridine, compared with its 4-demethyl analogue, C-857, results from the differences between the metabolic pathways for the...
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Synthesis of 3-(2-Alkylthio-4-chloro-5-methylbenzenesulfonyl)-2-(1-phenyl-3-arylprop-2-enylideneamino)guanidine Derivatives with Pro-Apoptotic Activity against Cancer Cells
PublicationThe untypical course of reaction between chalcones and benzenesulfonylaminoguanidines led to the new 3-(2-alkylthio-4-chloro-5-methylbenzenesulfonyl)-2-(1-phenyl-3-arylprop-2- enylideneamino)guanidine derivatives 8–33. The new compounds were tested in vitro for their impact on the growth of breast cancer cells MCF-7, cervical cancer cells HeLa and colon cancer cells HCT-116 by MTT assay. The results revealed that the activity of...
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Synthesis and characterization of mechanically alloyed nanostructured ternary titanium based alloy for bio-medical applications
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Preclinical toxicological examination of a putative prostate cancer-specific 4-methyl-1-nitroacridine derivative in rodents
PublicationW pracy przedstawiono wyniki przedklinicznych badań toksykologicznych zwiazków C-1748 i C-857 na szczurach Copenhagen i myszach BALB/c, po podaniu dootrzewnowym lub dożylnym. U myszy dawki letalne (LD50) dla C-1748 wynosiły odpowiednio 9 i 13,4 mg/kg w porównaniu z 2,2 i 3 mg/kg dla C-857. U szczurów po podaniu dootrzewnowym lub dożylnym dla C-1748 dawki LD50 wynosiły odpowiednio 4 i 1,3 mg/kg. Nie stwierdzono zmian w liczbie komórek...
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Synthesis, characterization and Luminescent Properties of New Coordination Polymers Based on p-tert Butylcalix[4]arene-tetracarboxylic acid and Lanthanine cations
PublicationA series of new coordination polymers based on p-tert-butylcalix[4]arene-tetracarboxylic acid with Eu3+, Tb3+wrer prepared by hydro and solvothermal methods. the obtained solid compounds were characterized by infrared and luminescence spectroscopy, powder X-ray diffraction, scianning electron microscopy and thermogravimetric anylisis. The infrared curves and the x-ray diffraction patterns indicate that the same crystalline structure...
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A spline-based FE approach to modelling of high frequency dynamics of 1-D structures
PublicationIn this paper a computational methodology leading to the development of a new class of FEs, based on the application of continuous and smooth approximation polynomials, being splines, has been presented. Application of the splines as appropriately defined piecewise elemental shape functions led the authors to the formulation of a new approach for FEM, named as spFEM, where contrary to the well-known NURBS approach, the boundaries...
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A comprehensive review on current and emerging technologies toward the valorization of bio‐based wastes and by products from foods
PublicationIndustries in the agro-food sector are the largest generators of waste in the world. Agro-food wastes and by products originate from the natural process of senescence, pretreatment, handling, and manufacturing processes of food and beverage products. Notably, most of the wastes are produced with the transformation of raw materials (such as fruits, vegetables, plants, tubers, cereals, and dairy products) into different processed...
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The Health Outcomes Prevention and Evaluation 4 (HOPE 4) project: A successful community-based intervention to lower cardiovascular risk in people with hypertension
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Characterization of structure and properties of polymer films made from blends of polyethylene with poly(4-methyl-1-pentene)
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Właściwości strukturalne i transportowe nadprzewodników Nd(2-x)CexCu(1+-y)O(4-z)
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32P-postabeling detection of DNA adducts formed by 4-methyl-1-nitro-9-aminoacridine C-1748
PublicationWykazano zdolność do tworzenia przez nową pochodną 1-nitroakrydyny o symbolu C-1748, adduktów z DNA komórek nowotworowych oraz z DNA w systemie bezkomórkowym.
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Population-based case-control study of alpha 1-antitrypsin and SLC11A1 in Crohn's disease and ulcerative colitis.
PublicationBackground: Crohn’s disease (CD) and ulcerative colitis (UC) are chronic inflammatory diseases of the digestive tract. Genetic factors and an abnormal immune response to infections are suspected to be involved in inflammatory bowel diseases. Methods: In the present study 300 blood samples from CD patients (n 100), UC patients (n 100), and healthy controls (n 100) were taken from a population-based case-control study. PCR assays...
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Inhibitors of Matriptase‐2 Based on the Trypsin Inhibitor SFTI‐1
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Quality assessment of ZnO-based varistors by 1/f noise
PublicationNoise has been used as a diagnostic tool of surge arrester varistor structures comprising of ZnO grains of various type and size. The physical and electrical properties of the measured samples have been described. In the experimental study, the applied measurement system and the results of noise measurements for the selected structures of varistors designed for the continuous working voltage 280 V, 440 V and 660 V have been presented....
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Polarization rotaror - analysis and design
PublicationW artykule przedstawiono metodę analizy wielosekcyjnego polaryzatora złożonego z periodycznych szyków obiektów cylindrycznych. W celu analizy badanej struktury zastosowano metodę pełnofalową opartą na metodzie dopasowania rodzajów.
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Investigations of broadband multilayered coupled line couplers
PublicationW pracy przedstawiono dwa układy szerokopasmowych sprzęgaczy 3dB. Pierwszy układ zrealizowany jest w oparciu o linie paskowe z rowkowanym ekranem. Drugi układ to zmodyfikowany układ sprzęgacza mikrofalowego zrealizowanego w oparciu o linie mikropaskowe ze wspólną masą. Zaproponowane układy sprzęgaczy odznaczają się szerszym pasmem pracy w porównaniu do układów prezentowanych w literaturze. Wyniki symulacji układów zostały zweryfikowane...
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Simultaneous determination of droxidopa and carbidopa by carbon paste electrode functionalized with NiFe2O4 nanoparticle and 2-(4-ferrocenyl-[1,2,3]triazol-1-yl)-1-(naphthalen-2-yl) ethanone
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Natural/bio-based sorbents as greener extractive materials for endocrine disrupting compounds in samples of different matrix composition
PublicationEndocrine-disrupting compounds (EDCs) are a group of chemicals that interfere with the endocrine system, leading to adverse effects on human health and the environment. Increasing concerns over the EDCs presence in various environmental compartments has driven the search for greener extraction materials. Recently, the use of polymers of natural origin (biopolymers) has been demonstrated to be an effective and promising research...
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Inline Microwave Filters With N+1 Transmission Zeros Generated by Frequency-Variant Couplings: Coupling-Matrix-Based Synthesis and Design
PublicationA general coupling-matrix-based synthesis methodology for inline Nth-order microwave bandpass filters (BPFs) with frequency-variant reactive-type couplings that generate N+1 transmission zeros (TZs) is presented in this brief. The proposed approach exploits the formulation of the synthesis problem as three inverse nonlinear eigenvalue problems (INEVPs) so that the coupling matrix is built from their sets of eigenvalues. For this...
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Structural and spectroscopic investigation of new luminescent hybrid materials based on calix[4]arene-tetracarboxylate and Ln 3+ ions (Ln = Gd, Tb or Eu)
PublicationLanthanide-calixarene hybrid materials are of particular interest due to the combination of the interesting properties of the ligand cavity-like structure and the luminescent features of lanthanides. The aim of this study was to synthesize and investigate the photophysical properties of Eu3+, Tb3+ and Gd3+ hybrids based on calix[4]arene-tetracarboxylate. The preparation of two structurally different...
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Increased plasma concentration of 4-pyridone-3-carboxamide-1-ß-D-ribonucleoside (4PYR) in lung cancer. Preliminary studies
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Lower rim substituted tert-butylcalix[4]arenes. Part 10. New Pb(II)-selective electrodes based on tetrasubstituted calix[4]arenes amides
PublicationOpracowano elektrody selektywne na jony Pb(II) oparte na lipofilowych tetrapodstawionych amidowych pochodnych kaliks[4] arenu. Charakterystyki elektrod mają nachylenie nernstowskie w szerokim zakresie stężeń 10 (-1.3) do 10 (-7.2).
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Pochodna 4-metylo-1-nitroakrydyny C-1748 oraz 1-nitroakrydyny C-857 - wpływ na przebieg cyklu życiowego oraz indukcję apoptozy lub starzenia komórek nowotworowych
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Fault diagnosis in electronic circuits based on bilinear transformation in 3-D and 4-D spaces
PublicationPrzedstawiono ideę nowych metod diagnostycznych 3-D i 4-D opartych na przek-ształceniu biliniowym. Metody te bazują na transformacjach operujących odpo-wiednio w trzy i czterowymiarowych przestrzeniach funkcji układowych. Dlatych metod omówiono algorytm lokalizacji i identyfikacji pojedynczych uszko-dzeń parametrycznych w liniowych układach elektronicznych oraz algorytm lo-kalizacji i identyfikacji pojedynczych uszkodzeń...
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The Suzuki cross-coupling reaction for the synthesis of porphyrazine possessing bulky 2,5-(biphenyl-4-yl)pyrrol-1-yl substituents in the periphery
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