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Search results for: TRIAZOLOAKRYDON C-1305
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Object serialization and remote exception pattern for distributed C++/MPI application
PublicationMPI is commonly used standard in development of scientific applications. It focuses on interlanguage operability and is not very well object oriented. The paper proposes a general pattern enabling design of distributed and object oriented applications. It also presents its sample implementations and performance tests.
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The Arnold conjecture in $ \mathbb C\mathbb P^n $ and the Conley index
Publicationn this paper we give an alternative, purely Conley index based proof of the Arnold conjecture in CP^n asserting that a Hamiltonian diffeomorphism of CP^n endowed with the Fubini-Study metric has at least (n+1) fixed points.
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Scattering of electrons from 1-butene, H2C=CHCH2CH3, and 2-methylpropene,H2C=C(CH3)2, molecules
PublicationZmierzono, wykorzystując liniową technikę transmisyjną, całkowite absolutne przekroje czynne (TCS) na rozpraszanie elektronów na cząsteczce 1-butenu (H2C=CHCH2CH3) oraz 2-metylpropene (H2C=C(CH3)2) w zakresie energii padających elektronów, od 1 do 400 eV oraz od 1 do 350 eV. Kształt przekroju czynnego dla obu badanych izomerów butenu jest podobny. Dwie struktury w uzyskanych krzywych TCS, są wyraźnie widoczne: mały pik w okolicy...
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The overexpression of CPR and P450 3A4 in pancreatic cancer cells changes the metabolic profile and increases the cytotoxicity and pro-apoptotic activity of acridine antitumor agent, C-1748
PublicationDrug resistance is one of the major cause of pancreatic cancer treatment failure. Thus, it is still imperative to develop new active compounds and novel approach to improve drug efficacy. Here we present 9-amino-1-nitroacridine antitumor agent, C-1748, developed in our laboratory, as a candidate for pancreatic cancer treatment. We examined (i) the cellular response of pancreatic cancer cell lines: Panc-1, MiaPaCa-2, BxPC-3 and...
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Low temperature processed MnCo2O4 and MnCo1.8Fe0.2O4 as effective protective coatings for solid oxide fuel cell interconnects at 750 °C
PublicationIn this study two materials, MnCo2O4 and MnCo1.8Fe0.2O4 are studied as potential protective coatings for Solid Oxide Fuel Cell interconnects working at 750 °C. First powder fabrication by a modified Pechini method is described followed by a description of the coating procedure. The protective action of the coating applied on Crofer 22 APU is evaluated by following the area specific resistance (ASR) of the scale/coating for 5500...
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Cytotoxicity of C-2028, QDgreen, QDred, QDgreen-FA, QDred-FA, QDgreen-FA-C-2028 and QDred-FA-C-2028 aginst LNCaP cancer cells
Open Research DataThis study presents absorbance values of formazan product (converted from MTT) which corresponds the cytotoxicity of C-2028, QDgreen, QDred, QDgreen-FA, QDred-FA, QDgreen-FA-C-2028 and QDred-FA-C-2028 aginst LNCaP cancer cells. FA (folic acid) was used as a linker between quantum dots (QDs) and compound (C-2028) at different concentration (50-200 µM).
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The effect of high pressure and sub-zero temperature on total antioxidant capacity and the content of vitamin C, fatty acids and secondary products of lipid oxidation in human milk
PublicationThe objective of this study was to compare of the effects of high pressure of 193 MPa at - 20°C and Low Temperature Long Time pasteurization (LTLT or holder pasteurization, 62,5°C; 30 min) on the content and composition of fatty acids (FAs), concentrations of secondary products of lipid oxidation (TBARS), the total antioxidant capacity (TAC), total vitamin C and ascorbic acid (AsA) content in human milk. It was shown that no significant...
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Area specific resistance (at 800 °C - 500 °C) of the SrTi0.50Fe0.50O3 porous oxygen electrodes sintered at different temperatures
Open Research DataIn this dataset are presented results of the polarization resistance of differently sintered SrTi0.50Fe0.50O3 porous oxygen electrodes in symetrical cell. Applied sintering temperatures were 900 °C, 950 °C and 1000 °C. The measurement temperature range was between 800 °C and 500 °C with synthetic air flow (21% O2, 40 ml min-1). Results converted to...
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Area specific resistance (at 800 °C - 500 °C) of the SrTi0.30Fe0.70O3 porous oxygen electrodes sintered at different temperatures
Open Research DataIn this dataset are presented results of the polarization resistance of differently sintered SrTi0.30Fe0.70O3 porous oxygen electrodes in symetrical cell. Applied sintering temperatures were 900 °C, 950 °C and 1000 °C. The measurement temperature range was between 800 °C and 500 °C with synthetic air flow (21% O2, 40 ml min-1). Results converted to...
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Area specific resistance (at 800 °C - 500 °C) of the SrTi0.65Fe0.35O3 porous oxygen electrodes sintered at different temperatures
Open Research DataIn this dataset are presented results of the polarization resistance of differently sintered SrTi0.65Fe0.35O3 porous oxygen electrodes in symetrical cell. Applied sintering temperatures were 900 °C, 950 °C and 1000 °C. The measurement temperature range was between 800 °C and 500 °C with synthetic air flow (21% O2, 40 ml min-1). Results converted to...
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Optical method supported by machine learning for dynamics of C‐reactive protein concentrations changes detection in biological matrix samples
PublicationIn this article we present the novel spectroscopy method supported with machine learning for real-time detection of infectious agents in wastewater. In the case of infectious diseases, wastewater monitoring can be used to detect the presence of inflammation biomarkers, such as the proposed C-reactive protein, for monitoring inflammatory conditions and mass screening during epidemics for early detection in communities of concern,...
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Multiaxial Fatigue Behaviour of SLM 18Ni300 Steel
PublicationFatigue behaviour of SLM 18Ni300 steel under proportional bending-torsion loading is studied. The fatigue tests are conducted under pulsating loading conditions using tubular specimens with a transversal circular hole. Three ratios of the normal stress to shear stress are considered, namely σ/τ=4,σ/τ=2 and σ/τ = 4/3. Crack initiation sites were found for two diametrically opposite points around the hole, whose locations are governed...
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Human CYP2 family of cytochrome P-450 takes part in metabolism of two acridine antitumor agents, C-1311 and C-1748, selected for I phase of clinical trials
PublicationPraca zawiera wyniki badań metabolicznej transformacji przeciwnowotworowych pochodnych akrydyny wobec zestawu 16 prób enzymów mikrosomalnych, pochodzących z wątroby 16 różnych pacjentów. Wykazano, że za metabolizm tych związków u człowieka odpowiedzialne są głównie izoenzymy z rodziny CYP2.
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Diminished toxicity of C-1748, 4-methyl-9-hydroxyethylamino-1-nitroacridine, compared with its demethyl analog, C-857, corresponds to its resistance to metabolism in HepG2 cells
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Cytotoxicity of C-2028, QDgreen, QDred, QDgreen-FA, QDred-FA, QDgreen-FA-C-2028 and QDred-FA-C-2028 aginst Du-145 cancer cells
Open Research DataThis study presents absorbance values of formazan product (converted from MTT) which corresponds the cytotoxicity of C-2028, QDgreen, QDred, QDgreen-FA, QDred-FA, QDgreen-FA-C-2028 and QDred-FA-C-2028 aginst H460 cancer cells. FA (folic acid) was used as a linker between quantum dots (QDs) and compound (C-2028) at different concentration (50-200 µM).
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Boron-doped carbon nanowalls for fast and direct detection of cytochrome C and ricin by matrix-free laser desorption/ionization mass spectrometry
PublicationDetecting proteins via surface assisted laser desorption/ionization mass spectrometry (SALDI-MS) method is still highly challenging, and only few examples of nanomaterials have been demonstrated to perform such detection so far. In this study, carbon nanowalls (CNWs), vertically aligned graphene sheet-based materials, presenting specific morphology, dimensions, and boron doping levels have shown improved performances for both qualitative...
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Projektowanie, synteza oraz badanie aktywności biologicznej amidosiarczanowych inhibitorów sulfatazy steroidowej zawierających w swojej konstytucji ugrupowania fosforowe lub wiązania C-F
PublicationWedług Światowej Organizacji Zdrowia (WHO) estrogeny są jednymi z głównych czynników stymulujących wzrost nowotworów hormonozależnych. Dlatego też, projektowanie oraz synteza nowych, skuteczniejszych środków wpływających na biosyntezę estrogenów stanowi ogromne wyzwanie dla współczesnej medycyny. W ostatnich latach liczne ośrodki naukowe na całym świecie prowadzą intensywne badania związane z poszukiwaniem nowych, skutecznych inhibitorów...
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Andrzej Klimczuk
PeopleAndrzej Klimczuk, PhD, a sociologist and public policy expert, assistant professor in the Department of Social Policy of the Collegium of Socio-Economics at the SGH Warsaw School of Economics, Poland. Editor and correspondent of publications about computer and video games in the years 2002-2009. In 2011-2013, Vice President of the Foundation's Laboratory Research and Social Action "SocLab." External expert of institutions such...
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Removal of diphenols using pine biochar. Kinetics, equilibrium, thermodynamics, and mechanism of uptake
PublicationThermal pyrolysis synthesized activated biochar from the Pinus elliottii sawdust (PS) at 600° C. The obtained activated biochar (PB600) was used for the removal of three diphenols, catechol (CAT), resorcinol (RES), and hydroquinone (HYD), which are utilized mainly in different industries. The PB600 was characterized by several analytical techniques. The BET surface area of 1473 m2.g−1 and a total pore volume of 0.707 cm3 g−1 was...
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In vitro biological evaluation of a novel folic acid-targeted receptor quantum dot−β−cyclodextrin carrier for C-2028 unsymmetrical bisacridine in the treatment of human lung and prostate cancers
PublicationTraditional small-molecule chemotherapeutics usually do not distinguish tumors from healthy tissues. However, nanotechnology creates nanocarriers that selectively deliver drugs to their site of action. This work is the next step in the development of the quantum dot−β−cyclodextrin−folic acid (QD−β−CD−FA) platform for targeted and selected delivery of C−2028 unsymmetrical bisacridine in cancer therapy.Herein, we report an initial...
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Analysis of cellular response induced by imidazoacridinone derivative C-1311 in Chinese hamster ovary carcinoma cells CHO with vorious expression level of cytochrome P450 reductase
PublicationRodzaj odpowiedzi komórkowej indukowanej przez pochodną C-1311 badany był w komórkach CHO o różnym poziomie reduktazy cytochromu P450. Wszystkie eksperymenty zostały przeprowadzone przy zastosowaniu stężenia związku odpowiadającego dawce EC80. Poziom ekspresji reduktazy cytochromu P450 nie miał istotnego wpływu na rodzaj odpowiedzi komórkowej indukowanej przez pochodną C-1311. Głównym efektem biologicznym wywieranym przez badany...
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Thermodynamics of Chemical Processes in the System of Nanocrystalline Iron–Ammonia–Hydrogen at 350 °C
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New Flavone C-Glycosides from Scleranthus perennis and Their Anti-Collagenase Activity
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The Thermal Parameters of Mortars Based on Different Cement Type and W/C Ratios
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Antinociceptive and Cytotoxic Activity of Opioid Peptides with Hydrazone and Hydrazide Moieties at the C-Terminus
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Kernel-Based Fuzzy C-Means Clustering Algorithm for RBF Network Initialization
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Molecular mechanism of the enzymatic oxidation investigated for imidazoacridinone antitumor drug C-1311.
PublicationPraca miala na celu określenie molekularnego mechanizmu enzymatycznej utleniającej aktywacji wymienionego związku przeciwnowotworowego w takim układzie modelowym, w którym wcześniej wykazano jego kowalencyjne wiązanie się do DNA. Badania struktur chemicznych produktów enzymatycznej aktywacji wykazały, że dwa z nich powstają w wyniku dealkilacji łańcucha bocznego cząsteczki, natomiast dwa inne w wyniku aktywacji pierścienia imidazoakrydonu....
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The effects of calcium–silicate–hydrate (C–S–H) seeds on reference microorganisms
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A facile synthesis method and electrochemical studies of a hierarchical structured MoS2/C-nanocomposite
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Oxygen evolution reaction on MoS2/C rods—robust and highly active electrocatalyst
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Analysis of polymorphism and hepatic expression of duodenal cytochrome b in chronic hepatitis C
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Proteins Structure Models in the Evaluation of Novel Variant (C.472_477del) in the MOCS2 Gene
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The Influence of the Mixed DPC:SDS Micelle on the Structure and Oligomerization Process of the Human Cystatin C
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TiO2/C Photocatalyst Prepared by Ethanol Vapour Treatment of TiO(OH)2
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Prolonged pharmacological inhibition of cathepsin C results in elimination of neutrophil serine proteases
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Lung Protection by Cathepsin C Inhibition: A New Hope for COVID-19 and ARDS?
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The Effect of WC/C Coating on the Wear of Bevel Gears Used in Coal Mines
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EKSPERTYZA GŁOWICY NAPOWIETRZNEJ ESS 123 C.31 PO ZWARCIU WEWNĘTRZNYM
PublicationW pracy określono poprawność wykonania i podłączenia głowic kablowych 110 kV oraz analizowano przebieg zdarzeń w sieci elektroenergetycznej w chwili wystąpienia zwarcia w układzie izolacyjnym.
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WPŁYW FRAKCJI C IEKŁEJ POFERMENTU NA PROCES MEZOFILOWEJ FERMENTACJI METANOWEJ
PublicationBadano wpływ zawrotu frakcji ciekłej pofermentu na przebieg procesu fermentacji mezofilowej w bioreaktorach laboratoryjnych o pojemności całkowitej 10 dm3 w procesie quasi-ciągłym. Ba-dania prowadzono jednocześnie w dwu bliźniaczych reaktorach, z których pierwszy (R1) pełnił rolę układu referencyjnego a do drugiego (R2) podawano biomasę zawierającą frakcję ciekłą pofermentu. W trakcie prowadzonych badań nie zauważono istotnego...
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TiO2-C nanocomposite synthesized via facile surfactant-assisted method as a part of less energy-consuming LED-based photocatalytic system for environmental applications
PublicationA novel facile method was used to incorporate carbon into the titania structure. An alternative synthesis method of carbon-doped TiO2 has been proposed by using a widely used and cheap surfactant. During the process, cetyltrimethylammonium bromide plays a dual role, as a morphology modifier and as a carbon source. The presented approach allows obtained TiO2-C nanostructures to be anatase nanocrystals with carbon being deposited...
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COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
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A&C-Revista de Direito Administrativo & Constitucional
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Revista Contabilidade e Controladoria-RC C
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Journal of The Institution of Engineers (India): Series C
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International Journal of Engineering Transactions C: Aspects
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SCIENCE IN CHINA SERIES C-LIFE SCIENCES
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Spotkanie TEST C - Nowy
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Cytotoxicity of C-2028, QDgreen, QDred, QDgreen-CD-FA, QDred-CD-FA, QDgreen-CD-FA-C-2028 and QDred-CD-FA-C-2028 aginst LNCaP cancer cells
Open Research DataTis study presents absorbance values of formazan product (converted from MTT) which corresponds the cytotoxicity of C-2028, QDgreen, QDred, QDgreen-CD-FA, QDred-CD-FA, QDgreen-CD-FA-C-2028 and QDred-CD-FA-C-2028 aginst LNCaP cancer cells. FA (folic acid) with cyclodextrin (CD) was used as a linker between quantum dots (QDs) and compound (C-2028).
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Cytotoxicity of C-2028, QDgreen, QDred, QDgreen-CD-FA, QDred-CD-FA, QDgreen-CD-FA-C-2028 and QDred-CD-FA-C-2028 aginst H460 cancer cells
Open Research DataThis study presents absorbance values of formazan product (converted from MTT) which corresponds the cytotoxicity of C-2028, QDgreen, QDred, QDgreen-CD-FA, QDred-CD-FA, QDgreen-CD-FA-C-2028 and QDred-CD-FA-C-2028 aginst H460 cancer cells. FA (folic acid) with cyclodextrin (CD) was used as a linker between quantum dots (QDs) and compound (C-2028).
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Manganese–Cobalt Based Spinel Coatings Processed by Electrophoretic Deposition Method: The Influence of Sintering on Degradation Issues of Solid Oxide Cell Oxygen Electrodes at 750 °C
PublicationThis paper seeks to examine how the Mn–Co spinel interconnect coating microstructure can influence Cr contamination in an oxygen electrode of intermediate temperature solid oxide cells, at an operating temperature of 750 °C. A Mn–Co spinel coating is processed on Crofer 22 APU substrates by electrophoretic deposition, and subsequently sintered, following both the one-step and two-step sintering, in order to obtain significantly...