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Search results for: CAMBER ANGELE
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Cancer associated thrombosis: comparison of characteristics, treatment, and outcomes in oncological and non-oncological patients followed by Pulmonary Embolism Response Team
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Algebraic periods and minimal number of periodic points for smooth self-maps of 1-connected 4-manifolds with definite intersection forms
PublicationLet M be a closed 1-connected smooth 4-manifolds, and let r be a non-negative integer. We study the problem of finding minimal number of r-periodic points in the smooth homotopy class of a given map f: M-->M. This task is related to determining a topological invariant D^4_r[f], defined in Graff and Jezierski (Forum Math 21(3):491–509, 2009), expressed in terms of Lefschetz numbers of iterations and local fixed point indices of...
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DNA-damaging imidazoacridinone C-1311 induces autophagy followed by irreversible growth arrest and senescence in human lung cancer cells
PublicationImidazoacridinone 5-diethylaminoethylamino-8-hydroxyimidazoacridinone (C-1311) is an antitumor inhibitor of topoisomerase II and FMS-like tyrosine kinase 3 receptor. In this study, we describe the unique sequence of cellular responses to C-1311 in human non-small cell lung cancer (NSCLC) cell lines, A549 and H460. In A549 cells, C-1311 (IC80 = 0.08 µM) induced G1 and G2/M arrests, whereas H460 cells (IC80 = 0.051 µM) accumulated...
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Reducing the number of periodic points in the smooth homotopy class of a self-map of a simply-connected manifold with periodic sequence of Lefschetz numbers
PublicationLet f be a smooth self-map of an m-dimensional (m >3) closed connected and simply-connected manifold such that the sequence of the Lefschetz num- bers of its iterations is periodic. For a fixed natural r we wish to minimize, in the smooth homotopy class, the number of periodic points with periods less than or equal to r. The resulting number is given by a topological invariant J[f] which is defned in combinatorial terms and is...
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The influence of 4-substituted and unsubstituted derivatives of 1-nitroacridine on the cell cycle and induction of apoptosis in human cancer HT29 and HeLa S3.
PublicationZbadano wpływ pochodnych 1-nitroakrydyny C-1748 i C-857, w stężeniach biologicznie istotnych, na cykl życiowy oraz indukcję apoptozy komórek raka jelita grubego HT29 oraz raka szyjki macicy HeLa S3. Metodą cytometrii przepływowej wykazano, że 4-metylo-1-nitroakrydyna C-1748 powoduje akumulację komórek HT29 w fazie S i komórek HeLa S3 w fazie G2 cyklu komórkowego zaś związek C-857 indukuje akumulację komórek HT29 i HeLa S3 w fazie...
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Virtual Engineering Object / Virtual Engineering Process: A specialized form of Cyber Physical System for Industrie 4.0
PublicationThis paper reviews the theories, parallels and variances between Virtual Engineering Object (VEO) / Virtual Engineering Process (VEP) and Cyber Physical System (CPS). VEO and VEP is an experience based knowledge representation of engineering objects and processes respectively. Cyber–physical systems (CPSs) are the next generation of engineered systems in which computing, communication, and control technologies are tightly integrated....
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Badanie rozpoznawania twarzy przez człowieka z wykorzystaniem systemu śledzenia fiksacji wzroku Cyber-Oko
PublicationW celu dokładniejszego zrozumienia sposobu rozpoznawania i zapamiętywania twarzy przez człowieka przeprowadzono doświadczenie na grupie 20 osób z wykorzystaniem wcześniej opracowanego systemu śledzenia fiksacji wzroku Cyber-Oko. Wykorzystując diody i kamerę podczerwieni wraz z dedykowanym oprogramowaniem Cyber-Oko, które pozwala na śledzenie punktu skupienia wzroku na ekranie. Każdej osobie biorącej udział w doświadczeniu pokazano...
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Mechanical Properties of 3D Printed Parts and Their Injection Molded Alternatives Subjected to Environmental Aging
PublicationAdditive manufacturing is the technology used in medical, industrial, or lifestyle applications. The scientific literature include works reporting various manufacturing parameters’ influence on changes in additive manufacturing components’ mechanical behavior, especially with fused filament fabrication (FFF). The changes in mechanical strength and toughness of FFF compared to injection molding parts were studied. In the study,...
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Rozmyty system wnioskowania do oszacowania maksymalnego naprężenia kontaktowego na powierzchni panewki endoprotezy stawu biodrowego w zależności od kąta Wiberga i masy ciała pacjenta = Fuzzy reasoning system for maximal contact stress estimation on acetabular surface in hip endoprosthesis based on Wiberg angle and weight of patient
PublicationPrzedstawiono możliwość wykorzystania systemu rozmytego, który wykorzystując rozumowanie przybliżone określa maksymalne naprężenie kontaktowe na powierzchni przenoszenia obciążeń panewki endoprotezy stawu biodrowego, biorąc pod uwagę kąt Wiberga oraz masę ciała pacjenta.
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Viewpoint independent shape-based object classification for video surveillance
PublicationA method for shape based object classification is presented.Unlike object dimension based methods it does not require any system calibration techniques. A number of 3D object models are utilized as a source of training dataset for a specified camera orientation. Usage of the 3D models allows to perform the dataset creation process semiautomatically. The background subtraction method is used for the purpose of detecting moving objects...
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PM10 concentration and microbiological assessment of air in relation to the number of acute cases of type 1 diabetes mellitus in the Lubelskie Voivodeship. Preliminary report
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Comparison of peptide cancer signatures identified by mass spectrometry in serum of patients with head and neck, lung and colorectal cancers: Association with tumor progression
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Chemopreventive activity of bioactive fungal fractions isolated from milk-supplemented cultures of Cerrena unicolor and Pycnoporus sanguineus on colon cancer cells
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Comparative Proteomic Profiling of Ectosomes Derived from Thyroid Carcinoma and Normal Thyroid Cells Uncovers Multiple Proteins with Functional Implications in Cancer
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Application of biocompatible and ultrastable superparamagnetic iron(iii) oxide nanoparticles doped with magnesium for efficient magnetic fluid hyperthermia in lung cancer cells
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Dual inhibition of PI3K/Akt signaling and the DNA damage checkpoint in p53-deficient cells with strong survival signaling: implications for cancer therapy
PublicationOporność komórek nowotworowych na leki uszkadzjące DNA związana jest ściśle ze zdolnością do utrzymywania blok z fazie G2 cyklu komórkowego. Blok ten regulowany jest przez mechanizmy punktu kontrolnego G2/M oraz szlaki przeżycia komórkowego. W pracy badaliśmy rolę szlaku kinazy PI3K/Akt w funkcjonowaniu punktu kontrolnego cyklu komórkowego i wpływ na przeżycie komórek traktowanych lekiem przeciwnowotworowym - cisplatyną. Nasze...
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Atmospheric Pressure Plasma-Mediated Synthesis of Platinum Nanoparticles Stabilized by Poly(vinylpyrrolidone) with Application in Heat Management Systems for Internal Combustion Chambers
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Folate-directed zinc (II) phthalocyanine loaded polymeric micelles engineered to generate reactive oxygen species for efficacious photodynamic therapy of cancer
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Urinary Measurement of Epigenetic DNA Modifications: A Non-Invasive Assessment of the Whole-Body Epigenetic Status in Healthy Subjects and Colorectal Cancer Patients
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Mutual Expression of ALDH1A1, LOX, and Collagens in Ovarian Cancer Cell Lines as Combined CSCs- and ECM-Related Models of Drug Resistance Development
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Cellular Effects of Selected Unsymmetrical Bisacridines on the Multicellular Tumor Spheroids of HCT116 Colon and A549 Lung Cancer Cells in Comparison to Monolayer Cultures
PublicationMulticellular tumor spheroids are a good tool for testing new anticancer drugs, including those that may target cancer stem cells (CSCs), which are responsible for cancer progression, metastasis, and recurrence. Therefore, we applied this model in our studies of highly active antitumor unsymmetrical bisacridines (UAs). We investigated the cellular response induced by UAs in 2D and 3D cultures of HCT116 colon and A549 lung cancer...
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Antiproliferative, Antiangiogenic, and Antimetastatic Therapy Response by Mangiferin in a Syngeneic Immunocompetent Colorectal Cancer Mouse Model Involves Changes in Mitochondrial Energy Metabolism
PublicationIn spite of the current advances and achievements in cancer treatments, colorectal cancer (CRC) persists as one of the most prevalent and deadly tumor types in both men and women worldwide. Drug resistance, adverse side effects and high rate of angiogenesis, metastasis and tumor relapse remain one of the greatest challenges in long-term management of CRC and urges need for new leads of anticancer drugs. We demonstrate that CRC...
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c-Myc Protein Level Affected by Unsymmetrical Bisacridines Influences Apoptosis and Senescence Induced in HCT116 Colorectal and H460 Lung Cancer Cells
PublicationUnsymmetrical bisacridines (UAs) are highly active antitumor compounds. They contain in their structure the drugs previously synthesized in our Department: C-1311 and C-1748. UAs exhibit different properties than their monomer components. They do not intercalate to dsDNA but stabilize the G-quadruplex structures, particularly those of the MYC and KRAS genes. Since MYC and KRAS are often mutated and constitutively expressed in cancer...
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Effect of COVID-19 pandemic lockdowns on planned cancer surgery for 15 tumour types in 61 countries: an international, prospective, cohort study
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Synthesis, physical–chemical properties and in vitro photodynamic activity against oral cancer cells of novel porphyrazines possessing fluoroalkylthio and dietherthio substituents
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Red Kale (Brassica oleracea L. ssp. acephala L. var. sabellica) Induces Apoptosis in Human Colorectal Cancer Cells In Vitro
PublicationThis article presents the results of studies investigating the effect of red kale (Brassica oleracea L. ssp. acephala L. var. sabellica) extract on cancer cells (HT-29). The cytotoxicity of the red kale extract was assessed using MTT and LDH assays, while qRT-PCR was employed to analyze the expression of genes associated with the p53 signaling pathway to elucidate the effect of the extract on cancer cells. Furthermore, HPLC-ESI-QTOF-MS/MS...
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PARP inhibition potentiates the cytotoxic activity of C-1305, a selective inhibitor of topoisomerase II, in human BRCA1-positive breast cancer cells
PublicationTwo cellular proteins encoded by the breast and ovarian cancer type 1 susceptibility (BRCA1 and BRCA2) tumor suppressor genes are essential for DNA integrity and the maintenance of genomic stability.Approximately 5-10% of breast and ovarian cancers result from inherited alterations or mutations in these genes.Remarkably, BRCA1/BRCA2-deficient cells are hypersensitive to selective inhibition of poly(ADPribose) polymerase 1 (PARP-1),...
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Physiological Biomarkers Assessed by Low‐Tech Exercise Tests Predict Complications and Overall Survival in Patients Undergoing Pneumonectomy Due to Lung Cancer
PublicationDue to its debilitating character pneumonectomy this is last‐resort procedure. Preoperative results of the 6‐min walking test (6MWT) help to identify high risk of postoperative complications and increased mortality in patients undergoing lobectomy for lung cancer. The aim of the study was to validate the value of 500 m in 6MWT as an indicator, which differentiates risk of complications in patients undergoing pneumonectomy. 125...
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Quantum dots conjugates with unsymmetrical bisacridines enhance cytotoxicity of these antitumor compounds in lung cancer cells and have protecting effects on normal cells
PublicationBackground: In recent years, with the rapid development of nanotechnology and its extensive applications in the medicine, nanocarriers for anticancer drug delivery have gained a great importance. Spherical semiconductor nanocrystals, frequently called quantum dots (QDs) are very attractive nanomaterials for bioimaging applications and they possess properties as potential candidates for drug carrier. Unsymmetrical bisacridines (UAs),...
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A Bayesian regularization-backpropagation neural network model for peeling computations
PublicationA Bayesian regularization-backpropagation neural network (BRBPNN) model is employed to predict some aspects of the gecko spatula peeling, viz. the variation of the maximum normal and tangential pull-off forces and the resultant force angle at detachment with the peeling angle. K-fold cross validation is used to improve the effectiveness of the model. The input data is taken from finite element (FE) peeling results. The neural network...
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The methodology of design of satellite working mechanism of positive displacement machine
PublicationIn this paper is described a methodology of design of satellite mechanism consisting of two noncircular gears (externally toothed rotor and internally toothed curvature) and circular gears (satellites). In the presented methodology is assumed that the rotor pitch line is known, and the curvature pitch line is necessary to designate. The presented methodology applies to mechanisms for which the number of the curvature humps is at...
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Determination of the dynamic critical maneuvering area in an encounter between two vessels: Operation with negligible environmental disruption
PublicationThis paper introduces the concept of Collision Avoidance Dynamic Critical Area (CADCA) for onboard Decision Support Systems (DSS). The indicator proposed is derived via identification of a minimum required maneuvering zone in an encounter between two vessels. The CADCA model accounts for ship maneuvering dynamics and associated hydrodynamic actions emerging from different rudder angles and forward speed effects. The method presented...
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Manoeuvring forces on azimuthing podded propulsor model
PublicationThis paper presents the preliminary part of comprehensive manoeuvring open- water tests of a gas carrier model. The paper focuses on open water experiments with an azimuthing podded propulsor. The test program was carried out in the cavitation tunnel and the large towing tank of Ship Hydromechanics Division, Ship Design and Research Centre, Gdańsk. The pod was tested as a pushing unit with a 161.3 mm diameter propeller. Steering...
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Relationship between copper(ii) complexes with FomA adhesin fragments ofF. nucleatumand colorectal cancer. Coordination pattern and ability to promote ROS production
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Study of Bioreductive Anticancer Agent RH-1-Induced Signals Leading the Wild-Type p53-Bearing Lung Cancer A549 Cells to Apoptosis
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Allelic length of a CA dinucleotide repeat in theegfr gene correlates with the frequency of amplifications of this sequence—first results of an inter-ethnic breast cancer study
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Anti-cancer effect of Rumex obtusifolius in combination with arginase/nitric oxide synthase inhibitors via downregulation of oxidative stress, inflammation, and polyamine synthesis
PublicationCancer continues to be a leading cause of death worldwide, making the development of new treatment methods crucial in the fight against it. With cancer incidence rates increasing worldwide, ongoing research must focus on identifying new and effective ways to prevent and treat the disease. The combination of herbal extracts with chemotherapeutic agents has gained much interest as a novel strategy to combat cancer. Rumex obtusifolius...
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Relationship between Telomere Length, TERT Genetic Variability and TERT, TP53, SP1, MYC Gene Co-Expression in the Clinicopathological Profile of Breast Cancer
PublicationThe molecular mechanisms of telomerase reverse transcriptase (TERT) upregulation in breast cancer (BC) are complex. We compared genetic variability within TERT and telomere length with the clinical data of patients with BC. Additionally, we assessed the expression of the TERT, MYC, TP53 and SP1 genes in BC patients and in BC organoids (3D cell cultures obtained from breast cancer tissues). We observed the same correlation in the...
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The Preoperative Maximum Standardized Uptake Value Measured by 18F-FDG PET/CT as an Independent Prognostic Factor of Overall Survival in Endometrial Cancer Patients
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Designing a High-sensitivity Microscale Triple-band Biosensor based on Terahertz MTMs to provide a perfect absorber for Non-Melanoma Skin Cancer diagnostic
PublicationNon-melanoma skin cancer (NMSC) is among the most prevalent forms of cancer originating in the top layer of the skin, with basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) being its primary categories. While both types are highly treatable, the success of treatment hinges on early diagnosis. Early-stage NMSC detection can be achieved through clinical examination, typically involving visual inspection. An alternative,...
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Improved cytotoxicity and preserved level of cell death induced in colon cancer cells by doxorubicin after its conjugation with iron-oxide magnetic nanoparticles
PublicationA promising strategy for overcoming the problem of limited efficacy in antitumor drug delivery and in drug release is the use of a nanoparticle-conjugated drug. Doxorubicin (Dox) anticancer chemotherapeutics has been widely studied in this respect, because of severe cardiotoxic side effects. Here, we investigated the cytotoxic effects, the uptake process, the changes in cell cycle progression and the cell death processes in the...
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Portico Farmhouses of the Vistula Delta: Architecture, Current State and Finite Element Modelling of Timber Roof Truss under Material and Cross-section Uncertainty
PublicationThe article focuses on the oldest surviving I-type portico houses located in the Vistula Delta, which were built in the 17th and 18th centuries. The study describes the houses’ origins, structure, details of roof structures and technical condition, and it also includes numerical modelling of a roof truss and its mechanical analysis. Numerical models of the roof trusses are defined and analysed by means of the finite element method....
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Computer vision techniques applied for reconstruction of seafloor 3D images from side scan and synthetic aperture sonars data
PublicationThe Side Scan Sonar and Synthetic Aperture Sonar are well known echo signal processing technologies that produce 2D images of the seafloor. Both systems combines a number of acoustic pings to form a high resolution image of seafloor. It was shown in numerous papers that 2D images acquired by such systems can be transformed into 3D models of seafloor surface by algorithmic approach using intensity information, contained in a grayscaled...
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Komputerowe stanowisko pomiarowe do analizy dokładności wykonania krawędzi ostrzy narzędzi z wykorzystaniem obrazów z kamer.
PublicationW referacie przedstawiono zaprojektowane, wykonane i wdrożone komputerowe stanowisko pomiarowe do analizy dokładności wykonania krawędzi ostrzy narzędzi. Analiza dokładności zrealizowana została na podstawie zarejestrowanych obrazów z kamer. Przedstawiono opisy konstrukcji części mechanicznej stanowiska, układu sterowania, a także ogólną charakterystykę algorytmów sterowania.
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Stability Enhancement of Grid-Connected Wind Power Generation System Using PSS, SFCL and STATCOM
PublicationThe stability related issues may occur in a power system due to disturbances in generating or loading conditions, especially in the presence of distributed generation (DG) based on renewable energy resources (RERs). This paper proposes a novel strategy for the stability enhancement of a wind power generation system (WPGS) by using a combination of three devices, namely, a power system stabilizer (PSS), resistive superconductor...
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Experimental results of full scattering profile from finger tissue-like phantom
PublicationHuman tissue is one of the most complex optical media since it is turbid and nonhomogeneous. We suggest a new optical method for sensing physiological tissue state, based on the collection of the ejected light at all exit angles, to receive the full scattering profile. We built a unique set-up for noninvasive encircled measurement. We use a laser, a photodetector and finger tissues-mimicking phantoms presenting different optical...
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Wpływ parametrów strugi paliwa wtryskiwanego do cylindra silnika okrętowego na początkową fazę rozpylania
PublicationPrzedmiotem rozprawy jest analiza procesu wtrysku oleju napędowego do cylindra silnika okrętowego z zapłonem samoczynnym i bezpośrednim wtryskiem paliwa. Analiza tego zagadnienia została przeprowadzona w aspekcie wpływu makro parametrów strugi na początkową fazę rozpylania oleju napędowego. Celem niniejszej pracy jest określenie wpływu współczynnika L/D (długość otworu/średnica) otworu wylotowego wtryskiwacza na zmianę charakterystyki...
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Favourable outcomes in patients with early-stage non-small-cell lung cancer operated on by video-assisted thoracoscopic surgery: a propensity score-matched analysis†
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Destabilization of β‐Hemocyanin from Helix pomatia in Presence of Choline Amino Acids Results in Improved Cell Specificity and Cytotoxicity against Human Breast Cancer
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<p>Potential effects of microbial air quality on the number of new cases of diabetes type 1 in children in two regions of Poland: a pilot study</p>
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