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Search results for: DRUGS RESIDUES
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Current View on Green Tea Catechins Formulations, Their Interactions with Selected Drugs, and Prospective Applications for Various Health Conditions
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Feasibility study of a Raman spectroscopic route to drug detection
PublicationWe present an surface-enhanced Raman spectroscopy (SERS) approach for detection of drugs of abuse in whole human blood. We utilize a near infrared laser with 830 nm excitation wavelength in order to reduce the influence of fluorescence on the spectra of blood. However, regular plasmon resonance peak of plasmonic nanoparticles, such as silver or gold fall in a much lower wavelength regime about 400 nm. Therefore, we have shifted...
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Biopolymer based nanomaterials in drug delivery systems: A review
PublicationDrug delivery systems (DDS) are used to achieve a higher therapeutic effects of a pharmaceutical drug or natural compound in a specific diseased site with minimal toxicological effect and these systems consists of liposomes, microspheres, gels, prodrugs and many. Nanotechnology is a rapidly developing multi-disciplinary science that ensures the fabrication of the polymers to nanometer scale for various medical applications. Uses...
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Chromogenic Substrates of Bovine β-Trypsin: The Influence of an Amino Acid Residue in P1 Position on Their Interaction with the Enzyme
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Folding kinetics of WW domains with the united residue force field for bridging microscopic motions and experimental measurements
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Residue-Pole Methods for Variability Analysis of S-parameters of Microwave Devices with 3D FEM and Mesh Deformation
PublicationThis paper presents a new approach for variability analysis of microwave devices with a high dimension of uncertain parameters. The proposed technique is based on modeling an approximation of system by its poles and residues using several modeling methods, including ordinary kriging, Adaptive Polynomial Chaos (APCE), and Support Vector Machine Regression (SVM). The computational cost is compared with the traditional Monte-Carlo...
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FPGA implementation of reverse residue conversion based on the new Chinese Remainder Theorem II- Part I
PublicationW pracy opisano implementację algorytmu konwersji z systemu resztowego do systemu binarnego opartą na nowej formie chińskiego twierdzenia o resztach określanego jako CRT II.Nowa forma CRT nie wymaga operacji modulo M , gdzie M jest zakresem liczbowym systemu resztowego, jednak wymagana jest pewna liczba mnożników. W środowisku FPGA jest zwykle dostępne są mnożniki, stąd mogą być one wykorzystane do realizacji konwertera. Głównym...
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Pipelined division of signed numbers with the use of residue arithmetic for small number range with the programmable gate array
PublicationIn this work an architecture of the pipelined signed residue divider for the small number range is presented. Its operation is based on reciprocal calculation and multiplication by the dividend. The divisor in the signed binary form is used to compute the approximated reciprocal in the residue form by the table look-up. In order to limit the look-up table address an algorithm based on segmentation of the divisor into two segments...
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Cancer stem cells in drug resistance and drug screening: can we exploit the cancer stem cell paradigm in search for new antitumor agents?
PublicationPraca przedstawia przegląd literatury dotyczącej hipotezy komórek pierwotnych nowotworu, w szczególności w ich oporności na istniejące terapie. Dyskutowane jest także zagadnienie możliwości wykorzystania wiedzy o tych komórkach do konstrukcji nowych testów do badań przesiewowych in vitro w celu poszukiwania nowych leków przeciwnowotworowych.
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Residual Effects of Different Cropping Systems on Physicochemical Properties and the Activity of Phosphatases of Soil
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Influence of circuit breaker operation upon transformeros residual flux and inrush current
PublicationPrzedstawiono model i wyniki obliczeń prądu i strumienia magnetycznego w układzie zawierającym transformator trójfazowy i wyłącznik. Opracowano obwodowy model łącznika z łukiem elektrycznym. Model łuku zbudowano w oparciu o jego statyczną charakterystykę prądowo-napięciową z uwzględnieniem uproszczonej charakterystyki dynamicznej. Przeprowadzone symulacje wykazały, że wartość maksymalna prądu włączania transformatora zależy zarówno...
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Numerical Analysis of Magnetic Core Properties Influence on Residual Current Device Behaviour
PublicationW artykule przedstawiono analizę wpływu kształtu prądu w uzwojeniu pierwotnym transformatora prądowego na pracę przekładnika różnicowo-prądowego. Przeprowadzono obliczenia symulacyjne dla wymuszenia o kształcie sinusoidy i sinusoidy wyprostowanej dla częstotliwości 50 Hz. Wzięto pod uwagę dwa typy charakterystyki magnesowania transformatora: dla materiału magnetycznie miękkiego i materiału o prostokątnej pętli histerezy. Analiza...
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Numerical calculation of three-phase transformer's residual flux in ATP and PSpice programs.
PublicationW artykule przedstawiono analizę przebiegów prądu i strumienia magnetycznego podczas wyłączania transformatora energetycznego, wykonaną w celu określenia strumieni szczątkowych. Wykorzystano do tego celu modele obwodowe zbudowane w oparciu o programy symulacyjne ATP (Alternative Transients Program) i PSpice. Wyniki obliczeń okazały się bardzo zbliżone dla obu modeli. Przy ich wykorzystaniu obliczono strumienie szczątkowe w kolumnach...
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Menopause: a trigger for simultaneous development of ulcerative colitis in sigmoid neovagina and residual colorectum?
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Supervised Model Reference Adaptive Control of Chlorine Residuals in Water Distribution Systems
PublicationControl of integrated quality and quantity in Drinking Water Distribution Systems within recently proposed hierarchical framework is considered in the paper. A supervised nonlinear Indirect Model Reference Adaptive Controller is derived for the lower control level of the control structure to operate as the fast feedback controller of chlorine residuals in the monitored nodes. The major supervisor role is to manage switching between...
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Identification of residual force in static load tests on instrumented screw displacement piles
PublicationOccurrence of the so-called residual force of an unknown value significantly disturbs interpretation of static load tests performed on piles equipped with additional measuring instruments. Screw displacement piles are the piling technology in which the residual force phenomenon is very common. Its formation mechanism is closely related to the installation method of this type of piles, which initiates generation of negative pile...
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Testing sensitivity of A-type residual current devices to earth fault currents with harmonics
PublicationIn many applications, modern current-using equipment utilizes power electronic converters to control the consumed power and to adjust the motor speed. Such equipment is used both in industrial and domestic installations. A characteristic feature of the converters is producing distorted earth fault currents, which contain a wide spectrum of harmonics, including high-order harmonics. Nowadays, protection against electric shock in...
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Advanced numerical modelling for predicting residual compressive strength of corroded stiffened plates
PublicationAn advanced methodology for predicting the residual compressive strength of corroded stiffened plates is developed here using the non-linear finite element method. The non-uniform loss of a plate thickness is accounted for on a macro-scale. In contrast, mechanical properties are changed using the constitutive model to reflect the corrosion degradation impact on a micro-scale. Three different stiffened plate thicknesses are considered,...
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An investigation on residual stress and fatigue life assessment of T-shape welded joints
PublicationThis paper aims to quantitatively evaluate the residual stress and fatigue life of T-type welded joints with a multi-pass weld in different direction. The main research objectives of the experimental test were to test the residual stress by changing direction along with multiple wielding passes and determine the fatigue life of the welded joints. The result shows that compressive residual stress increases in the sample gradually...
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Fault loop impedance measurement in low voltage network with residual current devices
PublicationW sieciach i instalacjach niskiego napięcia z wyłącznikami różnicowoprądowymi pomiar impedancji pętli zwarciowej jest kłopotliwy. Prąd pomiarowy powoduje ich zbędne zadziałanie, co uniemożliwia prawidłowe wykonanie pomiaru. W artykule omówiono przyczyny zbędnego zadziałania wyłączników różnicowoprądowych podczas pomiaru impedancji pętli zwarciowej oraz warunki, w jakich ten pomiar można wykonać poprawnie.
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Failure of cold-formed beam: How does residual stress affect stability?
PublicationIn machine industry, stresses are often calculated using simple linear FEM analysis. Occasional failures of elements designed in such a way require recomputation by means of more sophisticated methods, eg. including plasticity and non-linear effects. It usually leads to investigation of failure causes and improvement of an element in order to prevent its unwanted behavior in the future. The study presents the case where both linear...
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Improving sensitivity of residual current transformers to high frequency earth fault currents
PublicationFor protection against electric shock in low voltage systems residual current devices are commonly used. However, their proper operation can be interfered when high frequency earth fault current occurs. Serious hazard of electrocution exists then. In order to detect such a current, it is necessary to modify parameters of residual current devices, especially the operating point of their current transformer. The authors proposed...
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The role of fluids in high-pressure polymorphism of drugs: different behaviour of β-chlorpropamide in different inert gas and liquid media
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Recovery of Nonsteroidal Anti-Inflammatory Drugs from Wastes Using Ionic-Liquid-Based Three-Phase Partitioning Systems
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Quantitative structure—retention relationship modeling of the retention behavior of selected antipsychotic drugs in normal-phase thin-layer chromatography
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Maternal immune activation leads to age-related behavioral and immunological changes in male rat offspring - the effect of antipsychotic drugs
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Determination of nonsteroidal antiinflammatory drugs in water samples using liquid chromatography coupled with diode-array detector and mass spectrometry
PublicationOpracowano i zwalidowano metodykę do oznaczania śladowych ilości sześciu różnych związków z grupy niesteroidowych leków przeciwzapalnych w próbkach wodnych. Anality zostały wybrane spośród najczęsciej sprzedawanych leków w Polsce. Sprawdzono kilka różnych kolumienek ekstrakcyjnych i wybrano RP-18 jako najlepsze wypełnienie do wzbogacania oznaczanych związków. Opracowaną metodykę z powodzeniem zastosowano do analizy próbek rzeczywistych.
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Systematic review of the effect of D‑mannose with or without other drugs in the treatment of symptoms of urinary tract infections/cystitis (Review)
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Evaluation and cellular responses of modulators of TRF1/TRF2 protein’s function as potential anticancer drugs interfering with telomeric shelterin’s function
PublicationA number of proteins that interact with telomeres have been identified in human cells, indicating the high plasticity of human nucleoprotein complex organization. The most important complex is the "shelterin" complex, which consists of six proteins: TRF1, TRF2, TIN2, POT1, TPP1. The TRF1 and TRF2 directly bind to telomeric double-stranded DNA and the TIN2 protein. The TIN2 protein also binds to the TPP1 protein, stabilizing the...
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Determination of benzodiazepines and Z-hypnotic drugs in whole blood samples by GC–MS/MS: Method development, validation and application
PublicationBenzodiazepines (BZDs) and Z-drugs are widely used as anxiolytics, sedative hypnotics, anticonvulsants and muscle relaxants. “Designer benzodiazepines” (DBZDs) are a new psychoactive substance class consisting of benzodiazepine derivatives that are not allowed for medical use and are known for being used recreationally. From a toxicologist standpoint, the huge number of such substances implicate a necessity for developing fast...
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Impact of inorganic ions and pH variations on toxicity and endocrine potential of selected environmentally relevant pharmaceuticals
PublicationAssessment of the impact of pharmaceutical residues on living organisms is a very complex subject. Apart from taking into account the toxicity of individual compounds, environmental factors should also be taken into account. In this paper, attempts were made to assess the impact of coexisting inorganic ions and changes in pH on the toxicity of ten selected pharmaceuticals. Two bioassays were used to measure the estrogenic and androgenic...
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Cumulant-based expressions for the multibody terms for the correlation between local and electrostatic interactions in the united-residue force field
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Implementations of Nosé–Hoover and Nosé–Poincaré thermostats in mesoscopic dynamic simulations with the united-residue model of a polypeptide chain
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Micelle-bound conformations of neurohypophyseal hormone analogues modified with a Cα-disubstituted residue: NMR and molecular modelling studies
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Chemometrics of bi-heterocyclic kind of drug specimens in the THz domain
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Chitosan-Based Nanoparticles as Effective Drug Delivery Systems—A review
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Mesoporous silica nanoflakes – Biocompatibility, cellular uptake and drug transport
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Recent Advances in Polymer-Based Vaginal Drug Delivery Systems
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The Role of miRNA-7 in the Biology of Cancer and Modulation of Drug Resistance
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Controlled Drug Release by the Pore Structure in Polydimethylsiloxane Transdermal Patches
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Filling of Carbon Nanotubes: Containers for Magnetic Probes and Drug Delivery
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Synthetic strategies in construction of organic macromolecular carrier–drug conjugates
PublicationMany metabolic inhibitors, considered potential antimicrobial or anticancer drug candidates, exhibit verylimited ability to cross the biological membranes of target cells. The restricted cellular penetration ofthose molecules is often due to their highhydrophilicity. One of the possible solutions to this problem is aconjugation of an inhibitor with a molecular organic nanocarrier. The conjugate thus formed should beable to penetrate...
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Effective Drug Concentration and Selectivity Depends on Fraction of Primitive Cells
PublicationPoor efficiency of chemotherapeutics in the eradication of Cancer Stem Cells (CSCs) has been driving the search for more active and specific compounds. In this work, we show how cell density-dependent stage culture profiles can be used in drug development workflows to achieve more robust drug activity (IC50 and EC50) results. Using flow cytometry and light microscopy, we characterized the cytological stage profiles of the HL-60-,...
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Diatomaceous earth as a drug-loaded carrier in a glass-ionomer cement
PublicationThe effect of a natural filler (diatomaceous earth [DE], a promising drug-delivery agent) and its content was investigated on the performance of a model glass-ionomer cement (GIC). Three sample series, differing in DE content (0, 2.5 and 5 wt%), were prepared using a commercial GIC as a matrix (3M Ketac Molar Easymix). The resultant surface microhardness and roughness, wear performance, and compressive strength of the samples were...
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Pharmaceutical and forensic drug applications of chiral supercritical fluid chromatography
PublicationTHE SUPERCRITICAL FLUID IS AN EXCELLENT CHOICE AS THE CHROMATOGRAPHIC MOBILE PHASE BECAUSE IT ALLOWS RAPID SEPARATION WITH HIGH EFFICIENCY AND APPLICATIONS INVOLVING ENANTIORESOLUTION ARE COMMON. SUPERCRITICAL FLUID CHROMATOGRAPHY (SFC) IS INCREASINGLY USED FOR ANALYTICAL, SEMI-PREPARATIVE AND PREPARATIVE PURIFICATION OF CHIRAL COMPOUNDS, INCLUDING PRODUCTION OF ENANTIOMERS THAT ARE MAINLY ENCOUNTERED DURING DRUG DEVELOPMENT. SFC...
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Determination of pharmaceutical residues in drinking water in Poland using a new SPE-GC-MS(SIM) method based on Speedisk extraction disks and DIMETRIS derivatization
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Structural Insights into Autoreactive Determinants in Thyroid Peroxidase Composed of Discontinuous and Multiple Key Contact Amino Acid Residues Contributing to Epitopes Recognized by Patients’ Autoantibodies
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Copper(II) coordination properties of GxG peptides: Key role of side chains of central residues on coordination of formed systems; combined potentiometric and ITC studies
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Is sequential batch reactor an efficient technology to protect recipient against non-steroidal anti-inflammatory drugs and paracetamol in treated wastewater?
PublicationThe tested facility was a wastewater treatment plant (WWTP) in Swarzewo, where the wastewater treatment takes place in aeration chambers with activated sludge using sequential batch reactors (SBRs). The concentration of the following pharmaceuticals: ibuprofen, paracetamol, flurbiprofen, naproxen, diclofenac, and its metabolites 5OH-diclofenac and 4OH-diclofenac was tested in influents and effluents. Simultaneously, the conventional...
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Design, synthesis and biological evaluation of novel N-phosphorylated and O-phosphorylated tacrine derivatives as potential drugs against Alzheimer’s disease
PublicationIn this work, we designed, synthesised and biologically investigated a novel series of 14N- and O-phosphorylated tacrine derivatives as potential anti-Alzheimer’s disease agents. In the reaction of 9-chlorotacrine and corresponding diamines/aminoalkylalcohol we obtained diamino and aminoalkylhydroxy tacrine derivatives. Next, the compounds were acid to give final products 6–13 and 16–21 that were characterised by 1H, 13 C, 31P...