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Search results for: STD
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Epitaph of George Wildtberger in St. Mary's Church in Gdańsk
Open Research DataThe data set concerns epigraphy. It refers to the epitaph placed in St. Mary’s Church in Gdańsk which is dedicated to George Wildtberger, personal secretary to king Sigismund III Vasa of Sweden and Poland who died on 8th of February 1593 in Gdańsk. The data set contains one general photo of the epitaph, transcription of its text in Latin, its Polish...
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Epitaph of Henry Giese in St. Mary's Church in Gdańsk
Open Research DataThe data set concerns epigraphy. It refers to the epitaph placed in St. Mary’s Church in Gdańsk, that is dedicated to Henry Giese, a member of merchant family that came from Germany and settled down in Gdańsk in XVI century. Data set contains one general photo of the epitaph, transcription of its text in Latin, its translation in Polish, and the biography...
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Epitaph of Martin Ramus in St. Mary's Church in Gdańsk
Open Research DataThe data set concerns epigraphy. It refers to the epitaph placed in St. Mary’s Church in Gdańsk which is dedicated to Martin Ramus, teacher of the parochial school at the St. Mary church in Gdansk who died on 24th of June 1631 in Gdańsk. The data set contains one general photo of the epitaph, transcription of its text in Latin, its Polish translation,...
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Epitaph of Guldenstern family in St. Mary's Church in Gdańsk
Open Research DataThe data set concerns epigraphy. It refers to the epitaph placed in St. Mary’s Church in Gdańsk, that is dedicated to family Guldenstern, very noble family that came to Poland with the king of Sweden and Poland – Sigismund III Vasa, and to representatives of Swedish emigration. Data set contains one general photo of the epitaph, transcription of its...
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Epitaph of Oehm family in St. Mary's Church in Gdańsk
Open Research DataThe data set concerns epigraphy. It refers to the epitaph placed in St. Mary’s Church in Gdańsk, that is dedicated to Öhm family, rather unknown to Gdańsk. The epitaph was erected by two latest representatives of family – John and Andrew. Data set contains one general photo of the epitaph, transcription of its text in Latin, its translation in Polish,...
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Epitaph of James Schadius in St. Mary's Church in Gdańsk
Open Research DataThe data set concerns epigraphy. It refers to the epitaph placed in St. Mary’s Church in Gdańsk, that is dedicated to James Schadius city doctor of Gdańsk, who, after he had studied medicine in Italy, stayed in Gdańsk till his death on 7th of June 1588. The epitaph was erected by his wife and son. Data set contains one general photo of the epitaph,...
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Epitaph of John Schroeder in St. Mary's Church in Gdańsk
Open Research DataThe data set concerns epigraphy. It refers to the epitaph placed in St. Mary’s Church in Gdańsk, that is dedicated to John Schröder, son of Simon. John, as he was a single, erected this epitaph for himself. Data set contains one general photo of the epitaph, transcription of its text in Latin, its translation in Polish, and the biography of the deceased,...
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ANALIZA SCZEPNOŚCI MIĘDZYWARSTWOWEJ DWUWARSTWOWO WBUDOWANEJ PODBUDOWY ASFALTOWEJ NA ODCINKU KM 335+946 – 356+850 STR. P ORAZ JEJ WPŁYW NA TRWAŁOŚĆ KONSTRUKCJI NAWIERZCHNI „Budowa mostu przez rzekę Nogat w Malborku wraz z dojazdami w ciągu dróg krajowych nr 22 i 55"
PublicationCelem pracy jest ocena jakości połączenia dwóch warstw technologicznych podbudowy z betonu asfaltowego AC 22 35/50 o całkowitej grubości 18 cm oraz wpływ tego połączenia na trwałość konstrukcji nawierzchni drogi na odcinku km 355+946 – 356+850 str. P, wbudowanej w ramach realizacji kontraktu „Budowa mostu przez rzekę Nogat w Malborku wraz z dojazdami w ciągu dróg krajowych nr 22 i 55”.
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Porównywanie zdjęć roślin na podstawie miar podobieństwa różniących się wykładnikiem potęgi
PublicationArtykuł przedstawia studium przypadku poświęcone zastosowaniu różnych miar podobieństwa do porównywania zdjęćroślin. Miary te mają zastosowanie w przypadku użycia układu kamer składającej się z pięciu kamer umieszczonych w bliskiej odległości. Badany układ kamer, nazwany EBCA (Equal Baseline Camera Array), składa się z jednej kamery centralnej oraz kamer bocznych. Opisane miary podobieństwa...
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Protokoły drzewa opinającego - ataki i metody obrony
PublicationW pracy przedstawiono sposoby ataków na sieci wykorzystujące realizacje drzewa opinającego STP (IEEE 802.1d i IEEE 802.1w a także modyfikacji STP wprowadzonych przez Cisco) oraz znane metody obrony przed atakami na STP. Zaproponowano także nową koncepcje obrony przed atakami mechanizmu STP wykorzystującą pole flags ramek BPDU.
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Jarosław Chojnacki prof. dr hab. inż.
PeopleBorn in 1961 in Bydgoszcz, professional education started at the Chemical Technical Highschool (I. Łukasiewicz). He graduated from the Faculty of Chemistry at the Gdańsk University of Technology in 1986, defending the work on ion-selective electrodes. Subsequent studies were related to organic and siliconorganic synthesis and, from 2002 year on, to crystallography. The doctoral thesis concerned the Silanotiolanes of coinage metals...
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Ethnologia Balkanica. Journal for Southeast European Anthropology. Zeitschrift für die Anthropologie Südosteuropas. Journal d'anthropologie sud-est européen
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Recent progress in the development of steroid sulfatase inhibitors – examples of the novel and most promising compounds from the last decade
PublicationThe purpose of this review article is to provide an overview of recent achievements in the synthesis of novel steroid sulfatase (STS) inhibitors. STS is a crucial enzyme in the biosynthesis of active hormones (including estrogens and androgens) and, therefore, represents an extremely attractive molecular target for the development of hormone-dependent cancer therapies. The inhibition of STS may effectively reduce the availability...
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Zespół mieszkaniowo-usługowy ZUS przy ul. Partyzantów w Gdyni, jako przykład nowoczesnego zintegrowania funkcji i formy = / ZUS residential and service complex in Partyzantów St. in Gdynia as an example of modern integration of form and function
PublicationArtykuł dotyczy zespołu zabudowy, który powstał w Gdyni pod koniec lat 30. XX w. Ukończenie założenia przerwał wybuch II wojny, ale pomimo tego zrealizowana część dowodzi, że zastosowane rozwiązania przestrzenne i funkcjonalne należały do najnowocześniejszych w ówczesnej Polsce.
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New potent steroid sulphatase inhibitors based on 6-(1-phenyl-1H-1,2,3-triazol-4-yl)naphthalen-2-yl sulphamate derivatives
PublicationIn the present work, we report a new class of potent steroid sulphatase (STS) inhibitors based on 6-(1-phenyl-1H-1,2,3-triazol-4-yl)naphthalen-2-yl sulphamate derivatives. Within the set of new STS inhibitors, 6-(1-(1,2,3-trifluorophenyl)-1H-1,2,3-triazol-4-yl)naphthalen-2-yl sulphamate 3L demonstrated the highest activity in the enzymatic assay inhibiting the STS activity to 7.98% at 0.5 µM concentration. Furthermore, to verify...
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Jerzy Konorski dr hab. inż.
PeopleJerzy Konorski received his M. Sc. degree in telecommunications from Gdansk University of Technology, Poland, and his Ph. D. degree in computer science from the Polish Academy of Sciences, Warsaw, Poland. In 2007, he defended his D. Sc. thesis at the Faculty of Electronics, Telecommunications and Informatics, Gdansk University of Technology. He has authored over 150 papers, led scientific projects funded by the European Union,...
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Weronika Maria Mazurkiewicz dr inż. arch.
PeopleJest adiunktem na Wydziale Architektury Politechniki Gdańskiej w Katedrze Urbanistyki i Planowania Regionalnego oraz czynnym architektem urbanistą.Od 2018 roku jest również członkiem Zarządu Towarzystwa Urbanistów Polskich oraz stowarzyszenia AESOP (Thematic Group for Public Spaces and Urban Cultures). Odbyła staże badawcze w kilku instytucjach badawczych w tym University of Ljubljana, University of Technology of Wiena, University...
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Properties and Formation of Mineralized Veins in an Organic-Rich Shale Formation
PublicationAn earlier paper defined mineral and organic matter constituents in weak interfaces in shale formations (Ptaszynska, et. al., 2016). The formation studied in the earlier work and here is the Jurassic, early-Cretaceous Vaca Muerta formation in the Neuquen basin in Argentina. In this earlier work, mineralized "veins" were noted to be prevalent and complicated, sometimes being shear weak interfaces while in other cases they were not....
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Vestnik Sankt-Peterburgskogo Universiteta-Ekonomika-St Petersburg University Journal of Economic Studies
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Synthesis and biological evaluation of thiophosphate tricyclic coumarin derivatives as steroid sulfatase inhibitors
PublicationSteroid sulfatase (STS) enzyme inhibition is an important approach to the management of hormone-dependent breast cancer. In this paper, we report convenient methods for the synthesis and biological evaluation of thiophosphate tricyclic coumarin analogs exhibiting STS activity. The described methods are based on the straightforward preparation of 7-hydroxy-2,3-dihydro-1H-cyclopenta[c]chromen-2-one, 3-hydroxy- 7,8,9,10-tetrahydro-6H-benzo[c]chromen-6-one,...
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Epitaph of Eggert von Kempen in St. Mary's Church in Gdańsk
Open Research DataThe data set concerns epigraphy. It refers to the epitaph placed in St. Mary’s Church in Gdańsk which is dedicated to Eggert von Kempen, the progenitor of the von Kempen family, a wealthy Gdańsk merchant, alderman and councilor, and to his son John, an alderman and councilor who, due to unsuccessful financial operations, significantly depleted family...
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Epitaph of Anna and Daniel Zierenberg in St. Mary's Church in Gdańsk
Open Research DataThe data set concerns epigraphy. It refers to the epitaph placed in St. Mary’s Church in Gdańsk, that is dedicated to Anna and Daniel Zierenberg. Daniel was particularly interested in activities for the education of Gdańsk and was one of those mayors who in 1596 established the foundation called Bibliotheca Senatus Gedanensis (today PAN BG). Data set...
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Plaque of Dorothy and John Brandes in St. Mary's Church in Gdańsk
Open Research DataThe data set concerns epigraphy. It refers to the plaque placed in St. Mary’s Church in Gdańsk, that is dedicated to John Brandes, highly influential citizen of Gdańsk, whose official career was crowned with the function of mayor, and his wife Dorothy née Zimmermann. The plaque was placed in the church in 1586. Data set contains two photos of the plaque,...
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Epitaph of Choene-Jaski family in St. Mary's Church in Gdańsk
Open Research DataThe data set concerns epigraphy. It refers to the epitaph placed in St. Mary’s Church in Gdańsk, that is dedicated to family Chöne-Jaski, that came to Poland from Moldavia at the beginning of XVI century and was engaged in trade in amber. Later on, the representatives of the family were in city council as jurors, councilors, judges and city treasurers....
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Epitaph of Dorothy and John Brandes in St. Mary's Church in Gdansk
Open Research DataThe data set concerns epigraphy. It refers to the epitaph placed in St. Mary’s Church in Gdańsk, that is dedicated to John Brandes, highly influential citizen of Gdańsk, whose official career was crowned with the function of mayor, and his wife Dorothy née Zimmermann. The epitaph was founded by their family, and especially by their grandson John Speymann,...
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Epitaph of Clemens and Gabriel Coelmer in St. Mary's Church in Gdańsk
Open Research DataThe data set concerns epigraphy. It refers to the epitaph placed in St. Mary’s Church in Gdańsk which is dedicated to Clemens and Gabiel Coelmer, sons of a Gdańsk merchant; Clemens devoted himself to a clerical career in Gdańsk and became a councilor. The data set contains one general photo of the epitaph, transcription of its text in Latin, its Polish...
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Sepulchral plate of Thomas Tympfius in St. Mary's Church in Gdańsk
Open Research DataThe data set concerns epigraphy. It refers to the sepulchral plate placed in St. Mary’s Church in Gdańsk which is dedicated to Thomas Tympfius, a minter who, together with his brother Andrew, rented several mints in the Kingdom of Poland, and gave his name to the timpf - the silver zloty released by the Tympfius mint. Unfortunately, as a result of...
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Alms-panel of Anton Moeller in St. Mary's Church in Gdańsk
Open Research DataThe data set concerns epigraphy. It refers to the Alms-panel placed in St. Mary’s Church in Gdańsk, that is the work of Gdańsk painter Antoni Moller, made in 1607, or rather – to be more specific – to lower part of this work, which are the verses from Holy Bible. Data set contains one general photo of the inscription, transcription of its text in Latin...
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Residence time distribution in rapid multiphase reactors
PublicationResidence time distribution (RTD) provides information about average hydraulic residence time and the distribution of material in the reactor. A method for determining RTD for reactors with very short hydraulic residence times is deconvolution based on extraction of real RTD by the analysis of a non-ideal input signal. The mean residence time and dispersion were determined for the spinning fluids reactor (SFR). For the first time...
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Paweł Burdziakowski dr inż.
PeoplePaweł Burdziakowski, PhD, is a professional in low-altitude aerial photogrammetry and remote sensing, marine and aerial navigation. He is also a licensed flight instructor and software developer. His main areas of interest are digital photogrammetry, navigation of unmanned platforms and unmanned systems, including aerial, surface, underwater. He conducts research in algorithms and methods to improve the quality of spatial measurements...
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Development and experimental validation of a novel double-stage yield steel slit damper-buckling restrained brace
PublicationThis research is focused on the development and experimental validation of a novel double-stage yield steel slit damper-buckling restrained brace (SSD-DYB) system designed for seismic resistance of steel structures. The SSD-DYB integrates the energy dissipation capability of a steel slit damper (SSD) in its initial segment, enhancing performance in the case of lower seismic intensities levels while employing a larger segment for...
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Novel steroid sulfatase inhibitors based on N ‐thiophosphorylated 3‐(4‐aminophenyl)‐coumarin‐7‐O‐sulfamates
PublicationIn the present work, we described convenient methods for the synthesis ofN-thiophosphorylated 3-(4-aminophenyl)-coumarin-7-O-sulfamates as steroid sulfatase(STS) inhibitors. To design the structures of the potential STS inhibitors, molecularmodeling techniques were used. A computational docking method was used to deter-mine the binding modes of the synthesized inhibitors as well as to identify potentialinteractions between specified...
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A Novel Method for Intelligibility Assessment of Nonlinearly Processed Speech in Spaces Characterized by Long Reverberation Times
PublicationObjective assessment of speech intelligibility is a complex task that requires taking into account a number of factors such as different perception of each speech sub-bands by the human hearing sense or different physical properties of each frequency band of a speech signal. Currently, the state-of-the-art method used for assessing the quality of speech transmission is the speech transmission index (STI). It is a standardized way...
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Jan Buczkowski prof. dr hab. sztuki
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Sepulchral plate of Dorothy and Matthias Zimmermann in St. Mary's Church in Gdańsk
Open Research DataThe data set concerns epigraphy. It refers to the sepulchral plate placed in St. Mary’s Church in Gdańsk which is dedicated to Dorothy and Matthias Zimmermann, a wealthy merchant and Gdańsk mayor, trusted courtier of King Alexander Jagiellon. The data set contains one general photo of the sepulchral plate, transcription of its text in Latin, its Polish...
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Sepulchral plate of James von Werden in St. Mary's Church in Gdańsk
Open Research DataThe data set concerns epigraphy. It refers to the It refers to the sepulchral plate placed in St. Mary’s Church in Gdańsk which is dedicated to James von Werden, a rich merchant, a provisor of St. Mary Church in Gdańsk, father of Mayor John von Werden, a founder of this sepulchral plate. The data set contains one general photo of the sepulchral plate,...
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Jan Kreft prof. dr hab.
PeopleProf. dr hab. Jan Kreft, Politechnika Gdańska (WZiE), profesor Uniwersytetu Jagiellońskiego (WZiKS) 2013-2019. Kierownik Zakładu Zarządzania Algorytmicznego (Katedra Zarządzania) i Centrum Badań nad Zarządzaniem Algorytmicznym. Zainteresowania badawcze: zarządzanie organizacjami mediów i nowych technologii, teoria i praktyka manipulacji i propagandy. Wieloletni dziennikarz polskich mediów m.in. Agencji Reuters. Korespondent w...
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Performance Evaluation of Asphalt Binder Modified with Shear Thickening Fluid
PublicationThis paper aims at using a dilatant or shear thickening fluid (STF) [a non-Newtonian fluid consisting of particles of nano-silica suspended in a liquid medium, i.e., ethylene glycol (EG), which acts as a carrier fluid; proportion 40:60] as additive or modifier of bitumen in order to enhance its viscoelastic properties. A commonly-used performance grading (PG) system, storage stability test, and different conventional and rheological...
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From DNA damage to G2 arrest: the many roles of topoisomerase II. W: Prog-ress in Cell Cycle Research. Ed. Meijer L., Jezequel A., Roberge M. London: Plenum Publ. Comp. Ltd**2003 vol. 5 chapt. 30 s. 295-300 Od uszkodzeń DNA do bloku w G2: wiele ról dla topoizomerazy II.
PublicationInhibitory DNA topoizomerazy II sa jednymi z najbardziej szeroko stosowanymi lekami przeciwnowotworowymi. Związki te indukuja pekniecia nici DNA i bloku progresji cyklu komorkowego w fazie G2. Jednak topoizomeraza II jest nie tylko celem molekularnym dla lekow przeciwnowtworowych ale enzym ten pelniwazna role w odpowiedzi komorkowej na dzialanie wielu lekow uszkadzajacych DNA. Topoizomeraza tworzy kompleksy molekularne z bialkami...
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Approach Manoeuvre During Emergency Ship-to-Ship Transfer Operation with Oil Spill
PublicationOne of the major activities during Ship to Ship (STS) transfer operation at sea is to safe approach the Ship to be Lightered (SBL) which moves on a constant heading with slow speed or drifting. In the paper described the manoeuvring problem for approaching during emergency STS transfer operation with oil spill. The approach manoeuvre is considered as a sequence of navigation manoeuvres in specific navigational environment with...
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Space-Time Conservation Method applied to numerical solution of water hammer equations
PublicationArtykuł poświęcony jest metodzie czasoprzestrzennych objętości skończonych (STC) zastosowanej do przypadku uderzenia hydraulicznego w stalowym przewodzie pracującym pod ciśnieniem. Metoda STC ze względu na swoje własności numeryczne - m.in. wysoką dokładność - może być interesującą alternatywą dla tradycyjnych metod numerycznych, szczególnie w przypadku, gdy efekty numeryczne mają bardzo silny wpływ na rozwiązanie, tym samym utrudniając...
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Synthesis and biological evaluation of N-acylated tyramine sulfamates containing C-F bonds as steroid sulfatase inhibitors
PublicationSteroid sulfatase (STS) is responsible for the hydrolysis of biologically inactive sulfated steroids into their active un-sulfated forms and promotes the growth of various hormone-dependent cancers (e.g., breast cancer). Therefore, the STS enzyme is a promising therapeutic target for the treatment of steroid-sensitive cancers. Herein, we report the synthesis and biological evaluation of sulfamate analogs as potential STS inhibitors...
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Krzysztof Goczyła prof. dr hab. inż.
PeopleKrzysztof Goczyła, full professor of Gdańsk University of Technology, computer scientist, a specialist in software engineering, knowledge engineering and databases. He graduated from the Faculty of Electronics Technical University of Gdansk in 1976 with a degree in electronic engineering, specializing in automation. Since then he has been working at Gdańsk University of Technology. In 1982 he obtained a doctorate in computer science...
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Kazimierz Darowicki prof. dr hab. inż.
PeopleProf. dr hab. inż. Kazimierz Darowicki studia wyższe ukończył w czerwcu 1981 roku. Już w marcu 1981 roku został zatrudniony na Wydziale Chemicznym Politechniki Gdańskiej. Na Wydziale Chemicznym przeszedł kolejne szczeble rozwoju do stanowiska profesora zwyczajnego i kierownika Katedry Elektrochemii, Korozji i Inżynierii Materiałowej włącznie. W działalności naukowej reprezentuje nauki techniczne, a jego specjalność naukowa i zawodowa...
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Synthesis and biological evaluation of fluorinated 3-phenylcoumarin-7-O-sulfamate derivatives as steroid sulfatase inhibitors
PublicationIn the present work, we report the initial results of our study on a series of 3-phenylcoumarin sulfamate-based compounds containing C-F bonds as a novel inhibitors of steroid sulfatase (STS). The new compounds are potent STS inhibitors, possessing more than 10 times higher inhibitory potency than coumarin-7-O-sulfamate. In the course of our investigation, compounds 2b and 2c demonstrated the highest inhibitory effect in the enzymatic...
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Krzysztof Nyka dr hab. inż.
PeopleKrzysztof Nyka, received MSc (1986) PhD (2002) and DSc (2020) degrees in telecommunication and electrical engineering from the Faculty of Electronics, Telecommunications and Informatics (ETI) of Gdańsk University of Technology (GUT), Poland. He is currently an Associate Professor at the Department of Microwaves and Antenna Engineering, Faculty of ETI, GUT. Before his academic career, he worked for the electronic industry (1984-1986). Research...
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Nadzorowanie drgań układu nośnego robota przemysłowego IRB-6 za pomocą ste-rowania modalnego przy energetycznym wskaźniku jakości. W: Zagadnienia ana- lizy modalnej konstrukcji mechanicznych. Praca zbiorowa pod red. T. Uhla. Kraraków: Kated. Robotyki i Dynam. Masz. AGH**2003 s. 115-122, 2 rys. 1 tab. bibliogr. 4 poz.
PublicationW pracy rozważa się drgania modelowanego dyskretnie niestacjonarnego układunośnego manipulatora IRB6 metodą sztywnych elementów skończonych. Do nadzo-rowania drgań wykorzystano algorytm sterowania optymalnego przy energetycz-nym wskaźniku jakości w dziedzinie współrzędnych modalnych. Uwzględnia on zmianę w czasie, względem trajektorii ruchu zadanego, energii potencjalnej, kinetycznej oraz energii sygnału sterującego.
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Phosphate and Thiophosphate Biphenyl Analogs as Steroid Sulfatase Inhibitors
PublicationIn the present work, we report convenient methods for the synthesis and biological evaluation of phosphate and thiophosphate biphenyl derivatives exhibiting steroid sulfatase (STS) activity. The described synthesis is based on straightforward preparation of biphenyl-4-ol and 40-hydroxybiphenyl- 4-carboxylic acid ethyl ester modified with various phosphate or thiophosphate moieties. The inhibitory effects of these compounds were...
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Epitaph of Gabriel Schumann and his son Gabriel in St. Mary's Church in Gdańsk
Open Research DataThe data set concerns epigraphy. It refers to the epitaph placed in St. Mary’s Church in Gdańsk, that is dedicated to Gabriel Schumann, a noble citizen of Gdańsk, who was a juror and finally councilor of Gdańsk, and his son Gabriel, who was not only juror and councilor, but also a city treasurer. Data set contains one general photo of the epitaph, transcription...
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Synthesis and steroid sulfatase inhibitory activities of N-phosphorylated 3-(4-aminophenyl)-coumarin-7-O-sulfamates
PublicationIn the present work, we report convenient methods for the synthesis and biological evaluation of N-phosphorylated derivatives of 3-(4-aminophenyl)-coumarin-7-O-sulfamate as potential steroid sulfatase (STS) inhibitors. Their binding modes were modeled using docking techniques. The inhibitory effects of the synthesized compounds were tested on STS isolated from human placenta. All of the newly synthesised coumarin derivatives were...