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Search results for: AGENDY
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Ts2631 Endolysin from the Extremophilic Thermus scotoductus Bacteriophage vB_Tsc2631 as an Antimicrobial Agent against Gram-Negative Multidrug-Resistant Bacteria
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Incidence and Clinical Course of Respiratory Viral Coinfections in Children Aged 0–59 Months
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Contribution of UDP-glucuronosyltransferases (UGTs) in metabolism of acridinone antitumor agents, C-1311, C-1305, and their less active structural analogues, C-1330 and C-1299
PublicationCelem prowadzonych badań było określenie roli UDP-glukuronylotransferaz, uważanych za najważniejsze enzymy detoksykujące, w metabolizmie pochodnych imidazo- i triazoloakrydonu. Wykazano, że najbardziej aktywne przeciwnowotworowo związki z obu grup, tj. C-1311 i C-1305 są transformowane do O-glukuronidów, w przeciwieństwie do ich metoksylowych analogów, odpowiednio związku C-1330 i C-1299. Analiza składu mieszanin reakcyjnych zawierających...
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Novel 2-(2-alkylthiobenzenesulfonyl)-3-(phenylprop-2-ynylideneamino)guanidine derivatives as potent anticancer agents – Synthesis, molecular structure, QSAR studies and metabolic stability
PublicationA series of new 2-(2-alkylthiobenzenesulfonyl)-3-(phenylprop-2-ynylideneamino)guanidine derivatives have been synthesized and evaluated in vitro by MTT assays for their antiproliferative activity against cell lines of colon cancer HCT-116, cervical cancer HeLa and breast cancer MCF-7. The obtained results indicated that these compounds display prominent cytotoxic effect. The best anticancer properties have been observed for derivatives...
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Jakub Miler dr inż.
PeopleAcademic career: 2000: Master of Science - Gdansk University of Technology, Faculty of Electronics, Telecommunications and Informatics, thesis "Computer system for supporting risk management in a software engineering project", supervisor prof. Janusz Górski 2005: PhD - Gdansk University of Technology, Faculty of Electronics, Telecommunications and Informatics, thesis "A Method of Software Project Risk Identification and Analysis",...
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How to meet when you forget: log-space rendezvous in arbitrary graphs
PublicationTwo identical (anonymous) mobile agents start from arbitrary nodes in an a priori unknown graph and move synchronously from node to node with the goal of meeting. This rendezvous problem has been thoroughly studied, both for anonymous and for labeled agents, along with another basic task, that of exploring graphs by mobile agents. The rendezvous problem is known to be not easier than graph exploration. A well-known recent result...
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Oleksii Nosko dr hab. inż.
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CYP3A4 overexpression enhances apoptosis induced by anticancer agent imidazoacridinone C-1311, but does not change the metabolism of C-1311 in CHO cells
PublicationWe examine whether CYP3A4 overexpression influences the rate and pattern of antitumor imidazoacridinone C-1311 metabolism, in relation to the impact of this overexpression on cell cycle progression and final cellular response of CHO cells following C-1311 treatment. Methods: Three CHO cell lines: CHO-WT, wild type, CHO-HR, overexpressing cytochrome P450 reductase (CPR) and CHO-HR-3A4, coexpressing CPR and CYP3A4 were applied....
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Prospective study of brentuximab vedotin in relapsed/refractory Hodgkin lymphoma patients who are not suitable for stem cell transplant or multi-agent chemotherapy
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Drug-drug interaction potential of antitumor acridine agent C-1748: The substrate of UDP-glucuronosyltransferases 2B7, 2B17 and the inhibitor of 1A9 and 2B7
PublicationBackground The compound 9-(2′-hydroxyethylamino)-4-methyl-1-nitroacridine (C-1748), the promising antitumor agent developed in our laboratory was determined to undergo phase I metabolic pathways. The present studies aimed to know its biotransformation with phase II enzymes – UDP-glucuronosyltransferases (UGTs) and its potential to be engaged in drug-drug interactions arising from the modulation of UGT activity. Methods UGT-mediated...
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Fast collaborative graph exploration
PublicationWe study the following scenario of online graph exploration. A team of k agents is initially located at a distinguished vertex r of an undirected graph. At every time step, each agent can traverse an edge of the graph. All vertices have unique identifiers, and upon entering a vertex, an agent obtains the list of identifiers of all its neighbors. We ask how many time steps are required to complete exploration, i.e., to make sure...
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Fast Collaborative Graph Exploration
PublicationWe study the following scenario of online graph exploration. A team of k agents is initially located at a distinguished vertex r of an undirected graph. At every time step, each agent can traverse an edge of the graph. All vertices have unique identifiers, and upon entering a vertex, an agent obtains the list of identifiers of all its neighbors. We ask how many time steps are required to complete exploration, i.e., to make sure...
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Mrówczan sodu z nowym pakietem inhibitorów korozji jako ekologiczny środek do odladzania infrastruktury lotniczej.
PublicationPrzedstawiono wyniki badań korozji kadmowej powłoki na stali oraz korozji po zanurzeniu stopów metali w mrówczanie sodu z nowym pakietem inhibitorów korozji, zawierającym synergiczną kompozycję poliasparaginianu sodu oraz imidazolu. Ponadto wyznaczono zdolność penetracji lodu przez badany układ. Właściwo- ści opracowanej kompozycji odladzającej porównano z właściwościami środków dostępnych na rynku. Uzyskane wyniki wskazują, że otrzymany...
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The X-ray photoelectron spectroscopy of surface composition of aged mixed copper manganese oxide catalysts
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Metabolic responses to a 48-h ultra-marathon run in middle-aged male amateur runners
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Pregnane X receptor dependent up-regulation of CYP2C9 and CYP3A4 in tumor cells by antitumor acridine agents, C-1748 and C-1305, selectively diminished under hypoxia
PublicationInduction of proteins involved in drug metabolism and in drug delivery has a significant impact on drug-drug interactions and on the final therapeutic effects. Two antitumor acridine derivatives selected for present studies, C-1748 (9-(2’-hydroxyethylamino)-4-methyl-1-nitroacridine) and C-1305 (5-dimethylaminopropylamino-8-hydroxy-triazoloacridinone), expressed high and low susceptibility to metabolic transformations with liver...
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A new phosphonium calix[4]arene for selective anion recognition: synthesis and studies in solution and in ion selective electrodes
PublicationZaprezentowana została synteza i charakteryzacja tetra (trifenylofosfoniowego) p-tert-butylkaliks[4]arenu 2. Oddziaływania z anionami były badane z użyciem (1)H oraz (31)P NMR i spektrofotometrii absorpcyjnej UV. Badania wykazały oddziaływania z anionami: CLO4-, I-, oraz SCN-. Selektywność jonoforu 2 badano również w membranowych elektrodach jonoselektywnych (ISE) PCV/o-NPOE. Elektroda zawierająca związek 2 generuje odpowiedź potencjometryczną...
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Krzysztof Arendt dr inż.
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JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
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The absorption and fluorescence spectra of C-1305 derivatives (IKE1-IKE8), potential antifungal agents
Open Research DataOptical measurements of C-1305 derivatives (IKE1-IKE8). The absorption spectra were recorded at 300 - 800 nm for solutions with 16 μg / mL derivative concentration. The fluorescence emission spectra were determined at 420-800 nm with the excitation wavelengths 360 or 415 nm for solutions with 1 μg / mL derivative concentration. All measurements were...
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Student model representation for pedagogical virtual mentors
PublicationThe paper concerns technological aspects of virtual mentors construction, especially concentrating on the student model representation. The article distinguishes several types of information that is gathered by the pedagogical agents and other educational platforms, including student knowledge model, student progress tracking, interaction process patterns and learner preferences. A set of technologies used for the student model...
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Study of Bioreductive Anticancer Agent RH-1-Induced Signals Leading the Wild-Type p53-Bearing Lung Cancer A549 Cells to Apoptosis
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2,7-Dihydro-3H-pyridazino[5,4,3-kl]acridin-3-one derivatives, novel type of cytotoxic agents active on multidrug-resistant cell lines. Synthesis and biological evaluation.
PublicationOtrzymano serię pirydazyno akrydyn-3-onów w reakcji 9-okso-9,10-dihydroakrydyno-1-karboksylanu etylu z POCl3, następnie dodanie odpowiedniej alkiloaminoalkilohydrazyny. Badane związki wykazują w porównaniu z referencyjnymi cytostatykami DX, MIT niższe wartości indeksu RI, a także niższe aktywności cytotoksyczne.
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Human CYP2 family of cytochrome P-450 takes part in metabolism of two acridine antitumor agents, C-1311 and C-1748, selected for I phase of clinical trials
PublicationPraca zawiera wyniki badań metabolicznej transformacji przeciwnowotworowych pochodnych akrydyny wobec zestawu 16 prób enzymów mikrosomalnych, pochodzących z wątroby 16 różnych pacjentów. Wykazano, że za metabolizm tych związków u człowieka odpowiedzialne są głównie izoenzymy z rodziny CYP2.
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Proteolysis in dry-aged loins manufactured with sonicated pork and inoculated withLactobacillus caseiŁOCK 0900 probiotic strain
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How do institutions from Pomerania Province support professional activity of people aged 50 and over?
PublicationThe article presents the solutions that were implemented in last years in the pomorskie province with regard to the economic activation of individuals aged 50+. The author presents the priorities in this area included in regional policy and specific initiatives of different types of institutions operating in the region.
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Epidemiology of type 1 diabetes among Silesian children aged 0–14 years, 1989–2005
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Lower-rim-substituted tert-butylcalix[4]arenes. Part IX: one-pot synthesis of calix[4]arene-hydroxamates and calix[4]arene-amides
PublicationZaprezentowano prostą metodę selektywnej acylacji podstawionych i niepodstawionych hydroksyloamin za pomocą di i tetra podstawionych kaliks{4]aren-kwasów. Pokazano pierwszą strukturę krystalograficzną kaliks-hydroksyamidu.
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Intelligent Virtual Agents
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Viral agents as the cause of diseases classified to other chapters - Female, 29 - Tissue image [9220729551203171]
Open Research DataThis is the histopathological image of CERVIX UTERI tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Viral agents as the cause of diseases classified to other chapters - Female, 29 - Tissue image [9220729551203921]
Open Research DataThis is the histopathological image of CERVIX UTERI tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Viral agents as the cause of diseases classified to other chapters - Female, 29 - Tissue image [9220729551207901]
Open Research DataThis is the histopathological image of CERVIX UTERI tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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The absorption and fluorescence spectra of novel bisacridines (IKE15-19, IKE21) and IE10, potential antifungal agents
Open Research DataOptical measurements of novel bisacridines (IKE15-19, IKE21) and IE10 were conducted. The absorption spectra were recorded from 300 to 800 nm. The fluorescence emission spectra were determined with excitation and emission wavelengths described in the file. All measurements were recorded using a multiplate reader, Tecan Spark 10M.
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Algorithms and Tools for Intelligent Control of Critical Infrastructure Systems
PublicationCritical Infrastructure Systems (CIS) are spatially distributed and of a network structure. The dynamics are nonlinear, uncertain and with several time scales. There is a variety of different objectives to be reliably met under a wide range of operational conditions. The operational conditions are influenced by the disturbance inputs, operating ranges of the CIS, faults in the sensors and actuators and abnormalities occurring in...
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Regenerative Drug Discovery Using Ear Pinna Punch Wound Model in Mice
PublicationThe ear pinna is a complex tissue consisting of the dermis, cartilage, muscles, vessels, and nerves. Ear pinna healing is a model of regeneration in mammals. In some mammals, including rabbits, punch wounds in the ear pinna close spontaneously; in common-use laboratory mice, they remain for life. Agents inducing ear pinna healing are potential regenerative drugs. We tested the effects of selected bioactive agents on 2 mm ear pinna...
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AGENT PR Sylwester Wolak
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Antibiotic resistance in Staphylococcus aureus strains isolated from cows with mastitis in the eastern Poland and analysis of susceptibility of resistant strains to alternative non-antibiotic agents: lysostaphin, nisin and polymyxin B.
PublicationThe aim of the studies was analysis of resistance of Staphylococcus aureus isolates from bovine mastitis in eastern part of Poland to a set of 20 antibiotics and three alternative agents: lysostaphin, nisin and polymyxin B. Eighty-six out of 123 examined isolates were susceptible to all of 20 tested antibiotics (70 %). The highest percentage of resistance was observed in the case of β-lactam antibiotics: amoxicillin (n=22, 17.9...
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Synthesis and biological evaluation of 2,7-Dihydro-3H-dibenzo[de,h]cinnoli- ne-3,7-done derivatives a novel group of anticancer agents active on a multidrug resistance cell line.
PublicationZsyntezowano serię pochodnych pirydazonu z jednym lub dwoma łańcuchami bocznymi w różnych pozycjach chromoforu tetracyklicznego. Związki wykazały aktywność cytoksyczną na mysią białaczkę L1210 i ludzką k562 oraz na linii komórkowej oporności krzyżowej MDR (k562/DX). Dwa najbardziej aktywne związki przetestowano in vivo na mysiej białaczce P388. Wykazały one aktywność przeciwnowotworową porównywalną z aktywnością Mitoxantronu.
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Rola agentów edukacyjnych w środowiskach zdalnego nauczania
PublicationAgent edukacyjny jest inteligentnym i autonomicznym programem, który może być zastosowany w środowiskach kształcenia na odległość. W artykule podano definicję oraz klasyfikację agentów edukacyjnych ze szczególnym wskazaniem na agenty pedagogiczne, których celem jest wsparcie dla zdobywania kompetencji przez uczniów. Wskazano także miejsce agentów w kompleksowych środowiskach nauczania za pośrednictwem Internetu. W artykule omówiono...
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Joanna Wolszczak-Derlacz dr hab.
PeopleI am an Associate Professor at Gdańsk University of Technology, Faculty of Management and Economics. I gained my PhD in July 2006 for which I received the Polish Prime Ministry’s Award for the outstanding doctoral thesis. Between 2007 and 2008, I was a beneficiary of the Max Weber Fellowship at the European University Institute in Florence, Italy. I conducted part of my research at the Katholieke Universiteit Leuven, Belgium...
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Modelowanie i ograniczanie skutków ataków uzurpacji uprawnień w systemach teleinformatycznych wspierających różnicowanie poziomu QoS
PublicationW wieloagentowych systemach teleinformatycznych pracujących w paradygmacie Klient-Serwer i wspierających różnicowanie poziomu QoS poważnym zagrożeniem są ataki uzurpacji uprawnień metodą Fałszywego VIPa. Ich celem jest zapewnienie Klientowi nienależnie wysokiego poziomu QoS, co powoduje nadużycie zasobów Serwera i szkody dla innych Klientów. W referacie podjęto próbę sforma-lizowania modelu takich ataków oraz zaproponowa-no obustronnie...
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Drawing maps with advice
PublicationRozważamy następujący problem obliczeniowy. Agent zostaje umieszczony w wierzchołku nieznanego mu grafu. Wierzchołki grafu są nierozróżnialne, natomiast krawędzie posiadają numery portów. Zadaniem agenta jest wyznaczenie mapy, tzn. obliczenie izomorficznej kopii grafu, lub obliczenie dowolnego drzewa spinającego grafu. Bez dodatkowej informacji zadań tych nie można wykonać. W artykule wyznaczamy oszacowania na minimalną liczbę...
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Inteligentne hybrydowe systemy wyszukiwania informacji
PublicationIstnieje wiele metod wyszukiwania informacji. Artykuł przedstawia możliwości połączenia tych metod i skonstruowania uniwersalnego, hybrydowego systemu wyszukiwania. W artykule zaproponowana została architektura personalnego agenta wyszukiwania (PAW). Posiada on cechy systemu ekspertowego, wyszukiwarki oraz agenta komputerowego. PAW pozwala na pozyskiwanie informacji personalnych tj. numery telefonów osób znajomych. Ponadto umożliwia...
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The unrecognized and untapped potential of workers aged >=50 years: myth or fact, a study of the situation of the elderly workers in Poland
PublicationThe authors carried out a comparative analysis and quantitative synthesis of the results of primary research from Polish research centers on Polish employers' assessment of workers aged 50 years old and more and the possibilities and conditionsof using the potential of this group in enterprises.
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MRI-Derived Subcutaneous and Visceral Adipose Tissue Reference Values for Children Aged 6 to Under 18 Years
PublicationThe assessment of body composition in pediatric population is essential for proper nutritional support during hospitalization. However, currently available methods have limitations. This study aims to propose a novel approach for nutrition status assessment and introduce magnetic resonance imaging (MRI)-derived subcutaneous and visceral fat normative reference values. A total of 262 healthy subjects aged from 6 to 18 years underwent...
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Pre-clinical toxicology and pathology of 9-(2'-hydroxyethylamino)-4-methyl-1-nitroacridine (C-1748), a novel anti-cancer agent in male Beagle dogs
PublicationPraca zawiera wyniki badań przedklinicznych i morfologicznych pochodnej akrydyny o symbolu C-1748 przeprowadzonych na psach. Wyznaczono maksymalną dawkę tolerowaną oraz przeprowadzono analizy zmiany składu krwi i morfologii jej komórek, pracy aminotransferaz, fosfokinaz, fosfataz i innych enzymów funkcjonalnych. Obserwowano też zachowanie się zwierząt. Stwierdzono, że związek ten wykazuje stosunkowo niską toksyczność, co przy obserwowanej...
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The overexpression of CPR and P450 3A4 in pancreatic cancer cells changes the metabolic profile and increases the cytotoxicity and pro-apoptotic activity of acridine antitumor agent, C-1748
PublicationDrug resistance is one of the major cause of pancreatic cancer treatment failure. Thus, it is still imperative to develop new active compounds and novel approach to improve drug efficacy. Here we present 9-amino-1-nitroacridine antitumor agent, C-1748, developed in our laboratory, as a candidate for pancreatic cancer treatment. We examined (i) the cellular response of pancreatic cancer cell lines: Panc-1, MiaPaCa-2, BxPC-3 and...
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Lucyna Nyka prof. dr hab. inż. arch.
PeopleLucyna Nyka (Ph.D., D.Sc., Prof.) is a Professor at the Faculty of Architecture, Gdańsk University of Technology, in 2008-2016 a Vice-Dean for Research, and since 2016 – Dean of the Faculty of Architecture. Her research interests focus on issues concerning water-related architecture and urban landscapes. She is the author and co-author of many projects focused on urban renewal. She was an author of the EU-founded (Audiovisual...
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Inteligentne systemy agentowe w systemach zdalnego nauczania
PublicationW pracy omówiono inteligentne systemy agentowe w systemach zdalnego nauczania. Po krótkim przedstawieniu ewolucji systemów zdalnego nauczania i ich wybranych zastosowań, scharakteryzowano inteligentne agenty edukacyjne. Omówiono wykorzystanie programowania genetycznego oraz algorytmów neuro-ewolucyjnych do implementacji oprogramowania tej klasy. Ponadto, nawiązano do modelu Map-Reduce, który efektywnie wspiera architekturę nowoczesnego...
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AUTOMATED NEGOTIATIONS OVER COLLABORATION PROTOCOL AGREEMENTS
PublicationThe dissertation focuses on the augmentation of proactive document - agents with built-in intelligence to recognize execution context provided by devices visited during a business process, and to reach collaboration agreement despite conflicting requirements. The proposed solution, based on intelligent bargaining using neural networks to improve simple multi-issue negotiation between the document and thedevice, requires practically...