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Search results for: TUBULIN INTERACTION
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Preferred Benchmarking Criteria for Systematic Taxonomy of Embedded Platforms (STEP) in Human System Interaction Systems
PublicationThe rate of progress in the field of Artificial Intelligence (AI) and Machine Learning (ML) has significantly increased over the past ten years and continues to accelerate. Since then, AI has made the leap from research case studies to real production ready applications. The significance of this growth cannot be undermined as it catalyzed the very nature of computing. Conventional platforms struggle to achieve greater performance...
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Formation of Protein Networks between Mucins: Molecular Dynamics Study Based on the Interaction Energy of the System
PublicationMolecular dynamics simulations have been performed for a model aqueous solution of mucin. As mucin is a central part of lubricin, a key component of synovial fluid, we investigate its ability to form cross-linked networks. Such network formation could be of major importance for the viscoelastic properties of the soft-matter system and crucial for understanding the lubrication mechanism in articular cartilage. Thus,the inter- and...
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Load-carrying capacity of axially loaded concrete-filled steel tubular columns made of thin tubes
PublicationAn experimental investigation was conducted on 30 CFST columns. An influence of the following factors on load-carrying capacity of the investigated columns was analyzed: the column slenderness (l1 = 42, l2 = 27 and l3 = 15), the tube thickness (the reinforcement ratio was equal to 4% or 6%), the way of applying the load to CFST columns (through the concrete core or through the entire cross-section), the bond strength between a...
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Fatigue fracture surface metrology of thin-walled tubular austenitic steel specimens after asynchronous loadings
PublicationThis paper aims to study the effect of asynchronous axial-torsional strain-controlled loading histories on fracture surface behavior of thin-walled tubular X5CrNi18-10 (304/304L) austenitic steel specimens. Tests under pure axial loading and pure torsional loading are also conducted to better segregate the effect of multiaxiality. The fractures surface topographies were examined through the profiles over the entire surface with...
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Gesprachsforschung - Online-Zeitschrift zur verbalen Interaktion
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Interactions: Ege Journal of British and American Studies
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Anthrozoos; A Multidisciplinary Journal of the Interactions of People and Animals
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Intermolecular Interactions as a Measure of Dapsone Solubility in Neat Solvents and Binary Solvent Mixtures
PublicationDapsone is an effective antibacterial drug used to treat a variety of conditions. However, the aqueous solubility of this drug is limited, as is its permeability. This study expands the available solubility data pool for dapsone by measuring its solubility in several pure organic solvents: N-methyl-2-pyrrolidone (CAS: 872-50-4), dimethyl sulfoxide (CAS: 67-68-5), 4-formylmorpholine (CAS: 4394-85-8), tetraethylene pentamine (CAS:...
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Study of the Interactions between Neurophysin II and Dipeptide Ligand by Means of Molecular Dynamics
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Theoretical Study on Interactions of Bicyclic Vasopressin Analogues with Human Neurohypophyseal Hormone Receptors
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Structural Insights into σ1 Receptor Interactions with Opioid Ligands by Molecular Dynamics Simulations
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Phosphorescence response to excitonic interactions in Ir organic complex-based electrophosporescent emitters
PublicationSpadek kwantowej wydajności fosforescencji ze wzrostem natężenia światła wzbudzajacego w Ir(ppy)3 tworzącym 100% warstwę naparowaną próżniowo oraz w Ir(ppy)3 umieszczonym w matrycy polimerowej PC:TPD, jest wywołany odziaływaniami między ekscytonami trypletowymi. Stała oddziaływania tryplet-tryplet wynosi (1-3)x 10-12 cm3/s i tylko nieznacznie zależy od stężenia Ir(ppy)3 w warstwie.
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Hot spot identification by ligand-protein surface interactions mapping – in silico study
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Intermolecular Hydrogen Bonding Directed by Aryl–Perfluoroaryl π–π Stacking Interactions
PublicationThe crystal structures of five compounds capable of forming self-complementary hydrogen bonds but crystallizing as catemers or creating more complex crystal structures were compared with their complexes prepared by cocrystallization with perfluoroaryl compounds. The results of X-ray diffraction revealed that in all the cases the π–π stacking interactions caused reorganization of hydrogen bonds and induced creation of the expected...
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Quasi-one-dimensional exchange interactions and short-range magnetic correlations in CuTeO4
PublicationCuTeO4 has been proposed as a crystallographically distinct, yet electronic structure analog, of the superconducting cuprates. Here, we present a detailed characterization of the physical properties of CuTeO4 to address this proposal. Fitting of magnetic susceptibility data indicates unexpected quasi-one-dimensional, antiferromagnetic correlations at high temperature, with a nearest-neighbor Heisenberg exchange of 1=164(5) K....
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Evidence for interactions between homocysteine and genistein: insights into stroke risk and potential treatment
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How Do Intermolecular Interactions Evolve at the Nematic to Twist–Bent Phase Transition?
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Water-mediated long-range interactions between the internal vibrations of remote proteins
PublicationIt is generally acknowledged that the mobility of protein atoms and the mobility of water molecules in the solvation layer are connected. In this article, we answer the question whether a similar interdependence exists between the motions of atoms of proteins separated by the hydration layers of variable thickness. The system consisted of a kinesin catalytic domain and a tubulin dimer. It was studied using molecular dynamics simulations....
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Intramolecular interactions in crystals of tris(2,6-diisopropylphenoxy)silanethiol and its sodium salts
PublicationHydrolytically stable tris(2,6-diisopropylphenoxy)silanethiol has been obtained and reacted with sodium. Solid state interactions within and between the molecules of tris(2,6-diisopropylphenoxy)silanethiol including S-H---π-interactions between the S-H unit and the π-system of the arene have been analyzed. The interactions are documented by X-ray diffraction and FT-IR spectroscopy.
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Pilicides effectively hinder chaperone-usher interactions in all Gram-negative bacteria
PublicationThe chaperone-usher pathway of adhesive structures biogenesis is highly conserved in all Gram-negative bacteria. Pili are polymers of thousands protein subunits that possess conserved immunoglobuline-like structure denoted by lack of the seventh G strand. The effect of this structural defect is a hydrophobic acceptor cleft. The folding of protein subunits is strictly dependent on the action of specific periplasmic chaperone protein...
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Determination of Odour Interactions of Three-Component Gas Mixtures Using an Electronic Nose
PublicationThe paper presents an application of an electronic nose prototype comprised of six TGS-type sensors and one PID-type sensor to identify odour interaction phenomena in odorous three-component mixtures. The investigation encompassed eight odorous mixtures—toluene-acetone-triethylamine and formaldehyde-butyric acid-pinene — characterized by different odour intensity and hedonic tone. A principal component regression (PCR) calibration...
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Interactions of dissolved dsDNA with intercalating drug by anodic voltammetry and spectroscopy. Influence of pH
PublicationOddziaływanie związku przeciwnowotworowego C-1305 z DNA było badane przy pomocy impulsowej voltametrii różnicowej oraz spektroskopii UV/Vis. Triazoloakrydon C-1305 oddziałuje z DNA na dwóch drogach: przez interkalacje pomiedzy pary zasad oraz przez wiązanie sie w małym rowku helisy. W fizjologicznym pH (7,4) stałe wiązania wynoszą: K1=3,36E+5 i K2=0,18E+5 [1/M] a wielkość miejsca wiązania: n1=2,5 i n2=4,0, odpowiednio dla pierwszego...
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Dysfunctional prefrontal cortical network activity and interactions following cannabinoid receptor activation.
PublicationCoordinated activity spanning anatomically distributed neuronal networks underpins cognition and mediates limbic-cortical interactions during learning, memory, and decision-making. We used CP55940, a potent agonist of brain cannabinoid receptors known to disrupt coordinated activity in hippocampus, to investigate the roles of network oscillations during hippocampal and medial prefrontal cortical (mPFC) interactions in rats. During...
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How water mediates the long-range interactions between remote protein molecules
PublicationThe high crowding of macromolecules in the cytoplasm affects the processes that occur inside a living cell. It can, for example, promote the forming of various loosely connected structures of proteins. It also means that bulk water is, essentially, not present there. The relatively thin layer of solvent that separates macromolecules may be able to participate in the long-range interactions between them and make them respond to...
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Methods for Elucidation of DNA-Anticancer Drug Interactions and Their Applications in the Development of New Drugs
PublicationDNA damaging agents including anthracyclines, camptothecins and platinum drugs are among most frequently used drugs in the chemotherapeutic routine. Due to their relatively low selectivity for cancer cells, administration is associated with adverse side effects, whereas the inherent genotoxicity of these drugs is associated with risk of developing secondary cancers. Development of new drugs, which could be spared of these drawbacks...
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Analyzing and Visualizing Government-Citizen Interactions on Twitter to Support Public Policy-making
PublicationTwitter is widely adopted by governments to communicate with citizens. It has become a major source of data for analyzing how governments communicate with citizens and how citizens respond to such communication, uncovering important insights about government-citizen interactions that could be used to support public policy-making. This article presents research that aims at developing a software tool called Twitter Analytics for...
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Analysis of hull, propeller and engine interactions in regular waves by a combination of experiment and simulation
PublicationAnalysis of hull, propeller and engine interactions in regular waves by a combination of experiment and simulation
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Fluorescence of nanodiamond cocktails: pH-induced effects through interactions with comestible liquids
PublicationFluorescent nanodiamonds with nitrogen-vacancy centers have become important nanoscale probes for sensing and imaging. The surface chemistry of the nanodiamonds influences their emission, interactions, and quantum properties. In this work, we propose to utilize fluorescent nanodiamonds as photostable markers for investigation of comestible liquids. We prepared nanodiamond/comestibles suspensions/cocktails with a wide range of pH...
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Role of the Solvation Water in Remote Interactions of Hyperactive Antifreeze Proteins with the Surface of Ice
PublicationMost protein molecules do not adsorb onto ice, one of the exceptions being so-called antifreeze proteins. In this paper, we describe that there is a force pushing an antifreeze protein molecule away from the ice surface when it is not oriented with its ice-binding plane toward the ice and that this pushing force may be also present even when the protein is oriented with its ice-binding plane toward the ice. This force is absent...
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Microbiology
e-Learning CoursesMicrobiology interactive lectures are dedicated to those who are interested in the role of microorganisms on our planet and their interaction with other living organisms and inorganic elements as well as more complex chemical compounds.
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European Integration Online Papers-EIOP
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ACM Transactions on Interactive Intelligent Systems
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Journal of Interactional Research in Communication Disorders
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International Journal of Transport Development and Integration
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Euro-Mediterranean Journal for Environmental Integration
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Igor Garnik dr inż.
PeopleIgor Garnik graduated from the Faculty of Electronics at the Gdańsk University of Technology (1992). He works at the Gdańsk University of Technology since 1997 - first employed as an assistant in the Department of Ergonomics and Maintenance of Technical Systems at the Faculty of Management and Economics, and then - after obtaining the degree of doctor in 2006 as an assistant professor. In the years 2009–2015 he was the coordinator...
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CO2 EMISSION TO THE ATMOSPHERE FROM CARBONATE WATERS: THE STUDY CASE OF THE LUBLIN UPLAND AND ROZTOCZE REGIONS
PublicationThe concentration of carbon dioxide dissolved in water (CO2(aq)) was measured in consecutive phases of the hydrological cycle. Its potentially possible degassing from groundwaters to the atmosphere was also assessed. The research was conducted in the area of occurrence of carbonate rocks of the Lublin Upland and Roztocze (SE Poland). The results of the measurements of CO2(aq) concentration varied as follows (min-max/mean): precipitation...
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Information System Purchase and Integration Contingencies When Companies Merge
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The role of inland ports in integration of polish waterways with the european network
PublicationArtykuł zawiera główne wnioski z badan, prowadzonych przez autorke w ramach projektu EUREKA. Przedstawiono krótki opis aktualnego stanu dróg wodnych w Polsce, uwarunkowania prawne żeglugi, znaczenie transportu wodnego w systemie transportowym kraju i najważniejsze porty śródlądowe. Opisano bariery rozwoju dród wodnych w Polsce. W artykule wykorzystano zdjęcia z dwóch rejsów, w ktorych autorka brała udzial w 2006 r.
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Photodissociation of polyatomic systems: non-adiabatic effects and conical intersection
PublicationPodano przykłady mechanizmów fotodysocjacji w cząsteczkach chloru bromoacetylowego i rodnika winiksydowego. Zastosowano kwantowe symulacje dynamiczne.
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Indices of interations and periodic points of simplical maps of smooth type
PublicationW pracy dowodzi się symplicjalnego odpowiednika twierdzenia Chowa, Mallet-Paret i Yorke´a. Otrzymany wynik służy do badania punktów periodycznych odwzorowań symplicjalnych gładkiego typu.
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Gesture-based computer control system applied to the interactive whiteboard
PublicationIn the paper the gesture-based computer control system coupled with the dedicated touchless interactive whiteboard is presented. The system engineered enables a user to control any top-most computer application by using one or both hands gestures. First, a review of gesture recognition applications with a focus on methods and algorithms applied is given. Hardware and software solution of the system consisting of a PC, camera, multimedia...
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Gesture-based computer control system applied to the interactive whiteboard
PublicationIn the paper the gesture-based computer control system coupled with the dedicated touchless interactive whiteboard is presented. The system engineered enables a user to control any top-most computer application by using one or both hands gestures. First, a review of gesture recognition applications with a focus on methods and algorithms applied is given. Hardware and software solution of the system consisting of a PC, camera, multimedia...
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MULTILEVEL INTEGRATION OF DESIGN AND THE QUALITY OF LIFE IN URBAN SPACE ISSUE
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PF5 and PCl5 interacting with water – Comparative study at the molecular level
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Computer-Supported Polysensory Integration Technology for Educationally Handicapped Pupils
PublicationIn this paper, a multimedia system providing technology for hearing and visual attention stimulation is shortly presented. The system aims to support the development of educationally handicapped pupils. The system has been presented in the context of its configuration, architecture, and therapeutic exercise implementation issues. Results of pupils’ improvements after 8 weeks of training with the system are also provided. Training...
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A system solution for integration of process planning and control in flexible manufacturing
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A Ubiquitous System Using Semantic Knowledge in Dynamic Service Integration
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Conception of interactive information and decision support system - model and evaluation
PublicationThis article presents conception of interactive information and decision support system for urban and industrial air quality management. The emphasis of the project is on real-time analysis and multi-media information, and support of distributed and mobile clients through the Internet.
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Uniform Model Interface for Assurance Case Integration with System Models
PublicationAssurance cases are developed and maintained in parallel with corresponding system models and therefore need to reference each other. Managing the correctness and consistency of interrelated safety argument and system models is essential for system dependability and is a nontrivial task. The model interface presented in this paper enables a uniform process of establishing and managing assurance case references to various types...