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Wyniki wyszukiwania dla: DROSOPHILA AND HUMAN GENETICS
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Dibutyl phthalate disrupts conserved circadian rhythm in Drosophila and human cells
PublikacjaPeople are constantly exposed to phthalates, due to their common use in the production of plastics, pharmaceuticals, cosmetics and skin care products. The ability of phthalates to disrupt endocrine signaling, leading to developmental, reproductive and metabolic defects, has been studied, yet how phthalates interfere with these biological functions is still unclear. To uncover DBP interacting molecular pathways, we raised Drosophila...
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An insertion/deletion polymorphism of the dihydrofolate reductase (DHFR) gene is associated with serum and red blood cell folate concentrations in women
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Prediction of skin color, tanning and freckling from DNA in Polish population: linear regression, random forest and neural network approaches
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The Reduced Folate Carrier (SLC19A1) c.80G>A Polymorphism is Associated with Red Cell Folate Concentrations Among Women
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CCDC151 Mutations Cause Primary Ciliary Dyskinesia by Disruption of the Outer Dynein Arm Docking Complex Formation
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ZMYND10 Is Mutated in Primary Ciliary Dyskinesia and Interacts with LRRC6
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Effects of Intrauterine Environment on the Magnitude of Differences Within the Pairs of Monozygotic and Dizygotic Twins
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Myeloperoxidase Modulates Inflammation in Generalized Pustular Psoriasis and Additional Rare Pustular Skin Diseases
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Prevalence and Factors Associated With Intertwin Birth Weight Discordance Among Same-Sex Twins in Lombardy, Northern Italy
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Genetics algorithms in multi-objective optimization of detection observer
PublikacjaW rozdziale przedstawia się możliwości zastosowania podejścia genetycznegodo zagadnień wielokryterialnej optymalizacji w przestrzeniach wielowymiaro-wych z wykorzystaniem koncepcji optymalności w sensie Pareto. Jako przykładilustrujący rozważane podejście daje się zadanie syntezy obserwatorów stanusłużących wykrywaniu błądów występujących w układzie sterowania bezzałogowe-go statku latającego oraz w układzie napędowym jednostki...
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Behavioural genetics in Polish print news media between 2000-2014
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Prefrontal Dysfunctions and Temperament in Pathological Obesity - the Results of Neuropsychological, TEMPS-A and Genetics Studies
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Social Differentiation of the Perception and Human Tissues Donation for Research Purposes.
PublikacjaThe willingness to donate human biological material for research purposes is shaped by socio-cultural factors; however, there is a lack of studies analysing the social perception of different human tissues, which may affect such willingness. This study aimed to distinguish different sociocultural categories of human tissues and types of potential donors based on their willingness to donate material. Quantitative research was...
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Human hair as a biomarker of human exposure to persistent organic pollutants (POPs)
PublikacjaThe main aim of this article is to investigate the possibility of using human hair as a biomarker with particular emphasis on persistent organic pollutants (POPs). We report previous results of studies of this topic. We critically review the available information on analytical procedures applied during analysis of human hair. Finally, we discuss future trends and possibilities arising from hair analysis.
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An electrochemical biosensor for the determination of hormone Human Chorionic Gonadotropin (hCG) in human serum
PublikacjaThis work describes the modification of a gold electrode to create an electrochemical biosensor capable of detecting human chorionic gonadotropin (hCG). The biosensor was obtained by modifying the gold electrode with cysteamine and oligopeptide (PPLRINRHILTR). The modification steps of the gold electrode were confirmed by cyclic voltammetry (CV) and impedance electrochemical spectroscopy (EIS) measurements. The conducted EIS experiments...
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Towards discovering human urban activity—tactics of human spatial behavior
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Functional safety and human factors
PublikacjaRozdział przedstawia istotny problem uwzględnienia czynników ludzkich (H&OF) w analizie bezpieczeństwa funkcjonalnego, które wpływają istotnie na bezpieczeństwo przemysłowych obiektów podwyższonego ryzyka, nie ujęty jednak w normach bezpieczeństwa funkcjonalnego. Przedstawia się metody analizy niezawodności człowieka (HRA) w kontekście tych czynników, które wpływają na błędy człowieka. Czynniki ludzkie i organizacyjne powinny być...
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Nutrients and Bioactive Components of Human Milk After one Year of Lactation. Implication for Human Milk Banks
PublikacjaObjective: Specifying the nutrient content and bioactive compounds in milk from long-term lactation for the purpose of finding additional sources of donors’ milk for HMBs. Method: Human milk samples were collected from 43 mothers of term infants (term infant human milk, TIHM) (3–6 weeks of lactation) and 50 mothers who have breastfed for over a year (long-nursing human milk, LNHM). The milk collection time was 24 hours. The analyses...
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N6-methyladenosine regulates the stability of RNA:DNA hybrids in human cells
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Social differentiation of the perception and human tissues donation for research purposes
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Mechanical Properties of Human Stomach Tissue
PublikacjaThe dataset entitled Determination of mechanical properties of human stomach tissues subjected to uniaxial stretching contains: the length of the sample as a function of the corresponding load (tensile force) and the initial values of the average width and average thickness of the sample. All tests were conducted in a self-developed tensile test machine: PG TissueTester. The dataset allows the coefficients of various models of...
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Modeling of Human Tissue for Medical Purposes
PublikacjaThe paper describes the possibilities offered for medicine by modeling of human tissue using virtual and augmented reality. It also presents three proposals of breast modeling for the use in clinical practice. These proposals are the result of arrangements of medical and computer scientists team (the authors) and will be pursued and implemented in the near future. There is included also a brief description of the most popular methods...
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Algorithmic Human Resources Management - Perspectives and Challenges
PublikacjaTheoretical background: Technology – most notably processes of digitalisation, the use of artificial intelligence, machine learning, big data and prevalence of remote work due to pandemic – changes the way organizations manage human resources. One of the increasing trends is the use of so-called “algorithmic management”. It is notably different than previous e-HRM or HRIS (human resources information systems) applications, as it...
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Functional Safety Analysis including Human Factors
PublikacjaIn this paper selected aspects of human factors are discussed that should be taken into account during the design of safety-related functions for a complex hazardous installation and its protections. The layer of protection analysis (LOPA) methodology is used for simplified risk analysis based on defined accident scenarios. To control the risk the safety instrumented functions (SIFs) are identified and their safety integrity levels...
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Multichannel Human Body Communication
PublikacjaHuman Body Communication is an attractive alternative for traditional wireless communication (Bluetooth, ZigBee) in case of Body Sensor Networks. Low power, high data rates and data security makes it ideal solution for medical applications. In this paper, signal attenuation for different frequencies, using FR4 electrodes, has been investigated. Performance of single and multichannel transmission with frequency modulation of analog...
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Toward Human Chromosome Knowledge Engine
PublikacjaHuman chromosomes carry genetic information about our life. Chromosome classification is crucial for karyotype analysis. Existing chromosome classification methods do not take into account reasoning, such as: analyzing the relationship between variables, modeling uncertainty, and performing causal reasoning. In this paper, we introduce a knowledge engine for reasoning-based human chromosome classification that stores knowledge...
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Functional safety analysis including human factors
PublikacjaThe article addresses selected aspects of human factors that should be taken into account during the design of safety-related functions for a complex hazardous installation and its protections. In such installations the layer of protection analysis (LOPA) methodology is often used for simplified risk analysis based on defined accident scenarios. To control the risk the safety instrumented functions (SIFs) are identified and their...
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Application of human bile salts for in vitro digestion models
PublikacjaIn this study, experimental in vitro models simulating the environment of the human gastrointestinal tract were used to assess the impact of physiological surfactants, such as bile salts, on the kinetics of digestion. Bile salts are biosurfactants synthesised in the liver and secreted together with bile into the small intestine. There are many reports on the role of bile salts in lipolysis, but the knowledge of their influence...
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Human Centric Lighting. The New X Factor?
PublikacjaWe live in challenging times, and one could even claim we’re experiencing a revolution in lighting with LED technology taking over the world. Part of this rapid change involves a concept called Human Centric Lighting (HCL). In Frankfurt this year, during Light+Building, it was the buzzword, with nearly every second manufacturer’s stand claiming they had figured out the special formula necessary to create perfect HCL illumination....
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The role of the human factor in the companies' innovativeness
PublikacjaInnovation is one of the factors enabling the development of both individual companies and entire economies. While previously the possibilities offered by technology were focused on, including information and communication technology (ICT), recently the potential of human resources has been gaining more and more attention. This capital — often underestimated — can in the right conditions and with a conducive organizational culture...
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Human Factors in Nuclear Power Engineering in Polish Conditions
PublikacjaThe paper “Human factors in nuclear power engineering in polish conditions” focuses on analysis of dynamics of preparing polish society to build fi rst nuclear power plant in XXI century in Poland. Authors compare experience from constructing nuclear power plant Sizewell B (Great Britain) and Sizewell C, which is in preparation phase with polish nuclear power program. Paper includes aspects e.g. of creating nuclear safety culture and...
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Human factors in nuclear power engineering in Polish conditions
PublikacjaThe paper “Human factors in nuclear power engineering in polish conditions” focuses on analysis of dynamics of preparing polish society to build first nuclear power plant in XXI century in Poland. Authors compare experience from constructing nuclear power plant Sizewell B (Great Britain) and Sizewell C, which is in preparation phase with polish nuclear power program. Paper includes aspects e.g. of creating nuclear safety culture...
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AMO perspectives on the well-being of neurodivergent human capital
PublikacjaExisting management research and management practices frequently overlook the relationship between the above-average human capital of highly functioning neurodivergent employees, their subjective well-being in the workplace and performance outcomes. This paper calls for greater attention to the hidden human capital associated with neurodiversity by mainstreaming implementation of neurodiversity-friendly policies and practices. Drawing...
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Expression of estrogen receptors, PELP1, and SRC in human spermatozoa and their associations with semen quality
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Opitmalising Human Development Index with sensitivity analysis
PublikacjaResearch background: Composite indicators are commonly used not only to measure economic development, the standard of livin g, competitiveness, fairness, effectiveness but are also willingly implemented in to many different fields. How- ever, it seems that in most cases the variable weig hting procedure is avoided or erroneous since in most cases so-called “wights by belief” are...
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Mathematical Approach to Assess a Human Gait
PublikacjaA purpose of the paper was to create a mathematical approach to assess a human gait. The scope of the study was to model a normal gait in the sagittal plane and frontal plane of the body. Applying the Newton-Euler formulation, three multibody biomechanical models were derived to describe single support phase and double support phase of the gait. To model a gait in the sagittal plane the open-close sagittal 6DOF model and the open-close...
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Light-Modulated Sunscreen Mechanism in the Retina of the Human Eye
PublikacjaThe functioning of the human eye in the extreme range of light intensity requires a combination of the high sensitivity of photoreceptors with their photostability. Here, we identify a regulatory mechanism based on dynamic modulation of light absorption by xanthophylls in the retina, realized by reorientation of pigment molecules induced by trans–cis photoisomerization. We explore this photochemically switchable system using chromatographic...
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Human System Interaction in Review: Advancing the Artificial Intelligence Transformation
PublikacjaThe industrial advancement of human society has been fundamentally driven by diverse ‘systems’ that facilitate ‘human interaction’ within physical, digital, virtual, social and artificial environments, and upon the hyper-connected layers of system-system interactions across these environments. The research and practice of Human System Interaction (HSI) has undergone exponential development due to the enhanced capabilities, increased...
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Human Factors in designing the Instrumentation and Control Systems Important to Safety
PublikacjaThis work addresses selected aspects of human factors in designing the instrumentation and control (I&C) systems important to safety as a part of the functional safety management of industrial hazardous plants, in particular nuclear power plants. As it is known in such plants a concept of “defence in depth” (D-in-D) is widely applied and some layers of protection are designed with regard to functional safety (FS) concept given...
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MACHINE LEARNING APPLICATIONS IN RECOGNIZING HUMAN EMOTIONS BASED ON THE EEG
PublikacjaThis study examined the machine learning-based approach allowing the recognition of human emotional states with the use of EEG signals. After a short introduction to the fundamentals of electroencephalography and neural oscillations, the two-dimensional valence-arousal Russell’s model of emotion was described. Next, we present the assumptions of the performed EEG experiment. Detail aspects of the data sanitization including preprocessing,...
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Sensitivity analysis as a tool to optimise Human Development Index
PublikacjaResearch background: Composite indicators are commonly used as an approximation tool to measure economic development, the standard of living, competitiveness, fairness, effectiveness, and many others being willingly implemented into many different research disciplines. However, it seems that in most cases, the variable weighting procedure is avoided or erroneous since, in most cases, the so-called...
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Microwave heat treatment application to pasteurization of human milk
PublikacjaA prototype of microwave pasteurizer has been proposed as an alternative for holder pasteurization (HP) routinely used in Human Milk Bank (HMB), ensuring microbiological safety of human milk (HM). It was shown that the time of heat generation was about 15–16 min shorter by applying the microwave than in HP. Total inactivation of heat-sensitive bacteria Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Staphylococcus...
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A Human Behaviour Model Agent for Testing of Voluntary Computing Systems
PublikacjaPaper presents a design and performance of a voluntary-based distributed computing system testing agent, implementing a human behaviour model. The agent, nicknamed iRobot, was designed and implemented to enable controlled, large scale testing of core algorithms of Comcute - a new voluntary distributed computing platform complementary to BOINC. The main agent design goals were: emulation of human behaviour when browsing web pages,...
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Measurement of complex refractive index of human blood by low-coherence interferometry
PublikacjaIn this article, the usefulness of the optical technique for measurements of blood complex refractive index has been examined. Measurement of optical properties of human blood is difficult to perform because of its nonuniform nature. However, results of my investigation have shown the usefulness of low-coherencei nterferometry for measurement complex refractive index of human blood. Furthermore, mathematical analysis of spectrum...
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Employee Well-Being and its Potential Link With Human Knowledge Risks
PublikacjaEmployee well-being is an essential component of any organisation organisation. Conscious companies make every effort to create a healthy work environment. The well-being of employees and their overall emotional, physical and economic health is affected by various internal and external factors. When employees feel well, they tend to perform better. Therefore, the impact of employee well-being on the organisation is a fact and has...
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Mechanical properties of the human stomach under uniaxial stress action
PublikacjaThe aim of this study was to estimate the range of mechanical properties of the human stomach in order to use the collected data in numerical modelling of surgical stapling during resections of the stomach. The biomedical tests were conducted in a self-developed tensile test machine. Twenty-two fresh human stomach specimens were used for the experimental study of its general strength. The specimens were obtained from morbidly obese...
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Cognitive memory for intelligent systems of decision-making, based on human psychology
PublikacjaA model of memory, which allows to expand the functionality of autonomous decision-making systems for robotic and human-system-interface purposes, is discussed. The model provides functions and features which make the prospective robotic and interfacing systems more human-like as well as more efficient in solving interactive issues.
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Cognitive memory for intelligent systems of decision-making, based on human psychology
PublikacjaA model of memory, which allows to expand the functionality of autonomous decision-making systems for robotic and human-system-interface purposes, is discussed. The model provides functions and features which make the prospective robotic and interfacing systems more human-like as well as more efficient in solving interactive issues.
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Comparative in vitro research of the Human Aortic Bioprosthesis
PublikacjaE valuate of the usefulness and reliability of structures based on the analysis of recorded parameters determining the flow through the Human Aortic Bioprosthesis (HAB) have been dealt with. By flow parameters changes determining the performance environment of prosthesis analyzed change of the motion dynamics of the valve leaflets as a function of pressure, thereby determining the degree of alignment of the prosthesis to the performance...
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The effect of local anaesthetics on apoptosis and NETosis of human neutrophils in vitro: comparison between lidocaine and ropivacaine
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