Filtry
wszystkich: 2746
wybranych: 2503
-
Katalog
- Publikacje 2503 wyników po odfiltrowaniu
- Czasopisma 15 wyników po odfiltrowaniu
- Konferencje 12 wyników po odfiltrowaniu
- Osoby 35 wyników po odfiltrowaniu
- Projekty 4 wyników po odfiltrowaniu
- Kursy Online 53 wyników po odfiltrowaniu
- Wydarzenia 5 wyników po odfiltrowaniu
- Dane Badawcze 119 wyników po odfiltrowaniu
Filtry wybranego katalogu
wyświetlamy 1000 najlepszych wyników Pomoc
Wyniki wyszukiwania dla: IN VIVO MOUSE MODELS
-
Structural Adaptive, Self-Separating Material for Removing Ibuprofen from Waters and Sewage
Publikacja-cyclodextrin nanosponge (CDM) was used for the adsorption of ibuprofen (IBU) from water and sewage. The obtained material was characterized by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), Brunauer–Emmett–Teller (BET), Barrett– Joyner–Halenda (BJH), Harkins and Jura t-Plot, zeta potential, thermogravimetric analysis (TGA), differential scanning calorimetry (DSC) and elementary analysis (EA)....
-
Discovery of small-molecule regenerative drugs using a model of complex tissue injury in mice. Transcriptomic responses of neurodevelopmental genes during pharmacologically induced regeneration
PublikacjaDespite significant development in regenerative medicine, there is a deficit of effective therapies for wound healing and tissue regeneration. Research performed using animal wound models allows for a better understanding of this complex process, searching for compounds with pro-regenerative properties, and assessing their efficacy and safety. Unfortunately, the lack of adequate preclinical models proves to be an issue as no animal...
-
Cellulose and its derivatives, coffee grounds, and cross-linked, β-cyclodextrin in the race for the highest sorption capacity of cationic dyes in accordance with the principles of sustainable development
PublikacjaIn this study, seven different materials were analyzed and includes coffee grounds (CG), two types of cellulose (CGC and CC), two types of modified cellulose (CT and CTCD), and cross-linked β-cyclodextrin (CD-1 and CD-2) were tested as adsorbents for the removal of dyes from the wastewater. The composition, morphology, and presence of functional groups in the obtained sorption materials were characterized by elemental analysis,...
-
Transcriptomic responses to wounding: meta-analysis of gene expression microarray data
PublikacjaBackground A vast amount of microarray data on transcriptomic response to injury has been collected so far. We designed the analysis in order to identify the genes displaying significant changes in expression after wounding in different organisms and tissues. This meta-analysis is the first study to compare gene expression profiles in response to wounding in as different tissues as heart, liver, skin, bones, and spinal cord, and...
-
Similarities and differences in d6 low-spin ruthenium, rhodium and iridium half-sandwich complexes: synthesis, structure, cytotoxicity and interaction with biological targets
PublikacjaIn this paper, we discussed the similarities and diferences in d6 low-spin half-sandwich ruthenium, rhodium and iridium complexes containing 2,2′-biimidazole (H2biim). Three new complexes, {[RuCl(H2biim)(η6 -p-cymene)]PF6}2·H2O (1), [(η5 - Cp)RhCl(H2biim)]PF6 (2), and [(η5 -Cp)IrCl(H2biim)]PF6 (3), were fully characterized by CHN, X-ray difraction analysis, UV–Vis, FTIR, and 1 H, 13C and 15N NMR spectroscopies. The complexes exhibit...
-
Model neuronowy jako alternatywa dla numerycznego modelu okołodźwiękowego przepływu pary przez palisadę turbinową.
PublikacjaWystępowanie skośnej fali uderzeniowej w przepływie pary przez palisadę turbinową stanowi zagrożenie dla bezpiecznej pracy turbiny oraz dla jej elementów konstrukcyjnych. Detekcja oraz lokalizacja fali uderzeniowej, a także rozpoznanie przyczyny jej powstawania, nie są możliwe do osiągnięcia na drodze pomiarowej. Analizę zjawisk zachodzących wewnątrz kanału przepływowego umożliwiają natomiast modele numeryczne oraz neuronowe. Zaletą...
-
Prognozowanie ostrzegawcze w małej firmie
PublikacjaW artykule pokazano możliwości zastosowania prostych metod prognostycznych do ostrzegania w małej firmie przed niekorzystnymi zjawiskami. Przedmiotem badań jest sprzedaż, a ze względu na występowanie w szeregu czasowym sezonowości, w celu wyznaczenia sygnałów ostrzegawczych dokonano porównań trendów prognozowanych i rzeczywistych w okresach jednoimiennych za pomocą pierwszych różnic. Do prognozowania sprzedaży wykorzystano proste...
-
Thermal ablation modeling via bioheat equation
PublikacjaWe consider Pennes’ bioheat equation and discuss an implicit numerical scheme which has better stability properties than other approaches. Our discussion concerns Carthesian geometry problems, however it carries over to spherical geometry models and more complicated shapes.
-
Multi-objective design of miniaturized impedance transformers by domain segmentation
PublikacjaFast multi-objective design optimization of compact microstrip impedance transformers is discussed. Our approach exploits approximation models constructed using sampled coarse- mesh EM simulation data in a partitioned design space and response correction techniques for design refinement. Demonstra
-
Affective Learning Manifesto – 10 Years Later
PublikacjaIn 2004 a group of affective computing researchers proclaimed a manifesto of affective learning that outlined the prospects and white spots of research at that time. Ten years passed by and affective computing developed many methods and tools for tracking human emotional states as well as models for affective systems construction. There are multiple examples of affective methods applications in Intelligent Tutoring Systems (ITS)....
-
Framework for Integration Decentralized and Untrusted Multi-vendor IoMT Environments
PublikacjaLack of standardization is highly visible while we use historical data sets or compare our model with others that use IoMT devices from different vendors. The problem also concerns the trust in highly decentralized and anonymous environments where sensitive data are transferred through the Internet and then are analyzed by third-party companies. In our research we propose a standard that has been implemented in the form of framework...
-
Implementing artificial intelligence in forecasting the risk of personal bankruptcies in Poland and Taiwan
PublikacjaResearch background: The global financial crisis from 2007 to 2012, the COVID-19 pandemic, and the current war in Ukraine have dramatically increased the risk of consumer bankruptcies worldwide. All three crises negatively impact the financial situation of households due to increased interest rates, inflation rates, volatile exchange rates, and other significant macroeconomic factors. Financial difficulties may arise when the...
-
Role for chitin and chitooligomers in the capsular architecture of Cryptococcus neoformans
PublikacjaW pracy opisano wyniki badań nad rolą struktur zawierających N-acetylo-D-glukozaminę (GlcNAc) w tworzeniu kapsuły otaczającej komórki patogennych dla człowieka grzybów Cryptococcus neoformans. Ekspresja w warunkach in vivo chitooligomerów łączących polisacharydy kapsuły ze ścianą komórkową jest różna, w zależności od rodzaju zainfekowanej tkanki, co określono poprzez wykazanie różnej reaktywności komórek form drożdżowych C. neoformans...
-
Kwas mykofenolowy i jego analogi. Synteza i aktywność biologiczna = Mycophenolic acid (MPA) and its analogues. Synthesis and biological activity
PublikacjaW artykule opisano kwas mykofenolowy (MPA)oraz jego analogi. Kwas MPA został odkryty ponad 100 lat temu i nadal pozostaje atrakcyjnym celem badań biologicznych. Z uwagi na bardzo dużą tendencję do ulegania glukuronidyzacji in vivo, ograniczone są jego możliwości zastosowań jako potencjalnego chemoterapeutyka. Otrzymane dotychczas analogi m.in. zawierające różne cykliczne ugrupowania, monocykliczne fenole i niefenolowe analogi oraz...
-
Identification, cloning, expression, and characterizationof a highly thermostable single-stranded-DNA-binding protein (SSB) from Deinococcus murrayi
PublikacjaZidentyfikowano i scharakteryzowano białko SSB-podobne, pochodzące z Deinococcus murrayi (DmuSSB). Otrzymany w reakcji PCR fragment zawierający kompletny gen ssb sklonowano w systemie ekspresyjnym Escherichia coli. Gen składa się z 826 nt, kodujących 276 reszt aminokwasowych z wyliczoną teoretycznie masą cząsteczkową monomeru równą 30,14 kDa. DmuSSB zawiera dwie domeny wiążące jednoniciowe DNA OBna monomer I funkcjonuje jako homodimer....
-
Imidazoacridinone-dependent lysosomal photodestruction: a pharmacological Trojan horse approach to eradicate multidrug-resistant cancers
PublikacjaMultidrug resistance (MDR) remains a primary hindrance to curative cancer therapy. Thus, introduction of novel strategies to overcome MDR is of paramount therapeutic significance. Sequestration of chemotherapeutics in lysosomes is an established mechanism of drug resistance. Here, we show that MDR cells display a marked increase in lysosome number. We further demonstrate that imidazoacridinones (IAs), which are cytotoxic fluorochromes,...
-
LC-MS/MS dtermination of isoprostanes in plasma samples collected from mice exposed to doxorubicin or tert-butyl hydroperoxide
PublikacjaIsoprostanes are stable products of arachidonic acid peroxidation and are regarded as the most reliable markers of oxidative stress in vivo. Here we describe the LC-MS/MS procedure enabling simultaneous determination of four regioisomers (8-iso prostaglandin F2α, 8-iso-15(R)-prostaglandin F2α, 11β-prostaglandin F2α, 15(R)-prostaglandin F2α) in plasma samples collected from mice. The four plasma isoprostanes are determined by LC–ESI-MS/MS...
-
Noise in biological Raman spectroscopy
PublikacjaRaman spectroscopy is a widely used method to investigate chemical molecules by analyzing their vibrational transitions. It utilizes inelastic scattering of the laser light irradiating the investigated object. The scattered light requires appropriate filtering to reduce dominant laser light and expose much weaker components having shifted wavelengths of a characteristic spectral pattern. These components are measured by dispersing...
-
Multi-layered tissue head phantoms for noninvasive optical diagnostics
PublikacjaExtensive research in the area of optical sensing for medical diagnostics requires development of tissue phantoms with optical properties similar to those of living human tissues. Development and improvement of in vivo optical measurement systems requires the use of stable tissue phantoms with known characteristics, which are mainly used for calibration of such systems and testing their performance over time. Optical and mechanical...
-
A highly thermostable, homodimeric single-stranded DNA-binding protein from Deinococcus radiopugnans
PublikacjaWe report the identification and characterization of the single-stranded DNA-binding protein (SSB) from the mesophile and highly radiation-resistant Deinococcus radiopugnans (DrpSSB). PCR-derived DNA fragment containing the complete structural gene for DrpSSB protein was cloned and expressed in Escherichia coli. The gene consisting of an open reading frame of 900 nucleotides encodes a protein of 300 amino acids with a calculated...
-
Cu-HKUST-1 and Hydroxyapatite–The Interface of Two Worlds toward the Design of Functional Materials Dedicated to Bone Tissue Regeneration
PublikacjaA novel composite based on biocompatible hydroxyapatite (HA) nanoparticles and Cu-HKUST-1 (Cu-HKUST-1@HA) has been prepared following a layer-by-layer strategy. Cu-HKUST-1 was carefully selected from a group of four Cu-based metal−organic frameworks as the material with the most promising antimicrobial activity. The formation of a colloidal Cu- HKUST-1 layer on HA nanoparticles was confirmed by various techniques, e.g., infrared...
-
Evaluation of long‑term immunity and protection against T. gondii after immunization with multivalent recombinant chimeric T. gondii proteins
PublikacjaToxoplasmosis caused by the opportunistic, cosmopolitan protozoan Toxoplasma gondii is one of the most common parasitoses in the world. Although it may prove dangerous or even fatal for immunocompromised individuals, immunoprophylaxis for humans is still nonexistent. Thus, the aim of the current work was to assess the ability of two immunogenic recombinant chimeric T. gondii proteins, SAG2-GRA1-ROP1 (SGR) and SAG1-MIC1-MAG1-GRA2...
-
Functionalized Peptide Fibrils as a Scaffold for Active Substances in Wound Healing
PublikacjaTechnological developments in the field of biologically active peptide applications in medicine have increased the need for new methods for peptide delivery. The disadvantage of peptides as drugs is their low biological stability. Recently, great attention has been paid to self-assembling peptides that can form fibrils. Such a formulation makes bioactive peptides more resistant to enzymatic degradation and druggable. Peptide fibrils...
-
The Impact of the Antigenic Composition of Chimeric Proteins on Their Immunoprotective Activity against Chronic Toxoplasmosis in Mice
PublikacjaToxoplasmosis may pose a serious threat for individuals with weakened or undeveloped immune systems. However, to date, there is no specific immunoprophylaxis for humans. Thus, the aim of this study was to evaluate the immunogenicity of three trivalent—SAG2-GRA1-ROP1L (SGR), SAG1L-MIC1-MAG1 (SMM), and GRA1-GRA2-GRA6 (GGG)—and two tetravalent—SAG2-GRA1-ROP1-GRA2 (SGRG) and SAG1-MIC1-MAG1-GRA2 (SMMG)—chimeric T. gondii proteins, as...
-
Keratin-Butyrate Scaffolds Promote Skin Wound Healing in Diabetic Rats Through Down-Regulation of IL-1β and Up-Regulation of Keratins 16 and 17
PublikacjaImpaired wound healing particularly in diabetics creates a significant healthcare burden. The study aimed to evaluate the effect of keratin-butyrate fibers (FKDP +0.1%NaBu) in a full-thickness skin wound model in 30 diabetic rats. Physicochemical examination showed that the obtained dressing possesses a heterogeneous structure and butyrate was slowly released into the wound. Moreover, the obtained dressing is nontoxic and supports...
-
Is mesh fixation necessary in laparoendoscopic techniques for M3 inguinal defects? An experimental study.
Publikacjarepairs, in case of large direct hernias (M3) mesh fixation is recommended to reduce recurrence risk. Despite lack of highquality evidence, the recommendation was upgraded to strong by expert panel. The authors conducted a research experiment to verify the hypothesis that it is possible to preserve the mesh in the operating field in large direct hernias (M3) without the need to use fixing materials. Method The authors conducted...
-
N-doped carbon nanospheres as selective fluorescent probes for mercury detection in contaminated aqueous media: chemistry, fluorescence probing, cell line patterning, and liver tissue interaction
PublikacjaA precise nano-scale biosensor was developed here to detect Hg2+ in aqueous media. Nitrogen-doped carbon nanospheres (NCS) created from the pyrolysis of melamine–formaldehyde resin were characterized by FESEM, XRD, Raman spectra, EDS, PL, UV–vis spectra, and N2 adsorption–desorption, and were used as a highly selective and sensitive probe for detecting Hg2+ in aqueous media. The sensitivity of NCS to Hg2+ was evaluated by photoluminescence...
-
Synthesis of green benzamide-decorated UiO-66-NH2 for biomedical applications
PublikacjaMetal-organic frameworks (MOFs) biocompatible systems can host enzymes/bacteria/viruses. Herein we synthesized a series of fatty acid amide hydrolase (FAAH)-decorated UiO-66-NH2 based on Citrus tangerine leaf extract for drug delivery and biosensor applications. Five chemically manipulated FAAH-like benzamides were localized on the UiO-66-NH2 surface with physical interactions. Comprehensive cellular and molecular analyses were...
-
Polish internet mortgage market: towards fully developed fuzzy model
PublikacjaThe first part of the paper consists of introduction describing the Polish Internet Mortgage Market. Later there is presented the idea of the rule based model which may be used on this market. Next step consists of fuzzyfication of the model. This process begins with the initial set of variables which was used previously for the rule based model of the same market. As numerous aspects of the market cannot be presented in the crisp...
-
Dynamics of cutting power during sawing with circular saw blades as an effect of wood properties changes in the cross section
PublikacjaIn the paper the effect of the method calculation upon the cutting power is presented. In computations were used models in which fracture toughness was incorporated. The comparison concerned models as follows: FM-CM – classic model in which the sum of all uncut chip thicknesses of the simultaneously teeth engaged represented the mean uncut chip thickness, FM-FDM – full dynamical model in which besides variable uncut chip thickness...
-
Model of a Maturity Capsule in Managing IT Projects
PublikacjaThe main purpose of this article is to present a report on the development of a model of information technology management (MITM). This model is an answer to the need to support decision making in the selection of methods and information technologies. This article presents a multisequential model (MSM) of technology selection and a model for initial processing procedures (IPP) necessary for the MITM model. The presentation of the...
-
Performance and Power-Aware Modeling of MPI Applications for Cluster Computing
PublikacjaThe paper presents modeling of performance and power consumption when running parallel applications on modern cluster-based systems. The model includes basic so-called blocks representing either computations or communication. The latter includes both point-to-point and collective communication. Real measurements were performed using MPI applications and routines run on three different clusters with both Infiniband and Gigabit Ethernet...
-
Integration of natural and artificial intelligence in production systems
PublikacjaIntegration processes play an increasingly important role in modern economy, and seriously co-decide about the effectiveness of the company. Integration phase occurs in the system life cycle by preceding the final stages of its implementation and activation. In turn, used in software engineering (SE) iteration-evolutionary models, such as spiral model make that the integration activities can occur in varying degrees in all phases...
-
Ultrasonic Tomography of Brick Columns Based on FEM Calculations
PublikacjaUltrasonic tomography is one of the most developed method of non-destructive testing. Despite being used mainly in medicine, it is becoming more and more popular as a method for monitoring of structural elements. It allows to examine the internal structure and technical condition of the tested element. This paper investigates the influence of crosssectional geometry on an obtained tomographic image. Wave propagation signals were...
-
Expedited Design Closure of Antennas By Means Of Trust-Region-Based Adaptive Response Scaling
PublikacjaIn the letter, a reliable procedure for expedited design optimization of antenna structures by means of trust-region adaptive response scaling (TR-ARS) is proposed. The presented approach exploits two-level electromagnetic (EM) simulation models. A predicted high-fidelity model response is obtained by applying nonlinear frequency and amplitude correction to the low-fidelity model. The surrogate created this way is iteratively rebuilt...
-
Influence of fasteners and connections flexibility on deflections of steel building including the stressed skin effect
PublikacjaThe paper presents the analysis of the influence of fasteners and connections flexibility on displacements of symmetrical single-bay pitched-roof steel building, including trapezoidal cladding acting as a diaphragm. The purpose of the article was to compare numerical models with and without taking into consideration fasteners and connections flexibility in order to observe the differences in transverse stiffness of the building...
-
Możliwość oszacowania niezawodności silników o zapłonie samoczynnym z zastosowaniem teorii procesów semi-Markowa oraz podejmowania decyzji eksploatacyjnych z uwzględnieniem wiarygodności diagnozy o stanie technicznym tego rodzaju silników spalinowych = Possibility of estimating the reliability of diesel engines by applying the theory of semi-Markov processes and making operational decisions by considering reliability of diagnosis on technical state of this sort of combustion engines/
PublikacjaThe paper presents semi-Markov models of technical state transitions for diesel engines, useful for determining reliability of the engines. A possibility of application of a three-state model with a simplified matrix function, or even a two-state model, to determine reliability of the engines, has been described herein on examples of known from literature semi-Markov models, for the case when appropriate diagnosing systems (SDG)...
-
Verification of the Analytical Traffic Model of a Multidomain IMS/NGN Using the Simulation Model
PublikacjaIn this paper we verify the previously proposed analytical traffic model of a multidomain Next Generation Network (NGN), which is standardized for delivering multimedia services based on the IP Multimedia Subsystem (IMS). For this reason a proper simulation model used, in which not theoretical queuing system models but the operation of real network elements and standardized call scenarios are accurately implemented. Consequently,...
-
Modelling and simulations in time-fractional electrodynamics based on control engineering methods
PublikacjaIn this paper, control engineering methods are presented with regard to modelling and simulations of signal propagation in time-fractional (TF) electrodynamics. That is, signal propagation is simulated in electromagnetic media described by Maxwell’s equations with fractional-order constitutive relations in the time domain. We demonstrate that such equations in TF electrodynamics can be considered as a continuous-time system of...
-
Analysis of the Capability of Deep Learning Algorithms for EEG-based Brain-Computer Interface Implementation
PublikacjaMachine learning models have received significant attention for their exceptional performance in classifying electroencephalography (EEG) data. They have proven to be highly effective in extracting intricate patterns and features from the raw signal data, thereby contributing to their success in EEG classification tasks. In this study, we explore the possibilities of utilizing contemporary machine learning algorithms in decoding...
-
Modelling of elastic wave propagation in a bolted joint using a thin layer of shell elements
PublikacjaThere are many mathematical models describing the propagation of elastic waves through the imperfect boundary of two media. They were successfully applied to modelling of high frequency bulk waves and their interaction with local defects. On the other hand, the existing literature models of bolted connections ignore the aspect of imperfect connection between elements. Therefore, this paper presents the concept of application of...
-
Autonomous Ship Utility Model Parameter Estimation Utilising Extended Kalman Filter
PublikacjaIn this paper, a problem of autonomous ship utility model identification for control purposes is considered. In particular, the problem is formulated in terms of model parameter estimation (one-step-ahead prediction). This is a complex task due to lack of measurements of the parameter values, their time-variability and structural uncertainty introduced by the available models. In this work, authors consider and compare two utility...
-
Modelling of Longitudinal Elastic Wave Propagation in a Steel Rod Using the Discrete Element Method
PublikacjaThe paper deals with the issue of modelling elastic wave propagation using the discrete element method (DEM). The case of a longitudinal wave in a rod with a circular cross-section was considered. A novel, complex algorithm consisting of the preparation of models and simulation of elastic waves was developed. A series of DEM models were prepared for simulations, differing in discretisation and material parameters. Additional calculations...
-
Virtual reality technology in architectural education
PublikacjaContemporary virtual reality (VR) technology allows the recreation of non-existent architectural objects of which there may be no trace remaining. Virtual reality applications allow access to digital models, which visualise the lost architecture. The popularity of VR has resulted in it being applied not only to computer games, but also in visualising the past. Maps allow movement through historical trails and 3D models of architecture...
-
A comprehensive approach to SBR modelling for monitoring and control system design
PublikacjaThe aim of this research is to provide a comprehensive description of the Sequencing Batch Reactor (SBR) modelling for monitoring, control, and plant operational optimisation validation. The paper provides a detailed modelling of the SBR, its components and constituent processes. For this purpose, the mass balance principle and continuity equations were provided with a reactive term implemented using Activated Sludge Model (ASM)....
-
Metoda i algorytmy sterowania procesami miksowania dźwięku za pomocą gestów w oparciu o analizę obrazu wizyjnego
PublikacjaGłównym celem rozprawy było opracowanie systemu miksowania dźwięku za pomocą gestów rąk wykonywanych w powietrzu oraz zbadanie możliwości oferowanych przez takie rozwiązanie w porównaniu ze współczesną metodą miksowania sygnałów fonicznych, wykorzystującą środowisko komputera. Opracowany system rozpoznaje zarówno dynamiczne jak i statyczne gesty rąk. Rozpoznawanie gestów dynamicznych zrealizowano w oparciu o metody logiki rozmytej...
-
Rozprzestrzenianie się w podtorzu skutków katastrof kolejowych z udziałem materiałów niebezpiecznych
PublikacjaDuża część przewozów materiałów niebezpiecznych prowadzona jest koleją. W związku z tym bezpieczeństwo tych przewozów nabiera coraz większego znaczenia. Każda katastrofa z udziałem materiałów niebezpiecznych ma negatywny wpływ na uczestników tego zdarzenia oraz na otaczające środowisko, bowiem jej zasięg na ogół nie jest lokalny. Z tego wynika, że w przypadku zaistnienia katastrofy należy minimalizować jej skutki oraz w dalszych...
-
Analysis of transformer state by fuzzy TOPSIS and AHP method
PublikacjaThe paper presents mathematical models TOPSIS and AHP methods, which was utilized on insulating state of distribution transformer to analyze and sensibility of individual measurements methods mutual comparison. We can uniquely determine the importance of these measurements methods with this mathematical apparatus in these measurements methods in insulating state of transformers.
-
Magnetic signatures of land vehicles
PublikacjaThe results of numerical simulations of the magnetic field surrounding of land vehicles' models have been presented in this paper. Vehicle containing of ferromagnetic elements distorts the Earth's magnetic field. This distortion can be measured by magnetometers. It is possible to detect and identify an object on the basis of its magnetic signature.
-
Impact of power electronic Var compensators installed in certain grid points on the voltage failure
PublikacjaThe article presents the test results of the various types of static compensators FACTS models in the power system. The basic case, which was analyzed, it was behavior of compensators which are installed in select points of the system during voltage failure. The article presents selected results of studies conducted as part of a work [2].