Filtry
wszystkich: 2497
-
Katalog
- Publikacje 2266 wyników po odfiltrowaniu
- Czasopisma 62 wyników po odfiltrowaniu
- Konferencje 3 wyników po odfiltrowaniu
- Osoby 79 wyników po odfiltrowaniu
- Projekty 2 wyników po odfiltrowaniu
- Kursy Online 48 wyników po odfiltrowaniu
- Wydarzenia 1 wyników po odfiltrowaniu
- Dane Badawcze 36 wyników po odfiltrowaniu
wyświetlamy 1000 najlepszych wyników Pomoc
Wyniki wyszukiwania dla: KINETICS OF BIOCHEMICAL PROCESSES
-
Increased cytotoxicity of an unusual DNA topoisomerase II inhibitor compound C-1305 toward HeLa cells with downregulated PARP-1 activity results from re-activation of the p53 pathway and modulation of mitotic checkpoints
PublikacjaOur previous studies have shown that murine fibroblast cells, in which PARP-1 gene was inactivated by gene disruption, are extremely sensitive to triazoloacridone compound C-1305, an inhibitor of DNA topoisomerase II with unusual properties. Here, we show that pharmacological inhibition of PARP-1 activity by its inhibitor compound NU1025, sensitizes human cervical carcinoma HeLa cells to compound C-1305 compared to treatment with...
-
Antitumor 1-nitroacridine derivative C-1748, induces apoptosis, necrosis or senescence in human colon carcinoma HCT8 and HT29 cells.
PublikacjaC-1748 jest związkiem oddziaływującym z DNA i potencjalnym związkiem przeciwnowotworowym szczególnie wobec nowotworów prostaty i jelita grubego przeszczepialnych na myszach.W pracy badano odpowiedź komórek nowotworowych HCT8 i HT29 na działanie pochodnej C-1748, w stężeniach biologicznie istotnych (EC90). Analiza cyklu komórkowego linii HCT8 pokazała, że związek powoduje wzrost frakcji sub-G1, świadczący o apoptozie tych komórek...
-
Molecular basis of the osmolyte effect on protein stability: a lesson from the mechanical unfolding of lysozyme
PublikacjaOsmolytes are a class of small organic molecules that shift the protein folding equilibrium. For this reason, they are accumulated by organisms under environmental stress, and find applications in biotechnology where proteins need to be stabilized or dissolved. However, despite years of research, debate continues over the exact mechanisms underpinning the stabilizing and denaturing effect of osmolytes. Here, we simulated the mechanical...
-
Diminshed toxicity of C-1748, 4-methyl-9-hydroxyethylamino-1-nitroacridine, compared with its demethyl analog, C-857, corresponds to its resistance to metabolism in HepG2 cells
PublikacjaThe narrow "therapeutic window" of anti-tumour therapy may be the result of drug metabolism leading to the activation or detoxification of antitumour agents. The aim of this work is to examine (i) whether the diminished toxicity of a potent antitumour drug, C-1748, 9-(2'-hydroxyethylamino)-4-methyl-1-nitroacridine, compared with its 4-demethyl analogue, C-857, results from the differences between the metabolic pathways for the...
-
Targeting of FLT3-ITD kinase contributes to high selectivity of imidazoacridinone C-1311 against FLT3-activated leukemia cells
PublikacjaDrugs targeting receptor tyrosine kinase FLT3 are of particular interest since activating FLT3-internal tandem duplication (ITD) mutations abundantly occur in fatal acute myeloid leukemias (AMLs). Imidazoacridinone C-1311, a DNA-reactive inhibitor of topoisomerase II, has been previously shown to be a potent and selective inhibitor of recombinant FLT3. Here, we expand those findings by studying its effect on leukemia cells with...
-
PARP inhibition potentiates the cytotoxic activity of C-1305, a selective inhibitor of topoisomerase II, in human BRCA1-positive breast cancer cells
PublikacjaTwo cellular proteins encoded by the breast and ovarian cancer type 1 susceptibility (BRCA1 and BRCA2) tumor suppressor genes are essential for DNA integrity and the maintenance of genomic stability.Approximately 5-10% of breast and ovarian cancers result from inherited alterations or mutations in these genes.Remarkably, BRCA1/BRCA2-deficient cells are hypersensitive to selective inhibition of poly(ADPribose) polymerase 1 (PARP-1),...
-
Pregnane X receptor dependent up-regulation of CYP2C9 and CYP3A4 in tumor cells by antitumor acridine agents, C-1748 and C-1305, selectively diminished under hypoxia
PublikacjaInduction of proteins involved in drug metabolism and in drug delivery has a significant impact on drug-drug interactions and on the final therapeutic effects. Two antitumor acridine derivatives selected for present studies, C-1748 (9-(2’-hydroxyethylamino)-4-methyl-1-nitroacridine) and C-1305 (5-dimethylaminopropylamino-8-hydroxy-triazoloacridinone), expressed high and low susceptibility to metabolic transformations with liver...
-
Inhibition of T-type calcium channel disrupts Akt signaling and promotes apoptosis in glioblastoma cells.
PublikacjaGlioblastoma multiforme (GBM) are brain tumors that are exceptionally resitant to both radio- and chemotherapy regimens and novel approaches to treatment are needed. T-type calcium channels are one type of low voltage-gated channel (LVCC) involved in embryonic cell proliferation and differentiation; however they are often over-expressed in tumors, including GBM. In this study, we found that inhibition of T-type Ca channels in GBM...
-
Intercalation of imidazoacridinones to DNA and its relevance to cytotoxicand antitumor activity
Publikacja.
-
Molecular mechanism of the enzymatic oxidation investigated for imidazoacridinone antitumor drug C-1311.
PublikacjaPraca miala na celu określenie molekularnego mechanizmu enzymatycznej utleniającej aktywacji wymienionego związku przeciwnowotworowego w takim układzie modelowym, w którym wcześniej wykazano jego kowalencyjne wiązanie się do DNA. Badania struktur chemicznych produktów enzymatycznej aktywacji wykazały, że dwa z nich powstają w wyniku dealkilacji łańcucha bocznego cząsteczki, natomiast dwa inne w wyniku aktywacji pierścienia imidazoakrydonu....
-
International Conference on Software and System Processes (International Conference of Software and Systems Process (was ICSP prior to 2011))
Konferencje -
The Simulation of Activated Sludge System for Optimization of Predictive Aeration at Large WWTP
PublikacjaEffective use of biodegradable substrates as an internal carbon sources (ICS) for denitrification and EBPR and predicting performance of aeration systems during nitrification in activated sludge bioreactors, may be useful in realization the sustainable development by potentially saving energy consumption at WWTPs. A large number of WWTPs use activated sludge systems with an integrated removal of carbon, nitrogen and phosphorus...
-
Karol Flisikowski dr inż.
OsobyKarol Flisikowski jest profesorem uczelni w Katedrze Statystyki i Ekonometrii, Wydziału Zarządzania i Ekonomii Politechniki Gdańskiej. Jest odpowiedzialny jest za prowadzenie zajęć ze statystyki opisowej i matematycznej (w języku polskim i angielskim), a także badań naukowych w zakresie statystyki społecznej. Był uczestnikiem wielu konferencji o zasięgu krajowym, jak i międzynarodowym, gdzie prezentował wyniki prowadzonych przez...
-
Symulacje przepływu ciepła przez płytę betonową
PublikacjaW pracy przedstawiono symulacje numeryczne dojrzewania betonu w płycie górnej skrzynki czteroprzęsłowego mostu typu extradosed. Model matematyczny opisujący przepływ ciepła dedykowany jest do prognozowania dojrzałości i wytrzymałości twardniejącego betonu. Proponowany model zaimplementowano w autorskim programie numerycznym napisanym w środowisku Matlab. Podejście numeryczne zweryfikowano za pomocą danych doświadczalnych uzyskanych...
-
Advances in analysis, quantification and modelling of N2O emission in SBRs under various DO set points
PublikacjaNitrous oxide (N2O), considered a major greenhouse gas (GHG) in wastewater treatment plants (WWTPs), is produced during both nitrification and denitrification processes; hence, it needs to be controlled by internal and external strategies. Various factors, such as DO, temperature, and pH, could be incorporated into the mitigation of emissions in WWTPs. In this research, potential operational strategies were investigated in order...
-
Influence of silver-core gold-shell nanoparticle parameters on the variation of surface-enhanced Raman spectra
PublikacjaThe detection of molecules by surface-enhanced Raman spectroscopy (SERS) is dependent on the nanomaterial used to induce the enhancement effect. This depends on a variety of parameters of the substrate such as the metal used for their creation, their shape, size and size distribution, concentration, as well as the parameters of the solution, such as packing of the nanoparticles, the complexity of the sample, the solvent, etc. It...
-
Technical and Training Related Aspects of Resistance Training Using Blood Flow Restriction in Competitive Sport - A Review
Publikacja -
The Influence of Grip Width on Training Volume During the Bench Press with Different Movement Tempos
Publikacja -
Does Tempo of Resistance Exercise Impact Training Volume?
Publikacja -
Kinematic quantification of straight-punch techniques using the preferred and non-preferred fist in taekwon-do
Publikacja -
Seeking Optimal Nutrition for Healthy Body Mass Reduction Among Former Athletes
Publikacja -
The Effects of the Movement Tempo on the One-Repetition Maximum Bench Press Results
Publikacja -
Effects of Acute Caffeine Intake on Power Output and Movement Velocity During a Multiple-Set Bench Press Exercise Among Mild Caffeine Users
Publikacja -
The Effects of Plyometric Conditioning on Post-Activation Bench Press Performance
Publikacja -
Impact of Movement Tempo Distribution on Bar Velocity During a Multi-Set Bench Press Exercise
Publikacja -
A Comparison of Electromyographic Inter-Limb Asymmetry during a Standard versus a Sling Shot Assisted Bench Press Exercise
Publikacja -
Relationship among the Change of Direction Ability, Sprinting, Jumping Performance, Aerobic Power and Anaerobic Speed Reserve: A Cross-Sectional Study in Elite 3x3 Basketball Players
Publikacja -
A Comparison of Basic Training Variables in the Standard and Cambered Bar Bench Press Performed to Volitional Exhaustion
Publikacja -
Acute Effects of Caffeinated Chewing Gum on Volleyball Performance in High-Performance Female Players
Publikacja -
Comparison of Muscle Activity During 200 m Indoor Curve and Straight Sprinting in Elite Female Sprinters
Publikacja -
The Impact of Internal Compensatory Mechanisms on Musculoskeletal Pain in Elite Polish Sitting Volleyball Players – A Preliminary Study
Publikacja -
Metal enhanced fluorescence of flavin mononucleotide using new plasmonic platform
PublikacjaNew plasmonic platform was successfully obtained to investigate the increase of fluorescence intensity of a fluorophore in the presence of silver nanoparticles. A flavin mononucleotide, was selected by us as a fluorophore for this study as a very important biological compound playing a key role in many biochemical process. Plasmonic platforms were characterized by means of luminescence spectroscopy. Flavin mononucleotide deposited...
-
Effect of pH on optical sensing with poly-L-lysine-modified nanodiamonds
PublikacjaNitrogen-vacancy (NV) centers are crystallographic defects which provide diamonds with unique physical properties. The centers are known for their intensive, time-stable fluorescence, and an electron spin, which exhibits long coherence time and may be manipulated using external stimuli. Nanodiamonds containing the NV centers are promising tools in biolabeling, biosensing, and drug delivery due to the aforementioned properties of...
-
Epoxy/Ionic Liquid-Modified Mica Nanocomposites: Network Formation–Network Degradation Correlation
PublikacjaWe synthesized pristine mica (Mica) and N-octadecyl-N’-octadecyl imidazolium iodide (IM) modified mica (Mica-IM), characterized it, and applied it at 0.1–5.0 wt.% loading to prepare epoxy nanocomposites. Dynamic differential scanning calorimetry (DSC) was carried out for the analysis of the cure potential and kinetics of epoxy/Mica and epoxy/Mica-IM curing reaction with amine curing agents at low loading of 0.1 wt.% to avoid particle...
-
Krzysztof Goczyła prof. dr hab. inż.
OsobyKrzysztof Goczyła, profesor zwyczajny Politechniki Gdańskiej, informatyk, specjalista z inżynierii oprogramowania, inżynierii wiedzy i baz danych. Ukończył studia wyższe na Wydziale Elektroniki Politechniki Gdańskiej w 1976 r. jako magister inżynier elektronik w specjalności automatyka. Na Politechnice Gdańskiej pracuje od 1976. Na Wydziale Elektroniki PG w 1982 r. uzyskał doktorat z informatyki, a w 1999 r. habilitację. W 2012...
-
Nodal models of Pressurized Water Reactor core for control purposes – A comparison study
PublikacjaThe paper focuses on the presentation and comparison of basic nodal and expanded multi-nodal models of the Pressurized Water Reactor (PWR) core, which includes neutron kinetics, heat transfer between fuel and coolant, and internal and external reactivity feedback processes. In the expanded multi-nodal model, the authors introduce a novel approach to the implementation of thermal power distribution phenomena into the multi-node...
-
A review on carbon storage via mineral carbonation: Bibliometric analysis, research advances, challenge, and perspectives
PublikacjaMineral carbonation as a way of carbon storage has received a particular attention in the reduction of carbon dioxide (CO2) emission . This work gives a comprehensive description of the research trends and hotspots in the field of mineral carbonation for carbon storage based on bibliometric analysis. A total of 1507 articles were collected from the Web of Science database from 2010 to 2022 and analyzed in details, using a Citepace...
-
Milena Marycz dr inż.
Osoby -
The OpenMolcas Web: A Community-Driven Approach to Advancing Computational Chemistry
Dane BadawczeThe developments of the open-source OpenMolcas chemistry software environment since spring 2020 are described, with a focus on novel functionalities accessible in the stable branch of the package or via interfaces with other packages. These developments span a wide range of topics in computational chemistry and are presented in thematic sections: electronic...
-
Tuning Electrochemical Performance by Microstructural Optimization of the Nanocrystalline Functional Oxygen Electrode Layer for Solid Oxide Cells
PublikacjaFurther development of solid oxide fuel cell (SOFC) oxygen electrodes can be achieved through improvements in oxygen electrode design by microstructure miniaturisation alongside nanomaterials implementation. In this work, improved electrochemical performance of an La0.6Sr0.4Co0.2Fe0.8O3-d (LSCF) cathode was achieved by the controlled modification of the La0.6Sr0.4CoO3-d (LSC) nanocrystalline interlayer introduced between a porous...
-
Właściwości katalityczne i biomedyczne związków zawierających jony rutenu(II) oraz rutenu(III)
PublikacjaRuthenium complexes appear in scientific publications mainly as catalysts in the olefins metathesis process. In this review, we want to indicate the research niche regarding the use of ruthenium(II) and ruthenium(III) complexes in other catalytic processes, i.e. polymerization or epoxidation of olefins and depolymerization. We would like to combine the catalytic properties of ruthenium(II,III) complex compounds with their biomedical...
-
Tuning of the Electrochemical Properties of Transparent Fluorine-doped Tin Oxide Electrodes by Microwave Pulsed-plasma Polymerized Allylamine
PublikacjaWe report here the dry, one-step, and low-temperature modification of FTO surfaces using pulsed plasma polymerization of allylamine (PPAAm). PPAAm/FTO surfaces were characterized by X-ray photoelectron spectroscopy, spectroscopic ellipsometry, and contact angles to understand the morphological, structural, and optical properties. FTO were coated with a very thin layer of adherent cross-linked, pinhole-, and additive-free allylamine...
-
Determination of amikacin and ciprofloxacin by liquid chromatography with pre-column derivatization to evaluate sustained delivery of antibiotics from Drug-Eluting Biopsy Needle
PublikacjaDetermination of chosen antibacterial antibiotics: amikacin and ciprofloxacin was carried out by HPLC-UV after derivatization with 9-fluorenylmethyl chloroformate and in their native form by HPLC-MS/MS. Developed methods have been applied to control the kinetics of antibiotic release from polymer-based controlled drug delivery system.
-
3D Computer Model of the Hip Joint Cartilage
PublikacjaThis paper presents 3D computer model of the hip joint cartilage in the ANSYS program. Model is made on the basis of anatomy and collected data on the material constants of bone and cartilage components. Analysis and comparison of biochemical model, viscoelastic and molecular mixed - aggregation serves to facilitate the creation of the next model of reality, which could be used in the design of joint prostheses. The correctness...
-
Influence of iron content on water uptake and charge transport in BaCe0.6Zr0.2Y0.2−xFexO3−δ triple-conducting oxides
PublikacjaIn this work, we studied the BaCe0.6Zr0.2Y0.2−xFexO3−δ system which belongs to the triple-conducting oxides (TCOs) group. The electrochemical properties of BaCe0.6Zr0.2Y0.2−xFexO3−δ were investigated using electrochemical impedance spectroscopy (EIS) and the water uptake was analyzed using thermogravimetry (TG). All investigated materials exhibited water uptake, with proton concentration increasing with decreasing iron content....
-
Synergistic effects of nitrogen-doped carbon and praseodymium oxide in electrochemical water splitting
PublikacjaHybrid materials featuring perovskite-type metal oxide in conjunction with heteroatom-doped graphene hold immense promise as alternatives to costly noble metal catalysts for electrochemical water splitting, facilitating the generation of environmentally friendly hydrogen. In this study, perovskite-type oxide containing praseodymium, barium, strontium, cobalt, and iron atoms dispersed in a carbon matrix as a catalyst is synthesized...
-
Mechanics I, W/C, MiBM, sem. 02, lato 22/23 (PG_00050273)
Kursy OnlineThe course provides students with basic knowledge of Classical Mechanics. Terms, assumptions, principles and methods of Statics, Kinematics and Kinetics are treated. General methods based on the principles of conservation of momentum and energy are considered for a particle, a body and a system of bodies. The main emphasis is on the development of skills to efficiently schematise, solve and analyse typical problems.
-
Mechanics II, W/C, MiBM, sem. 03, zima 22/23 (PG_00055119)
Kursy OnlineThe course provides students with basic knowledge of Classical Mechanics. Terms, assumptions, principles and methods of Statics, Kinematics and Kinetics are treated. General methods based on the principles of conservation of momentum and energy are considered for a particle, a body and a system of bodies. The main emphasis is on the development of skills to efficiently schematise, solve and analyse typical problems.
-
Mechanics II, W/C, ZiIP, sem. 03, zima 23/24 (PG_00055119)
Kursy OnlineThe course provides students with basic knowledge of Classical Mechanics. Terms, assumptions, principles and methods of Statics, Kinematics and Kinetics are treated. General methods based on the principles of conservation of momentum and energy are considered for a particle, a body and a system of bodies. The main emphasis is on the development of skills to efficiently schematise, solve and analyse typical problems.
-
Mechanics I, W/C, ZiIP, sem. 02, lato 23/24 (PG_00050273)
Kursy OnlineThe course provides students with basic knowledge of Classical Mechanics. Terms, assumptions, principles and methods of Statics, Kinematics and Kinetics are treated. General methods based on the principles of conservation of momentum and energy are considered for a particle, a body and a system of bodies. The main emphasis is on the development of skills to efficiently schematise, solve and analyse typical problems.