Wyniki wyszukiwania dla: PATIENTS
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Active Dynamic Thermography in Medical Diagnostics
PublikacjaThis is an overview of active thermal imaging methods in medical diagnostics using external thermal stimulation. In this chapter, several clinical cases diagnosed using the active dynamic thermography method, ADT, are presented. Features of this technology are discussed and main advantages underlined. Applications in skin burn diagnostics and quantitative evaluation leading to modern classification of burned patients for further...
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Role of miR-15b/16–2 cluster network in endometrial cancer: An in silico pathway and prognostic analysis
PublikacjaEndometrial cancer (EC) is the second most common cancer in women. A large number of human cancers exhibit dysregulation of microRNA expression including EC. MiR-15b/16–2 is one of the best-known miRNA clusters that is expressed in many types of cancer tissues. Herein, we analyzed the expression of individual miR-15b/16–2 cluster members, its paralogues, and their target network analysis, as well as their prognostic significance...
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Generating actionable evidence from free-text feedback to improve maternity and acute hospital experiences: A computational text analytics & predictive modelling approach
PublikacjaBackground Patient experience surveys are a key source of evidence for supporting decision-making and quality improvement in healthcare services. These surveys contain two main types of questions: closed and open-ended, asking about patients’ care experiences. Apart from the knowledge obtained from analysing closed-ended questions, invaluable insights can be gleaned from free-text data. Advanced analytics techniques are increasingly...
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Numerical and Clinical Analysis of an Eyeball Injuries under Direc Impact
PublikacjaObjectives: The objective of this study was to develop a numerical model of the eyeball and orbit to simulate a blunt injury to the eyeball leading to its rupture, as well as to conduct a comparative analysis of the results obtained using the finite element method against the clinical material concerning patients who had suffered an eyeball rupture due to a blunt force trauma. Material and Methods: Using available sclera biometric and...
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US not bright but right method of thyroid volume estimation even in large and substernal extended goitres. Comparison of US and three methods of CT thyroid evaluation - prospective study.ON LINE
PublikacjaBackground Ultrasound is nowadays a method of choice for thyroid volume assessment. However, its disadvantage is some inaccuracy, which is said to be higher in huge, especially substernally extended goitres. Aims The aim of the study was to compare the US and CT thyroid volumetric measurements: multi-observers (CT MO) and one-observer (CT OO) to CT planimetry results (CT Pl) in patients with large goitres. Materials & Methods The...
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Real-Time Facial Features Detection from Low Resolution Thermal Images with Deep Classification Models
PublikacjaDeep networks have already shown a spectacular success for object classification and detection for various applications from everyday use cases to advanced medical problems. The main advantage of the classification models over the detection models is less time and effort needed for dataset preparation, because classification networks do not require bounding box annotations, but labels at the image level only. Yet, after passing...
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Dissecting gamma frequency activities during human memory processing
PublikacjaGamma frequency activity (30-150 Hz) is induced in cognitive tasks and is thought to reflect underlying neural processes. Gamma frequency activity can be recorded directly from the human brain using intracranial electrodes implanted in patients undergoing treatment for drug-resistant epilepsy. Previous studies have independently explored narrowband oscillations in the local field potential and broadband power increases. It is not...
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2-Methoxyestradiol and Hydrogen Peroxide as Promising Biomarkers in Parkinson’s Disease
PublikacjaEstrogens function in numerous physiological processes including controlling brain cell growth and differentiation. 2-Meth- oxestradiol (2-ME2), a 17β-estradiol (E2) metabolite, is known for its anticancer effects as observed both in vivo and in vitro. 2-ME2 affects all actively dividing cells, including neurons. The study aimed to determine whether 2-ME2 is a potentially cancer-protective or rather neurodegenerative agent in a...
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Preeclampsia Risk Prediction Using Machine Learning Methods Trained on Synthetic Data
PublikacjaThis paper describes a research study that investigates the use of machine learning algorithms on synthetic data to classify the risk of developing preeclampsia by pregnant women. Synthetic datasets were generated based on parameter distributions from three real patient studies. Four models were compared: XGBoost, Support Vector Machine (SVM), Random Forest, and Explainable Boosting Machines (EBM). The study found that the XGBoost...
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Monitoring of CRT by means of impedance multiple measurements - simulation studies
PublikacjaCardiac resynchronization therapy (CRT) is a very promising treatment for patients with congestive heart failure. An Impedance Cardiography (ICG) is used for evaluation of heart mechanical activity. A simulation study with the use of a FEM model was performed. The developed realistic model of the thorax, based on CT data obtained from examination of a 68-year-old man, consisted of 212 000 tetrahedral elements. Different configurations...
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Genotyping of clinical isolates of fluconazole-resistant Candida albicans
PublikacjaThe aim of the study was to compare the discriminatory power of RAPD-PCR method with using RSD10 primer and microsatellite analysis with using (GACA)4 primer for genotyping clinical isolates of fluconazole-resistant C. albicans. Isolates were received from patients of Children's Memorial Health Institute in Warsaw. However in the case of both tested methods low number of amplified fragments was generated, nine and six different...
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Ergonomics in Polish outpatient clinics
PublikacjaOutpatient clinics are structures In which ergonomics play a key role. This fact is associated with an often occurring risk of developing hospital-acquired infection. The risk increases with mistakes made in wrong planning the functional and spatial lay-out is subordinated to high utilitarian requirements, including hygienic and sanitary, and technological requirements. A properly planned structure allows to reduce dangers more...
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Non-invasive blood glucose monitoring with Raman spectroscopy: prospects for device miniaturization
PublikacjaThe number of patients with diabetes has reached over 350 million, and still continues to increase. The need for regular blood glucose monitoring sparks the interest in the development of modern detection technologies. One of those methods, which allows for noninvasive measurements, is Raman spectroscopy. The ability of infrared light to penetrate deep into tissues allows for obtaining measurements through the skin without its...
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Zespół wypalenia zawodowego i zmęczenie w kontekście pracy zmianowej i stresu zawodowego wśród pielęgniarek chirurgicznych
PublikacjaTwo aspects of work-related consequences among surgery nurses are discussed: burnout syndrome and fatigue, having an impact on the quality of medical care and safety of patients. Siegrist's effort-reward imbalance model has been adopted as a concept of occupational stress. The organization of working time, i.e. the length of shifts and their rotation, was considered. Nurses on twelve-hour shifts worked much harder, were more tired...
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BIOMATERIALS AND IMPLANTS IN CARDIAC AND VASCULAR SURGERY - REVIEW
PublikacjaCurrently, on prosthesis in cardiac blood vessels and heart valves are used materials of animal or synthetic origin. For animal materials include, among others pericardial sac in which is the heart. Materials such as this (natural) are characterized by a remarkable biocompatibility within the human body, but their main disadvantage is the relatively low durability. In turn, synthetic materials, which include the austenitic chromium-nickel-molybdenum...
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Global sensitivity analysis of membrane model of abdominal wall with surgical mesh
PublikacjaThe paper addresses the issue of ventral hernia repair. Finite Element simulations can be helpful in the optimization of hernia parameters. A membrane abdominal wall model is proposed in two variants: a healthy one and including hernia defect repaired by implant. The models include many uncertainties, e.g. due to variability of abdominal wall, intraabdominal pressure value etc. Measuring mechanical properties with high accuracy...
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Computing methods for fast and precise body surface area estimation of selected body parts
PublikacjaCurrently used body surface area (BSA) formulas give satisfactory results only for individuals with typical physique, while for elderly, obese or anorectic people accurate results cannot be expected. Particularly noteworthy are the results for individuals with severe obesity (body-mass index greater than 35 kg/m2), for which BSA estimation errors reached 80%. The main goal of our study is the development of precise BSA models for...
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A Novel Approach to the Assessment of Cough Incidence
PublikacjaIn this paper we consider the problem of identication of cough events in patients suffering from chronic respiratory diseases. The information about frequency of cough events is necessary to medical treatment. The proposed approach is based on bidirectional processing of a measured vibration signal - cough events are localized by combining the results of forward-time and backward-time analysis. The signal is at rst transformed...
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VUV photofragmentation of the six-membered heterocyclic molecules containing oxygen
PublikacjaCancer is a significant public health concern worldwide, which results in millions of deaths each year. The standard cure routine for cancer is surgery, and nowadays, radiotherapy or a hadrontherapy. Depending on the type of cancer, patients may undergo additional treatment, including targeted therapy. A combination of radio- or hadron-therapy with proper drug treatment can inhibit the proliferation of cancer cells and thus can...
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Experimental Investigation of the Performance of an Innovative Implantable Left Ventricular Assist Device—Proof of Concept
PublikacjaThis paper presents the results of experimental performance of an innovative left ventricular assist device working on a specially designed test stand. The introduced invention is mainly applied for supporting the heart in patients with end-stage heart failure accompanied by mitral valve regurgitation and pulmonary hypertension. Moreover, the developed device has the form of a flexible balloon forming an intracardiac inert gas-filled...
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Catheter-induced coronary artery and aortic dissections. A study of the mechanisms, risk factors, and propagation causes
PublikacjaBackground: Only the incidence, management, and prognosis of catheter-induced coronary artery and aortic dissections have been systematically studied until now. We sought to evaluate their mechanisms, risk factors, and propagation causes. Methods: Electronic databases containing 76,104 procedures and complication registries from 2000– –2020 were searched and relevant cineangiographic studies adjudicated. Results: Ninety-six dissections...
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Ripple oscillations in the left temporal neocortex are associated with impaired verbal episodic memory encoding
PublikacjaBACKGROUND: We sought to determine if ripple oscillations (80-120 Hz), detected in intracranial electroencephalogram (iEEG) recordings of patients with epilepsy, correlate with an enhancement or disruption of verbal episodic memory encoding. METHODS: We defined ripple and spike events in depth iEEG recordings during list learning in 107 patients with focal epilepsy. We used logistic regression models (LRMs) to investigate the...
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Exposure to Bisphenol A Analogs and the Thyroid Function and Volume in Women of Reproductive Age—Cross-Sectional Study
PublikacjaBisphenols (BPs) are commonly known plastifiers that are widely used in industry. The knowledge about the impact of BPs on thyroid function is scarce. Proper thyroid functioning is especially important for women of reproductive age, as hypothyroidism affects fertility, pregnancy outcomes and the offspring. There are no studies analyzing the influence of BPs on thyroid function and volume in non-pregnant young women. The aim of...
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Bias mitigation benchmark that includes two datasets
Dane BadawczeISIC-2020 is the largest skin lesion dataset divided into two classes -- benign and malignant. It contains 33126 dermoscopic images from over 2000 patients. The diagnoses were confirmed either by histopathology, expert agreement or longitudinal follow-up. The dataset was gathered by The International Skin Imaging Collaboration (ISIC) from several medical...
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Hospital chaplains facing the pandemic. A qualitative study
PublikacjaThe article explores hospital chaplains perspective on the impact of the coronavirus pandemic on the provision of spiritual care in Poland. Semi-structured interviews with sixteen hospital chaplains providing spiritual care in hospitals during the COVID-19 pandemic were performed. Six main themes emerged during the interviews: chaplains' experience of the pandemic, chaplaincy during the outbreak, patients' needs, health professionals...
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The interplay between Disinhibition and Present-Hedonistic time perspective in the relation between Borderline Personality Organization and depressive symptoms
PublikacjaThe purpose of the current study was to examine the moderating effect between borderline personality organization (BPO) and depressive symptoms of factors associated with impulsive behavior – Present-Hedonistic time perspective and Disinhibition. The research sample consisted of 720 adults from Poland (518 females), who participated in a survey through the research panel. In the case of low levels of Disinhibition, the positive...
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A new diagnostic method for evaluation of cardiosurgery wound healing
PublikacjaOne of important and still unsolved problems in medicine is the question of objective and quantitative evaluation of post-surgery wound healing. The aim of this research is to analyse possibility and value of using the newly elaborated infrared imaging procedure – Active Dynamic Thermography (ADT) – for quantitative description of wound healing processes in cardiosurgery. Both, classical thermal figures of merit as well as ADT...
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Cross-domain applications of multimodal human-computer interfaces
PublikacjaDeveloped multimodal interfaces for education applications and for disabled people are presented, including interactive electronic whiteboard based on video image analysis, application for controlling computers with mouth gestures and audio interface for speech stretching for hearing impaired and stuttering people and intelligent pen allowing for diagnosing and ameliorating developmental dyslexia. The eye-gaze tracking system named...
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The design of an intelligent medical space supporting automated patient interviewing
PublikacjaThe article presents the architecture and results of implementing an application for the intelligent medical space UbiDoDo (Ubiquitous Domestic Doctor's Office). The main purpose of the application is real-time monitoring of the biomedical parameters of a patient in his domestic environment. It allows an immediate reaction to appearing symptoms and provides means to automatically interview the patient and deliver his results to...
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A novel chemiluminescent immunoassay based on original acridinium ester labels as better solution for diagnosis of human toxoplasmosis than conventional ELISA test
PublikacjaToxoplasma gondii infection is one of the most common human zoonosis. Laboratory diagnosis of this disease is mainly based on the results of serological methods detecting specific antibodies in the patient’s sera. In this study we aimed to evaluate the performance of a chemiluminescence immunoassay (CLIA) based on the use of a novel immunochemical reagent in the form of the conjugate of original acridinium label (AL) attached to...
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Modern Material Solutions Applied in Pediatric Facilities
PublikacjaNew tendencies in forming of the health services functional buildings’ systems shaped along with the emergence of caring for patient’s mental condition in medical sciences. The interior design harmonized with the medical function became an incredibly important feature. This opened up new opportunities for the architecture of health care facilities. A positive architecture’s impact on the user’s well-being is remarkably important...
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New Analogues of Mycophenolic Acid
PublikacjaMycophenolic acid (MPA) possesses antibacterial, antifungal, antiviral, immunosuppressive and anticancer properties. It is a non-competitive and reversible inhibitor of dehydrogenase inosine-5'-monophosphate (IMPDH). This compound belongs to the immunosuppressive drugs used for the prevention of both acute and chronic transplant rejection. Until now, two derivatives of MPA have been used clinically: mycophenolate mofetil (MMF,...
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A new assay based on terminal restriction fragment length polymorphism of homocitrate synthase gene fragments for Candida species identification
PublikacjaCandida sp. have been responsible for an increasing number of infections, especially in patients with immunodeficiency. Species specific differentiation of the Candida sp. is difficult in routine diagnosis. This identification can have a highly significant association in therapy and prophylaxis. This work has shown a new application of terminal restriction fragment length polymorphism (t-RFLP) method in molecular identification...
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A PRELIMINARY STUDY ON THE OPTIMAL CHOICE OF AN IMPLANT AND ITS ORIENTATION IN VENTRAL HERNIA REPAIR
PublikacjaThis paper addresses the problem of ventral hernia repair. The main goals are to find an optimal surgical mesh for hernia repair and to define its optimal orientation in the abdominal wall to minimise the maximum force at the tissue-implant juncture. The optimal mesh is chosen from a set of orthotropic meshes with different stiffness ratios for typical hernia placement in the abdominal area. The implant is subjected to an anisotropic...
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Multimodal Approach For Polysensory Stimulation And Diagnosis Of Subjects With Severe Communication Disorders
Publikacjais evaluated on 9 patients, data analysis methods are described, and experiments of correlating Glasgow Coma Scale with extracted features describing subjects performance in therapeutic exercises exploiting EEG and eyetracker are presented. Performance metrics are proposed, and k-means clusters used to define concepts for mental states related to EEG and eyetracking activity. Finally, it is shown that the strongest correlations...
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SZTUKA WIZUALNA W OBIEKTACH MEDYCZNYCH = VISUAL ARTS IN MEDICAL FACILITIES
PublikacjaWspółczesna architektura obiektów służby zdrowia podlega dynamicznym przeobrażeniom formalnym wynikającym zarówno z rozwoju technologii medycznych, zmian zachodzących w podejściu wobec pacjenta. Narastający w naukach medycznych kierunek holistyczny ustawia pacjenta jako użytkownika w trzech wymiarach: biologicznym, społecznym i psychologicznym. Stąd pojawiające się w procesie projektowym dotyczącym szpitali czy przychodni nowe...
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Green Therapy w projektowaniu ośrodków medycznych Green Therapy in complex design of health centres
PublikacjaKoncepcja przestrzenna ogrodu terapeutycznego podporządkowana jest generalnej idei otwierania się projektantów na poszukiwanie nowych możliwości poprawy samopoczucia odbiorcy - poprzez zapewnienie użytkownikom poczucia bezpieczeństwa, komfortu i odprężenia, harmonii. Dotyczy to nie tylko grupy osób chorych, które dręczone są przez niepokoje i napięcia wywołane przez niepełnosprawność czy chorobę, ale także pacjentów w różnym wieku...
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Linezolid-resistant Enterococcus faecium strains isolated from one hospital in Poland –commensals or hospital-adapted pathogens?
PublikacjaOne of the most pressing problems of enterococci infections is occurring resistance to linezolid, which is an antibiotic used in the treatment of infections caused by vancomycin-resistant strains (VRE). The main objective of our research was to investigate the relationship of 19 linezolid-resistant E. faecium isolates from 18 patients hospitalized at Clinical Hospital in Gdansk (Poland). One of the LZDREF was isolated in 2003...
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Fluid–Structure Interaction methods for the progressive anatomical and artificial aortic valve stenosis
PublikacjaCardiovascular system diseases, as aortic valve stenosis, are the main cause of mortality and morbidity among patients. There is still a room for enhancement of the diagnostic and therapeutic procedures, which will lead to improvement of the treatment. One of the remedies are the computer tools to support the medical diagnoses and prostheses design. The development of a procedure for modeling the aortic valves: anatomical tricuspid...
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New recombinant chimeric antigens, P35-MAG1, MIC1-ROP1, and MAG1-ROP1, for the serodiagnosis of human toxoplasmosis
PublikacjaThe aim of the study was to evaluate the usefulness of 3 chimeric Toxoplasma gondii antigens, P35-MAG1,MIC1-ROP1 andMAG1-ROP1, in the serodiagnosis of an acute toxoplasmosis in humans. Proteins were produced as fusion proteins containing His tags ends and then further purified by metal affinity chromatography. Their application for the diagnosis of recently acquired T. gondii infection was tested in IgG and IgM enzyme-linked immunosorbent...
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Tools for Automatic Wound Healing Evaluation
PublikacjaFinal results of the research project devoted to development of a new objective and quantitative method of post cardiosurgery wound healing diagnostics, already preliminary discussed at the QIRT 2014 Conference, is presented. We assumed that thermal processes should be effective in subtle description of temporal changes of tissue thermal properties after surgical interventions. To prove this assumption more than 400 patients after...
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Direct brain stimulation modulates encoding states and memory performance in humans
PublikacjaPeople often forget information because they fail to effectively encode it. Here, we test the hypothesis that targeted electrical stimulation can modulate neural encoding states and subsequent memory outcomes. Using recordings from neurosurgical epilepsy patients with intracranially implanted electrodes, we trained multivariate classifiers to discriminate spectral activity during learning that predicted remembering from forgetting,...
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Open smart glasses development platform for AAL applications
PublikacjaThis paper describes an open platform for multi sensory electronic glasses that supports new and enhanced methods for intelligent interaction with patients, with smart objects, or to be used as new data input modalities like proximity sensor or smart textile interfaces. All the activities have been developed, investigated and evaluated within EU CHIST-ERA eGlasses project...
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COVID-19 severity forecast based on machine learning and complete blood count data
PublikacjaProper triage of COVID-19 patients is a key factor in eective case management, especially with limited and insucient resources. In this paper, we propose a machine-aided diagnostic system to predict how badly a patient with COVID-19 will develop disease. The prognosis of this type is based on the parameters of commonly used complete blood count tests, which makes it possible to obtain data from a wide range of patients.We chose...
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COVID-19 severity forecast based on machine learning and complete blood count data
PublikacjaProper triage of COVID-19 patients is a key factor in eective case management, especially with limited and insucient resources. In this paper, we propose a machine-aided diagnostic system to predict how badly a patient with COVID-19 will develop disease. The prognosis of this type is based on the parameters of commonly used complete blood count tests, which makes it possible to obtain data from a wide range of patients.We chose...
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Intracranial electrophysiological recordings from the human brain during memory tasks with pupillometry
PublikacjaData comprise intracranial EEG (iEEG) brain activity represented by stereo EEG (sEEG) signals, recorded from over 100 electrode channels implanted in any one patient across various brain regions. The iEEG signals were recorded in epilepsy patients (N=10) undergoing invasive monitoring and localization of seizures when they were performing a battery of four memory tasks lasting approx. 1 hour in total. Gaze tracking on the task...
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Molecular Imaging and Nanotechnology—Emerging Tools in Diagnostics and Therapy
PublikacjaPersonalized medicine is emerging as a new goal in the diagnosis and treatment of diseases. This approach aims to establish differences between patients suffering from the same disease, which allows to choose the most effective treatment. Molecular imaging (MI) enables advanced insight into molecule interactions and disease pathology, improving the process of diagnosis and therapy and, for that reason, plays a crucial role in personalized...
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Development and validation of a model that includes two ultrasound parameters and the plasma D-dimer level for predicting malignancy in adnexal masses: an observational study
PublikacjaBackground: Pre-operative discrimination of malignant from benign adnexal masses is crucial for planning additional imaging, preparation, surgery and postoperative care. This study aimed to define key ultrasound and clinical variables and develop a predictive model for calculating preoperative ovarian tumor malignancy risk in a gynecologic oncology referral center. We compared our model to a subjective ultrasound assessment (SUA)...
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Engineering Challenges in the Design of Cochlear Implants
PublikacjaHearing aids such as cochlear implants have been used by both adults and children for a long time. In addition, cochlear implants are used by patients who have severe hearing loss either by birth or after an accident. This paper aims to investigate the engineering challenges bounding the design of cochlear implants and present its possible solution...
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Treatment of Odontogenic Maxillary Sinusitis with the Use of Growth Factors in Advanced Platelet-Rich Fibrin for Immediate Closure of Oro-Antral Communication: A Case Report
PublikacjaChronic odontogenic maxillary sinusitis (COMS), a prolonged inflammation of the maxillary sinus lasting over 12 weeks, is often a result of periapical lesions, marginal periodontitis, and complications like oro-antral communication (OAC) and fistula (OAF). OAC, commonly emerging post-teeth extraction in the lateral maxilla, lacks documented treatments using advanced platelet-rich fibrin (A-PRF). This study evaluates A-PRF’s efficacy...