Wyniki wyszukiwania dla: FUNCTIONS OF TRANSFER
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Therapeutic Potential of Carnosine and Its Derivatives in the Treatment of Human Diseases
PublikacjaDespite significant progress in the pathogenesis, diagnosis, treatment, and prevention of cancer and neurodegenerative diseases, their occurrence and mortality are still high around theworld. The resistance of cancer cells to the drugs remains a significant problem in oncology today,while in the case of neuro-degenerative diseases, therapies reversing the process are still yet to be found. Furthermore, it is important to seek new...
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Fundamentals of Data-Driven Surrogate Modeling
PublikacjaThe primary topic of the book is surrogate modeling and surrogate-based design of high-frequency structures. The purpose of the first two chapters is to provide the reader with an overview of the two most important classes of modeling methods, data-driven (or approx-imation), as well as physics-based ones. These are covered in Chap-ters 1 and 2, respectively. The remaining parts of the book give an exposition of the specific aspects...
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Efficient and robust quadratures for isogeometric analysis: Reduced Gauss and Gauss–Greville rules
PublikacjaThis work proposes two efficient quadrature rules, reduced Gauss quadrature and Gauss–Greville quadrature, for isogeometric analysis. The rules are constructed to exactly integrate one-dimensional B-spline basis functions of degree p, and continuity class C^{p−k}, where k is the highest order of derivatives appearing in the Galerkin formulation of the problem under consideration. This is the same idea we utilized in Zou et al....
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Direct electrical stimulation of the human brain has inverse effects on the theta and gamma neural activities
PublikacjaObjective: Our goal was to analyze the electrophysiological response to direct electrical stimulation (DES) systematically applied at a wide range of parameters and anatomical sites, with particular focus on neural activities associated with memory and cognition. Methods: We used a large set of intracranial EEG (iEEG) recordings with DES from 45 subjects with electrodes...
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Simulator for Performance Evaluation of ASON/GMPLS Network
PublikacjaThe hierarchical control plane network architecture of Automatically Switched Optical Network with utilization of Generalized Multi-Protocol Label Switching protocols is compliant to next generation networks requirements and can supply connections with required quality of service, even with incomplete domain information. Considering connection control, connection management and network management, the controllers of this architecture...
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Smart Virtual Product Development (SVPD) System to Support Product Inspection Planning in Industry 4.0
PublikacjaThis paper presents the idea of supporting product inspection planning process during the early stages of product life cycle for the experts working on product development. Aim of this research is to assist a collaborative product development process by using Smart Virtual Product Development (SVPD) system, which is based on Set of Experience Knowledge Structure (SOEKS) and Decisional DNA (DDNA). The proposed system is developed...
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Secure Italian domination in graphs
PublikacjaAn Italian dominating function (IDF) on a graph G is a function f:V(G)→{0,1,2} such that for every vertex v with f(v)=0, the total weight of f assigned to the neighbours of v is at least two, i.e., ∑u∈NG(v)f(u)≥2. For any function f:V(G)→{0,1,2} and any pair of adjacent vertices with f(v)=0 and u with f(u)>0, the function fu→v is defined by fu→v(v)=1, fu→v(u)=f(u)−1 and fu→v(x)=f(x) whenever x∈V(G)∖{u,v}. A secure Italian dominating...
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Smart Approach for Glioma Segmentation in Magnetic Resonance Imaging using Modified Convolutional Network Architecture (U-NET)
PublikacjaSegmentation of a brain tumor from magnetic resonance multimodal images is a challenging task in the field of medical imaging. The vast diversity in potential target regions, appearance and multifarious intensity threshold levels of various tumor types are few of the major factors that affect segmentation results. An accurate diagnosis and its treatment demand strict delineation of the tumor affected tissues. Herein, we focus on...
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Multi-objective optimization of the cavitation generation unit structure of an advanced rotational hydrodynamic cavitation reactor
PublikacjaHydrodynamic cavitation (HC) has been widely considered a promising technique for industrial-scale process intensifications. The effectiveness of HC is determined by the performance of hydrodynamic cavitation reactors (HCRs). The advanced rotational HCRs (ARHCRs) proposed recently have shown superior performance in various applications, while the research on the structural optimization is still absent. The present study, for the...
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MODELING THE pH EFFECTS ON NITROGEN REMOVAL IN THE ANAMMOX-ENRICHED GRANULAR SLUDGE
PublikacjaThe aim of the study was to determine the pH effects on nitrogen removal in the anammox-enriched 10 granular sludge. The experimental data were extracted from a 4L completely-mixed batch reactor with the 11 granular sludge at different initial pH values (6.5, 7, 7.5, 8, 8.5, 9, 9.5, 10, 10.5) and constant temperature 12 T=30℃. Simulations were run in GPS-X 6.4 using a comprehensive mechanistic model Mantis2. Two 13 kinetic parameters,...
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Planning the City Against Barriers. Enhancing the Role of Public Spaces
PublikacjaContemporary cities are being fragmented by growing number of technical barriers like roads, railways, infrastructural objects, that generate variety of problems of different nature. The aim of the research is to present the issues connected with such barriers in the city and the ways of solving them. Main problems are e.g.: the destruction of the complexity of urban fabric, functional disadvantages, environmental and landscape...
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Electron collisions with X(CH3)4 molecules (X = C, Si, Ge)
PublikacjaAbsolute grand-total cross sections (TCSs) for electron scattering from tetramethylmethane [C(CH3)4], tetramethylsilane [Si(CH3)4], and tetramethylgermane [Ge(CH3)4] molecules have been measured at electron-impact energies extending from around 0.5 to 300 eV in the linear electron-transmission experiment. The measured TCS energy dependences show very pronounced broad enhancement, peaking near 5.5 eV for Si(CH3)4 and Ge(CH3)4 molecules...
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Functional safety and reliability analysis methodoloogy for hazardous industrial plants
PublikacjaThis monograph is devoted to current problems and methods of the functional safety and reliability analyses of the programmable control and protection systems for industrial hazardous plants. The results of these analyses are useful in the process of safety management in life cycle, for effective reducing relevant risks at the design stage, and then controlling these risks during the operation of given installation. The methodology...
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Linear-scaling calculation of Hartree-Fock exchange energy with Non-orthogonal Generalised Wannier Functions
PublikacjaWe present a method for the calculation of four-centre two-electron repulsion integrals in terms of localised non-orthogonal generalised Wannier functions (NGWFs). Our method has been imple- mented in the ONETEP program and is used to compute the Hartree-Fock exchange energy component of Hartree-Fock and Density Functional Theory (DFT) calculations with hybrid exchange-correlation functionals. As the NGWFs are optimised in situ...
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The impact of training and neurotrophins on functional recovery after spinal cord transection: cellular and molecular mechanisms contributing to motor improvement
PublikacjaBeneficial effects of locomotor training on the functional recovery after complete transection of the spinal cord indicate that in chronic spinal animals spontaneous recovery processes are enhanced and shaped by the training. The mechanisms of that use-dependent improvement are still not fully understood. This review tackles three aspects of this issue: (1) neurochemical attributes of functional improvement...
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Problemy zarządzania bezpieczeństwem obiektu przemysłowego podwyższonego ryzyka
PublikacjaW rozdziale przedstawiono wybrane zagadnienia dotyczące zarządzania bezpieczeństwem w zautomatyzowanym złożonym obiekcie podwyższonego ryzyka. Pokazano, że ryzyko strat można istotnie ograniczyć stosując odpowiednie rozwiązania techniczne w postaci warstwowego systemu zabezpieczeń, który obejmuje podstawowy system sterowania procesem, człowieka-operatora i system automatyki zabezpieczeniowej. Podkreślono znaczenie właściwego zaprojektowania...
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An effective method for studying intermolecular interactions in binary liquids with hydrogen bonds: FTIR spectra and ab initio calculations in the N-methylformamide - methanol system
PublikacjaMolecular complexes in methanol (MeOH)−N-methylformamide (NMF) mixtures were studied based on their FTIR-ATR spectra, to which two methods of analysis were applied: factor analysis and a quantitative version of the difference-spectra method. The mean composition of a complex between NMF and MeOH molecules over the whole range of mixture compositions was determined. Absorbing species differentiated with regard to the interaction...
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The role of glucuronidation in drug resistance
PublikacjaThe final therapeutic effect of a drug candidate, which is directed to a specific molecular target strongly depends on its absorption, distribution, metabolism and excretion (ADME). The disruption of at least one element of ADME may result in serious drug resistance. In this work we described the role of one element of this resistance: phase II metabolism with UDP-glucuronosyltransferases (UGTs). UGT function is the transformation...
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Two-phase optimizing approach to design assessments of long distance heat transportation for CHP systems
PublikacjaCogeneration or Combined Heat and Power (CHP) for power plants is a method of putting to use waste heat which would be otherwise released to the environment. This allows the increase in thermodynamic efficiency of the plant and can be a source of environmental friendly heat for District Heating (DH). In the paper CHP for Nuclear Power Plant (NPP) is analyzed with the focus on heat transportation. A method for effectivity and feasibility...
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ISLAMIC TAKAFUL: CZY SKUTECZNIE ZASTĄPIŁ UBEZPIECZENIA KOMERCYJNE? : ISLAMIC TAKAFUL: HAS IT SUCCESSFULLY SUBSTITUTED CONVENTIONAL INSURANCE?
PublikacjaIslamic finance is a fast developing sector mainly present in the Middle East, South-East Asia, Central Asia and to a smaller extent in Africa and Central Europe. Together with the rebirth of Islam in the second half of the 20th century, Islamic finance tends to cover the economic needs of all Muslims (including insurances). The Islamic finance system is based on several principles including three main prohibitions: Gharar (deceptive uncertainty),...
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Static electric and magnetic multipole susceptibilities for Dirac one-electron atoms in the ground state
PublikacjaWe present tabulated data for several families of static electric and magnetic multipole susceptibilities for hydrogenic atoms with nuclear charge numbers from the range $1\leq Z\leq137$. Atomic nuclei are assumed to be point-like and spinless. The susceptibilities considered include the multipole electric polarizabilities $\alpha_{\mathrm{E}L\to\mathrm{E}L}$ and magnetizabilities (magnetic susceptibilities) $\chi_{\mathrm{M}L\to\mathrm{M}L}$...
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Atmospheric opacity estimation based on IWV derived from GNSS observations for VLBI applications
PublikacjaThermal emission of atmospheric water vapor has a great influence on the calibration of radio astronomical observations at millimeter wavelengths. The phenomenon of an atmospheric water vapor emits noise signal and attenuates astronomical emission. At 22 GHz, integrated water vapor (IWV) obtained from global navigation satellite systems (GNSS) is strictly related to atmospheric opacity (τ0), which is a crucial parameter for data...
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Multi-Criteria Approach in Multifunctional Building Design Process
PublikacjaThe paper presents new approach in multifunctional building design process. Publication defines problems related to the design of complex multifunctional buildings. Currently, contemporary urban areas are characterized by very intensive use of space. Today, buildings are being built bigger and contain more diverse functions to meet the needs of a large number of users in one capacity. The trends show the need for recognition of...
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Commercial function as a treat to the monument - 25 years of experience in the commercialization of monuments in Gdansk, Poland
PublikacjaThe principles of the market economy adopted in Poland in the nineties have significantly touched the resources of immovable monuments. As a result, monuments have become a product of culture subject to the rules of the free market; and state ownership, patronage and decision-making practice has now been replaced by private interest. Practical monument use has also changed with the shift in ownership of objects after privatization...
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Chitosan-based nanomaterials for removal of water pollutants
PublikacjaThe rise of micropollutants presents a significant threat to both the environment and human well-being, requiring effective strategies for their mitigation. Chitin serves as the precursor for chitosan, composed of two monomers featuring acetamido and amino groups. Chitosan possesses several noteworthy attributes, including its ability to bind water and fat, humidity content, solubility, consistent molecular weight, and various...
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Study on extraction and characterization of anchote (Coccinia abyssinica) starch and reinforced enset (Ensete ventricosum) fiber for the production of reinforced bioplastic film
PublikacjaPopulation expansion is causing an increase in dependence on plastic materials. The worst aspects of conventional plastics were their inability to biodegrade, their poor capacity to transmit water vapor, and their production of greenhouse gases. Usages of bioplastics are necessary for the advancement of a green economy and environment in order to eradicate these drawbacks of traditional plastics. In this study, reinforced bioplastic...
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Application of Nanomaterials for Cadmium Adsorption for Sustainable Treatment of Wastewater: a Review
PublikacjaMany heavy metals, particularly cadmium, are detrimental to both people and the environment when present in large quantities. In wastewater treatment plants, several conventional approaches are employed for cadmium abatement to restore the ecosystem, food supplies, and health of people and animals. Ion exchange, coagulation, membrane filtration, and chemical precipitation are a few examples of ways for removing heavy metals from...
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Time fractional analysis of Casson fluid with application of novel hybrid fractional derivative operator
PublikacjaA new approach is used to investigate the analytical solutions of the mathematical fractional Casson fluid model that is described by the Constant Proportional Caputo fractional operator having non-local and singular kernel near an infinitely vertical plate. The phenomenon has been expressed in terms of partial differential equations, and the governing equations were then transformed in non-dimensional form. For the sake of generalized...
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Sugar matters: sugar moieties as reactivity-tuning factors in quercetin O-glycosides
PublikacjaQuercetin, one of the most abundant flavonoids in plant-based foods, commonly occurs in nature in various glycosylated forms. There is still a less explored aspect regarding the cause of its glycosides diversity, depending on the sugars moiety attached. This work focuses on four widespread quercetin glycosides—hyperoside, isoquercitrin, quercitrin and rutin—by testing property-tuning capacity of different sugar moieties and thus...
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Open-source software (OSS) and hardware (OSH) in UAVs
PublikacjaThe popularity of the Open Source Tool (OST) has expanded significantly. This is the case for Unmanned Aerial Vehicles (UAVs) based on open-source hardware (OSH) as well. Open-source software (OSS) and OSH can be applied in a wide range of applications and can improve several technologies. The chapter begins with an introduction to OSS depicting its rationale, description of fundamental differences between OSS and proprietary software...
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Implementation of Hermite-Ritz method and Navier’s Technique for Vibration of Functionally Graded Porous Nanobeam Embedded in Winkler-Pasternak Elastic Foundation Using bi-Helmholtz type of nonlocal elasticity
PublikacjaPresent study is devoted to investigating the vibration characteristics of Functionally Graded (FG) porous nanobeam embedded in an elastic substrate of Winkler-Pasternak type. Classical beam theory (CBT) or Euler-Bernoulli beam theory (EBT) has been incorporated to address the displacement of the FG nanobeam. Bi-Helmholtz type of nonlocal elasticity is being used to capture the small scale effect of the FG nanobeam. Further, the...
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Wear of electroplated diamond tools in lap-grinding of Al2O3 ceramic materials
PublikacjaCurrent development of modern products, together with ever-increasing demands for their operation and usage, necessitate the search for new processing methods. Abrasive machining is widely used in many industrial areas, especially for processing difficult-to-machine materials such as advanced ceramics. Grinding with lapping kinematics, also called lap-grinding, is still one of the innovative methods of abrasive processing being...
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The atlas of inequality aversion: theory and empirical evidence on 55 countries from the Luxembourg Income Study database
PublikacjaResearch background: In the distributive analysis, the constant relative inequality aversion utility function is a standard tool for ethical judgements of income distributions. The sole parameter ε of this function expresses a society’s aversion to inequality. However, the profession has not committed to the range of ε. When assessing inequality and other welfare characteristics, analysts assume an arbitrary level of ε, common...
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Migration of container terminals as their natural process of evolution: Case study of Gdańsk and Gdynia ports
PublikacjaThe paper proposes a theoretical model of container terminals and container port development, based on the life cycle theory, threshold theory and catastrophe theory, and in references to Kuznets' swings (interpreted as waves of infrastructural investments), and Kondratiev long economic waves. The aim of this model is to explain the development process of a container terminal and a port within one technological generation, as...
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A spline-based FE approach to modelling of high frequency dynamics of 1-D structures
PublikacjaIn this paper a computational methodology leading to the development of a new class of FEs, based on the application of continuous and smooth approximation polynomials, being splines, has been presented. Application of the splines as appropriately defined piecewise elemental shape functions led the authors to the formulation of a new approach for FEM, named as spFEM, where contrary to the well-known NURBS approach, the boundaries...
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New Materiality-towards ‘Media Environments
PublikacjaArticle presents media solutions providing new materiality of architectural spaces. Media solutions in architecture evolve in new forms. Articlepresentsboth the developmentof new technological solutionsas well as new ways of application of media solutions in relation toarchitectural form. The aim of the article is to show technical aspects of new materiality - intelligent materials, allowing transmission of changeable visual content...
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Linear game non-contextuality and Bell inequalities—a graph-theoretic approach
PublikacjaWe study the classical and quantum values of a class of one-and two-party unique games, that generalizes the well-known XOR games to the case of non-binary outcomes. In the bipartite case the generalized XOR(XOR-d) games we study are a subclass of the well-known linear games. We introduce a 'constraint graph' associated to such a game, with the constraints defining the game represented by an edge-coloring of the graph. We use the...
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A Generalized Framework Towards Structural Mechanics of Three-layered Composite Structures
PublikacjaThree-layered composite structures find a broad application. Increasingly, composites are being used whose layer thicknesses and material properties diverge strongly. In the perspective of structural mechanics, classical approaches to analysis fail at such extraordinary composites. Therefore, emphasis of the present approach is on arbitrary transverse shear rigidities and structural thicknesses of the individual layers. Therewith...
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The interaction parameters for solutions of n-butylurea in aqueous solutions of N-methylacetamide – The volumetric and compressibility studies between 288.15 K and 308.15 K
PublikacjaDensities and speed of sound were measured for solutions of n-butylurea in aqueous solution of Nmethylacetamide 2, 4, 6 and 8 (mol/kg) at T = (288.15, 298.15 and 308.15) K. From these data the apparent molar volumes, Vf, the apparent molar isentropic compressions, KSf, of the solute were determined. The concentration dependencies of the calculated quantities have been used to obtain the standard partial molar parameters. The latter...
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Determination of Surfactants in Environmental Samples. Part III. Non-Ionic Compounds
PublikacjaNon-ionic surface active agents are a diverse group of chemicals which have an uncharged polar head and a non-polar tail. They have different properties due to amphiphilic structure of their molecules. Commercial available non-ionic surfactants consist of the broadest spectrum of compounds in comparison with other types of such agents. Typically, non-ionic compounds found applications in households and industry during formulation...
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Multiple transcriptional factors regulate transcription of the rpoE gene in Escherichia coli under different growth conditions and when the lipopolysaccharide biosynthesis is defective.
PublikacjaThe RpoE sigma factor is essential for the viability of Escherichia coli. RpoE regulates extracytoplasmic functions including lipopolysaccharide (LPS) translocation and some of its non-stoichiometric modifications. Transcription of the rpoE gene is positively autoregulated by EσE and by unknown mechanisms that control the expression of its distally located promoter(s). Mapping of 5′ ends of rpoE mRNA identified five new transcriptional...
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Molecular basis and quantitative assessment of TRF1 and TRF2 protein interactions with TIN2 and Apollo peptides
PublikacjaShelterin is a six-protein complex (TRF1, TRF2, POT1, RAP1, TIN2, and TPP1) that also functions in smaller subsets in regulation and protection of human telomeres. Two closely related proteins, TRF1 and TRF2, make high-affinity contact directly with double-stranded telomeric DNA and serve as a molecular platform. Protein TIN2 binds to TRF1 and TRF2 dimer-forming domains, whereas Apollo makes interaction only with TRF2. To elucidate...
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Molecular Recognition in Complexes of TRF Proteins with Telomeric DNA
PublikacjaTelomeres are specialized nucleoprotein assemblies that protect the ends of linear chromosomes. In humans and many other species, telomeres consist of tandem TTAGGG repeats bound by a protein complex known as shelterin that remodels telomeric DNA into a protective loop structure and regulates telomere homeostasis. Shelterin recognizes telomeric repeats through its two major components known as Telomere Repeat-Binding Factors, TRF1...
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A pilot study to assess an in-process inspection method for small diameter holes produced by Direct Metal Laser Sintering
PublikacjaPurpose The purpose of this research is to evaluate the geometric quality of small diameter holes in parts printed by DMLS technology. An in-process optical inspection method is proposed and assessed during a pilot study. The influence of the theoretical hole diameter assumed in a CAD system and the sample thickness (hole length) on the hole clearance was analysed. Design/methodology/approach The samples made of two different...
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OOA-modified Bi-LSTM network: An effective intrusion detection framework for IoT systems
PublikacjaCurrently, the Internet of Things (IoT) generates a huge amount of traffic data in communication and information technology. The diversification and integration of IoT applications and terminals make IoT vulnerable to intrusion attacks. Therefore, it is necessary to develop an efficient Intrusion Detection System (IDS) that guarantees the reliability, integrity, and security of IoT systems. The detection of intrusion is considered...
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Smart Knowledge Engineering for Cognitive Systems: A Brief Overview
PublikacjaCognition in computer sciences refers to the ability of a system to learn at scale, reason with purpose, and naturally interact with humans and other smart systems, such as humans do. To enhance intelligence, as well as to introduce cognitive functions into machines, recent studies have brought humans into the loop, turning the system into a human–AI hybrid. To effectively integrate and manipulate hybrid knowledge, suitable technologies...
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Hotspot of human verbal memory encoding in the left anterior prefrontal cortex
PublikacjaBackground: Treating memory and cognitive deficits requires knowledge about anatomical sites and neural activities to be targeted with particular therapies. Emerging technologies for local brain stimulation offer attractive therapeutic options but need to be applied to target specific neural activities, at distinct times, and in specific brain regions that are critical for memory formation. Methods: The areas that are critical...
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Molecular level interpretation of excess infrared spectroscopy
PublikacjaInfrared (IR) spectroscopy is an invaluable tool in studying intermolecular interactions in solvent mixtures. The deviation of the IR spectrum of a mixture from the spectra of its pure components is a sensitive measure of the non-ideality of solutions and the modulation of intermolecular interactions introduced by mutual influence of the components. Excess IR spectroscopy, based on the established notion of excess thermodynamic...
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Displacement piles - classification and methods for the calculation of bearing capacity.
PublikacjaDisplacement piles belong to a group of technologies whose main idea is to install or make a pile without extracting ground material. According to definition, contained in PN-EN:1997-1:2008, displacement piles should be considered as driven, pressed in using vibrators and made with the use of spread augers. The classification of piles used so far with regard to the technology of execution is modified. An additional element is the...
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PARP inhibition potentiates the cytotoxic activity of C-1305, a selective inhibitor of topoisomerase II, in human BRCA1-positive breast cancer cells
PublikacjaTwo cellular proteins encoded by the breast and ovarian cancer type 1 susceptibility (BRCA1 and BRCA2) tumor suppressor genes are essential for DNA integrity and the maintenance of genomic stability.Approximately 5-10% of breast and ovarian cancers result from inherited alterations or mutations in these genes.Remarkably, BRCA1/BRCA2-deficient cells are hypersensitive to selective inhibition of poly(ADPribose) polymerase 1 (PARP-1),...