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Wyniki wyszukiwania dla: population genetics
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Neotenic phenomenon in gene expression in the skin of Foxn1- deficient (nude) mice - a projection for regenerative skin wound healing
PublikacjaMouse fetuses up to 16 day of embryonic development and nude (Foxn1- deficient) mice are examples of animals that undergo regenerative (scar-free) skin healing. The expression of transcription factor Foxn1 in the epidermis of mouse fetuses begins at embryonic day 16.5 which coincides with the transition point from scar-free to scar-forming skin wound healing. In the present study, we tested the hypothesis that Foxn1 expression...
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Changes in gene methylation patterns in neonatal murine hearts: Implications for the regenerative potential
PublikacjaBackground The neonatal murine heart is able to regenerate after severe injury; this capacity however, quickly diminishes and it is lost within the first week of life. DNA methylation is an epigenetic mechanism which plays a crucial role in development and gene expression regulation. Under investigation here are the changes in DNA methylation and gene expression patterns which accompany the loss of regenerative potential. Results The...
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A prototypical non-malignant epithelial model to study genome dynamics and concurrently monitor micro-RNAs and proteins in situ during oncogene-induced senescence
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Correction to: A prototypical non-malignant epithelial model to study genome dynamics and concurrently monitor micro-RNAs and proteins in situ during oncogene-induced senescence
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Transcriptomic responses to wounding: meta-analysis of gene expression microarray data
PublikacjaBackground A vast amount of microarray data on transcriptomic response to injury has been collected so far. We designed the analysis in order to identify the genes displaying significant changes in expression after wounding in different organisms and tissues. This meta-analysis is the first study to compare gene expression profiles in response to wounding in as different tissues as heart, liver, skin, bones, and spinal cord, and...
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Comparative analysis of mRNA transcripts of HT-29 cell line expressed in identical quantities for pathogenic E. coli strains UM146 and UM147 with control Escherichia coli Nissle 1917
PublikacjaAim of study was comparative analysis of mRNA transcripts of HT-29 cell line, expressed in identical quantities for the combination of pathogenic and non-pathogenic Escherichia coli strains. HT-29 confluent monolayers infection with two pathogenic E. coli strains UM146 and UM147 resulted in two sets of mRNA transcripts that were identical with RNA transcripts obtained for non-pathogenic one strain E. coli Nissle 1917. In this study...
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Stochastic equivalence scales in log-normal distributions of expenditures
PublikacjaIn the paper, the properties of the stochastic equivalence scales (SES) are analysed when expenditure distributions are log-normal. The SES provides the equivalent distribution of expenditures when the population of households is heterogeneous with respect to such attributes as household size, demographic cpmposition, etc. For log-normal expenditure distributions, the non-parametric SES deflators are proportional to the ration...
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An assessment of Islamic banking in Bosnia and Herzegovina – a comparative analysis using the CAMELS approach
PublikacjaThis paper examines the phenomenon of Islamic banking in Bosnia and Herzegovina. Although almost half of the Bosnian population is recognized as Islamic, there is only one bank purely based on Sharia operating in this country. The aim of the article is to conduct a comparative analysis of the financial standing of this bank and the banking sector in this country and region. The chosen method of analysis is CAMELS which examines...
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"Srebrni przedsiębiorcy" w świetle badań europejskich
PublikacjaArtykuł poświęcony jest przedsiębiorczości ludzi w wieku dojrzałym. Stanowi próbę przybliżenia tej tematyki głównie poprzez pryzmat teorii i dotychczas przeprowadzonych badań empirycznych, głównie europejskich. Szczególnie dużo miejsca poświęcono w nim motywacjom „srebrnych przedsiębiorców”, dokonano również podziału tej populacji na różne profile, wynikające z czynników jakie miały wpływ na ich decyzje przedsiębiorcze.
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IPMSM rotor position estimator based on analysis of phase current derivatives
PublikacjaThis paper describes an algorithm for estimation of IPMSM angular rotor position. The algorithm uses derivatives of motor phase currents resulting from PWM modulation to obtain the rotor position. The presented method is designed for medium- and high-speed range, since it is based on determination of the EMF vector. Algorithm is characterised by a very simple formulae. The calculation of rotor position is performed in every PWM...
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Modified SPWM Technique with Zero-Sequence Voltage Injection for a Five-Phase, Three-Level NPC Inverter
PublikacjaThis article presents a modified sinusoidal pulse-width modulation (SPWM) scheme for a five-phase, three-level neutral-point-clamped inverter. The modulation scheme deploys a modified min–max function to inject the zero-sequence components into the reference modulating signals; hence enabling the effective utilization of the DC-link voltage. Balanced split-input DC-link voltages were achieved through further incorporation of adjustable...
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Sex contribution to average age at onset of Huntington's disease depends on the number of (CAG)n repeats
PublikacjaHuntington’s disease (HD) is a hereditary neurodegenerative disorder caused by the extension of the CAG repeats in exon 1 of the HTT gene and is transmitted in a dominant manner. The present study aimed to assess whether patients’ sex, in the context of mutated and normal allele length, contributes to age on onset (AO) of HD. The study population comprised a large cohort of 3723 HD patients from the European Huntington’s Disease...
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Approval of an Arrangement in the Restructuring Proceedings and the Financial Condition of Companies Listed on the Stock Exchanges in Warsaw. Is There Any Relationship?
PublikacjaThis paper attempts to identify the financial indicators differentiating companies that are insolvent or at risk of insolvency and have successfully entered into an arrangement with their creditors from those that have not. In addition, a two-factor model for predicting the odds of an arrangement has been proposed. The research was conducted using a population of companies listed on stock exchanges in Warsaw that initiated restructuring...
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Personalized nutrition in ageing society: redox control of major-age related diseases through the NutRedOx Network (COST Action CA16112)
PublikacjaA healthy ageing process is important when it is considered that one-third of the population of Europe is already over 50 years old, although there are regional variations. This proportion is likely to increase in the future, and maintenance of vitality at an older age is not only an important measure of the quality of life but also key to participation and productivity. So, the binomial “nutrition and ageing” has different aspects...
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Fluctuation enhanced gas sensing with WO3-based nanoparticle gas sensors modulated by UV light at selected wavelengths
PublikacjaThe sensitivity and selectivity of WO3-based gas sensors can be enhanced by UV-irradiation-induced modulation, especially if different wavelengths are employed. We used fluctuation-enhanced gas sensing, based on measurements of resistance fluctuations in the gas sensor, to study the effects of such modulation on the noise intensity for ambient atmospheres of synthetic air without and with additions of small amounts of ethanol,...
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Multi-criterion decision making in distributed systems by quantum evolutionary algorithms
PublikacjaDecision making by the AQMEA (Adaptive Quantum-based Multi-criterion Evolutionary Algorithm) has been considered for distributed computer systems. AQMEA has been extended by a chromosome representation with the registry of the smallest units of quantum information. Evolutionary computing with Q-bit chromosomes has been proofed to characterize by the enhanced population diversity than other representations, since individuals represent...
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Informal employment in Poland: an empirical spatial analysis
PublikacjaThe main goal of our article is to bridge the gap in the regional analysis of informal employment in Poland and in particular to indicate the propensity for informal work in the working-age population, to test if informal activities are typical for marginalized people (less educated, unemployed, older) and to identify the regional and spatial heterogeneity in the propensity. We use data from the ‘Human Capital Balance 2010–2014’...
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On a Method of Efficiency Increasing in Kaplan Turbine
PublikacjaThis paper presents a method of increasing efficiency in Kaplan-type turbine. The method is based on blade profile optimisation together with modelling the interaction between rotor and stator blades. Loss coefficient was chosen as the optimisation criterion, which is related directly to efficiency. Global optimum was found by means of Genetic Algorithms, and Artificial Neural Networks were utilised for approximations to reduce...
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Increasing the Utilization of dc-link Voltage of a Five-Leg VSI Based on Rotor Angle Control of Dual Induction Motors
PublikacjaThis paper introduces an increased utilization of the dc-link voltage of a five-leg voltage source inverter (VSI) based on the rotor flux angle control technique for dual induction motors, IM. The main purpose is to utilize additional abilities provided by a multi-motor drive system in limited operating conditions. Generally, a multi-motor drive system is widely used in electric vehicles (EVs), traction systems and in several industrial...
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Test Stand for Multi-option Stretching of Soft Tissues
PublikacjaThe paper presents the genesis of the design and possibilities of the test stand for stretching soft tissues as well as examples of tests carried out on this device.
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Test Stand for Multi-option Stretching of Soft Tissues
PublikacjaThe paper presents the genesis of the design and possibilities of the test stand for stretching soft tissues as well as examples of tests carried out on this device.
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Oxide nanoparticle exsolution in Lu-doped (Ba,La)CoO3
PublikacjaThis study investigated Lu doping of Ba0.5La0.5CoO3 and its influence on the exsolution of oxide nanoparticles (NPs). As a result of Lu doping, we observed the phase segregation into the main Ba0.4La0.6Co0.85Lu0.15O3 (BLCO–Lu) phase and the secondary Ba0.85La0.15Co0.75Lu0.25O3 (BCO–Lu) phase. We noticed the exsolution of BCO–Lu nanoparticles on the main BLCO–Lu phase. Moreover, the BLCO–Lu phase exsolved in the form of nanoparticles...
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Scarabaeidae as human food – A comprehensive review
PublikacjaRising global population and sustainable protein demand have sparked interest in unique food sources. Entomophagy, or insect consumption, presents a solution and Scarab beetles, part of the Scarabaeidae family, offer a novel food option. The comprehensive review underscores their potential as human food, with strong nutrition, low environmental impact, and the ability to ease strain on conventional agriculture. Nutritional analysis...
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Optimisation of turbine shaft heating process under steam turbine run-up conditions
PublikacjaAn important operational task for thermal turbines during run-up and run-down is to keep the stresses in the structural elements at a right level. This applies not only to their instantaneous values, but also to the impact of them on the engine lifetime. The turbine shaft is a particularly important element. The distribution of stresses depends on geometric characteristics of the shaft and its specific locations. This means a groove manufactured...
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A Simplified SVPWM Technique for Five-leg Inverter with Dual Three-phase Output
PublikacjaThis article proposes a simplified space vector pulse-width modulation (SVPWM) technique five-leg inverter with dual three-phase output. An idea to fed the dual tree-phase machine by the multiphase voltage source inverters (VSIs) is not new. Dual- and multi-motor drive systems are widely used in the industry applications. The most popular fields are: electric vehicles (EVs) and traction systems. Moreover, the specific characteristic...
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Influence of silver-core gold-shell nanoparticle parameters on the variation of surface-enhanced Raman spectra
PublikacjaThe detection of molecules by surface-enhanced Raman spectroscopy (SERS) is dependent on the nanomaterial used to induce the enhancement effect. This depends on a variety of parameters of the substrate such as the metal used for their creation, their shape, size and size distribution, concentration, as well as the parameters of the solution, such as packing of the nanoparticles, the complexity of the sample, the solvent, etc. It...
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Gender approach to multi-objective optimization of detection systems by pre-selection of criteria
PublikacjaA novel idea of performing evolutionary computations for solving highly-dimensional multi-objective optimization (MOO) problems is proposed. The information about individual genders is applied. This information is drawn out of the fitness of individuals and applied during the parental crossover in the evolutionary multi-objective optimization (EMO) processes. The paper introduces the principles of the genetic-gender approach (GGA)...
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Gender approach to multi-objective optimization of detection systems by pre-selection of criteria
PublikacjaA novel idea of performing evolutionary computations for solving highly-dimensional multi-objective optimization (MOO) problems is proposed. The information about individual genders is applied. This information is drawn out of the fitness of individuals and applied during the parental crossover in the evolutionary multi-objective optimization (EMO) processes. The paper introduces the principles of the genetic-gender approach (GGA)...
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Gender approach to multi-objective optimization of detection systems by pre-selection of criteria
PublikacjaA novel idea of performing evolutionary computations for solving highly-dimensional multi-objective optimization (MOO) problems is proposed. The information about individual genders is applied. This information is drawn out of the fitness of individuals and applied during the parental crossover in the evolutionary multi-objective optimization (EMO) processes. The paper introduces the principles of the genetic-gender approach (GGA)...
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Future of medicine: personalized oncology
PublikacjaUnderstanding genetic and epigenetic mechanisms of tumorigenesis allows identifying many vital mutations affected the formation of various malignancies. This led to the discovery of a new therapeutic approach, based on molecular mechanisms in the world of medicine, which is called personalized medicine (PM). This review aims to outline the state of the art of the personalized medicine in treatment, taking into account anti-cancer...
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Epoxy/Ionic Liquid-Modified Mica Nanocomposites: Network Formation–Network Degradation Correlation
PublikacjaWe synthesized pristine mica (Mica) and N-octadecyl-N’-octadecyl imidazolium iodide (IM) modified mica (Mica-IM), characterized it, and applied it at 0.1–5.0 wt.% loading to prepare epoxy nanocomposites. Dynamic differential scanning calorimetry (DSC) was carried out for the analysis of the cure potential and kinetics of epoxy/Mica and epoxy/Mica-IM curing reaction with amine curing agents at low loading of 0.1 wt.% to avoid particle...
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Scalable Maintenance of Address Mapping and Autodetecion in Environments Where Agents are Uncapable of Self-Registration
PublikacjaWhen working with multi-agent systems it is often desirable to manage the agent set. The existing methods of central monitoring stems from two different fields of application. The first has its roots in in computer network monitoring, the other in mutli-agent simulation environments. Both approaches are not general enough to cater for loosely controlled environments, where the total agent population is not known and often fluctuating,...
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The trajectories of the financial crisis of companies at risk of bankruptcy
PublikacjaThis article concerns the assessment of the trajectory of the collapse of enterprises in Central Europe. The author has developed a model of a Kohonen artificial neural network. This model was used to determine 6 different classes of risk and was allowed to graphically determine the 5- to 10-year trajectory of going bankrupt. The study used data on 140 companies listed on the Warsaw Stock Exchange. This population was divided into...
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Association between the NAT1 1095C > A polymorphism and homocysteine concentration
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Microbial diversity of inflamed and noninflamed gut biopsy tissues in inflammatory bowel disease.
PublikacjaBACKGROUND: Inflammatory bowel disease (IBD) is a chronic gastrointestinal condition without any known cause or cure. An imbalance in normal gut biota has been identified as an important factor in the inflammatory process. METHODS: Fifty-eight biopsies from Crohn's disease (CD, n = 10), ulcerative colitis (UC, n = 15), and healthy controls (n = 16) were taken from a population-based case-control study. Automated ribosomal intergenic...
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A Comparability of Renal Length and Volume Measurements in MRI and Ultrasound in Children
PublikacjaIntroduction: Despite the significant increase in use of magnetic resonance imaging (MRI) in children, there is still a lack of normal reference values of renal size in this method and reference values are being interpolated from the ultrasound (US) studies. The study provides comparative analysis of agreement in renal length and volume measurements between MRI and ultrasound. Materials and Methods: Ninety-three children with a...
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Analiza kohortowa przyczyn bierności zawodowej osób w wieku 45+
PublikacjaZmiany demograficzne następujące w ostatnich latach w krajach rozwiniętych stawiają nowe wyzwania przed badaczami i praktykami rynku pracy. Jedną z najbardziej zauważalnych konsekwencji „starzenia społeczeństw” jest wydłużenie czasu bierności zawodowej. Jednocześnie w wolniejszym tempie występuje proces wydłużenia czasu aktywności zawodowej. Z punktu widzenia stabilności systemu emerytalnego istotne jest zatem określenie przyczyn...
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Application of Maximum Lenght Sequence in Silent Sonar
PublikacjaSilent sonars are designed to reduce the distance over which their sounding pulses can be detected by intercept sonars. In order to meet this objective, we can use periodical sounding signals that have low power, a very long duration and wide spectrum. If used in the silent sonar's receiver, matched filtration ensures very good detection of motionless or slow moving targets. However, it is more difficult to detect echo signals...
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High Efficiency Dual-Active-Bridge Converter with Triple-Phase-Shift Control for Battery Charger of Electric Vehicles
PublikacjaAn optimal modulation scheme with triple-phase-shift (TPS) control could increase the efficiency in the entire load range for a dual-active-bridge (DAB) converter under wide output voltage range conditions. Therefore, this study proposes a convergent approach to TPS mode selection, coupled with an optimal modulation scheme, ensuring the circuit’s efficiency over the entire range in the realm of a high-power and high-efficiency...
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A Method for Optimising the Blade Profile in Kaplan Turbine
PublikacjaThis paper introduces a method of blade profile optimisation for Kaplan-type turbines, based on modelling the interaction between rotor and stator blades. Rotor and stator blade geometry is described mathematically by means of a midline curve and thickness distribution. Genetic algorithms are then used to find a global optimum that minimises the loss coefficient. This allows for variety of possible blade shapes and configurations....
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Detekcja osoby w wannie
PublikacjaStarzenie się społeczeństwa powoduje narastanie problemów chorób wieku starczego. Częstym problemem są zasłabnięcia w wannie podczas kąpieli. Celem publikacji jest przedstawienie metody identyfikacji tkanki ożywionej w wodzie z wykorzystaniem technik elektromagnetycznych. Obserwując zmiany amplitudy i częstotliwości pracy generatorów, pracujących w pętli sprzężenia zwrotnego z cewką, istnieje możliwość scharakteryzowania i określenia...
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Control strategy for the multilevel cascaded H-bridge converter
PublikacjaThe paper presents the control strategy for Cascaded H-bridge (CHB) converter . The converter output voltage using Space-Vector Pulse Width Modulation (SV-PWM) strategy is controlled. The DC-link voltages are controlled by appropriate choice of H-Bridges and appropriate choice of active and passive vectors.
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Inner-shell fragmentation of molecules into neutral fragments in high-Rydberg states induced by soft X-ray excitation with pulsed-field ionization
PublikacjaIn the present communication, we will show the results of measurements probing the production of neutral high-Rydberg fragments at the K edges of the molecules containing oxygen and nitrogen atoms. The experiments were performed at the Gas Phase beamline of the Elettra synchrotron radiation laboratory (Trieste, Italy), exploiting a combined soft X-ray excitation with pulsed-field ionization and ion time-of-flight (TOF) spectrometry...
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Model of Rules for IT Organization Evolution
PublikacjaThe aim of this paper is to introduce the Model of Rules for IT Organization Evolution which shall be in compliance with the Generic IT Organization Evolution Model. Due to its general nature, a set of practical adjustments is proposed in order to adapt the Generic Model to the IT Service Management domain. Further, two sets of rules describing the evolution of the IT Service Management area are defined based on two types of rules...
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Uczenie maszynowe do samoorganizacji systemów rozproszonych w zastosowaniach gospodarczych
PublikacjaW pracy omówiono uczenie maszynowe do samoorganizacji systemów rozproszonych w zastosowaniach gospodarczych ze szczególnym uwzględnieniem sieci neuronowych do predykcji finansowych oraz szacowania ratingu przedsiębiorstw. Oprócz sieci neuronowych, istotną rolę w przygotowaniu i testowaniu informatycznych systemów finansowych może pełnić programowanie genetyczne. Z tego powodu omówiono uczenie maszynowe w aplikacjach konstruowanych...
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Algorytmy genetyczne i ewolucyjne
PublikacjaAlgorytmy ewolucyjne istnieją dzięki wieloletnim obserwacją procesów zachodzących wśród żywych organizmów. Korzystają one z nazw i określeń występujących w genetyce np.: gen, chromosom. Algorytmy genetyczne oraz ewolucyjne używa się w procesach optymalizacyjnych w celu poszukiwania ekstremów.
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Determination of amikacin and ciprofloxacin by liquid chromatography with pre-column derivatization to evaluate sustained delivery of antibiotics from Drug-Eluting Biopsy Needle
PublikacjaDetermination of chosen antibacterial antibiotics: amikacin and ciprofloxacin was carried out by HPLC-UV after derivatization with 9-fluorenylmethyl chloroformate and in their native form by HPLC-MS/MS. Developed methods have been applied to control the kinetics of antibiotic release from polymer-based controlled drug delivery system.
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First report of seroprevalence of Toxoplasma gondii infection in sheep in Pomerania, northern Poland
PublikacjaIntroduction and objective. Toxoplasmosis is parasitic disease which has economic relevance for both veterinary and human medicine. In sheep, toxoplasmosis is a major cause of abortion and can thus cause reproductive problems. The current study aimed to determine the occurrence of anti-Toxoplasma gondii IgG antibodies in sheep from 13 districts of northern Poland and thereby obtain actual data about T. gondii seroprevalence in...
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Folate/homocysteine metabolism and lung cancer risk among smokers
PublikacjaBackground: Folate and homocysteine are involved in DNA synthesis and methylation processes, which are deregulated during carcinogenesis. Objectives: The aim of this study was to assess the relationship between folate/homocysteine concentrations, the functional polymorphisms of folate/homocysteine genes and lung cancer risk among cigarette smokers. Study design: The study included 132 lung cancer patients and 396 controls from...
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Influence of iron content on water uptake and charge transport in BaCe0.6Zr0.2Y0.2−xFexO3−δ triple-conducting oxides
PublikacjaIn this work, we studied the BaCe0.6Zr0.2Y0.2−xFexO3−δ system which belongs to the triple-conducting oxides (TCOs) group. The electrochemical properties of BaCe0.6Zr0.2Y0.2−xFexO3−δ were investigated using electrochemical impedance spectroscopy (EIS) and the water uptake was analyzed using thermogravimetry (TG). All investigated materials exhibited water uptake, with proton concentration increasing with decreasing iron content....