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20-Hydroxycholecalciferol, Product of Vitamin D3 Hydroxylation by P450scc, Decreases NF-κB Activity by Increasing IκBα Levels in Human Keratinocytes
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Single nucleotide polymorphisms in A4GALT spur extra products of the human Gb3/CD77 synthase and underlie the P1PK blood group system
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Zinc Oxide Nanoparticles Impair the Integrity of Human Umbilical Vein Endothelial Cell Monolayer <I>In</I> <I>Vitro</I>
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Muscle Cell Morphogenesis, Structure, Development and Differentiation Processes Are Significantly Regulated during Human Ovarian Granulosa Cells In Vitro Cultivation
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Piperine Targets Different Drug Resistance Mechanisms in Human Ovarian Cancer Cell Lines Leading to Increased Sensitivity to Cytotoxic Drugs
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Toxic potencies of metabolite(s) of non-cylindrospermopsin producing Cylindrospermopsis raciborskii isolated from temperate zone in human white cells
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Interplay between Structure and Charge as a Key to Allosteric Modulation of Human 20S Proteasome by the Basic Fragment of HIV-1 Tat Protein
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Ultra-high performance liquid chromatographic determination of levofloxacin in human plasma and prostate tissue with use of experimental design optimization procedures
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Application of Ion Chromatography for the Determination of Inorganic Ions, Especially Thiocyanates, in Human Semen Samples as Biomarkers of Environmental Tobacco Smoke Exposure.
PublikacjaPalenie tytoniu stanowi istotne źródło zanieczyszczenia powietrza wewnętrznego. Szkodliwość palenia tytoniu potwierdzają zarówno badania doświadczalne, jak i opracowania epidemiologiczne. Celem przeprowadzonych prac badawczych było uzyskanie informacji o poziomie zawartości jonów nieorganicznych, a zwłaszcza jonów rodankowych (jako biomarkerów narażenia na szkodliwe składniki obecne w środowiskowym dymie tytoniowym) w próbkach...
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Antitumor 1-nitroacridine derivative C-1748, induces apoptosis, necrosis or senescence in human colon carcinoma HCT8 and HT29 cells.
PublikacjaC-1748 jest związkiem oddziaływującym z DNA i potencjalnym związkiem przeciwnowotworowym szczególnie wobec nowotworów prostaty i jelita grubego przeszczepialnych na myszach.W pracy badano odpowiedź komórek nowotworowych HCT8 i HT29 na działanie pochodnej C-1748, w stężeniach biologicznie istotnych (EC90). Analiza cyklu komórkowego linii HCT8 pokazała, że związek powoduje wzrost frakcji sub-G1, świadczący o apoptozie tych komórek...
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Application of ion chromatography for the determination of inorganic ions, especially thiocyanates in human saliva samples as biomarkers of environmental tobacco smoke exposure
PublikacjaŚrodowiskowy dym tytoniowy jest jednym z czynników decydujących o jakości powietrza wewnętrznego różnego typu pomieszczeń zamkniętych. Toksyczne składniki wydzielające się wraz z głównym i bocznym strumieniem dymu tytoniowego mają istotny wpływ na skład chemiczny płynów biologicznych. Jednym z biomarkerów narażenia na szkodliwe składniki środowiskowego dymu tytoniowego są jony rodankowe. Celem badań było znalezienie korelacji pomiędzy...
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The hypoxia‐induced changes in miRNA‐mRNA in RNA ‐induced silencing complexes and HIF ‐2 induced miRNAs in human endothelial cells
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Substrate profiling of Finegoldia magna SufA protease, inhibitor screening and application to prevent human fibrinogen degradation and bacteria growth in vitro
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The influence of 4-substituted and unsubstituted derivatives of 1-nitroacridine on the cell cycle and induction of apoptosis in human cancer HT29 and HeLa S3.
PublikacjaZbadano wpływ pochodnych 1-nitroakrydyny C-1748 i C-857, w stężeniach biologicznie istotnych, na cykl życiowy oraz indukcję apoptozy komórek raka jelita grubego HT29 oraz raka szyjki macicy HeLa S3. Metodą cytometrii przepływowej wykazano, że 4-metylo-1-nitroakrydyna C-1748 powoduje akumulację komórek HT29 w fazie S i komórek HeLa S3 w fazie G2 cyklu komórkowego zaś związek C-857 indukuje akumulację komórek HT29 i HeLa S3 w fazie...
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Human poverty - measuring relative deprivation from basic achievements: a comparative study for 144 countries over the period 1990-2010
PublikacjaPoverty – differently defined and measured – still remains one the crucial parts of the world development debate. It`s broadly perceived as multidimensional phenomenon which deprives people from basic capabilities and freedoms, limits their opportunity to educate and fully participate in the labor market contributing to overall country`s socioeconomic performance. Referring to seminal works of Sen and many others(see e.g. Morris...
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The effective elastic properties of human trabecular bone may be approximated using micro-finite element analyses of embedded volume elements.
PublikacjaBoundary conditions (BCs) and sample size affect the measured elastic properties of cancellous bone. Samples too small to be representative appear stiffer under kinematic uniform BCs (KUBCs) than under periodicity-compatible mixed uniform BCs (PMUBCs). To avoid those effects, we propose to determine the effective properties of trabecular bone using an embedded configuration. Cubic samples of various sizes (2.63, 5.29, 7.96, 10.58...
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Using creative approaches for discovering biomorphic forms for appropriate human habitation in natural environments. Case study of Kashubian Lake District
PublikacjaThe research process consisted of studies of natural and cultural conditions of the Kashubian Lake District This is an area of exceptional natural conditions. For centuries, it has seen human habitation with respect to landscape values. Given its extensive forest cover and the lack of heterogeneity of natural conditions, the area has become an interesting inspiration for the author’s original project. The project is aimed at searching...
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Paenibacillus alvei MP1 as a Producer of the Proteinaceous Compound with Activity against Important Human Pathogens, Including Staphylococcus aureus and Listeria monocytogenes
PublikacjaAn emerging need for new classes of antibiotics is, on the one hand, evident as antimicrobial resistance continues to rise. On the other hand, the awareness of the pros and cons of chemically synthesized compounds’ extensive use leads to a search for new metabolites in already known reservoirs. Previous research showed that Paenibacillus strain (P. alvei MP1) recovered from a buckwheat honey sample presented a wide spectrum of...
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Unconventional and user-friendly sampling techniques of semi-volatile organic compounds present in an indoor environment: An approach to human exposure assessment
PublikacjaThe commonly applied solutions used to assess the potential risk of human exposure to semi-volatile organic compounds (SVOCs) are based on the investigation of biological samples collected in an invasive or non-invasive manner. For SVOCs, which are typically introduced to humans through the respiratory system, dermal adsorption, or digestive system, sampling solutions generally used in the indoor environments are classified as...
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Effect of oxidation and in vitro intestinal hydrolysis on phospholipid toxicity towards HT29 cell line serving as a model of human intestinal epithelium
PublikacjaOxidation of food-derived phospholipids (PLs) can influence nutrient digestion and induce oxidative stress in gastrointestinal epithelium. In this study, hen egg yolk PL fraction was used to evaluate the effect of lipoxygenase (LOX)-induced PL oxidation on the rate of PL hydrolysis catalyzed by pancreatic phospholipase A2 (PLA2) in the presence of bile salts (BSs). Then, PL/BS solutions containing native or oxidized PLs were used...
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Combined anticancer therapy with imidazoacridinone analogue C‐1305 and paclitaxel in human lung and colon cancer xenografts—Modulation of tumour angiogenesis
PublikacjaThe acridanone derivative 5-dimethylaminopropylamino- 8- hydroxytriazoloacridinone (C-1305) has been described as a potent inhibitor of cancer cell growth. Its mechanism of action in in vitro conditions was attributed, among others, to its ability to bind and stabilize the microtubule network and subsequently exhibit its tumour- suppressive effects in synergy with paclitaxel (PTX). Therefore, the objective of the present study...
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Higher Absorption of Vitamin C from Food than from Supplements by Breastfeeding Mothers at Early Stages of Lactation
PublikacjaThe aim of the present study was to determine the effect of vitamin C supply in the diet of lactating women on vitamin C concentra¬tions in human milk (n = 97) sampled at different stages of lactation. Vitamin C levels were measured by liquid chromatography. Dietary intake of vitamin C was determined based on 3-day food dairies kept by breastfeeding mothers. Maternal dietary intakes of vitamin C from natural sources on lactation...
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Occurrence of West Nile Virus Antibodies in Wild Birds, Horses, and Humans in Poland
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Clinical Application of Bioextracts in Supporting the Reproductive System of Animals and Humans: Potential and Limitations
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Impact of slow breathing on the blood pressure and subarachnoid space width oscillations in humans
PublikacjaThe aim of the study was to assess cardiac and respiratory blood pressure (BP) and subarachnoid space (SAS) width oscillations during the resting state for slow and fast breathing and breathing against inspiratory resistance. Experiments were performed on a group of 20 healthy volunteers (8 males and 12 females; age 25.3 ± 7.9 years; BMI = 22.1 ± 3.2 kg/m2). BP and heart rate (HR) were measured using continuous finger-pulse photoplethysmography....
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Nutritional properties of mussels Mytilus galloprovincialis
PublikacjaCelem badań było oznaczenie jakości markerów oraz oszacowanie wpływu diety wzbogaconej w małże pochodzące z zanieczyszczonych i niezanieczyszczonych obszarów na wybrane markery metabolizmu białek i lipidów u szczurów, których pokarm zawierał różne dawki cholesterolu. Obszerny zakres przeprowadzonych testów w warunkach in vitro wykazał, że małże pochodzące z zanieczyszczonych terenów charakteryzują się wyższą zawartością białek,...
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Evaluation of candidate reference material obtained from selenium - enriched sprouts for the purpose of selenium speciation analysis
PublikacjaSelenium is an essential element in animals and humans. Diet supplementation with selenium-rich vegetables has better chemoprotective effect than Se (IV) and SeMet. The production of selenium-enriched vegetables requires a preliminary stage in soil preparation, which may subsequently pose a risk of soil contamination. It seems that the sprouting of seeds under controlled conditions would be a good solution for delivering SeMetSeCys...
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Supplementation of garlic lowers lipids and increases antioxidant capacity in plasma of rats
PublikacjaZbadano bioaktywność surowego i gotowanego czosnku (Allium sativium L.). Stwierdzono, że gotowanie czosnku w temperaturze 100 °C przez 20 minut nie wpływa na jego bioaktywność.Samcom szczurów (z badanej populacji) podzielonym losowo na 10 grup, podawano żywność z różnym dodatkiem czosnku. Natomiast grupa kontrolna była karmiona dietą podstawową złożoną ze skrobi pszenicznej, oleju sojowego, celulozy, minerałów i mieszaniny witamin....
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Mutagenic and Carcinogenic Compounds in Food
PublikacjaFood is a major environmental human cancer risk factor. One of the reasons for this is that food products contain substances that exhibit mutagenic and carcinogenic potential which may induce the transformation of normal somatic cells into cancerous cells. These compounds occur in food as a result of microbial contaminations (mycotoxins produced by molds), are generated from natural food components upon processing (e.g. heterocyclic...
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Alternatywne modele żywienia w cukrzycy typu 2
PublikacjaCukrzyca typu 2 jest chorobą diagnozowaną u coraz większej liczby osób. Brak codziennej aktywności fizycznej, ale także spożywanie w dużych ilościach przetworzonej, wysokokalorycznej i ubogiej w włókno pokarmowe żywności przyczynia się do wzrostu masy ciała co w konsekwencji zwiększa możliwość zachorowania na owe schorzenie. Dlatego w dietoterapii cukrzycy typu 2 rekomenduje się wprowadzenie diety o niskim indeksie glikemicznym...
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The impact of addition of olive oil on thermal degradation of refined rapeseed oil
PublikacjaFats are an important component of the everyday diet and have a significant impact on the proper functioning of human organism. However, during the process of frying chemical transformations take place in the oil; hence fats characterised by high oxidative stability should be given preference. The aim of this work was to determine the quality of rapeseed oil, blended oil, and refined olive oil, all sourced from the domestic market....
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PARP inhibition potentiates the cytotoxic activity of C-1305, a selective inhibitor of topoisomerase II, in human BRCA1-positive breast cancer cells
PublikacjaTwo cellular proteins encoded by the breast and ovarian cancer type 1 susceptibility (BRCA1 and BRCA2) tumor suppressor genes are essential for DNA integrity and the maintenance of genomic stability.Approximately 5-10% of breast and ovarian cancers result from inherited alterations or mutations in these genes.Remarkably, BRCA1/BRCA2-deficient cells are hypersensitive to selective inhibition of poly(ADPribose) polymerase 1 (PARP-1),...
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Metabolic activity of tree saps of different origin towards cultured human cells in the light of grade correspondence analysis and multiple regression modeling
PublikacjaTree saps are nourishing biological media commonly used for beverage and syrup production. Although the nutritional aspect of tree saps is widely acknowledged, the exact relationship between the sap composition, origin, and effect on the metabolic rate of human cells is still elusive. Thus, we collected saps from seven different tree species and conducted composition-activity analysis. Saps from trees of Betulaceae, but not from...
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A population of human brain cells expressing phenotypic markers of more than one lineage can be induced in vitro to differentiate into mesenchymal cells
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The effect of lyophilization on selected biologically active components (vitamin c, catalase, lysozyme), total antioxidant capacity and lipid oxidation in human milk
PublikacjaHuman milk is rich in polyunsaturated fatty acids, as well as lysozyme, vitamin C and other bioactive compounds. The effect of lyophilization on the content of antioxidants (vitamin C and catalase CAT), bactericidal compounds (lysozyme), total antioxidant capacity (TAC) and lipid peroxidation in human milk was investigated in this study. Samples of mature human milk were collected from five healthy women who gave birth on the scheduled...
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Simultaneous determination of Na+, K+, Ca2+, Mg2+ and Cl- in unstimulated and stimulated human saliva using all solid state multisensor platform
PublikacjaHuman saliva is one of the body fluids which collection method is relatively simple and non-invasive. The article is dedicated to assess concentration (activity) of Na+, K+, Ca2+, Mg2+ and Cl- in fresh, unstimulated or stimulated human saliva samples using single solid contact ion-selective electrodes with conventional reference electrode and self-made multisensor platform (MP) equipped with ion-selective membranes for Na+, K+,...
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Biotransformation of Modified Benzylisoquinoline Alkaloids: Boldine and Berberine and In Silico Molecular Docking Studies of Metabolites on Telomerase and Human Protein Tyrosine Phosphatase 1B
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High Quality Independent From a Donor: Human Amniotic Fluid Derived Stem Cells—A Practical Analysis Based on 165 Clinical Cases
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Agrimoniin up-regulates collagen biosynthesis through increase in expression of β1-integrin receptor and prolidase activity in cultured human skin fibroblasts
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Phenylalanine derivatives with modulating effects on human α1-glycine receptors and anticonvulsant activity in strychnine-induced seizure model in male adult rats
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Analysis of interactions responsible for vasopressin binding to human neurohypophyseal hormone receptors—molecular dynamics study of the activated receptor–vasopressin–Gα systems
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Combination of ABT-737 and resveratrol enhances DNA damage and apoptosis in human T-cell acute lymphoblastic leukemia MOLT-4 cells
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Human Umbilical Vein Endothelial Cells (HUVECs) Co-Culture with Osteogenic Cells: From Molecular Communication to Engineering Prevascularised Bone Grafts
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‘Heart development and morphogenesis’ is a novel pathway for human ovarian granulosa cell differentiation during long‑term in�vitro cultivation‑a microarray approach
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One- and two-photon induced fluorescence of Pacific Blue-labeled human serum albumine deposited on different core size silver colloids
PublikacjaPublikacja opisuje jedno i dwufotonowo indukowaną Fluorescencje znakowanej barwnikiem ''Pacific Blue'' ludzkiej albuminy osadzonej na srebrnych koloidach różnych rozmiarów
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The induction of autophagy in human colon wt p53 and p53-null HCT116 cells by 4-methyl-1-nitroacridine derivative C-1748
PublikacjaPrzeprowadzone badania miały na celu określenie zdolności pochodnej 4-metylo-1-nitroakrydyny C-1748 do uruchomienia autofagii komórek ludzkiego raka okrężnicy HCT116 posiadających dziki gen p53 oraz podlinii nie posiadającej tego genu. Wszystkie eksperymenty przeprowadzone zostały przy stężeniu hamującym proliferację komórek nowotworowych w 90%. Wykazano, że indukowana przez C-1748 autofagia w komórkach raka okrężnicy jest zależna...
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Human red blood cells targeted metabolome analysis of glycolysis cycle metabolites by capillary electrophoresis using an indirect photometric detection method
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A rapid spectrofluorimetric method for the determination of malondialdehyde in human plasma after its derivatization with thiobarbituric acid and vortex assisted liquid–liquid microextraction
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Pollution characteristics and human health risks of potentially (eco)toxic elements (PTEs) in road dust from metropolitan area of Hefei, China
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Reconstructing human impact on peatland development during the past 200 years in CE Europe through biotic proxies and X-ray tomography
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