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wyświetlamy 1000 najlepszych wyników Pomoc
Wyniki wyszukiwania dla: MCF10A CELLS
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Carbon Nanotubes Chemically Derivatize with Redox Systems as Mediators for Biofel Cell Applicatoions
PublikacjaEnzymatyczne bioogniwa paliwowe to urządzenia wykorzystujące enzymy do przemiany energii chemicznej w elektryczną. Zyskana w ten sposób energia może służyć do zasilania wszczepialnych urządzeń (np. czujników glukozy, rozruszników serca).Przedstawiono sposób otrzymywania i właściwości bioelektrod, w których wykorzystano nanorurki węglowe modyfikowane mediatorami enzymatycznych reakcji redoks. Do nanorurek przyłączano zarówno mediatory...
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Carbon Nanotubes Chemically Derivatized with Redox Systems as Mediators for Biofuel Cell Applications
PublikacjaEnzymatyczne bioogniwa paliwowe to urządzenia wykorzystujące enzymy do przemiany energii chemicznej w elektryczną. Zyskana w ten sposób energia może służyć do zasilania wszczepialnych urządzeń (np. czujników glukozy, rozruszników serca). Przedstawiono sposób otrzymywania i właściwości bioelektrod, w których wykorzystano nanorurki węglowe modyfikowane mediatorami enzymatycznych reakcji redoks. Do nanorurek przyłączano zarówno mediatory...
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High temperature oxidation of porous alloys for solid oxide fuel cell applications
PublikacjaW pracy proszki PI600, 317L i 430L stali użyto do przygotowania porowatych metalowych podłoży dla tlenkowych ogniw paliwowych. Po spiekaniu w różnych temperaturach oceniana była ich porowatość i wysokotemperaturową odporność na korozję. Cykliczna analiza termograwimetryczna, dyfraktometria rentgenowska i obrazów SEM były używane do opisu właściwości tych porowatych stopów. Właściwości elektryczne badano dla wybranych próbek. Wpływ...
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Carbon nanotubes chemically derivatized with rebox systems as mediators for biofuel cell applications
PublikacjaEnzymatyczne bioogniwa paliwowe to urządzenia wykorzystujące enzymy do przemiany energii chemicznej w elektryczną. Zyskana w ten sposób energia może służyć do zasilania wszczepialnych urządzeń (np. czujników glukozy, rozruszników serca).Przedstawiono sposób otrzymywania i właściwości bioelektrod, w których wykorzystano nanorurki węglowe modyfikowane mediatorami enzymatycznych reakcji redoks. Do nanorurek przyłączano zarówno mediatory...
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On doubts about Mott-Schottky plot of organic planar heterojunction in photovoltaic cell
PublikacjaNa wykresie Motta-Schottky'ego przedstawione są wyniki pomiarów przeprowadzonych na komórkach fotowoltaicznych z planarnym heterozłączem organicznym. W pracy pokazano, że fotowoltaiczne układy z planarnym heterozłączem organicznym, podobnie jak planarne złącza półprzewodnikowe, mogą prowadzić do liniowych charakterystyk na wykresie Motta-Schottky'ego. Pokazano jednak, że parametry uzyskane z analizy otrzymanych prostych nie mogą...
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Nucleotides metabolizing ectoenzymes as possible markers of mesenchymal stem cell osteogenic differentiation
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Cytotoxic effect on human melanoma cell lines and tyrosinase inhibition of Hottonia palustris
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B26 Differential mitochondrial DNA levels in HD patients depending on the cell type
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Hydrophilic domain II of Escherichia coli Dr fimbriae facilitates cell invasion
PublikacjaStosując techniki mutagenezy ukierunkowanej oraz mikroskopii elektronowej stwierdzono, że hydrofilowa domena II białka podjednostkowego DraE fimbrii jest odpowiedzialna za inwazję komórki. Otrzymane wyniki są zgodne z interpretacją, że fenotypy fimbrii Dr wiązania i inwazji komórki HeLa mogą być oddzielone.
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Single chamber solid oxide fuel cell - current stage of development and prospects
PublikacjaOgniwa paliwowe należą do jednego z najbardziej wydatnych żródeł energii. W konwencjonalnych ogniwach paliwo i powietrze są dostarczane do ogniwa oddzielnie. Jednokomorowych ogniwo dziala zasilane mieszanina paliwa i powietrza. W pracy przedstawiono obecny stan i perspektywy dlaszego rozwoju jednokomorowych tlenkowych ogniw paliwowych.
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Process control strategy deployment with part measuring activity in a flexible machining cell
PublikacjaRozwinięto zintegrowany model planowania i sterowania przebiegu procesu w rzeczywistym, zrobotyzowanym elastycznym gnieździe obróbki (EGO) ze współrzędnościową maszyną pomiarową, realizującą funkcje pomiarowo-kontrolne wytwarzanych przedmiotów. Analizowano współzależności wybranych heurystycznych planów kontroli przedmiotów oraz strategii szeregowania operacji procesów technologicznych, z zastosowaniem programowalnych modeli symulacyjnych...
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Photovoltaic properties of a sandwich cell consisting of bromophosphorus phthalocyanine and titanium dioxide layers
PublikacjaPraca omawia wyniki badań doświadczalnych właściwości fotowoltaicznych układu: ITO/bromofosforowa ftalocyjanina/dwutlenek tytanu/tetracen/Au.
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Imunofan—RDKVYR Peptide—Stimulates Skin Cell Proliferation and Promotes Tissue Repair
PublikacjaRegeneration and wound healing are vital to tissue homeostasis and organism survival. One of the biggest challenges of today’s science and medicine is finding methods and factors to stimulate these processes in the human body. Effective solutions to promote regenerative responses will accelerate advances in tissue engineering, regenerative medicine, transplantology, and a number of other clinical specialties. In this study, we...
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A Novel Cryptic Clostridial Peptide That Kills Bacteria by a Cell Membrane Permeabilization Mechanism
PublikacjaThis work reports detailed characteristics of the antimicrobial peptide Intestinalin (P30), which is derived from the LysC enzyme of Clostridium intestinale strain URNW. The peptide shows a broader antibacterial spectrum than the parental enzyme, showing potent antimicrobial activity against clinical strains of Gram-positive staphylococci and Gram-negative pathogens and causing between 3.04 ± 0.12 log kill for Pseudomonas aeruginosa...
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The Effect of Conjugation with Octaarginine, a Cell-Penetrating Peptide on Antifungal Activity of Imidazoacridinone Derivative
PublikacjaAcridine cell-penetrating peptide conjugates are an extremely important family of compounds in antitumor chemotherapy. These conjugates are not so widely analysed in antimicrobial therapy, although bioactive peptides could be used as nanocarriers to smuggle antimicrobial compounds. An octaarginine conjugate of an imidazoacridinone derivative (Compound 1-R8) synthetized by us exhibited high antifungal activity against reference...
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Enhanced Activity of P4503A4 and UGT1A10 Induced by Acridinone Derivatives C-1305 and C-1311 in MCF-7 and HCT116 Cancer Cells: Consequences for the Drugs’ Cytotoxicity, Metabolism and Cellular Response
PublikacjaActivity modulation of drug metabolism enzymes can change the biotransformation of chemotherapeutics and cellular responses induced by them. As a result, drug-drug interactions can be modified. Acridinone derivatives, represented here by C-1305 and C-1311, are potent anticancer drugs. Previous studies in non-cellular systems showed that they are mechanism-based inhibitors of cytochrome P4503A4 and undergo glucuronidation via UDP-glucuronosyltranspherase...
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Novel therapeutic compound acridine–retrotuftsin action on biological forms of melanoma and neuroblastoma
PublikacjaPURPOSE: As a continuation of our search for anticancer agents, we have synthesized a new acridine-retrotuftsin analog HClx9-[Arg(NO2)-Pro-Lys-Thr-OCH3]-1-nitroacridine (named ART) and have evaluated its activity against melanoma and neuroblastoma lines. Both tumors develop from cells (melanocytes, neurons) of neuroectodermal origin, and both are tumors with high heterogeneity and unsatisfactory susceptibility to chemotherapies....
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The Influence of Cold Atmospheric Pressure Plasma-Treated Media on the Cell Viability, Motility, and Induction of Apoptosis in Human Non-Metastatic (MCF7) and Metastatic (MDA-MB-231) Breast Cancer Cell Lines
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Photovoltaic phenomena in devices with perfluorozincphthalocyanine layer
PublikacjaThe course of photovoltaic phenomenon in organic photovoltaic cells utilizing thin layers of perfluorozincphthalocyanine was studied in few single and planar bilayer configurations. Mechanisms of photogeneration and recombination of free charge carriers were determined and active interfaces were localized. In case of single layer cells these interfaces were located at the front electrode/F16ZnPc junctions, whereas photogeneration...
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In vitro biological evaluation of a novel folic acid-targeted receptor quantum dot−β−cyclodextrin carrier for C-2028 unsymmetrical bisacridine in the treatment of human lung and prostate cancers
PublikacjaTraditional small-molecule chemotherapeutics usually do not distinguish tumors from healthy tissues. However, nanotechnology creates nanocarriers that selectively deliver drugs to their site of action. This work is the next step in the development of the quantum dot−β−cyclodextrin−folic acid (QD−β−CD−FA) platform for targeted and selected delivery of C−2028 unsymmetrical bisacridine in cancer therapy.Herein, we report an initial...
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Titania Nanofiber Scaffolds with Enhanced Biointegration Activity—Preliminary In Vitro Studies
PublikacjaThe increasing need for novel bone replacement materials has been driving numerous studies on modifying their surface to stimulate osteogenic cells expansion and to accelerate bone tissue regeneration. The goal of the presented study was to optimize the production of titania-based bioactive materials with high porosity and defined nanostructure, which supports the cell viability and growth. We have chosen to our experiments TiO2...
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The overexpression of CPR and P450 3A4 in pancreatic cancer cells changes the metabolic profile and increases the cytotoxicity and pro-apoptotic activity of acridine antitumor agent, C-1748
PublikacjaDrug resistance is one of the major cause of pancreatic cancer treatment failure. Thus, it is still imperative to develop new active compounds and novel approach to improve drug efficacy. Here we present 9-amino-1-nitroacridine antitumor agent, C-1748, developed in our laboratory, as a candidate for pancreatic cancer treatment. We examined (i) the cellular response of pancreatic cancer cell lines: Panc-1, MiaPaCa-2, BxPC-3 and...
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Metabolism of antitumour agent 1-nitroacridine derivative, C-1748 in pancreatic cancer cell lines
PublikacjaPancreatic cancer has the highest mortality rate of all major cancers because of limited treatment options. Surgical removal of the tumour is possible only in its early stage, nevertheless the asymptomatic development very often makes unable an accurate diagnose. In the case of metastatic pancreatic cancer only chemotherapy, mainly with gemcitabine, can be offered to patients. However, common resistance towards gemcitabine imposes...
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Koncepcja i modelowanie wysokoobrotowego napędu elektrycznego turbosprężarki. Zastosowanie w ogniwach paliwowych pojazdów samochodowych
PublikacjaAbstract: Electrical vehicles powered by hydrogen fuel cells become a potential alternative to conventional vehicles. The polymer electrolyte membrane (PEM) are typical fuel cells used in fuel cell vehicle (FCV). The global efficiency of a PEM fuel cell stack is greatly impacted by the use of a motorized compressor for the air supply system. The motor-compressor set-up may consume up to 19 % of the energy supplied by the PEM fuel...
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Antitumor potential of new low molecular weight antioxidative preparations from the white rot fungus Cerrena unicolor against human colon cancer cells
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Genes responsible for proliferation, differentiation, and junction adhesion are significantly up-regulated in human ovarian granulosa cells during a long-term primary in vitro culture
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Ion homeostasis and transport are regulated by genes differentially expressed in porcine buccal pouch mucosal cells during long-term culture in vitro – a microarray approach
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Analysis of Circulating Tumor Cells in Patients with Non-Metastatic High-Risk Prostate Cancer before and after Radiotherapy Using Three Different Enumeration Assays
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New Gene Markers Expressed in Porcine Oviductal Epithelial Cells Cultured Primary In Vitro Are Involved in Ontological Groups Representing Physiological Processes of Porcine Oocytes
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“Biological Adhesion” is a Significantly Regulated Molecular Process during Long-Term Primary In Vitro Culture of Oviductal Epithelial Cells (Oecs): A Transcriptomic and Proteomic Study
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Induction of G2/M phase arrest and apoptosis of human pancreatic cancer BxPC-3 cells by potenet antitumor 1-nitroacridine derivative C-1748
PublikacjaPancreatic ductal adenocarcinoma (PDA) is among the most lethal human cancers, in part because it is insensitive to many chemotherapeutic drugs. Gemcitabine still remains the best chemotherapeutic agent available for the treatment of advanced pancreatic cancer. However, gemcitabine treatment results in only a marginal survival advantage. Thus, there is a strong need for the continuous development of novel therapeutic agents...
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Improving osteoblasts cells proliferation via femtosecond laser surface modification of 3D-printed poly-ε-caprolactone scaffolds for bone tissue engineering applications
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A Specific CD44lo CD25lo Subpopulation of Regulatory T Cells Inhibits Anti-Leukemic Immune Response and Promotes the Progression in a Mouse Model of Chronic Lymphocytic Leukemia
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Corrigendum to “The role of phoenixin in the proliferation and migration of ectopic epithelial cells in vitro” [Biochem. Biophys. Res. Commun. 646 (26 February 2023) 44–49]
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Anthrapyridones, a novel group of antitumour non-cross resistant anthraqui-none analogues. Synthesis and molecular basis of the cytotoxic activity towards K562/DOX cells
PublikacjaOpracowano syntezę nowej grupy związków z grupy antrapirydonów z odpowiednimi hydrofobowymi lub hydrofilowymi podstawnikami. Badano działanie tych związków na komórkach K562/S i K562/DOX (nadekspresja P-glikoproteiny). Stwierdzono, że zwiększenie lipofilowości zwiększa szybkość P-gp zależnego efluksu z komórki.
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Profiles of a broad spectrum of epigenetic DNA modifications in normal and malignant human cell lines: Proliferation rate is not the major factor responsible for the 5-hydroxymethyl-2′-deoxycytidine level in cultured cancerous cell lines
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Increased cytotoxicity of an unusual DNA topoisomerase II inhibitor compound C-1305 toward HeLa cells with downregulated PARP-1 activity results from re-activation of the p53 pathway and modulation of mitotic checkpoints
PublikacjaOur previous studies have shown that murine fibroblast cells, in which PARP-1 gene was inactivated by gene disruption, are extremely sensitive to triazoloacridone compound C-1305, an inhibitor of DNA topoisomerase II with unusual properties. Here, we show that pharmacological inhibition of PARP-1 activity by its inhibitor compound NU1025, sensitizes human cervical carcinoma HeLa cells to compound C-1305 compared to treatment with...
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FMO1 Is Involved in Excess Light Stress-Induced Signal Transduction and Cell Death Signaling
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EDS1-Dependent Cell Death and the Antioxidant System in Arabidopsis Leaves is Deregulated by the Mammalian Bax
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Lysosome Alterations in the Human Epithelial Cell Line HaCaT and Skin Specimens: Relevance to Psoriasis
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A Proliferation-Inducing Ligand and B-Cell Activating Factor Are Upregulated in Patients with Essential Thrombocythemia
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Across-shift changes in upper airways after exposure to bacterial cell wall components
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Applications of spin coating of polymer precursor and slurrysuspensions for Solid Oxide Fuel Cell fabrication
PublikacjaW pracy przedstawiono możliwości zastosowania w tlenkowych ogniwach paliwowych metody nanoszenia wirowego prekursorów polimerowych i zawiesin. Przedstawiono przykłady zastosowania tej metody do wytworzenia elektrolitu oraz warstw ochronnych dla stali nierdzewnych.
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Large-scale Rowe cell experimental study on coefficient of consolidation of coal mine tailings
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Electroporation with Cisplatin against Metastatic Pancreatic Cancer:In VitroStudy on Human Primary Cell Culture
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Structure–bioavailability relationship study of genistein derivatives with antiproliferative activity on human cancer cell
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Induced-fit binding of laccase to gold and carbon electrodes for the biological fuel cell applications
PublikacjaAnalogues of laccase natural substrates (syringic, veratric, ferulic, vanillic, isovanillic, 3,5-dimethoxybenzoic aldehydes) were employed to bind and orient laccase molecules in a way which facilitates adsorption of the catalyst molecules and their electrical connection with the conductive support. Laccase was bound efficiently to these substrates both on gold and carbon electrodes forming, respectively, 2D and 3D films sensitive...
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Changes in the Cell Wall Proteome of Leaves in Response to High Temperature Stress in Brachypodium distachyon
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Serum of obstructive sleep apnea patients impairs human coronary endothelial cell migration
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Covalent DNA modification by products of myrosinase catalysed glucosinolate degradation in cell-free system
PublikacjaThe bioactive phytochemicals found in Brassica vegetables belonging to glucosinolates (GLS) and especially the products of their degradation isothiocyanates (ITC) and indoles are regarded as the most promising cancer chemopreventive compounds. These secondary metabolites constitute defence system repelling or preventing the development of agrophages attacking brassica plants. The antibiological properties of these compounds suggest...