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Wyniki wyszukiwania dla: TRANSCRIPTOMIC PROFILING
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Coordinated reprogramming of renal cancer transcriptome, metabolome and secretome associates with immune tumor infiltration
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Non-steroidal anti-inflammatory drugs are safe with respect to the transcriptome of human dermal fibroblasts
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Transcriptome sequencing of Brassica napus highlights the complex issues with soil supplementation with sewage sludge
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Transcriptomics‐Based and AOP‐Informed Structure–Activity Relationships to Predict Pulmonary Pathology Induced by Multiwalled Carbon Nanotubes
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Cardiovascular, anthropometric, metabolic and hormonal profiling of normotensive women with polycystic ovary syndrome with and without biochemical hyperandrogenism
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The optimisation of analytical parameters for routine profiling of antioxidants in complex mixture by HPLC coupled post-column derivatisation
PublikacjaIntroduction: The wide application of natural and artificial antioxidants in food, cosmetic and pharmaceutical industry as well as the recognition of the importance of food antioxidants for supporting human health created demand for reliable and industrially applicable methods of determining antioxidative activity. This requirement can be fullfilled with the recently proposed HPLC-post-column derivatisation approach enabling the...
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Providing for continuous risk management in distributed software projects.
PublikacjaArtykuł prezentuje koncepcję ciągłego zarządzania ryzykiem w rozproszonych projektach informatycznych. Proponowane podejście koncentruje się na dostarczeniu uczestnikom projektu szerokiego i łatwo dostępnego kanału komunikacyjnego, przez który mogą oni komunikować informację o ryzyku. Zebrane informacje mogą być później analizowane pod różnymi kątami tak, by wybrać największe zagrożenia dla projektu lub też by prześledzić...
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Probiotic Bacteria: A Promising Tool in Cancer Prevention and Therapy
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Challenges in providing support for management of evidence-based arguments
PublikacjaThe paper considers selected challenges related to the application of evidence based arguments and maps them on the tool support level. In particular, we consider: communication and teamwork, handling large arguments, evidence management and integration, argument assessment and communication, change control and reporting, evidence reuse, user data security and argument portfolio management. Then we explain how these challenges...
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Providing Differentiated Levels of Service Availability in VANET Communications
PublikacjaInter-vehicle communications seems to be a promising remedy not only for a number of road-safety issues, but also to improve the efficiency of road traffic, as well as to support the on-board infotainment applications. However, it often encounters disruptions due to high mobility of vehicles causing frequent failures of communication links. In this paper, we utilize the idea of multipath vehicle-to-vehicle routing to provide protection...
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Fluctuation-Enhanced Sensing (FES): A Promising Sensing Technique
PublikacjaFluctuation-enhanced sensing (FES) is a very powerful odor and gas sensing technique and as such it can play a fundamental role in the control of environments and, therefore, in the protection of health. For this reason, we conduct a comprehensive survey on the state-of-the-art of the FES technique, highlighting potentials and limits. Particular attention is paid to the dedicated instrumentation necessary for the application of...
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Non-Targeted Metabolite Profiling Reveals Host Metabolomic Reprogramming during the Interaction of Black Pepper with Phytophthora capsici
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Discrimination of Selected Cold-Pressed and Refined Oils by Untargeted Profiling of Phase Transition Curves of Differential Scanning Calorimetry
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Post-Chromatographic Derivatization Coupled with Mass Spectrometry as a Method of Profiling and Identification of Antioxidants; Ligustrum vulgare Phytocomplex as an Example
PublikacjaHigh-performance liquid chromatography (HPLC) and high-performance thin-layer chromatography (HPTLC) coupled with radical scavenging assays, such as 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid (ABTS) can be both used for the detection of the antioxidants in plant extracts. In this study, the ethanolic (70% v/v) extracts from different morphological parts of Ligustrum vulgare collected...
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Transcriptome Changes in Three Brain Regions during Chronic Lithium Administration in the Rat Models of Mania and Depression
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Whole-body cryotherapy – promising add-on treatment of depressive disorders
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Government in the metaverse: Requirements and suitability for providing digital public services
PublikacjaDigital government comprises all means to enable governments to interact with their constituents digitally. The metaverse provides a virtual reality environment where various activities can be carried out without physically visiting the places of interest, including the public authorities. Yet, how governments can use the metaverse is unknown. This paper aims to extend the understanding of the metaverse architecture requirements...
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CAES – Energy storage providing stability for national power system
PublikacjaThis paper presents a short characteristics of the power system. It also describes various types of energy storage technologies. The suggested solution of accumulation and generation of electric power is based on the cooperation of gas turbine with Compressed Air Storage Energy systems – CAES. This analysis describes also various types of cooperation of CAES and renewable sources of energy, particularly wind power systems.
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Microporous Polyurethane Thin Layer as a Promising Scaffold for Tissue Engineering
PublikacjaThe literature describes that the most efficient cell penetration takes place at 200–500 µm depth of the scaffold. Many different scaffold fabrication techniques were described to reach these guidelines. One such technique is solvent casting particulate leaching (SC/PL). The main advantage of this technique is its simplicity and cost efficiency, while its main disadvantage is the scaffold thickness, which is usually not less than...
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2-Methoxyestradiol and Hydrogen Peroxide as Promising Biomarkers in Parkinson’s Disease
PublikacjaEstrogens function in numerous physiological processes including controlling brain cell growth and differentiation. 2-Meth- oxestradiol (2-ME2), a 17β-estradiol (E2) metabolite, is known for its anticancer effects as observed both in vivo and in vitro. 2-ME2 affects all actively dividing cells, including neurons. The study aimed to determine whether 2-ME2 is a potentially cancer-protective or rather neurodegenerative agent in a...
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“Biological Adhesion” is a Significantly Regulated Molecular Process during Long-Term Primary In Vitro Culture of Oviductal Epithelial Cells (Oecs): A Transcriptomic and Proteomic Study
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Discovery of small-molecule regenerative drugs using a model of complex tissue injury in mice. Transcriptomic responses of neurodevelopmental genes during pharmacologically induced regeneration
PublikacjaDespite significant development in regenerative medicine, there is a deficit of effective therapies for wound healing and tissue regeneration. Research performed using animal wound models allows for a better understanding of this complex process, searching for compounds with pro-regenerative properties, and assessing their efficacy and safety. Unfortunately, the lack of adequate preclinical models proves to be an issue as no animal...
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Activity-based protein profiling guided identification of urine proteinase 3 activity in subclinical rejection after renal transplantation
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Gene Expression and Activity Profiling Reveal a Significant Contribution of Exo‐Phosphotransferases to the Extracellular Nucleotides Metabolism in HUVEC Endothelial Cells
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Direct injection liquid chromatography-mass spectrometry (DI-LC-MS) analysis for rapid lipidomic profiling of extracellular vesicles
PublikacjaExtracellular vesicles (EVs) are small, spherical particles produced by eukaryotic and prokaryotic cells, surrounded by a bilayer membrane and carrying various bioactive molecules, such as proteins, surface receptors, membrane and soluble proteins, lipids, and nucleic acids. EVs are of substantial interest because of their important roles in cell communication, epigenetic regulation and possible application in disease diagnosis...
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Determination of flavanols by liquid chromatography with fluorescence detection. Application to the characterization of cranberry-based pharmaceuticals through profiling and fingerprinting approaches
PublikacjaIn this work, a new method based on reversed-phase high-performance liquid chromatography (HPLC) with fluorescence detection (FLD) was established for the determination of catechins and related oligomeric proanthocyanidins (PACs) in cranberry-based pharmaceuticals. Compounds were recovered by liquid extraction using methanol/water/hydrochloric acid (60:39:1, v:v:v) as the extraction solvent. The chromatographic separation was carried...
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Utilizing Genome-Wide mRNA Profiling to Identify the Cytotoxic Chemotherapeutic Mechanism of Triazoloacridone C-1305 as Direct Microtubule Stabilization
PublikacjaRational drug design and in vitro pharmacology profiling constitute the gold standard in drug development pipelines. Problems arise, however, because this process is often dicult due to limited information regarding the complete identification of a molecule’s biological activities. The increasing aordability of genome-wide next-generation technologies now provides an excellent opportunity to understand a compound’s diverse eects...
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Plasma free amino acid profiling as metabolomic diagnostic and prognostic biomarker in paediatric cancer patients: a follow‑up study
PublikacjaAmino acids (AAs) play a crucial role in cancer cell metabolism. Levels of 22 plasma AAs at the time of diagnosis and after treatment were established among 39 pediatric cancer patients and 33 healthy children. Glutamic acid levels decreased and tryptophan levels increased during treatment. Cancer patients presented significantly lower levels of glutamine and leucine post-treatment while levels of 12 other AAs were higher comparing...
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Bystander Effects Induced by Medium From Irradiated Cells: Similar Transcriptome Responses in Irradiated and Bystander K562 Cells
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Kalibracja profili poborów wody w węzłach SW
PublikacjaZnajomość profili poborów wody w węzłach systemu wodociągowego (SW) ma zasadnicze znaczenie dla dopuszczalności wyznaczanego w oparciu o model SW sterowania. Powszechnie stosowane jest traktowanie poborów wody jako zakłóceń stanowiących jedną z kategorii wielkości wejściowych SW i jego modelu. Jakość prognoz poborów wody oparta o dane historyczne uzależniona jest od ilości i jakości dostępnych danych. Istotne znaczenie przy wyznaczaniu...
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Sewage sludge disintegration - A promising way to minimize negative environmental impact
PublikacjaW artykule przedstawiono przegląd technologii dezintegracji osadów ściekowych. Efektem stosowania dezintegracji jest intensyfikacja produkcji biogazu oraz poprawa właściwości osadu przefermentowanego. Zaprezentowano także wyniki badań dotyczące mechanicznej dezintegracji osadów ściekowych pochodzących z komunalnej oczyszczalni ścieków w Gdańsku. Określono wpływ rodzaju dezintegracji (homogenizator, ultradźwięki) na jakość cieczy...
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Modification of Ground Tire Rubber—Promising Approach for Development of Green Composites
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Enzyme Conjugation - A Promising Tool for Bio-catalytic and Biotransformation Applications – A Review
PublikacjaEnzymes have revolutionized conventional industrial catalysts as more efficient, eco-friendly, and sustainable substitutes that can be used in different biotechnological processes, food, and pharmaceutical industries. Yet, the enzymes from nature are engineered to make them adapt and enhance their durability in the industrial environment. One promising approach involves the combined use of multiple enzymes that catalyze highly...
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The development of organizational, legal and ideological formation of the institutions providing insurance services
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Poroelastic Road Surface – a Promising Road Traffic Noise Abatement Solution
PublikacjaRoad surfaces have a direct impact on the generation of noise by rolling tyres, the main and dominant source of noise of moving vehicles, as well as may affect propagation of noise emitted by all noise sources of a vehicle. Thus there is no doubt that pavement should be considered as one of the major potential road traffic noise abatement measure. Low noise pavements of existing types may in new conditions provide up to 8 dB of...
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Network Graph Transformation Providing Fast Calculation of Paths for Resilient Routing
PublikacjaProtection of transmission against failures can be appropriately dealt with by alternative paths. However, common schemes (e.g., Bhandaris scheme) are characterized by a remarkable delay while determining the transmission paths. This in turn may have a serious impact on serving dynamic demands (characterized by relatively short duration time). As a remedy to this problem, we introduce an approach to pre-compute the sets of disjoint...
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Modification of Ground Tire Rubber—Promising Approach for Development of Green Composites
PublikacjaGround tire rubber (GTR) was mechano-chemically modified using a road bitumen 100/150 and two types of organic peroxides: di-(2-tert-butyl-peroxyisopropyl)-benzene (BIB) and dicumyl peroxide (DCP). The impact of used additives on reactive sintering efficiency and physico-mechanical properties of modified GTR was investigated using oscillating disc rheometer measurements, followed by tensile tests and swelling behavior studies....
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Genes involved in angiogenesis and circulatory system development are differentially expressed in porcine epithelial oviductal cells during long-term primary in vitro culture – a transcriptomic study
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Proteomic Profiling of Ectosomes Derived from Paired Urothelial Bladder Cancer and Normal Cells Reveals the Presence of Biologically-Relevant Molecules
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Substrate profiling of Finegoldia magna SufA protease, inhibitor screening and application to prevent human fibrinogen degradation and bacteria growth in vitro
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Phenol-rich alternatives for Rosa x damascena Mill. Efficient phytochemical profiling using different extraction methods and colorimetric assays
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Metabolic Profiling of Jasminum grandiflorum L. Flowers and Protective Role against Cisplatin-Induced Nephrotoxicity: Network Pharmacology and In Vivo Validation
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Improvement of speech intelligibility in the presence of noise interference using the Lombard effect and an automatic noise interference profiling based on deep learning
PublikacjaThe Lombard effect is a phenomenon that results in speech intelligibility improvement when applied to noise. There are many distinctive features of Lombard speech that were recalled in this dissertation. This work proposes the creation of a system capable of improving speech quality and intelligibility in real-time measured by objective metrics and subjective tests. This system consists of three main components: speech type detection,...
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Correction to: Plasma free amino acid profiling as metabolomic diagnostic and prognostic biomarker in paediatric cancer patients: a follow-up study
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AOP173 key event associated pathway predictor – online application for the prediction of benchmark dose lower bound (BMDLs) of a transcriptomic pathway involved in MWCNTs-induced lung fibrosis
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Uwarunkowania i ograniczenia cyfrowego pomiaru nierówności profili powierzchni
PublikacjaPomiar zdeterminowanych wartości nierówności profili powierzchni wyrażanych cyfrowo jest złożonym problemem interdyscyplinarnym, który zawiera istotne ograniczenia techniczne i metrologiczne, często niezauważane w praktyce pomiarowej i analizie ich wyników. Należy odpowiednio przyjąć cyfrowe parametry pomiaru profili powierzchni przed pomiarami, by spełnione były różne uwarunkowania zależne od charakteru nierówności oraz celu i...
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Tribenzoporphyrazines with dendrimeric peripheral substituents and their promising photocytotoxic activity against Staphylococcus aureus
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Photochemical properties and promising activity against staphylococci of sulfanyl porphyrazines with dendrimeric moieties
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Nanoparticles associated with antimicrobial peptides (AMPs) promising combination for biomedical and veterinary applications
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Ni-MOF-based electrodes: A promising strategy for efficient overall water splitting
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