wyświetlamy 1000 najlepszych wyników Pomoc
Wyniki wyszukiwania dla: ENDOCRINE DISRUPTION
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Evaluating Accuracy of Respiratory Rate Estimation from Super Resolved Thermal Imagery
PublikacjaNon-contact estimation of Respiratory Rate (RR) has revolutionized the process of establishing the measurement by surpassing some issues related to attaching sensors to a body, e.g. epidermal stripping, skin disruption and pain. In this study, we perform further experiments with image processing-based RR estimation by using various image enhancement algorithms. Specifically, we employ Super Resolution (SR) Deep Learning (DL) network...
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Telomere uncapping by common oxidative guanine lesions: Insights from atomistic models
PublikacjaOxidative damage to DNA is widely known to contribute to aging and disease. This relationship has been extensively studied for telomeres – structures that cap chromosome ends – due to their role in cell proliferation and senescence, and exceptional susceptibility to oxidation. Indeed, the repetitive telomeric DNA sequence contains the 5′-GGG-3′ motif that has the lowest ionization potential of all trinucleotides. Accordingly, experiments...
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Novel N-(aryl/heteroaryl)-2-chlorobenzenesulfonamide derivatives: synthesis and anticancer activity evaluation
PublikacjaA new series of N-(aryl/heteroaryl)-2-chlorobenzenesulfonamide derivatives 4-21 have been synthesized, and evaluated at the National Cancer Institute (USA) for their in vitro activities against a panel of 60 different human cancer cell lines. Among them, compounds 16, 20 and 21 exhibited remarkable cytotoxic activity against numerous human cancer cell lines. We found that sulfonamide derivative 21 appeared to be more selective...
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Targeting shelterin proteins for cancer therapy.
PublikacjaAs a global health challenge, cancer prompts continuous exploration for innovative therapies that are also based on new targets. One promising avenue is targeting the shelterin protein complex, a safeguard for telomeres crucial in preventing DNA damage. The role of shelterin in modulating ataxia- telangiectasia mutated (ATM) and ataxia-telangiectasia and Rad3-related (ATR) kinases, key players in the DNA damage response (DDR),...
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Quality Evaluation of Novel DTD Algorithm Based on Audio Watermarking
PublikacjaEcho cancellers typically employ a doubletalk detection (DTD) algorithm in order to keep the adaptive filter from diverging in the presence of near-end speech signal or other disruptive sounds in the microphone signal. A novel doubletalk detection algorithm based on techniques similar to those used for audio signal watermarking was introduced by the authors. The application of the described DTD algorithm within acoustic echo cancellation...
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Measures of region failure survivability for wireless mesh networks
PublikacjaWireless mesh networks (WMNs) are considered as a promising alternative to wired local, or metropolitan area networks. However, owing to their exposure to various disruptive events, including natural disasters, or human threats, many WMN network elements located close to the failure epicentre are frequently in danger of a simultaneous failure, referred to as a region failure. Therefore, network survivability, being the ability...
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Biomass-Derived Nitrogen Functionalized Carbon Nanodots and Their Anti-Biofouling Properties
PublikacjaThe prevalence of the antibiotic resistant bacteria remains a global issue. Cheap, sustainable and multifunctional antibacterial membranes are at the forefront of filtrating materials capable of treating multiple flow streams, such as water cleansing treatments. Carbon nanomaterials are particularly interesting objects shown to enhance antibacterial properties of composite materials. In this article, amino-functionalized, photoluminescent...
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Occurrence of Surface Active Agents in the Environment
PublikacjaDue to the specific structure of surfactants molecules they are applied in different areas of human activity (industry, household). After using and discharging from wastewater treatment plants as effluent stream, surface active agents (SAAs) are emitted to various elements of the environment (atmosphere, waters, and solid phases), where they can undergo numerous physic-chemical processes (e.g., sorption, degradation) and freely...
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Risk of Cost Overruns in Implementation of Building Investment in Urban Conditions in the Aspect of Historical Background of its Location
PublikacjaThe article is a continuation of the authors' analyzes on the risk of delays in implementation of building investment in urban conditions in the aspect of historical background of its location. In case of construction investment located in the historic part of the city, the possible accumulation of many unfavourable factors, which in course of its implementation, may constitute a serious source of cost overruns and disruptions,...
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IMPULSE NOISE ASSOCIATED WITH FIRING HANDHELD MILITARY WEAPONS
PublikacjaSports, hunting and military shooting grounds are well known sources of noise that can be disruptive both for people present at those facilities, as well as for people and animals that live nearby. What is more, shooters are also subjected to very painful and dangerous impulse noise. The paper discusses the issues related to the noise immission during firing of small firearms of military type that are typical for Poland. The experiments...
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Global Digital Technology Convergence: Driving Diffusion via Network Effects
PublikacjaSince the 1970s, we have witnessed unprecedented diffusion of digital technologies in both speed and geographic coverage. These technologies are pervasive and disruptive, and lead to profound shifts and transformations in societies and economies. Many claim that emerging network externalities are the principal phenomenon driving the process of technology diffusion and determining its in-time dynamics. This book analyses the unique...
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Binary Mixtures of Selected Bisphenols in the Environment: Their Toxicity in Relationship to Individual Constituents
PublikacjaBisphenol A (BPA) is one of the most popular and commonly used plasticizer in the industry. Over the past decade, new chemicals that belong to the bisphenol group have increasingly been used in industrial applications as alternatives to BPA. Nevertheless, information on the combined effects of bisphenol (BP) analogues is insufficient. Therefore, our current study aimed to find the biological response modulations induced by the...
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ANALYSIS OF POSSIBILITIES FOR THE USE OF VOLUME-DELAY FUNCTIONS IN THE PLANNING MODULE OF THE TRISTAR SYSTEM
PublikacjaTravel time is a measure commonly used for traffic flow modelling and traffic control. It also helps to evaluate the quality of traffic control systems in urban areas. Traffic control systems that use traffic models to predict changes and disruptions in vehicle flows have to use vehicle speed-prediction models. Travel time estimation studies the effects of traffic volumes on a street section at an average speed. The TRISTAR Integrated...
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Risk of Delays in Implementation of Building Investment in Urban Conditions in the Aspect of Historical Background of its Location
PublikacjaThe implementation of a construction investment in urban conditions is extremely complex, and at the same time exposed to a high risk of a specific character. In case of construction investment located in the historic part of the city, the possible accumulation of many unfavourable factors, which in course of its implementation, may constitute a serious source of delays and disruptions, should be taken into account at the preparation...
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How personality traits, sports anxiety, and general imagery could influence the physiological response measured by SCL to imagined situations in sports?
Dane BadawczeThe data were collected to understand how individual differences in personality (e.g. neuroticism), general imagery, and situational sports anxiety are linked to arousal measuring with skin conductance level (SCL) in situational imagery (as scripted for sport-related scenes). Thirty persons participated in the study, aged between 14 and 42 years, with...
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Adenoma, NOS - Female, 31 - Tissue image [6260730021895241]
Dane BadawczeThis is the histopathological image of OTHER ENDOCRINE GLANDS AND RELATED STRUCTURES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 1000 slide scanner (20x magnification) and saved to DICOM format.
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Adenoma, NOS - Female, 62 - Tissue image [4260730006791061]
Dane BadawczeThis is the histopathological image of OTHER ENDOCRINE GLANDS AND RELATED STRUCTURES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Adenoma, NOS - Female, 76 - Tissue image [427073000781411]
Dane BadawczeThis is the histopathological image of OTHER ENDOCRINE GLANDS AND RELATED STRUCTURES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Neoplasm, benign - Female, 79 - Tissue image [5150730018703751]
Dane BadawczeThis is the histopathological image of OTHER ENDOCRINE GLANDS AND RELATED STRUCTURES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Adenoma, NOS - Female, 76 - Tissue image [4130730018857021]
Dane BadawczeThis is the histopathological image of OTHER ENDOCRINE GLANDS AND RELATED STRUCTURES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Adenoma, NOS - Female, 62 - Tissue image [4260730006796511]
Dane BadawczeThis is the histopathological image of OTHER ENDOCRINE GLANDS AND RELATED STRUCTURES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Adenoma, NOS - Female, 76 - Tissue image [427073000781671]
Dane BadawczeThis is the histopathological image of OTHER ENDOCRINE GLANDS AND RELATED STRUCTURES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Adenoma, NOS - Female, 76 - Tissue image [4130730018859261]
Dane BadawczeThis is the histopathological image of OTHER ENDOCRINE GLANDS AND RELATED STRUCTURES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Neoplasm, benign - Female, 79 - Tissue image [515073001870831]
Dane BadawczeThis is the histopathological image of OTHER ENDOCRINE GLANDS AND RELATED STRUCTURES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Neoplasm, benign - Female, 57 - Tissue image [5140730006558051]
Dane BadawczeThis is the histopathological image of OTHER ENDOCRINE GLANDS AND RELATED STRUCTURES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Development of a simple biogas analyzer module (BAM) for real-time biogas production monitoring
PublikacjaAnaerobic digestion (AD) relies on the cooperation of specific microbial communities, making it susceptible to process disruptions that could impact biogas production. In this regard, this study presents a technological solution based on the Arduino platform, in the form of a simple online monitoring system that can track the produced biogas profile, named as biogas analyzer module (BAM). The applicability of the BAM focused on...
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Neoplasm, benign - Female, 83 - Tissue image [5150730018705561]
Dane BadawczeThis is the histopathological image of OTHER ENDOCRINE GLANDS AND RELATED STRUCTURES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Neoplasm, benign - Female, 83 - Tissue image [5150730018705071]
Dane BadawczeThis is the histopathological image of OTHER ENDOCRINE GLANDS AND RELATED STRUCTURES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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The estrogenicity of wastewater samples.
Dane BadawczeThe principle of operation of the kit is based on the fact that the tested sample with endocrine activity (containing compounds capable of binding to the human estrogen receptor α, hERα) releases the fluorescently labeled ligand (FluormoneTM ES2) from the receptor-ligand complex, which results in a reduction of the polarization value fluorescence. The...
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Influence of the Spectral Quality of Light on Daytime Alertness Levels in Humans
PublikacjaExposure to light is very important for human health. However, the characteristics of the light stimulus and the appropriate timing of such exposure are essential. Studies that have used monochromatic light exposure have shown no systematic patterns for the effects of blue light compared to longer wavelengths. Previous studies have shown that red light exposure increases objective and subjective measures of alertness at night without...
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Assessment of Failure Occurrence Rate for Concrete Machine Foundations Used in Gas and Oil Industry by Machine Learning
PublikacjaConcrete machine foundations are structures that transfer loads from machines in operation to the ground. The design of such foundations requires a careful analysis of the static and dynamic effects caused by machine exploitation. There are also other substantial differences between ordinary concrete foundations and machine foundations, of which the main one is that machine foundations are separated from the building structure....
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The role of glucuronidation in drug resistance
PublikacjaThe final therapeutic effect of a drug candidate, which is directed to a specific molecular target strongly depends on its absorption, distribution, metabolism and excretion (ADME). The disruption of at least one element of ADME may result in serious drug resistance. In this work we described the role of one element of this resistance: phase II metabolism with UDP-glucuronosyltransferases (UGTs). UGT function is the transformation...
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Proximal fibular osteotomy as a treatment for degenerative meniscal extrusion
PublikacjaMeniscal extrusion treatment is a key focus area for research and clinical study of degenerative knee pathology. The contact forces between the meniscus and the bones cause external displacements of the meniscus that are resisted by the circumferential fibres. The main risk factors for the excessive deformation of the meniscus are meniscal root tears, disruption of the circumferential fibres, knee malalignment and high body mass...
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Comprehensive Enhancement of Prepolymer-Based Flexible Polyurethane Foams’ Performance by Introduction of Cost-Effective Waste-Based Ground Tire Rubber Particles
PublikacjaMaterial innovations in polyurethane (PU) foams should ideally combine performance enhancement, environmental impact limitation, and cost reduction. These goals can be achieved by applying recycled or waste-based materials without broader industrial applications, implicating their low price. Herein, from 5 to 20 parts by weight of ground tire rubber (GTR) particles originated from the recycling of postconsumer car tires were incorporated...
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Conjugates of Ciprofloxacin and Levofloxacin with Cell-Penetrating Peptide Exhibit Antifungal Activity and Mammalian Cytotoxicity
PublikacjaSeven conjugates composed of well-known fluoroquinolone antibacterial agents, ciprofloxacin (CIP) or levofloxacin (LVX), and a cell-penetrating peptide transportan 10 (TP10-NH2) were synthesised. The drugs were covalently bound to the peptide via an amide bond, methylenecarbonyl moiety, or a disulfide bridge. Conjugation of fluoroquinolones to TP10-NH2 resulted in congeners demonstrating antifungal in vitro activity against human...
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Separation of the effects of notch and macro residual stress on the MFL signal characteristics
PublikacjaMagnetic flux leakage (MFL) distribution for three configurations of samples has been investigated in order to study the influence of notch and plastic deformation separately as well as together. Samples have been made of S355 steel. The MFL signal measurements were carried out along the longest dimension of the sample over a length of 120 mm. Two components of magnetic field were measured: 1) tangential to the main axis and 2)...
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Design, synthesis, and biological evaluation of tetrahydroquinolinones and tetrahydroquinolines with anticancer activity
PublikacjaColorectal cancer (CRC) is the most commonly diagnosed cancer in Europe and the United States and the second leading cause of cancer related mortality. A therapeutic strategy used for the treatment of CRC involves targeting the intracellular levels of reactive oxygen species (ROS). In this study, we synthesized a series of novel tetrahydroquinolinones and assessed their ability to inhibit CRC growth and proliferation by evoking...
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Mobile Cloud computing architecture for massively parallelizablegeometric computation
PublikacjaCloud Computing is one of the most disruptive technologies of this century. This technology has been widely adopted in many areas of the society. In the field of manufacturing industry, it can be used to provide advantages in the execution of the complex geometric computation algorithms involved on CAD/CAM processes. The idea proposed in this research consists in outsourcing part of the load to be com- puted in the client machines...
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House dust as a source of analytical information on concentration of polybrominated diphenyl ethers (PBDEs) - first approach
PublikacjaPolybrominated diphenyl ethers (PBDEs), which are best recognized as flame retardants, were in 2001, by virtue of Stockholm Convention, listed in a group of Persistent Organic Compounds (POPs). Increasing concentration levels of PBDEs, reported in human tissues (e.g., blood, serum, breast milk, etc.) haverecently caught worldwide concern due to their potential tendency to disrupt thyroid hormones, neurobehavioral deficits and endocrine...
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Chromium (III) removal by perennial emerging macrophytes in floating treatment wetlands
PublikacjaFloating treatment wetlands (FTWs) are a sustainable solution to treat polluted water, but their role in chromium (Cr(III)) removal under neutral pH conditions remains poorly understood. This study evaluated the potential of FTWs planted with two perennial emergent macrophytes, Phragmites australis and Iris pseudacorus, to remove Cr(III) and nutrients (N and PO4-P) from water containing 7.5 mg/L TN, 1.8 mg/L PO4-P, and Cr(III)...
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Adenoma, NOS - Female, 46 - Tissue image [8020729577641011]
Dane BadawczeThis is the histopathological image of OTHER ENDOCRINE GLANDS AND RELATED STRUCTURES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Adenoma, NOS - Female, 46 - Tissue image [8020729577647971]
Dane BadawczeThis is the histopathological image of OTHER ENDOCRINE GLANDS AND RELATED STRUCTURES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Adenoma, NOS - Female, 46 - Tissue image [8020729577646791]
Dane BadawczeThis is the histopathological image of OTHER ENDOCRINE GLANDS AND RELATED STRUCTURES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Adenoma, NOS - Female, 46 - Tissue image [8020729577644181]
Dane BadawczeThis is the histopathological image of OTHER ENDOCRINE GLANDS AND RELATED STRUCTURES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Adenoma, NOS - Female, 46 - Tissue image [8020729577646121]
Dane BadawczeThis is the histopathological image of OTHER ENDOCRINE GLANDS AND RELATED STRUCTURES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Disaster Resilience of Optical Networks: State of the Art, Challenges, and Opportunities
PublikacjaFor several decades, optical networks, due to their high capacity and long-distance transmission range, have been used as the major communication technology to serve network traffic, especially in the core and metro segments of communication networks. Unfortunately, our society has often experienced how the correct functioning of these critical infrastructures can be substantially hindered by massive failures triggered by natural...
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Does the Use of Cell Phones and Headphones at the Signalised Pedestrian Crossings Increase the Risk of Accident?
PublikacjaReduction of the number of fatalities among pedestrians remains a topical issue in Poland. For many years, this percentage has remained at around 30% of all those who were killed on the road. At the same time, there is an increase in the use of electronic devices by pedestrians and cyclists that may affect their perception when crossing the road. This can lead to traffic accidents. In order to investigate the problem, field studies...
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Increased cytotoxicity of an unusual DNA topoisomerase II inhibitor compound C-1305 toward HeLa cells with downregulated PARP-1 activity results from re-activation of the p53 pathway and modulation of mitotic checkpoints
PublikacjaOur previous studies have shown that murine fibroblast cells, in which PARP-1 gene was inactivated by gene disruption, are extremely sensitive to triazoloacridone compound C-1305, an inhibitor of DNA topoisomerase II with unusual properties. Here, we show that pharmacological inhibition of PARP-1 activity by its inhibitor compound NU1025, sensitizes human cervical carcinoma HeLa cells to compound C-1305 compared to treatment with...
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Frequency Response Functions for Sandvik CoroBore 825 XL boring tool, 733 mm
Dane BadawczeFrequency Response Functions (FRF) obtained for Sandvik CoroBore® 825 XL mounted at WHN 13-15 TOS VARNSDORF CNC machine at the minimum extension of the spindle adaptor. Tool set to bore a hole with a diameter 733mm
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Assessment of ecotoxicity and total volatile organic compound (TVOC) emissions from food and children's toy products
PublikacjaThe development of new methods for identifying a broad spectrum of analytes, as well as highly selective tools to provide the most accurate information regarding the processes and relationships in the world, has been an area of interest for researchers for many years. The information obtained with these tools provides valuable data to complement existing knowledge but, above all, to identify and determine previously unknown hazards. Recently,...