wyświetlamy 1000 najlepszych wyników Pomoc
Wyniki wyszukiwania dla: METABOLIC DETOXIFICATION
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JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
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Jacek Ryl dr hab. inż.
OsobyStopień doktora nauk technicznych uzyskał w roku 2010. W tym samym roku podjął pracę w Katedrze Elektrochemii, Korozji i Inżynierii Materiałowej na Wydziale Chemicznym. W 2018 roku uzyskał stopień doktora habilitowanego nauk technicznych w dyscyplinie technologia chemiczna. Od 2021 roku zatrudniony w Instytucie Nanotechnologii i Inżynierii Materiałowej Wydziału Fizyki Technicznej i Matematyki Stosowanej PG. W pracy naukowej skupia...
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Gracjana Klein-Raina dr hab.
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Versatility of putative aromatic aminotransferases from Candida albicans.
PublikacjaAmino acids constitute the key sources of nitrogen for growth of Candida albicans. In order to survive inside the host in different and rapidly changing environments, this fungus must be able to adapt via its expression of genes for amino acid metabolism. We analysed the ARO8, ARO9, YER152C, and BNA3 genes with regards to their role in the nutritional flexibility of C. albicans. CaAro8p is undoubtedly the most versatile enzyme...
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Thyroid Peroxidase as an Autoantigen in Hashimoto’s Disease: Structure, Function, and Antigenicity
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Thyroid Peroxidase Revisited – Whatʼs New?
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Evidence for interactions between homocysteine and genistein: insights into stroke risk and potential treatment
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The model homologue of the partially defective human 5,10-methylenetetrahydrofolate reductase, considered as a risk factor for stroke due to increased homocysteine level, can be protected and reactivated by heat shock proteins
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Factors and processes modulating phenotypes in neuronopathic lysosomal storage diseases
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Mitochondrial DNA levels in Huntington disease leukocytes and dermal fibroblasts
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Sweet grass protection against oxidative stress formation in the rat brain
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Adipokine and cytokine levels in non-functioning adrenal incidentalomas (NFAI)
PublikacjaDue to the fact that overweight or obesity is accompanied by hormonally active adrenal tumors: Cushing Syndrome-(CS) and Subclinical Cushing Syndrome (SCS), it is of high interest the correlation between different adipokines and cytokines secreted by adipose tissue, with metabolic disorders and hormonal activity in this group. Even in non-functioning adrenal incidentalomas (NFAI) elevated risk for cardiovascular disease and metabolic...
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Technological Problems in Lapping on Flat Surfaces of Ceramic Parts
PublikacjaThis paper will present the results of research on single-disc lapping of flat surfaces of small ceramic elements. Machining with the use of different tools such as metallic, two-metallic and abrasive-metallic will be analyzed. The basics and techniques of reinforcement of laps will be discussed. The results of the influence of parameters on the surface quality of ceramic conponents (sealing) for three treatments on lapping machines...
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In vivo imaging of the human eye using a two-photon excited fluorescence scanning laser ophthalmoscope
PublikacjaBACKGROUND. Noninvasive assessment of metabolic processes that sustain regeneration of human retinal visual pigments (visual cycle) is essential to improve ophthalmic diagnostics and to accelerate development of new treatments to counter retinal diseases. Fluorescent vitamin A derivatives, which are the chemical intermediates of these processes, are highly sensitive to UV light; thus, safe analyses of these processes in humans...
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Transcriptomic Effects of Estrogen Starvation and Induction in the MCF7 Cells. The Meta-analysis of Microarray Results
PublikacjaEstrogen is one of the most important signaling molecules which targets a number of genes. Estrogen levels regulate cell proliferation and a plethora of metabolic processes, which may interfere with a range of medical conditions and drug metabolism. The MCF7 breast cancer cell line, expressing the estrogen receptor α, is a well-studied model of cellular answer to estrogen. The aim of this study was to characterize transcriptomic...
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BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
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Exposure scenario and risk assessment of infants and newborns to bisphenols and their derivatives from diapers
PublikacjaNewborns and infants are more sensitive to harmful compounds such as bisphenols and their derivatives because of their not fully developed detoxification mechanism. Exposure to these substances can lead to developmental problems and health consequences in adulthood. Since disposable baby diapers are used from the first days of life and remain in contact with the baby skin, it seems important to monitor the levels of endocrine disrupting chemicals...
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Urine headspace analysis in medical diagnostics
PublikacjaThe analysis of the volatile organic compounds in the bodily fluids such as urine may provide useful information on the patients’ general health. The potential application of urine headspace analysis could facilitate the diagnostics of various diseases such as metabolic disorders, urinary tract diseases and gastrointestinal conditions. Described in this paper are the currently available techniques of urine sample analysis as well...
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System of breath collection and analysis for diseases detection
PublikacjaCollection and study of composition of the exhaled air is now intensively investigated to develop non-invasive medical diagnostics based on presence of metabolic compounds in the exhaled air. The process of collecting and processing of the exhaled air must fulfill relevant conditions to achieve satisfactory results. The paper presents the system of collecting samples of exhaled breath and the proposed methods of its analysis, using...
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Graphene hydrogels with embedded metal nanopatricles as efficient catalysts in 4-nitrophenol reduction and methylene blue decolorization
PublikacjaSynthesis and characterization of the graphene hydrogels with three different metallic nanoparticles, that is Au, Ag and Cu, respectively is presented. Synthesized in a one-pot approach graphene hydrogels with embedded metallic nanoparticles were tested as heterogeneous catalysts in a model reaction of 4-nitrophenol reduction. The highest activity was obtained for graphene hydrogel with Cu NPs and additional reaction of methylene...
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Lifestyle changes in patients with morbid obesity and type 2 diabetes mellitus during the COVID-19 pandemic
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Isolation and properties of recombinant trehalose synthase
PublikacjaBiosynthesis of trehalose is carried out via various matabolic pathways, including the use of trehalose synthase. Bacteria of the genus Deionococcus are microorganisms which produce trehalose synthase catalizing conversion of maltose into trehalose. In this work recombinant trehalose synthase from D.radiodurans was characterized.
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Novel Resveratrol-Based Substrates for Human Hepatic, Renal, and Intestinal UDP-Glucuronosyltransferases
PublikacjaTrans-Resveratrol (tRes) has been shown to have powerful antioxidant, anti-inflammatory, anti-carcinogenic, and anti-aging properties; however, its use as a therapeutic agent is limited by its rapid metabolism into its conjugated forms by UDP-Glucuronosyltransferases (UGTs). The aim of the current study was to test the hypothesis that the limited bioavailability of tRes can be improved by modifying its structure to create analogs...
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Instrumental techniques used in the analysis of exhaled air
PublikacjaExhaled air composition changes depending on the health status of the patient, making it possible to use breath analysis for diagnosis and monitoring purposes. Despite the fact that it is not yet used in every day medical practice, it potential application could facilitate the diagnostics of various diseases such as metabolic disorders, respiratory tract and gastrointestinal diseases. Described in this paper are different application...
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Calculation of Induced Sheath Voltages in Power Cables – Single Circuit System versus Double Circuit System
PublikacjaThis paper presents comparison of values of induced sheath voltages in power cable metallic sheaths when one or two cables per phase are used. Calculation of voltages is performed for various phase sequences of the power cables. Three types of the sheaths bonding and earthing are considered. Shock hazard and voltage stress of non-metallic outer sheath of cables are evaluated. The proposed, optimal configuration of the power cable...
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Cardinal regenerative features of the MRL mouse
PublikacjaIn this review, we discuss recent studies relating to major features of adult MRL mouse biology that contribute to the regenerative responses seen. These include an increased inflammatory cell profile, a unique glycolytic metabolic state typically found during embryogenesis, and a cell cycle phenotype of DNA damage and G2/M arrest. These traits have been found in other mammalian and non-mammalian regenerative systems. How these...
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Comparison of nitrogen and VFA removal pathways in autotrophic and organotrophic anammox reactors
PublikacjaOrganotrophic anammox is a promising process for treating both nitrogen and organic containing wastewater than that of the traditional autotrophic anammox for sole nitrogen removal. However pathways of nitrogen removal particularly at metagenomic level in both processes are still unknown. Here we report, metabolic pathways of nitrogen removal in two lab-scale sequencing batch reactors (SBR), one autotrophic and another organotrophic...
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Pharmaceuticals wastewater treatment via different advanced oxidation processes: Reaction mechanism, operational factors, toxicities, and cost evaluation – A review
PublikacjaPharmaceuticals comprises different drugs used for treating different infections in human being and animals. The huge quantities of pharmaceuticals used are found to discharge into different water resources and cause different health and environmental problems. The continuous and large-scale discharge of pharmaceuticals increases their persistency which can consequently make them more toxic. The different advanced oxidation processes...
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Computer-aided Analysis of Induced Sheath Voltages in High Voltage Power Cable System
PublikacjaThis paper concerns the effect of configuration of high voltage power cables on induced voltages in their metallic sheaths. One, two or three cables per phase and phase sequence of the cables are considered. Computing of the voltages was performed for a normal operation and in case of earth fault. Various ways of the sheaths bonding are considered as well. Shock hazard and voltage stress of non-metallic outer sheath of cables are...
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Resonance Frequency Calculation of Spherical Microstrip Structure Using Hybrid Technique
PublikacjaIn this paper the spherical microstrip structure is considered. The structure is composed of a metallic patch with an arbitrary shape placed on a dielectric coated metallic sphere. In the analysis the hybrid technique is utilized. In this approach the finite-difference technique is applied in a cavity model to determine the current basis functions on the patch. Next, using method of moments, the resonance frequency of the structure...
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C-1305 inactivation of recombinant human cytochrome P450, CYP1A2 and CYP3A4, is due to mechanism-based inhibition
PublikacjaPodjęto próbę określenia mechanizmu obserwowanej inhibicji izoenzymów CYP1A2 i CYP3A4 przez pochodną triazoloakrydonu C-1305.W pierwszym kroku stwierdzono, że hamowanie aktywnosci obu enzymów jest procesem nieodwracalnym. W kolejnych etapach badań wykazano między innymi, że obecność NADPH zwiększa istotnie stopień obserwowanej inhibicji, co wskazało, że mamy do czynienia z inhibicją samobójczą opartą na mechanizmie działania (ang....
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Agata Kot-Wasik prof. dr hab. inż.
OsobyAgata Kot-Wasik, urodzona w 1964 r. w Siedlcach (woj. mazowieckie), ukończyła studia magisterskie w 1988 r. na Wydziale Chemicznym Politechniki Gdańskiej, w specjalności Analityka Techniczna i Przemysłowa. W latach 1988–1992 była zatrudniona w Katedrze Chemii Organicznej na macierzystym wydziale na stanowisku naukowo-technicznym. W 1990 r. ukończyła na PG studia podyplomowe „Techniki Instrumentalne w Analizie Śladów i Ochronie...
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Left-handed propagation characteristics of a dielectric and metal-loaded periodic circular waveguide
PublikacjaIn this paper, a periodic dielectric/metallic rod is located in a circular waveguide to obtain left-handed operation. Two geometries of the dielectric/metallic rod are proposed and examined. The dispersion characteristics of the investigated waveguides are obtained using a surface impedance model. Moreover, equivalent circuit models are proposed allowing for calculation of the dispersion characteristics and scattering parameters...
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Robert Skrzypczyński dr inż.
OsobyFaculty Member at the Gdansk University of Technology, Department of Urban Design and Regional Planning. My research interests revolve around modelling degrowth-oriented urban/regional metabolism scenarios as well as policy formulation for degrowth transitions.
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Transformation of bimetallic Ag–Cu thin films into plasmonically active composite nanostructures
PublikacjaFormation of plasmonically active silver, copper and composite silver-copper nanostructures were studied in this paper. Metallic nanostructures were fabricated by thermal disintegration, so called dewetting, of the thin films in an argon atmosphere. The formation process of the nanostructures was in-situ observed by a novel method, based on resistance measurements. The influence of the material and thickness of the initial thin...
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TEM imaging of metal nanoparticle cross section
Dane BadawczeTEM microscope was used for a imaging of metallic nanostructures. Metallic nanostructures were manufactured by thermal annealing of thin films. Gold and silver nanostructures were chosen for measurements. Samples were annealed for 15 and 60 minutes at 550 deg.
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Disposition of Drugs of Abuse and Their Metabolites in Wastewater as a Method of the Estimation of Drug Consumption
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Amphotericin B and Its New Derivatives - Mode of Action
PublikacjaAmphotericin B (AmB) is a well known antifungal and antiprotozoal antibiotic used in the clinic for several decades. Clinicalapplications of AmB, however, are limited by its nephrotoxicity and many other acute side effects which are not acceptable by patientswhen their life is not threaten. In order to improve the therapeutic index of this drug, lipid formulations have been introduced and manyefforts have been made to obtain less...
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Acridinone antitumor agents: C-1311, C-1330 and C-1305 are metabolized by flavin-containing monooxygenase isoenzymes: FMO1, FMO3 and FMO5 with different rates
PublikacjaRekombinantowe ludzkie monooksygenazy flawinowe: FMO1, FMO3, FMO5 indukują przemiany metaboliczne wybranych do badań pochodnych akrydonu. Biotransformacja związków C-1311, C-1330 i C-1305 przez FMO prowadzi do jednego produktu o strukturze N-tlenku. Wyniki badań wskazują, że najbardziej podatna na przemiany wobec FMO jest pochodna triazoloakrydonu C-1305. Wydaje się więc, że głównymi enzymami pierwszej fazy przemian metabolicznych...
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Genistein: a lysosomal stimulator for treatment of various lysosomal diseases
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The molecular mechanism of genistein action in lysosomal storage diseases: A transcriptomic approach
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Genetic Determinants of Vitamin D-Related Disorders; Focus on Vitamin D Receptor
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Evidence for sex differences in the determinants of homocysteine concentrations
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Hyperproteic diet modifies microbiota composition and associated metabolites in rats
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Role of Human UDP-Glucuronosyltransferases in the Biotransformation of the Triazoloacridinone and Imidazoacridinone Antitumor Agents C-1305 and C-1311 : Highly Selective Substrates for UGT1A10
Publikacja5-Diethylaminoethylamino-8-hydroxyimidazoacridinone, C-1311 (NSC-645809), is an antitumor agent shown to be effective against breast cancer in phase II clinical trials. A similar compound, 5-dimethylaminopropylamino-8-hydroxytriazoloacridinone, C-1305, shows high activity against experimental tumors and is expected to have even more beneficial pharmacological properties than C-1311. Previously published studies showed that these...
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The Imidazoacridinone Antitumor Drug, C-1311, Is Metabolized by Flavin Monooxygenases but Not by Cytochrome P450s.
PublikacjaPrezentowane w publikacji wyniki badań mają na celu wyjaśnienie roli enzymów wątrobowych w metabolizmie przeciwnowotworowych pochodnych C-1311 oraz C-1330. Oba związki inkubowane były z frakcją mikrosomalną oraz enzymami rekombinantowymi należącymi do grypy cytochromu P450, FMO oraz UGT. Badania wykazały, że oba związki są metabolizowane przez enzymy frakcji mikrosomalnej, ale nie przez enzymy cytochromu P450. Aktywność enzymatyczna...
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The role of intestine and liver in glucuronidation of the imidazo- and triazoloacridinone antitumor agents, C-1311 and C-1305: High affinity substrates for UGT1A10
PublikacjaCelem przeprowadzonych badań było określenie roli poszczególnych izoform UDP-glukuronylotransferazy (UGT)oraz mikrosomów jelita(HIM)i wątroby (HLM) wyizolowanych od różnych pacjentów w metabolizmie pochodnych akrydonu, związków C-1311 i C-1305. Wykazano, że rodziną UGT katalizującą przemiany C-1305 i C-1311 jest UGT1A, z najwyższą aktywnością wykazywaną przez pozawątrobowy izoenzym UGT1A10. Rozkład aktywności frakcji mikrosomalnych...
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Biotransformation of abused synthetic cannabinoids, JWH-018 and JWH-073, by human cytochromes P450 and UDP-glucuronosyltransferases
PublikacjaZwiązki oznaczone symbolami JWH-018 i JWH-073 są syntetycznymi pochodnymi kanabinoidów, obecnymi w preparatach o działaniu psychoaktywnym (K2/Spice). Wcześniejsze badań wykazały, że u osób przyjmujących tzw. ''legalną marihuanę'', głównymi produktami biotransformacji obecnymi w moczu były hydroksylowe pochodne obu związków, jak również ich glukuronidy. W związku z tym celem prowadzonych badań było określenie roli poszczególnych...
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Bioactive Ingredients with Health-Promoting Properties of Strawberry Fruit (Fragaria x ananassa Duchesne)
PublikacjaStrawberries (Fragaria x ananassa Duchesne) belong to the berry group and are characterized primarily by delightful sensory properties. Due to their chemical composition, these fruits are a rich source of bioactive compounds that can modify the metabolic and physiological functions of the body. The aim of this work is to present the current state of research on bioactive ingredients found in these fruits in the context of their...
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Disturbances of Earth magnetic field caused by eddy currents of airplane
PublikacjaThe uniform magnetic field of the Earth in the surrounding of a mobile, metallic object undergoes deformation by eddy currents. The influence of the moving, conducting object on the Earth's total magnetic field depends on the object's shape, position and speed of the changes relative to the magnetic field vector of the Earth, as well as the electric conductivity and the relative magnetic permeability of the material. Disturbances...