Filters
total: 11212
filtered: 3274
displaying 1000 best results Help
Search results for: CELL CYCLE, CELL PROTEOME, DIAMOND NANOFILM, EXTRACELLULAR MATRIX, INVASION, LIVER CANCER
-
Panax quinquefolium L. Ginsenosides from Hairy Root Cultures and Their Clones Exert Cytotoxic, Genotoxic and Pro-Apoptotic Activity towards Human Colon Adenocarcinoma Cell Line Caco-2
Publication -
Effect of modification of 6-[(aminoalkyl)amino]-7H-benzo[e]-perimidin-7-ones on their cytotoxic activity toward sensitive and multidrug resistant tumor cell lines. Synthesis and biological evaluation
PublicationPrzeprowadzono syntezę szeregu nowych pochodnych benzoperimidynowych, a mianowicie: monohydroksybenzoperimidyny i 2-aminobenzoperimidyny. Oznaczono aktywność przeciwnowotworową in vitro powyższych związków względem komórek nowotworowych bez oporności oraz z wykształconą opornością wielolekową. Wyznaczono również powinowactwo pochodnych do błony komórkowej, na kolumnie HPLC z odpowiednim wypełnieniem.
-
Synthesis and biological evaluation of 2,7-Dihydro-3H-dibenzo[de,h]cinnoli- ne-3,7-done derivatives a novel group of anticancer agents active on a multidrug resistance cell line.
PublicationZsyntezowano serię pochodnych pirydazonu z jednym lub dwoma łańcuchami bocznymi w różnych pozycjach chromoforu tetracyklicznego. Związki wykazały aktywność cytoksyczną na mysią białaczkę L1210 i ludzką k562 oraz na linii komórkowej oporności krzyżowej MDR (k562/DX). Dwa najbardziej aktywne związki przetestowano in vivo na mysiej białaczce P388. Wykazały one aktywność przeciwnowotworową porównywalną z aktywnością Mitoxantronu.
-
Correction: Bocheńska, K. et al. Lysosome Alterations in the Human Epithelial Cell Line HaCaT and Skin Specimens: Relevance to Psoriasis. Int. J. Mol. Sci. 2019, 20, 2255
Publication -
From DNA damage to G2 arrest: the many roles of topoisomerase II. W: Prog-ress in Cell Cycle Research. Ed. Meijer L., Jezequel A., Roberge M. London: Plenum Publ. Comp. Ltd**2003 vol. 5 chapt. 30 s. 295-300 Od uszkodzeń DNA do bloku w G2: wiele ról dla topoizomerazy II.
PublicationInhibitory DNA topoizomerazy II sa jednymi z najbardziej szeroko stosowanymi lekami przeciwnowotworowymi. Związki te indukuja pekniecia nici DNA i bloku progresji cyklu komorkowego w fazie G2. Jednak topoizomeraza II jest nie tylko celem molekularnym dla lekow przeciwnowtworowych ale enzym ten pelniwazna role w odpowiedzi komorkowej na dzialanie wielu lekow uszkadzajacych DNA. Topoizomeraza tworzy kompleksy molekularne z bialkami...
-
The life cycle cost of a building from the point of view of environmental criteria of selecting the most beneficial offer in the area of competitive tendering
PublicationThe article analyses environmental and ecological criteria of selecting the most beneficial offer in the aspect of LCC. Construction works contracts and the potential method of defining the above criteria, among others, is pondered on (for example by the recommendation of a material, which is supposed to be used, a ban on substances that are harmful for human health as well for the environment). In the relation to the above, it...
-
Rubrene Thin Films with Viably Enhanced Charge Transport Fabricated by Cryo-Matrix-Assisted Laser Evaporation
PublicationAmong organic semiconductors, rubrene (RB; C42H28) is of rapidly growing interest for the development of organic and hybrid electronics due to exceptionally long spin diffusion length and carrier mobility up to 20 cm2V−1s−1 in single crystals. However, the fabrication of RB thin films resembling properties of the bulk remains challenging, mainly because of the RB molecule’s twisted conformation. This hinders the formation of orthorhombic...
-
Perturbations of the hepatic proteome behind the onset of metabolic disorders in mouse offspring developed following embryo manipulation
Publication -
Proteome changes in renal cortex and medulla induced by dietary supplementation with inulin‐type fructans in growing pigs
Publication -
Hepatic proteome changes induced by dietary supplementation with two levels of native chicory inulin in young pigs
Publication -
Impact of the depletion of high-abundance proteins in blood plasma/serum on the proteome of these media in growing farm animals
Publication -
Indole-Acrylonitrile Derivatives as Potential Antitumor and Antimicrobial Agents—Synthesis, In Vitro and In Silico Studies
PublicationA series of 2-(1H-indol-2-yl)-3-acrylonitrile derivatives, 2a–x, 3, 4a–b, 5a–d, 6a–b, and 7, were synthesized as potential antitumor and antimicrobial agents. The structures of the prepared compounds were evaluated based on elemental analysis, IR, 1H- and 13NMR, as well as MS spectra. X-ray crystal analysis of the representative 2-(1H-indol-2-yl)-3-acrylonitrile 2l showed that the acrylonitrile double bond was Z-configured. All...
-
Automated measurement method for assessing thermal-dependent electronic characteristics of thin boron-doped diamond-graphene nanowall structures
PublicationThis paper investigates the electrical properties of boron-doped diamond-graphene (B:DG) nanostructures, focusing on their semiconductor characteristics. These nanostructures are synthesized on fused silica glass and Si wafer substrates to compare their behaviour on different surfaces. A specialized measurement system, incorporating Python-automated code, was developed for an in-depth analysis of electronic properties under various...
-
Manufacturing and Recycling Impact on Environmental Life Cycle Assessment of Innovative Wind Power Plant Part 1/2
PublicationWind power plants are considered as ecologically-clean source of energy. However, manufacturing processes cannot be treated that way. Manufacturing processes consume huge amount of electrical and thermal energy and significant amount of materials, e.g. steel, polymers, oils and lubricants. All of the above could be potentially harmful for environment. There are not many works and publications regarding life-cycle analysis of wind...
-
Molecular mechanism and energetics of coupling between substrate binding and product release in the F 1 -ATPase catalytic cycle
PublicationF1-ATPase is a motor protein that couples the rotation of its rotary γ subunit with ATP synthesis or hydrolysis. Single-molecule experiments indicate that nucleotide binding and release events occur almost simultaneously during the synthesis cycle, allowing the energy gain due to spontaneous binding of ADP to one catalytic β subunit to be directly harnessed for driving the release of ATP from another rather than being dissipated...
-
Tin oxide nanoparticles from laser ablation encapsulated in a carbonaceous matrix – a negative electrode in lithium-ion battery applications
PublicationThis report concerns carbonaceous electrodes doped with tin(II) oxide nanoparticles. Tin nanoparticles are obtained by pulsed laser ablation in water. Crystalline nanoparticles have been encapsulated in a carbonaceous matrix formed after pyrolysis of a mixture consisting of tin/tin(IV) oxide nanoparticles and gelatine. The obtained material is characterized by means of X-ray diffraction, selected area diffraction, scanning electron...
-
Electrochemical simulation of enzymatic transformations studied for the selected antitumor acridine derivatives
PublicationThe elucidation of the metabolic pathways and the biotransformation mechanisms of potential drugs is a crucial point in drug development. It allows to know the activation routes of the new biologically active compounds, especially in respect to their possible toxicity. Generally, in vivo or in vitro experiments with liver microsomes or hepatocytes are performed. However, these testing schemes are tedious, time consuming and of...
-
Electrochemistry meets enzymes: Investigation of the biotransformation pathway of C-1311 based on electrochemical simulation in comparison to in vitro methods.
PublicationThe knowledge of the metabolic pathways and the biotransformation of new drugs is one of the major challenges in pharmaceutical research. It is crucial for elucidation of degradation routes of the new biologically active compounds, especially in the area of possible toxicity. Conventional in vitro drug metabolism studies are based on incubating drug candidate with e.g. hepatocytes or, most importantly, liver cell microsomes and...
-
Synthesis of green benzamide-decorated UiO-66-NH2 for biomedical applications
PublicationMetal-organic frameworks (MOFs) biocompatible systems can host enzymes/bacteria/viruses. Herein we synthesized a series of fatty acid amide hydrolase (FAAH)-decorated UiO-66-NH2 based on Citrus tangerine leaf extract for drug delivery and biosensor applications. Five chemically manipulated FAAH-like benzamides were localized on the UiO-66-NH2 surface with physical interactions. Comprehensive cellular and molecular analyses were...
-
Reduction of human chorionic gonadotropin beta subunit expression by modified U1 snRNA caused apoptosis in cervical cancer cells
Publication -
Preclinical toxicological examination of a putative prostate cancer-specific 4-methyl-1-nitroacridine derivative in rodents
PublicationW pracy przedstawiono wyniki przedklinicznych badań toksykologicznych zwiazków C-1748 i C-857 na szczurach Copenhagen i myszach BALB/c, po podaniu dootrzewnowym lub dożylnym. U myszy dawki letalne (LD50) dla C-1748 wynosiły odpowiednio 9 i 13,4 mg/kg w porównaniu z 2,2 i 3 mg/kg dla C-857. U szczurów po podaniu dootrzewnowym lub dożylnym dla C-1748 dawki LD50 wynosiły odpowiednio 4 i 1,3 mg/kg. Nie stwierdzono zmian w liczbie komórek...
-
Theoretical Encapsulation of Fluorouracil (5-FU) Anti-Cancer Chemotherapy Drug into Carbon Nanotubes (CNT) and Boron Nitride Nanotubes (BNNT)
PublicationIntroduction: Chemotherapy with anti-cancer drugs is considered the most common approach for killing cancer cells in the human body. However, some barriers such as toxicity and side effects would limit its usage. In this regard, nano-based drug delivery systems have emerged as cost-effective and efficient for sustained and targeted drug delivery. Nanotubes such as carbon nanotubes (CNT) and boron nitride nanotubes (BNNT) are promising...
-
Anticancer Properties of Amino Acid and Peptide Derivatives of Mycophenolic Acid
PublicationBackground: Although Mycophenolic Acid (MPA) is applied as prodrugs in clinic as an immunosuppressant, it also possesses anticancer activity. MPA acts as Inosine-5’-Monophosphate Dehydrogenase (IMPDH) inhibitor, where the carboxylic group at the end of the side chain interacts with Ser 276 of the enzyme via hydrogen bonds. Therefore, MPA derivatives with other polar groups indicated high inhibition too. On the other hand, potent...
-
Molecular basis for the DNA damage induction and anticancer activity of asymmetrically substituted anthrapyridazone PDZ-7
Publicationnthrapyridazones, imino analogues of anthraquinone, constitute a family of compounds with remarkable anti-cancer activity. To date, over 20 derivatives were studied, of which most displayed nanomolar cytotoxicity towards broad spectrum of cancer cells, including breast, prostate and leukemic ones. BS-154, the most potent derivative, had IC50 values close to 1 nM, however, it was toxic in animal studies. Here, we characterize another...
-
Gene Expression and Activity Profiling Reveal a Significant Contribution of Exo‐Phosphotransferases to the Extracellular Nucleotides Metabolism in HUVEC Endothelial Cells
Publication -
Extracellular biosynthesis of cobalt ferrite nanoparticles by Monascus purpureus and their antioxidant, anticancer and antimicrobial activities: Yield enhancement by gamma irradiation
Publication -
Electrochemical determination of nitroaromatic explosives at boron-doped diamond/graphene nanowall electrodes: 2,4,6-trinitrotoluene and 2,4,6-trinitroanisole in liquid effluents
PublicationThe study is devoted to the electrochemical detection of trace explosives on boron-doped diamond/graphene nanowall electrodes (B:DGNW). The electrodes were fabricated in a one-step growth process using chemical vapour deposition without any additional modifications. The electrochemical investigations were focused on the determination of the important nitroaromatic explosive compounds, 2,4,6-trinitrotoluene (TNT) and 2,4,6-trinitroanisole...
-
Effects of safety barrier life cycle cost factors - identification and analysis
PublicationThe costs borne by road infrastructure authorities for managing and maintaining road devices such as safety barriers may be very high. This has prompted the need for identifying and analysing in detail all factors that influence the costs of safety barriers throughout their service life. To meet that need, the authors used international experience and field data collected under the LifeRoSE project to define the cost structure...
-
Neural Network Application for Recognition of Geometry Degradation of Power Cycle Components
PublicationPrzedyskutowano problem rozpoznawania degradacji geometrycznej. Skuteczne zastosowanie wybranego typu sieci neuronowej (SSN) jest prezentowane w referacie. SSN wykrywająca typy degradacji geometrycznej wykazała wysoką jakość. Pokazano pewną możliwość ekstrapolacji takich SSN. Pokazano możliwość wykrywania typów degradacji geometrycznej nawet w przypadku pozyskiwania niepełnych danych pomiarowych.
-
Comparison of traditional district heating with low temperature district heating systems featuring organic Rankine cycle and heat pump
PublicationPaper presents a comparison between a traditional district heating system with conventional boilers as a source of heat and electricity purchases from power utilities and a low temperature DH system incorporating the CHP with organic Rankine Cycle providing electricity and local heat pump raising the temperature of the DH fluid to the required temperature in the dwelling, meaning that both heat and electricity are produced within...
-
Utilizing Genome-Wide mRNA Profiling to Identify the Cytotoxic Chemotherapeutic Mechanism of Triazoloacridone C-1305 as Direct Microtubule Stabilization
PublicationRational drug design and in vitro pharmacology profiling constitute the gold standard in drug development pipelines. Problems arise, however, because this process is often dicult due to limited information regarding the complete identification of a molecule’s biological activities. The increasing aordability of genome-wide next-generation technologies now provides an excellent opportunity to understand a compound’s diverse eects...
-
The variant allele of the rs188140481 polymorphism confers a moderate increase in the risk of prostate cancer in Polish men
Publication -
Cardioprotection during cancer chemotherapy with the use of natural antioxidants: review of literature and results of own studies
PublicationDoniesienie poświęcone jest wykorzystaniu naturalnych antyoksydantów w ochronie mięśnia sercowego przed toksycznym działaniem antracyklin wykorzystywanych w leczeniu nowotworów. Pokazane zostało działanie ochronne kilku związków oraz zwierających je składników żywności w tym buraka czerwonego, który był przedmiotem badań własnych.
-
Health-related quality of life data from a phase 3, international, randomized, open-label, multicenter study in patients with previously treated mantle cell lymphoma treated with ibrutinib versus temsirolimus
Publication -
Multi-modality imaging in the CIRCULATE-AMI pilot study cohort: a framework for an imaging-based randomized controlled trial of Wharton jelly mesenchymal stem cell use to stimulate myocardial repair/regeneration
Publication -
High efficacy and safety of VTD as an induction protocol in patients with newly diagnosed multiple myeloma eligible for high dose therapy and autologous stem cell transplantation: A report of the Polish Myeloma Study Group
Publication -
Protective Effect of Black Tea Against Ethanol-Induced Oxidative Modifications of Liver Proteins and Lipids
Publication -
Is there any association between HCV multiplication and iron induced liver injury in chronic hepatitis C?
Publication -
Coexistence of HFE and rare UGT1A1 genes mutations in patients with iron overload related liver injury
Publication -
A negative effect of carbon phase on specific capacity of electrode material consisted of nanosized bismuth vanadate embedded in carbonaceous matrix
PublicationLithium-ion batteries (LIBs) are widely used all over the world. The LIBs belong to a renewable energy source and energy storage devices. The increase in energy demand causes that new materials of higher energy and higher power densities are still under investigation. Herein, we compare electrochemical properties of bismuth vanadate (BiVO4) embedded and not embedded into carbonaceous matrix as an anode material along with structural...
-
Synthesis and biological evaluation of fluorinated N-benzoyl and N-phenylacetoyl derivatives of 3-(4-aminophenyl)-coumarin-7-O-sulfamate as steroid sulfatase inhibitors
PublicationIn the present work, we report convenient methods for the synthesis of 3-(4-aminophenyl)-coumarin-7-O-sulfamate derivatives N-acylated with fluorinated analogues of benzoic or phenylacetic acid as steroid sulfatase (STS) inhibitors. The design of these potential STS inhibitors was supported by molecular modeling techniques. Additionally, computational docking methods were used to determine the binding modes of the synthesized inhibitors...
-
Electrochemical oxidation of ionic liquids at highly boron doped diamond electrodes
Publication -
Local impedance imaging of boron-doped polycrystalline diamond thin films
Publication -
Optoelectronic monitoring of plasma discharge optimized for thin diamond film synthesis
PublicationPraca dotyczy optoelektronicznego monitoringu wyładowań jarzeniowych podczas syntezy diamentu cienkowarstwowego. Analizę składu plazmy wykonano za pomoca optycznej spektroskopii emisyjnej. Badania mają na celu zdalne określenie składu plazmy oraz jego wpływu na systezę warstw diamentopodobnych.
-
The ab initio calculations of single nitrogen-vacancy defect center in diamond.
PublicationW artykule zaprezentowano rezultaty kwantowomechanicznych obliczeń ''ab initio'' struktury elektronowej defektu azot-wakans w diamencie. Do obliczeń wykorzystano model złożony z 63 atomów. Otrzymane wyniki zostały porównane z wcześniejszymi pracami teoretycznymi i doświadczalnymi.
-
Patterned hydrophobic and hydrophilic surfaces of ultra-smooth nanocrystalline diamond layers
Publication -
Biophotonic low-coherence sensors with boron-doped diamond thin layer
PublicationLow-coherence sensors using Fabry-Perot interferometers are finding new applications in biophotonic sensing, especially due to the rapid technological advances in the development of new materials. In this paper we discuss the possibility of using boron-doped nanodiamond layers to protect mirror in a Fabry-Perot interferometer. A low-coherence sensor using Fabry-Perot interferometer with a boron-doped nanodiamond (B-NCD) thin protective...
-
Electrochemical oxidation of ionic liquids at highly boron doped diamond electrodes
PublicationUtlenianie elektrochemiczne przy zastosowaniu elektrod diamentowych wysoko domieszkowanych borem (BDD) było badane pod względem przydatności do utylizacji roztworów zawierających ciecze jonowe (ILs). Dwustronne elektrody Si/BDD przygotowano metodą chemicznego osadzania z fazy lotnej wspomaganego plazmą (MW PE CVD). Badanie przy użyciu skaningowej mikroskopii elektronowej (SEM) potwierdziło, że wytworzone warstwy były ciągłe i miały...
-
Tuning a Hybrid GPU-CPU V-Cycle Multilevel Preconditioner for Solving Large Real and Complex Systems of FEM Equations
PublicationThis letter presents techniques for tuning an accelerated preconditioned conjugate gradient solver with a multilevel preconditioner. The solver is optimized for a fast solution of sparse systems of equations arising in computational electromagnetics in a finite element method using higher-order elements. The goal of the tuning is to increase the throughput while at the same time reducing the memory requirements in order to allow...
-
Nanocrystalline Polymer Impregnated [Fe(pz)Pt(CN)4] Thin Films Prepared by Matrix-Assisted Pulsed Laser Evaporation
PublicationIn this work, the fabrication of [Fe(pz)Pt(CN)4] (pz = pyrazine) thin films by means of matrix-assisted pulsed laser evaporation (MAPLE) was investigated. As starting material, a cryogenically cooled suspension of anocrystalline [Fe(pz)Pt- (CN)4] (0.35wt.-%) in a mixture of 1,1-dichloroethane and polyethylene glycol (PEG) was used. Films of a thickness up to 150–200 nm were deposited on Si substrates by laser ablation at λ = 1064...