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Search results for: regeneration
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Effect of Chitosan Deacetylation on Its Affinity to Type III Collagen: A Molecular Dynamics Study
PublicationThe ability to form strong intermolecular interactions by linear glucosamine polysaccharides with collagen is strictly related to their nonlinear dynamic behavior and hence bio-lubricating features. Type III collagen plays a crucial role in tissue regeneration, and its presence in the articular cartilage affects its bio-technical features. In this study, the molecular dynamics methodology was applied to evaluate the effect of...
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From Bioink to Tissue: Exploring Chitosan-Agarose Composite in the Context of Printability and Cellular Behaviour
PublicationThis study presents an innovative method for producing thermosensitive bioink from chitosan hydrogels saturated with carbon dioxide and agarose. It focuses on a detailed characterisation of their physicochemical properties and potential applications in biomedicine and tissue engineering. The ORO test approved the rapid regeneration of the three-dimensional structure of chitosan–agarose composites in a unidirectional bench press...
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Thermosensitive composite based on agarose and chitosan saturated with carbon dioxide. Preliminary study of requirements for production of new CSAG bioink.
PublicationThis study introduces a method for producing printable, thermosensitive bioink formulated from agarose (AG) and carbon dioxide-saturated chitosan (CS) hydrogels. The research identified medium molecular weight chitosan as optimal for bioink production, with a preferred chitosan hydrogel content of 40–60 %. Rheological analysis reveals the bioink's pseudoplastic behavior and a sol-gel phase transition between 27.0 and 31.5 °C. The...
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Effect of Nanohydroxyapatite on Silk Fibroin–Chitosan Interactions—Molecular Dynamics Study
PublicationFibroin–chitosan composites, especially those containing nanohydroxyapatite, show potential for bone tissue regeneration. The physicochemical properties of these biocomposites depend on the compatibility between their components. In this study, the intermolecular interactions of fibroin and chitosan were analyzed using a molecular dynamics approach. Two types of systems were investigated: one containing acetic acid and the other...
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Angiopoietin-like growth factor-derived peptides as biological activators of adipose-derived mesenchymal stromal cells
PublicationAdipose-derived mesenchymal stromal cells (AD-MSCs) are an essential issue in modern medicine. Extensive preclinical and clinical studies have shown that mesenchymal stromal/stem cells, including AD-MSCs, have specific properties (ability to differentiate into other cells, recruitment to the site of injury) of particular importance in the regenerative process. Ongoing research aims to elucidate factors supporting AD-MSC culture...
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Polish waterfront in the process of transformation: The case of Elbląg port city
PublicationThe topic of waterfront transformation is a vast and challenging issue, which in small and medium-sized cities is still unexplored. With growing global interest in the matter of regeneration of city-water relationship and increasing public awareness of the value of waterfront public spaces, actions to transform abandoned waterfront areas have been undertaken in many Polish port cities. City of Elbląg, located in northern Poland,...
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Wielkie wydarzenia jako katalizator procesów rewitalizacji
PublicationCelem referatu jest naświetlenie procesów rewitalizacji towarzyszących organizacji wielkich wydarzeń w dwóch aspektach: 1) rewitalizacja jako motor lub jako skutek działań; 2) lokalność i regionalność procesów rewitalizacji. Omówieniu tych zjawisk służą przykłady miast-organizatorów wielkich wydarzeń, Sydney (IO 2000), Pekin (IO 2008), Londyn (IO 2012) oraz Gdańsk (Euro 2012) i Szczecin (The Tall Ships Races 2013). Kluczową kwestią...
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Agri-food waste biosorbents for volatile organic compounds removal from air and industrial gases – A review
PublicationApproximately 1.3 billion metric tons of agricultural and food waste is produced annually, highlighting the need for appropriate processing and management strategies. This paper provides an exhaustive overview of the utilization of agri-food waste as a biosorbents for the elimination of volatile organic compounds (VOCs) from gaseous streams. The review paper underscores the critical role of waste management in the context of a...
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Selected aspects of performance of organic Rankine cycles incorporated into bioenergy with carbon capture and storage using gasification of sewage sludge
PublicationThe study aims to investigate the application of the Organic Rankine Cycle (ORC) in the bioenergy with carbon capture and storage (BECCS) using gasification of sewage sludge. The tool used in the investigation is the Aspen Plus software with REFPROP property methods for calculating fluid properties. The reason for this study is that a detailed analysis of the proposed BECCS process flow diagram indicates that a certain amount of...
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Imunofan—RDKVYR Peptide—Stimulates Skin Cell Proliferation and Promotes Tissue Repair
PublicationRegeneration and wound healing are vital to tissue homeostasis and organism survival. One of the biggest challenges of today’s science and medicine is finding methods and factors to stimulate these processes in the human body. Effective solutions to promote regenerative responses will accelerate advances in tissue engineering, regenerative medicine, transplantology, and a number of other clinical specialties. In this study, we...
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Deep Eutectic Solvents: Properties and Applications in CO2 Separation
PublicationNowadays, many researchers are focused on finding a solution to the problem of global warming. Carbon dioxide is considered to be responsible for the “greenhouse” effect. The largest global emission of industrial CO2 comes from fossil fuel combustion, which makes power plants the perfect point source targets for immediate CO2 emission reductions. A state-of-the-art method for capturing carbon dioxide is chemical absorption using...
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Green monoterpenes based deep eutectic solvents for effective BTEX absorption from biogas
PublicationThe combustion of biogas which contains significant amounts of monoaromatic hydrocarbons, i.e. benzene, ethylbenzene, toluene, and xylene (BTEX) can cause many technological, environmental, and health problems. Therefore, in these studies, a new physical absorption method based on deep eutectic solvents (DES) consisting of monoterpenes and carboxylic acids was developed for BTEX removal. A total of 39 DES were synthesized, of which...
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Keratin-Butyrate Scaffolds Promote Skin Wound Healing in Diabetic Rats Through Down-Regulation of IL-1β and Up-Regulation of Keratins 16 and 17
PublicationImpaired wound healing particularly in diabetics creates a significant healthcare burden. The study aimed to evaluate the effect of keratin-butyrate fibers (FKDP +0.1%NaBu) in a full-thickness skin wound model in 30 diabetic rats. Physicochemical examination showed that the obtained dressing possesses a heterogeneous structure and butyrate was slowly released into the wound. Moreover, the obtained dressing is nontoxic and supports...
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The study on the appearance of deformation defects in the yacht lamination process using an AI algorithm and expert knowledge
PublicationThis article describes the application of the A-priori algorithm for defining the rule-based relationships between individual defects caused during the lamination process, affecting the deformation defect of the yacht shell. The data from 542 yachts were collected and evaluated. For the proper development of the algorithm, a technological process of the yacht lamination supported by expert decisions was described. The laminating...
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Modelling and Simulation of a New Variable Stiffness Holder for Milling of Flexible Details
PublicationModern industry expectations in terms of milling operations often demand the milling of the flexible details by using slender ball-end tools. This is a difficult task because of possible vibration occurrence. Due to existence of certain conditions (small depths of cutting, regeneration phenomena), cutting process may become unstable and self-excited chatter vibration may appear. Frequency of the chatter vibration is close to dominant...
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Titania Nanofiber Scaffolds with Enhanced Biointegration Activity—Preliminary In Vitro Studies
PublicationThe increasing need for novel bone replacement materials has been driving numerous studies on modifying their surface to stimulate osteogenic cells expansion and to accelerate bone tissue regeneration. The goal of the presented study was to optimize the production of titania-based bioactive materials with high porosity and defined nanostructure, which supports the cell viability and growth. We have chosen to our experiments TiO2...
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Functionalized nanodiamonds as a perspective green carbo-catalyst for removal of emerging organic pollutants
PublicationRapid industrial and urban development jointly with rising global population strongly affect the large-scale issues with drinking, groundwater, and surface water pollution. Concerns are not limited to environmental issues but also human health impact becoming serious global aspect. Organic pollution becomes a primarily serious hazard, therefore, the novel sophisticated approaches to treat them are thoroughly investigated. Among...
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Wpływ rodzaju zanieczyszczenia powierzchni odlewu ze staliwa LH14 na jakość napoin wykonanych elektrodą otuloną
PublicationNapawanie jest szeroko stosowaną metodą naprawiania powierzchni. Pozwala między innymi na uzupełnienie miejsc, w których uprzednio wystąpiły wżery korozyjne. Techniki napawania wykorzystywane są również do przywracania pierwotnego kształtu zużytych części. W pracy wykonano badania napoin wykonanych elektrodami otulonymi na czołowych powierzchniach cylindrycznych próbek ze staliwa LH14. Proces wykonywano dwoma rodzajami elektrod:...
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Imunofan - RDKVYR peptide - stimulates skin cell proliferation and promotes tissue repair
PublicationRegeneration and wound healing are vital to tissue homeostasis and organism survival. One of the biggest challenges of today's science and medicine is finding methods and factors to stimulate these processes in the human body. Effective solutions to promote regenerative responses will accelerate advances in tissue engineering, regenerative medicine, transplantology, and a number of other clinical...
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PVA-Based Films with Strontium Titanate Nanoparticles Dedicated to Wound Dressing Application
PublicationBioactive materials may be applied in tissue regeneration, and an example of such materials are wound dressings, which are used to accelerate skin healing, especially after trauma. Here, we proposed a novel dressing enriched by a bioactive component. The aim of our study was to prepare and characterize poly(vinyl alcohol) films modified with strontium titanate nanoparticles. The physicochemical properties of films were studied,...
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Expermental investigation on adsorption of methylene blue dye from waste water using corncob cellulose-based hydrogel
PublicationHydrogel from corncob cellulose was synthesized in this investigation. The synthesized Hydrogel was characterized by SEM, XRD, and FTIR instruments. As the results indicate the synthesized hydrogel has required and important features, these suggest the suitability of hydrogel for the adsorption of methylene blue dye (MBD). Three important process variables (dosage, contact time, and initial concentration) with three levels were...
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In vivo imaging of the human eye using a two-photon excited fluorescence scanning laser ophthalmoscope
PublicationBACKGROUND. Noninvasive assessment of metabolic processes that sustain regeneration of human retinal visual pigments (visual cycle) is essential to improve ophthalmic diagnostics and to accelerate development of new treatments to counter retinal diseases. Fluorescent vitamin A derivatives, which are the chemical intermediates of these processes, are highly sensitive to UV light; thus, safe analyses of these processes in humans...
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Chitosan-based inks for 3D printing and bioprinting
PublicationThe advent of 3D-printing/additive manufacturing in biomedical engineering field has introduced great potential for the preparation of 3D structures that can mimic native tissues. This technology has accelerated the progress in numerous areas of regenerative medicine, especially led to a big wave of biomimetic functional scaffold developments for tissue engineering demands. In recent years, the introduction of smart bio-inks has...
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Electrically Conductive Carbon‐based (Bio)‐nanomaterials for Cardiac Tissue Engineering
PublicationA proper self-regenerating capability is lacking in human cardiac tissue which along with the alarming rate of deaths associated with cardiovascular disorders makes tissue engineering critical. Novel approaches are now being investigated in order to speedily overcome the challenges in this path. Tissue engineering has been revolutionized by the advent of nanomaterials, and later by the application of carbon-based nanomaterials...
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Microporous Polyurethane Thin Layer as a Promising Scaffold for Tissue Engineering
PublicationThe literature describes that the most efficient cell penetration takes place at 200–500 µm depth of the scaffold. Many different scaffold fabrication techniques were described to reach these guidelines. One such technique is solvent casting particulate leaching (SC/PL). The main advantage of this technique is its simplicity and cost efficiency, while its main disadvantage is the scaffold thickness, which is usually not less than...
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Vibration Surveillance System with Variable Stiffness Holder for Milling Flexible Details
PublicationEfficient milling of the flexible details (i.e. rotor blades, thin-walled elements) using slender ball-end tools is a difficult task due to possibility of vibration occurrence. Because of the existence of certain conditions (small depths of cutting, regeneration phenomena), cutting process may lose stability and self-excited chatter vibration may appear. Frequency of the chatter vibration is close to dominant natural frequency...
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Polyurethane based hybrid ciprofloxacin-releasing wound dressings designed for skin engineering purpose
PublicationPurpose Even in the 21st century, chronic wounds still pose a major challenge due to potentially inappropriate treatment options, so the latest wound dressings are hybrid systems that enable clinical management, such as a hybrid of hydrogels, antibiotics and polymers. These wound dressings are mainly used for chronic and complex wounds, which can easily be infected by bacteria. Materials and methods Six Composite Porous Matrices...
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Polyurethanes Crosslinked with Poly(vinyl alcohol) as a Slowly-Degradable and Hydrophilic Materials of Potential Use in Regenerative Medicine
PublicationNovel, slowly-degradable and hydrophilic materials with proper mechanical properties and surface characteristics are in great demand within the biomedical field. In this paper, the design, synthesis, and characterization of polyurethanes (PUR) crosslinked with poly(vinyl alcohol) (PVA) as a new proposition for regenerative medicine is described. PVA-crosslinked PURs were synthesized by a two-step polymerization performed in a solvent...
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Release systems based on self-assembling RADA16-I hydrogels with a signal sequence which improves wound healing processes
PublicationSelf-assembling peptides can be used for the regeneration of severely damaged skin. They can act as scaffolds for skin cells and as a reservoir of active compounds, to accelerate scarless wound healing. To overcome repeated administration of peptides which accelerate healing, we report development of three new peptide biomaterials based on the RADA16-I hydrogel functionalized with a sequence (AAPV) cleaved by human neutrophil elastase...
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Redesigning Informal Beirut: Shaping the Sustainable Transformation Strategies
PublicationLebanon is distinguished by its strategic geographical location among the Arab countries. Beirut, as the capital city and the major commercial and cultural centre of the country, is a point of interest for migrants. The region has witnessed many changes since the end of World War II, which have resulted in internal and external conflicts, migrations, the centralization of the country’s economy, etc. Furthermore, the city has witnessed...
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The Impact of Material Selection on Durability of Exhaust Valve Faces of a Ship Engine – A Case Study
Publicationwo alloys were used in order to extend the service life of marine engine exhaust valve head. Layers of cobalt base alloys were made of the powders with with chemical composition as follow: the layer marked L12; C-1,55%; Si-1,21%; Cr-29,7%; W-9%; Ni-2%; Mo<0,01%; Fe-1,7%; Co-54,83% and the layer marked N; C-1,45%; Co-38,9%; Cr-24,13%; Ni-10,43%; W-8,75%; Fe-7,64%; Mo-7,56%; Si-2,59%. Base metal was valve steel after heat treatment....
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Collaborative urban studios in Poland. Teaching collective problem solving via live projects
PublicationThe requirements of contemporary architectural and urban design practice places a growing importance on the ability to generate new solutions to complex design challenges. Such an approach is particularly relevant in the context of contemporary urban projects in need of urban innovation and socially engaged practice, i.e. urban regeneration or street quality improvement projects. Meaningful involvement in such topics requires a...
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Carbon dioxide sequestration by industrial wastes through mineral carbonation: Current status and perspectives
PublicationMineral carbonation using natural minerals or industrial wastes is a safe and promising strategy for CO2 sequestration. Application of industrial wastes for this purpose has significant ecological and environmental value, which is one of the key green technologies in the global carbon mitigation. This review summarizes the current research status of CO2 mineralization by industrial wastes. This work surveys the mechanisms and capacities...
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Sequence variants of p21 gene of the MRL/MpJ mouse: a possible association with the deficit of p21 protein and regenerative phenotype.
PublicationThe MRL/MpJ mouse is known for its enhanced regeneration abilities that manifested themselves by scarless ear-hole wound closure. The deficit of p21 found in the MRL is associated with the regenerative capacity as the p21 gene knockout in a mouse strain unrelated to the MRL mouse results in an ear-hole closure effect, similar to that observed in the MRL mouse. Cdkn1a gene encodes p21 protein, a cyclin-dependent kinase inhibitor,...
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Functionalized Peptide Fibrils as a Scaffold for Active Substances in Wound Healing
PublicationTechnological developments in the field of biologically active peptide applications in medicine have increased the need for new methods for peptide delivery. The disadvantage of peptides as drugs is their low biological stability. Recently, great attention has been paid to self-assembling peptides that can form fibrils. Such a formulation makes bioactive peptides more resistant to enzymatic degradation and druggable. Peptide fibrils...
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Transcriptomic responses to wounding: meta-analysis of gene expression microarray data
PublicationBackground A vast amount of microarray data on transcriptomic response to injury has been collected so far. We designed the analysis in order to identify the genes displaying significant changes in expression after wounding in different organisms and tissues. This meta-analysis is the first study to compare gene expression profiles in response to wounding in as different tissues as heart, liver, skin, bones, and spinal cord, and...