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Search results for: DNA PURINE BASES
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Adaptive dynamic control allocation for dynamic positioning of marine vessel based on backstepping method and sequential quadratic programming
PublicationIt is generally assumed in dynamic positioning of over-actuated marine vessels that the control effectiveness matrix (input matrix) is known and constant, or, in case of fault information, it is estimated by the fault detection and diagnosis system. The purpose of the study is to develop the adaptive dynamic positioning control system for an over-actuated marine vessel in the presence of uncertainties and with emphasis on limited...
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Effects of Column Base Flexibility on Seismic Response of Steel Moment-Frame Buildings
PublicationSteel Moment Resisting Frames (SMRFs) are very popular lateral load resisting systems in many seismically active regions. However, their seismic response is strongly dependent on the rotational fixity of column base connections. Despite many studies (both experimental and numerical) in this particular area, available approaches for estimating column base flexibility have been validated only against laboratory test data. In the...
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Numerical evaluation of dynamic response of an experimentally tested base-isolated and fixed-base steel structure model
PublicationSeismic isolation is recognized as one of the most popular and effective methods of protecting structures during earthquake. The present paper is focused on the comparison be-tween the dynamic responses of buildings with fixed and isolated bases exposed to seismic exci-tations. The aim of the study is to investigate the effectiveness of a simplified base isolation numerical modelling technique using the linear springs. One-storey...
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Squamous cell carcinoma, keratinizing, NOS - Unknown, 62 - Tissue image [3300730069389211]
Open Research DataThis is the histopathological image of FLOOR OF MOUTH tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Squamous cell carcinoma, keratinizing, NOS - Unknown, 62 - Tissue image [3300730069383311]
Open Research DataThis is the histopathological image of FLOOR OF MOUTH tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Squamous cell carcinoma, keratinizing, NOS - Unknown, 62 - Tissue image [3300730069389741]
Open Research DataThis is the histopathological image of FLOOR OF MOUTH tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Squamous cell carcinoma, keratinizing, NOS - Unknown, 62 - Tissue image [3300730069389141]
Open Research DataThis is the histopathological image of FLOOR OF MOUTH tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Squamous cell carcinoma, keratinizing, NOS - Unknown, 62 - Tissue image [3300730069386931]
Open Research DataThis is the histopathological image of FLOOR OF MOUTH tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Squamous cell carcinoma, keratinizing, NOS - Unknown, 62 - Tissue image [3300730069385851]
Open Research DataThis is the histopathological image of FLOOR OF MOUTH tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Squamous cell carcinoma, keratinizing, NOS - Unknown, 62 - Tissue image [3300730069386301]
Open Research DataThis is the histopathological image of FLOOR OF MOUTH tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Squamous cell carcinoma, keratinizing, NOS - Unknown, 62 - Tissue image [3300730069382641]
Open Research DataThis is the histopathological image of FLOOR OF MOUTH tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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H2O˙+ and OH+ reactivity versus furan: experimental low energy absolute cross sections for modeling radiation damage
PublicationRadiotherapy is one of the most widespread and efficient strategies to fight malignant tumors. Despite its broad application, the mechanisms of radiation-DNA interaction are still under investigation. Theoretical models to predict the effects of a particular delivered dose are still in their infancy due to the difficulty of simulating a real cell environment, as well as the inclusion of a large variety of secondary processes. This...
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EASY ACCESS TOOL FOR SMALL INTERFERING RNA (siRNA) DATA
PublicationFor many decades it was an accepted dogma of molecular genetics that the expression of genes is a “one-way-road” leading only in one direction from DNA to RNA to proteins. Recent discoveries in modern molecular genetics have challenged this dogma showing that specific RNA molecules play a central role in controlling the activity of genes by changing the structure of DNA sequences, targeting other RNAs for degradation or blocking...
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The New LM-PCR/Shifter Method for the Genotyping of Microorganisms Based on the Use of a Class IIS Restriction Enzyme and Ligation Mediated PCR
PublicationThis study details and examines a novel Ligation-Mediated - Polymerase Chain Reaction (LM-PCR) method. Named the LM-PCR/Shifter, it relies on the use of a Class IIS restriction enzyme giving restriction fragments with different 4 base, 5' overhangs, this being the Shifter, and the ligation of appropriate oligonucleotide adapters. A sequence of 4-base, 5' overhangs of the adapter and a 4-base sequence of the 3' end of the primer(s)...
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From tryptophan to novel mitochondria-disruptive agent, synthesis and biological evaluation of 1,2,3,6-tetrasubstituted carbazoles
PublicationMitochondrial targeting plays an important role in anticancer therapy. The Mn(III)-promoted cyclization of 5- (1H-indol-3-yl)-3-oxopentanoic acid allow to obtain novel substituted carbazole derivatives that can act as mitochondria-disruptive agents. The starting materials used for the synthesis of these new aminocarbazoles are oxopentanoate derivatives of tryptophan. The scope and limitation of this method of synthesis are determined...
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Palindromic carbazole derivatives: unveiling their antiproliferative effect via topoisomerase II catalytic inhibition and apoptosis induction
PublicationHuman DNA topoisomerases are essential for crucial cellular processes, including DNA replication, transcription, chromatin condensation, and maintenance of its structure. One of the significant strategies employed in cancer treatment involves the inhibition of a specific type of topoisomerase, known as topoisomerase II (Topo II). Carbazole derivatives, recognised for their varied biological activities, have recently become a significant...
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Induction of G2/M phase arrest and apoptosis of human leukemia cells by potent antitumor triazoloacridinone C-1305
PublicationWykazaliśmy, że pochodna triazoloakrydonu C-1305 w stężeniach biologicznie istotnych indukuje blok cyklu komórkowego w fazie G2/M i apoptozę w komórkach białaczek ludzkich MOLT4 i HL60. Zjawisko apoptozy zostało określone na podstawie charakterystycznych zmian morfologicznych jak i biochemicznych tj. fragmentacji DNA, aktywacji kaspazy 3, cięcia PARP, spadku potencjału mitochondrialnego i ATP oraz eksternalizacji fosfatydyloseryny.
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Electron ionization and low energy electron attachment to molecules of biological interest
PublicationEthylenediaminetetraacetic acid (EDTA) and 2-amino-2-(hydroxymethyl)-1,3-propanediol (TRIS) were investigated by electron impact ionization and low energy electron attachment. Both compounds are components of biological buffers and often are used as DNA stabilizers in irradiation studies. hus it is of a great importance to understand their potential interactions with radiation. Our results revealed that at least one of them, EDTA, may...
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Indukcja apoptozy w komórkach białaczek ludzkich molt4 i hl60 przez acyloksytriazoloakrydony - nową grupe związków o właściwościach przeciwnowotworowych
PublicationWykazazno, że acyloksytriazoloakrydony, podobnie jak badane wcześniej triazoloakrydony, indukują apoptozę w komórkach białaczek ludzkich MOLT4 i HL60 w stężeniach biologicznie istotnych, odpowiadających wartościom EC90 i EC80. Zjawisko apotozy zbadano w oparciu o zmiany morfologiczne w komórkach (ciałka apoptotyczne), międzynukleosomalną fragmentację DNA, zmiany w budowie błony cytoplazmatycznej, spadek mitochondrialnego potencjału...
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Electron ionization and low energy electron attachment to molecules of biological interest
PublicationEthylenediaminetetraacetic acid (EDTA) and 2-amino-2-(hydroxymethyl)-1,3-propanediol (TRIS) were investigated by electron impact ionization and low energy electron attachment. Both compounds are components of biological buffers and often are used as DNA stabilizers in irradiation studies. hus it is of a great importance to understand their potential interactions with radiation. Our results revealed that at least one of them, EDTA, may...
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Seafloor backscattering: numerical simulation vs. filter theory approach.
PublicationPrzedstawiono model opisujący rozpraszanie sygnału akustycznego na nierównomiernej, regularnie sfalowanej powierzchni dna morskiego jako filtr liniowy z odpowiedzią impulsową o zmieniającej się w czasie chwilowej dominującej częstotliwości. Porównano przewidywania modelu z wynikami otrzymanymi w wyniku złożonych obliczeniowo symulacji numerycznych opartych na fizycznym modelu zjawiska wykorzystującym aproksymację Kirchhoffa. Wstępnie...
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Cardinal regenerative features of the MRL mouse
PublicationIn this review, we discuss recent studies relating to major features of adult MRL mouse biology that contribute to the regenerative responses seen. These include an increased inflammatory cell profile, a unique glycolytic metabolic state typically found during embryogenesis, and a cell cycle phenotype of DNA damage and G2/M arrest. These traits have been found in other mammalian and non-mammalian regenerative systems. How these...
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Analysis of a gene expression model
PublicationWe study a mathematical model of gene transcription and protein synthesis with negative feedback. We consider a system of equations taking into account the number of active binding sites, the way in which dimers bind to DNA and time delay in translation process. For a simplified model that consist of three ordinary differential equations with time delay we derive conditions for stability of the positive steady state and for the...
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Konkurencyjność w handlu usługami wybranych krajów Europy Środkowo-Wschodniej
PublicationCelem artykułu jest ocena pozycji konkurencyjnej w handlu usługami wybranych krajów Europy Środkowo-Wschodniej – Czech, Estonii, Litwy, Łotwy, Polski, Słowacji oraz Węgier na tle gospodarki światowej. Dane wykorzystane do analizy pochodzą z bazy danych WIOD i obejmują lata 1995 – 2011. Podstawą oceny pozycji konkurencyjnej jest wskaźnik RCA obliczony na podstawie krajowej wartości dodanej oraz na podstawie eksportu brutto. Źródłem...
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Targeting yeast topoisomerase II by imidazo and triazoloacridinone derivatives resulting in their antifungal activity
PublicationFungal pathogens are considered as serious factors for deadly diseases and are a case of medical concern. Invasive fungal infections also complicate the clinical course of COVID-19, leading to a significant increase in mortality. Furthermore, fungal strains' multidrug resistance has increased the demand for antifungals with a different mechanism of action. The present study aimed to identify antifungal compounds targeting yeast...
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Results from a Genome-Wide Association Study (GWAS) in Mastocytosis Reveal New Gene Polymorphisms Associated with WHO Subgroups
PublicationMastocytosis is rare disease in which genetic predisposition is not fully understood. The aim of this study was to analyze associations between mastocytosis and single nucleotide polymorphisms (SNPs) by a genome-wide association study (GWAS) approach. A total of 234 patients were enrolled in our study, including 141 with cutaneous mastocytosis (CM; 78 children and 63 adults) and 93 with systemic mastocytosis (SM, all adults)....
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The comparison of cytotoxic and genotoxic activities of glucosinolates, isothiocyanates, and indoles
PublicationChemopreventive properties of Brassica vegetables are attributed mainly to their characteristic compounds—glucosinolates (GLs) and their main hydrolysis products—isothiocyanates (ITCs) and indoles. In this study, we compared antiproliferative activity (MTT test in HT29 cells) and genotoxic effects (comet assay in HT29 cells and restriction analysis in a cell-free system) of three GLs (sinigrin (SIN), glucotropaeolin (GTL), and...
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Anticancer Imidazoacridinone C-1311 is Effective in Androgen-Dependent and Androgen-Independent Prostate Cancer Cells
PublicationAndrogen receptor (AR) plays a crutial role in prostate cancer (PCa) development and metastasis. Here, we reported potent anti-PCa activity of a small molecule imidazoacridinone C-1311. In AR-positive PCa cells, C-1311 was found to inhibit the transcriptional activity of AR uncovering a novel mechanism that may be relevant for its anticancer effect. Mechanistically, C-1311 decreased AR binding to prostate-specific antigen (PSA)...
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Diagnostic Accuracy of Liquid Biopsy in Endometrial Cancer
PublicationBackground: Liquid biopsy is a minimally invasive collection of a patient body fluid sample. In oncology, they offer several advantages compared to traditional tissue biopsies. However, the potential of this method in endometrial cancer (EC) remains poorly explored. We studied the utility of tumor educated platelets (TEPs) and circulating tumor DNA (ctDNA) for preoperative EC diagnosis, including histology determination. Methods:...
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Service time distribution influence on end-to-end call setup delay calculation in networks with Session Initiation Protocol
PublicationThe most important GoS parameter for networks with SIP protocol is end-to-end call setup delay. So far there were no coherent models allowing calculation of these parameters for networks with SIP protocol. Few models were developed but they are insufficient. In the paper we propose model which allows end-to-end call setup delay calculation for networks with SIP protocol. The model is using chain of M/G/1/K models and is applicable...
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Nodal models of Pressurized Water Reactor core for control purposes – A comparison study
PublicationThe paper focuses on the presentation and comparison of basic nodal and expanded multi-nodal models of the Pressurized Water Reactor (PWR) core, which includes neutron kinetics, heat transfer between fuel and coolant, and internal and external reactivity feedback processes. In the expanded multi-nodal model, the authors introduce a novel approach to the implementation of thermal power distribution phenomena into the multi-node...
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Machine learning applied to acoustic-based road traffic monitoring
PublicationThe motivation behind this study lies in adapting acoustic noise monitoring systems for road traffic monitoring for driver’s safety. Such a system should recognize a vehicle type and weather-related pavement conditions based on the audio level measurement. The study presents the effectiveness of the selected machine learning algorithms in acoustic-based road traffic monitoring. Bases of the operation of the acoustic road traffic...
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Galerkin formulations of isogeometric shell analysis: Alleviating locking with Greville quadratures and higher-order elements
PublicationWe propose new quadrature schemes that asymptotically require only four in-plane points for Reissner–Mindlin shell elements and nine in-plane points for Kirchhoff–Love shell elements in B-spline and NURBS-based isogeometric shell analysis, independent of the polynomial degree p of the elements. The quadrature points are Greville abscissae associated with pth-order B-spline basis functions whose continuities depend on the specific...
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Machine learning applied to acoustic-based road traffic monitoring
PublicationThe motivation behind this study lies in adapting acoustic noise monitoring systems for road traffic monitoring for driver’s safety. Such a system should recognize a vehicle type and weather-related pavement conditions based on the audio level measurement. The study presents the effectiveness of the selected machine learning algorithms in acoustic-based road traffic monitoring. Bases of the operation of the acoustic road traffic...
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Inverse Flood Routing Using Simplified Flow Equations
PublicationThe paper considers the problem of inverse flood routing in reservoir operation strategy. The aim of the work is to investigate the possibility of determining the hydrograph at the upstream end based on the hydrograph required at the downstream end using simplified open channel flow models. To accomplish this, the linear kinematic wave equation, the diffusive wave equation and the linear Muskingum equation are considered. To achieve...
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Value co‐creation (VCC) and value co‐destruction (VCD) via open government data (OGD): Empirical case of Tanzania
PublicationHaving emphasized upon the potential benefits of Open Government Data (OGD) initiatives via value derivation and innovation pursuits of the stakeholders, it falls in place to complement this line of OGD research in the specific case of Tanzania, a developing country, to support the inferences. Specifically, it is important to understand the manner in which OGD VCC-one of the hinges of OGD initiatives- and OGD VCD-a possible fall...
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Polyacrylamide substrate viscosity impact on temozolomide activity in glioblastoma cells by flow cytometry and rheological measurements
Open Research DataDataset includes raw data on cell lines LN-229 and LN-18 treated with temozolomide measured by flow cytometry, rheometry and cell projections. It also includes calculations necessary for creation of figures and conclusions based on those figures in the publication titiled: "Substrate viscosity impairs temozolomide-mediated inhibition of glioblastoma...
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EPI-REG The epigenetic basis of regeneration in mammals: Genome-wide DNA methylation profiling in the MRL mouse
ProjectsProject realized in Faculty of Chemistry according to UMO-2011/01/B/NZ2/05352 agreement from 2011-12-27
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PCR detection of Scopulariopsis brevicaulis
PublicationScopulariopsis brevicaulis is known as a most common etiological factor of the mould toenail infections. There are also reports indicating that S. brevicaulis could cause organ and disseminated infections. Nowadays microscopic observations from the direct sample and culture are crucial for the appropriate recognition of the infection. In this paper is presented a PCR-based method for S. brevicaulis detection. The specificity of...
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Molecular detection of Candida krusei
PublicationThe species identification of fungi belonging to genus Candida is an important issue as this genus becomes the emerging problem of nosocomial infections. As Candida krusei presents intrinsicresistance to the fluconazole that is the drug of the first choice in case of invasive candidiasis the PCR identifying the DNA of C. krusei was elaborated. The analytical sensitivity of the assay on spiked blood samples was estimated at 3-5...
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Isolation and identification of Mycobacterium avium subspecies silvaticum from a horse
PublicationPo raz pierwszy opracowano metodę identyfikacji Mycobacterium avium subsp. silvaticum na podstawie analizy sekwencji DNA alfa antygenu. Zastosowanie enzymu HhaI do trawienia produktu PCR z uzyskanego z udziałem starterów specyficznych wobec genu kodującego alfa antygen pozwoliło na identyfikację Mycobacterium avium subsp. silvaticum. Opracowana nowa metoda pozwala na prowadzenie badań epidemiologicznych bezpośrednio z próbek pochodzących...
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Charakterystyka bakterii rodzaju Thermus i ich przydatność w biotechnologii
PublicationGram ujemne, termofilne bakterie rodzaju Thermus o optymalnych temperaturach wzrostu mieszczących się w zakresie 55-85 C są przydatne jako źródło nukleaz, polimeraz DNA oraz wielu innych termostabilnych enzymów. W przedstawionym artykule wymieniono występowanie i morfologię bakterii rodzaju Thermus, sposoby odżywiania i warunki ich wzrostu, budowę struktur powierzchniowych, sposoby adaptacji do wzrostu w podwyższonej temperaturze...
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Nowoczesne metody diagnostyki zakażeń dermatofitowych
PublicationGrzyby należące do rodzajów Microsporum, Trichophyton i Epidermophyton są główną przyczyną powierzchownych zakażeń grzybiczych. Klasyczna identyfikacja gatunkowa czynnika etiologicznego tych grzybic oparta na obserwacjach mikro- i makroskopowych możliwa jest dopiero po uzyskaniu czystej hodowli dermatofitów. W związku z powolnym tempem wzrostu jest ona możliwa po dwóch, trzech tygodniach po pobrania próbki. Molekularne metody diagnostyczne...
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Relationship between conversion rate of glucosinolates to isothiocyanates/indoles and genotoxicity of individual parts of Brassica vegetables
PublicationThe studies on the characterisation of glucosinolates (GLs) and their breakdown products in Brassicaceae species focus mainly on the edible parts. However, other products, e.g., dietary supplements, may be produced also from non-edible parts such as roots or early forms of growth: seeds or sprouts. Biological activity of these products depends on quantitative and qualitative GL composition, but is also strictly determined by GL...
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Relation of the polymorphism of cyp51A sequence and the susceptibility of Aspergillus fumigatus isolates to triazoles determined by commercial gradient test (Etest) and by reference methods
PublicationThe aim of this study was to evaluate the accuracy of commercial gradient test (Etest) in the detection of triazole resistant Aspergillus fumigatus isolates using reference microdilution methods and the analysis of sequences of the cyp 51A gene. The study was performed on twenty clinical isolates which were identified as Aspergillus fumigatus based on the DNA sequences of the ITS1-2 fragment of ribosomal DNA and the β-tubulin gene,...
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Epigenetic inhibitor zebularine activates ear pinna wound closure in the mouse
PublicationBackground:Most studies on regenerative medicine focus on cell-based therapies and transplantations.Small-molecule therapeutics, though proved effective in different medical conditions, have not been extensivelyinvestigated in regenerative research. It is known that healing potential decreases with development and devel-opmental changes are driven by epigenetic mechanisms, which suggests epigenetic repression of regenerativecapacity.Methods:We...
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Koncepcja międzynarodowej konkurencyjności makrootoczenia przedsiębiorstw
PublicationCelem badań przedstawionych w niniejszym artykule jest opracowanie koncepcji konkurencyjności międzynarodowej (IC) krajów, której podstawą jest makroekonomiczne otoczenie przedsiębiorstw. Motywem podjęcia tych badań były poważne wady metodologii pomiaru IC gospodarek stosowanej przez Światowe Forum Ekonomiczne (WEF). WEF rekomenduje Globalny Indeks Konkurencyjności (GCI) jako globalną miarę produktywności kraju. WEF utrzymuje,...
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Epigenetic regulation and regeneration: the search for differentially methylated genes in the MRL mouse
PublicationThe MRL mouse is an inbred laboratory strain, which was developed in the 60’s of the 20th century and has been extensively used as a model of lupus erythematosus. The regenerative abilities of the strain were discovered in the 90' when the MRL mouse was shown to close 2 mm hole punches made in the ear pinnae four weeks after injury without scarring. The phenomenon has not been observed in other mouse strains, where the holes...
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First detection of spectral resonance structures of the ionospheric Alfvén resonance in ULF/ELF magnetic field recorded at Suwałki, Poland
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“Electromagnetic ULF/ELF Fields on Earth and in Space” Conference, Warsaw, Poland, 2019. Preface
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