Search
Filters
total: 2901
filtered: 1781
-
Catalog
Chosen catalog filters
displaying 1000 best results Help
Search results for: AMINO COLUMN
-
Retention modeling of some saccharides separated on an amino column.
PublicationUsing an amino column (Supelcosil LC-NH2) and different mixtures of acetonitrile-water, quantitative structure-retention relationship models are discussed. These models are based on computed molecular descriptors representing numerically structured features of some saccharides. The obtained results are underlining the lipophilicity/hydrophilicity balance, and how this is controlling the separation of the saccharides. The resulting...
-
Aparatura, kolumna, sprawność rozdzielania, przepuszczalność kolumny.
PublicationOmówiona została aparatura chromatograficzna. Opisano budowę i zasady działania najważniejszych modułów składowych aparatu HPLC tj. pompy, zaworu dozującego lub automatycznego podajnika próbek, kolumny chromatograficznej, termostatu kolumn i zaworów proporcjonujących. Omówiono elucję gradientową, problemy z jej stosowaniem i zalecenia praktyczne. Szczegółowo omówiono detektory stosowane w chromatografii cieczowej. Przedstawiono...
-
Influence of the Type of Amino Acid on the Permeability and Properties of Ibuprofenates of Isopropyl Amino Acid Esters
Publication -
The Synthesis of 3-Amino-pyrazine-2-carbohydrazide and 3-Amino-N'-methylpyrazine-2-carbohydrazide Derivatives
PublicationW poszukiwaniu biologicznie aktywnych związków otrzymano szereg pochodnych 3-Amino-pirazyno-2-karbohydrazydu i 3-Amino-N'-metylopirazyno-2-karbohydrazydu w wyniku reakcji hydrazydu aminopirazynoinowegokwasu z izocyjanianami, aldehydami, ketonami, CS2 i kwasem mrówkowym.
-
Chirality Measures of α-Amino Acids
Publication -
Amino acid formation by electron irradiation
PublicationW artykule zaprezentowano procedurę badania reakcji indukowanych przez niskoenergetyczne elektrony w mieszanych warstwach molekularnych CH3COOD:NH3.
-
Biosynthetic and synthetic access to amino sugars.
PublicationAmino sugars are important constituents of a number of biomacromolecules and products of mi crobial secondary metabolism, including antibiotics. For most of them, the amino group is located at the positions C1, C2 or C3 of the hexose or pentose ring. In biological systems, amino sugars are formed due to the catalytic activity of specific aminotransferases or amidotransferases by introducing an amino functionality derived from L-glutamate...
-
Buckling analysis of cold formed steel column
PublicationW pracy przedstawiono analizę słupa zimnogiętego o przekroju otwartym. Przeprowadzono analizy statyczne liniowe i nieliniowe. Analizowano wpływ podłoża sprężystego oraz sztywność połączenia dwóch sąsiednich słupów.
-
Buckling Analysis of Cold Formed Silo Column
PublicationThe paper is devoted to stability analysis of different models of steel cold formed silo column. The steel cylindrical silos are often composed of corrugated walls and vertical open-sectional columns uniformly placed along the silo circumference. Both the whole 3D silo, a simplified model consisting of one column with a part of the silo walls, and a single column resting on elastic foundation provided by the silo walls were analyzed....
-
Applications of Unnatural Amino Acids in Protease Probes
Publication -
Inhibitors of amino acids biosynthesis as antifungal agents
PublicationFungal microorganisms, including the human pathogenic yeast and filamentous fungi, are able to synthesize all proteinogenic amino acids, including nine that are essential for humans. A number of enzymes catalyzing particular steps of human-essential amino acid biosynthesis are fungi specific. Numerous studies have shown that auxotrophic mutants of human pathogenic fungi impaired in biosynthesis of particular amino acids exhibit...
-
Amino Acid and Peptide‐Based Antiviral Agents
PublicationA significant number of antiviral agents used in clinical practice are amino acids, short peptides, or peptidomimetics. Among them, several HIV protease inhibitors (e. g. lopinavir, atazanavir), HCV protease inhibitors (e. g. grazoprevir, glecaprevir), and HCV NS5A protein inhibitors have contributed to a significant decrease in mortality from AIDS and hepatitis. However, there is an ongoing need for the discovery of new antiviral...
-
Biogenne aminy
PublicationW rozdziale omówiono zagadnienia związane z powstawaniem biogennych amin w surowcach i produktach żywnościowych oraz ich wpływ na zdrowie konsumentów.
-
Amino Acid Based Antimicrobial Agents – Synthesis and Properties
PublicationStructures of several dozen of known antibacterial, antifungal or antiprotozoal agents are based on the amino acid scaffold. In most of them, the amino acid skeleton is of a crucial importance for their antimicrobial activity, since very often they are structural analogs of amino acid intermediates of different microbial biosynthetic pathways. Particularly, some aminophosphonate or aminoboronate analogs of protein amino acids are...
-
Determination of the shape of the CFGFT cylindrical column based on laboratory tests
PublicationAnalyses were carried out on glass-fibre-reinforced polymer tube columns with reference to laboratory tests. The angles of the glass fibre beams were 20◦, 55◦ and 85◦. The study employed non-classical operational calculus. Various modulated harmonic signal shapes were considered for columns and tubes at buckling. The buckling loads were assessed and compared for different models.
-
THE INTERACTION BETWEEN STEEL COLUMN CHORD AND CLOSELY SPACED REINFORCEMENT.
PublicationNowadays, more often than before, civil engineering designers are willing to use steel build-up members composed of single or doubled cold-formed chords interconnected using different mechanical connectors. This paper subject is an analysis of cooperation of a closely spaced built-up cold-formed chord interconnected with series of bolts that are located along the length of the member in a specific spacing. This distance along the...
-
Oxygen accumulation rate with and without live bacteria in column bioreactors
PublicationBadano wnikanie i akumulację tlenu w reaktorach airlift z cyrkulacją zewnetrzną. Stosowano reaktory z odwrotną warstwą fluidalną w strefie opadania, warstwą fluidalną w strefie wznoszenia oraz reaktor z cyrkulującą zawiesiną. Badano wpływ prędkości przepływu powietrza oraz stężenia cząstek stałych na szybkośc akumulacji tlenu w cieczy w reaktorach nie zawierających bakterii oraz w obecności bakterii Acinetobacter calcoaceticus...
-
Influence of stirrups in a concrete shell on strengthening reinforced concrete column
PublicationTwelve concrete columns, with a 150x150mm square section and three columns with a circular section (d=200mm), are tested to investigate the effect of strengthening by RC jacket. Based on a confined concrete model for axial static loading, an analytical methods, reported in the literature are proposed to predict the behavior of columns with RC jacket. The results support the conception that the effect of strengthening depends...
-
α-Amino Acids In Water: A Review Of VCD And ROA Spectra
Publication -
Calix[4]arene phosphonates - recognition of amino alcohols in water.
PublicationOpracowano syntezę nowych rozpuszczalnych w wodzie pochodnych kaliks[4]arenów posiadających grupy fosfonowe w górnej części pierścieni aromatycznych. Zaprezentowano wyniki kompleksowania tych gospodarzy aminoalkoholi takich jak efedryna, norefedryna i noradrenalina.
-
Immunosuppressive properties of amino acid and peptide derivatives of mycophenolic acid
PublicationMycophenolic acid (MPA) was coupled with amino acids and biologically active peptides including derivatives of tuftsin to modify its immunosuppressive properties. Both amino acid unit in the case of simple MPA amides and modifications within peptide moiety of MPA - tuftsin conjugates influenced the observed activity. Antiproliferative potential of the obtained conjugates was investigated in vitro and MPA amides with threonine methyl...
-
Synthesis and biological activity of mycophenolic acid-amino acid derivatives
Publication -
The Relationship between the Structure and Properties of Amino Acid Ionic Liquids
Publication -
Symmetrical and unsymmetrical diphosphanes with diversified alkyl, aryl and amino substituents
PublicationWe present the comprehensive study of diphosphanes with diversified substituents regarding their syntheses, structures, and properties. To this end, we have synthesized a series of novel unsymmetrical alkyl, aryl and amino-substituted diphosphanes of the general formula R1R2P-PR3R4 (where R1, R2, R3, R4 = tBu, Ph, Et2N or iPr2N) via salt metathesis reactionof halophosphanes with metal phosphides in high yield. We vastly expanded...
-
Atropoisomerism in Mono- and Diaryl-Substituted 4-Amino-2,6-lutidines
Publication -
Synthesis and biological activity of mycophenolic acid-amino acid derivatives
PublicationIn search of new immunosuppressants, mycophenolic acid (MPA) was coupled with amino acid methyl esters followed by hydrolysis to analogs bearing free carboxylic groups. The obtained compunds were tested in vitro as growth inhibitors of lymphoid cell line (Jurkat) and human peripheral blood mononuclear cells (PBMC) from healthy donors. According to obtained results recovering of free carboxylic group increased their activity. Additionally,...
-
Hydration of amino acids: FTIR spectra and molecular dynamics studies
PublicationThe hydration of selected amino acids, alanine, glycine, proline, valine, isoleucine and phenylalanine, has been studied in aqueous solutions by means of FTIR spectra of HDO isotopically diluted in H2O. The difference spectra procedure and the chemometric method have been applied to remove the contribution of bulk water and thus to separate the spectra of solute-affected HDO. To support interpretation of obtained spectral results,...
-
Anticancer Properties of Amino Acid and Peptide Derivatives of Mycophenolic Acid
PublicationBackground: Although Mycophenolic Acid (MPA) is applied as prodrugs in clinic as an immunosuppressant, it also possesses anticancer activity. MPA acts as Inosine-5’-Monophosphate Dehydrogenase (IMPDH) inhibitor, where the carboxylic group at the end of the side chain interacts with Ser 276 of the enzyme via hydrogen bonds. Therefore, MPA derivatives with other polar groups indicated high inhibition too. On the other hand, potent...
-
Molecular targets for antifungals in amino acid and protein biosynthetic pathways
PublicationFungi cause death of over 1.5 million people every year, while cutaneous mycoses are among the most common infections in the world. Mycoses vary greatly in severity, there are long-term skin (ringworm), nail or hair infections (tinea capitis), recurrent like vaginal candidiasis or severe, life-threatening systemic, multiorgan infections. In the last few years, increasing importance is attached to the health and economic problems...
-
Soil improvement by short stone columns.
PublicationW artykule przedstawiono sposób dogęszczania podłoża gruntowego wykorzystywany do renowacji istniejących nawierzchni placów składowych i dróg. Proponowany sposób polega na formowaniu w gruncie kolumny o niewielkiej średnicy. Kolumnę tą formuje się poprzez wbijanie w rozluźnione podłoże trzpienia stalowego, z jednoczesnym dosypywaniem gruntu.Sposób ten stosuje się przede wszystkim jako metodę wzmocnienia podłoża pod nawierzchniami...
-
Free vibration of truncated-cone columns
Publication -
Behaviour of steel columns under impact
PublicationOne of import issues related to the idea of sustainable society is the safety of civil engineering structures. The safety and reliability of steel structures under impact loading is among a number of different aims during the design state. The aim of this paper is to present the results of investigation focused on dynamic behaviour of steel columns under impact loading. Modal and transient dynamic analyses using Finite Element...
-
Post-peak behaviour of CFST columns
PublicationArtykuł dotyczy zachowania pokrytycznego słupów CFST. Parametrami zmiennymi w badaniach są: wysokość słupów, grubość stalowego płaszcza, wytrzymałość betonu i stali, przyczepność między stalowym płaszczem a betonowym rdzeniem oraz sposób przykładania obciążenia. W artykule dokonano analizy wpływu tych parametrów na zachowanie pokrytyczne badanych słupów.
-
Local buckling of composite channel columns
PublicationThe investigation concerns local buckling of compressed flanges of axially compressed composite channel columns. Cooperation of the member flange and web is taken into account here. The buckling mode of the member flange is defined by rotation angle a flange about the line of its connection with the web. The channel column under investigation is made of unidirectional fibre-reinforced laminate. Two approaches to member orthotropic...
-
Installation of CMC columns in overconsolidated clays
PublicationDuring rigid inclusions execution in the subsoil some monitoring data are registered by a drilling rig for quality control. The use of these data can improve the design procedure of soil improvement as they can provide some information about the position of bearing strata and the energy necessary to install the column in the ground. In this paper the parameters registered in a drilling machine are described, the installation...
-
The verification of the estimation of transport and sorption parameters in the MATLAB environment. Column test
Publication -
THE PULSE DESCRIPTORS IN SENSITIVITY STUDIES OF HYBRID SORPTION COLUMN TRANSPORT MODELS
Publication -
Torsional buckling of thin walled I beam column with warping stiffeners.
Publication.
-
Buckling and post-buckling behavior of column with central non-linear restraint
PublicationW pracy bada się wyboczenie giętne i zachowanie pokrytyczne ściskanego osiowo pręta z nieliniową sprężystą podporą w środku rozpiętości przęsła. Rozwiązanie problemu wyznaczono za pomocą metody małego parametru. Podano przykład numeryczny wyboczenia i zachowania pokrytycznego swobodnie podpartego pręta z nieliniową sprężytą podporą w środku rozpiętości. Wykazano istotny wpływ nieliniowości podpory na zachowanie pokrytyczne pręta.
-
Production of fine droplet emulsions in the agitated draft-tube column reactor
PublicationBadano rozkłady wielkości kropel emulsji woda - olej parafinowy w reaktorze dwukolumnowym z mieszaniem w kolumnie wewnętrznej jako strefie wznoszenia. Stosując model dyspersyjny w układzie zamkniętym z całkowitą recyrkulacją, wyznaczono obwodowe i strefowe współczynniki dyspersji
-
Mechanical characterization of a gravel column in a calibration chamber operating as a triaxial cell
PublicationA series of tests considering the behavior of gravel columns was performed. A segment of column with a height of 1 m and a diameter of 0.53 m was modelled in a calibration chamber used as a triaxial cell at three different lateral stress applied. The vertical load transferred on the column head was simulated with steady increase of water pressures in the upper and lower membranes. During the loading the volumetric changes in the...
-
Stability and limit load analysis of a cold-formed channel section column
PublicationThe paper presents stability and limit load analysis of a steel column 1440 mm high of a cold-formed channel section, subjected to a combination of compression and bending. Experimental results were compared to the resistance of a code procedure and to the outcome of numerical non-linear analysis. Comparison was made of numerical solutions by means of static (Riks) and dynamic (Explicit and Implicit) methods. Perfectly elastic...
-
Analysis of floor-to-column pounding of buildings founded on different soil types
PublicationThe aim of this study is to investigate the effect of the soil type on buildings experiencing floor-to-column pounding during earthquakes. Five buildings with 4-storeys, 6-storeys, and 7-storeys were considered. Three types of the 4-storey building with different total heights were taken into account which leads to floor-to-column pounding at 1/3, 1/2 and 2/3 of the height of the impacted column. Two pounding scenarios were considered,...
-
N-alkyl derivatives of 2-amino-2-deoxy-D-glucose
PublicationMono- i di-N-alkilowe pochodne 1,3,4,6-tetra-O-acetylo-2-amino-2-deoksy-beta-D-glukozy (alkil = metyl, etyl, propyl, butyl, pentyl, heksyl, benzyl) otrzymano w wyniku redukcyjnej alkilacji per-O-acetylo-D-glukozaminy. (N-etylo, N-propylo, N-butylo, N-pentylo, N-heksylo)-1,3,4,6-tetra-O-acetylo-2-amino-2-deoksy-beta-D-glukozy deacetylowano w celu podjęcia prób enzymatycznej fosforylacji. Wszystkie produkty scharakteryzowano za pomocą...
-
Spectroscopic Studies of Amino Acid Ionic Liquid-Supported Schiff Bases
Publication -
Benzalkonium Salts of Amino Acids – Physicochemical Properties and Anti-Microbial Activity
Publication -
Synthesis of conjugates of amino-combretastatin with tuftsin derivatives as potential anticancer agents
PublicationOpisano syntezę nowych koniugatów 3'-N-(tuftsyno lub retro-tuftsyno)-amino-kombretastatyny jako potencjalnych związków przeciw-nowotworowych. Do syntezy amino-kombretastatyny (amino-CA-4) wykorzystano reakację Wittiga a koniugatów metodę DPPA. Mamy nadzieję, że połączenie pochodnych tuftsyny z amino-CA-4 wpłynie na polepszenie właściwości terapeutycznych CA-4.
-
Synthesis and antimicrobial activity of amino acid and peptide derivatives of mycophenolic acid
PublicationThe series of 16 novel amino acid and peptide mycophenolic acid (MPA) derivatives was obtained as potential antibacterial agents. Coupling of MPA with respective amines was optimized with condensing reagents such as EDCI/DMAP and T3P/TEA. Amino acid analogs were received both as methyl esters and also with the free carboxylic group. The biological activity of the products was tested on five references bacterial strains: Klebsiella...
-
Oligomers and peptidomimetics consisting of methyl 3-amino-2,3-dideoxyhexopyranosiduronic acids
Publication -
Synthesis of linear tuftsin analogues modified at the epsilon-amino group of lysine
PublicationZsyntetyzowano na fazie stałej nowe analogi tuftsyny i retro-tuftsyny zawierające wiązanie isopeptydowe na epsilon-aminowej grupie lizyny jako potencjalne immunostymulatory. Do syntezy wykorzystano standardową procedurę Fmoc. Po zdjęciu osłon kwasem TFA końcowe związki były oczyszczane, liofilizowane i charakteryzowane: MS, HPLC i NMR.