Search
Filters
total: 14431
filtered: 12032
-
Catalog
- Publications 12032 available results
- Journals 230 available results
- Conferences 47 available results
- People 238 available results
- Inventions 3 available results
- Projects 55 available results
- Laboratories 5 available results
- Research Teams 12 available results
- Research Equipment 9 available results
- e-Learning Courses 692 available results
- Events 42 available results
- Offers 1 available results
- Open Research Data 1065 available results
Chosen catalog filters
displaying 1000 best results Help
Search results for: MODELE IN VITRO
-
Application of human bile salts for in vitro digestion models
PublicationIn this study, experimental in vitro models simulating the environment of the human gastrointestinal tract were used to assess the impact of physiological surfactants, such as bile salts, on the kinetics of digestion. Bile salts are biosurfactants synthesised in the liver and secreted together with bile into the small intestine. There are many reports on the role of bile salts in lipolysis, but the knowledge of their influence...
-
Correlation between in vitro and in vivo data on food digestion. What can we predict with static in vitro digestion models?
PublicationDuring the last decade, there has been a growing interest in understanding food's digestive fate in order to strengthen the possible effects of food on human health. Ideally, food digestion should be studied in vivo on humans but this is not always ethically and financially possible. Therefore, simple in vitro digestion models mimicking the gastrointestinal tract have been proposed as alternatives to in vivo experiments. Thus,...
-
Specificity of Infant Digestive Conditions: Some Clues for Developing Relevant In Vitro Models
PublicationDigestion of nutrients is an essential function of the newborn infant gut to allow growth and development and understanding infant digestive function is essential to optimize nutrition and oral drug delivery. Ethical considerations prohibit invasive in vivo trials and as a consequence in vitro assays are often conducted. However, the choice of in vitro model parameters are not supported by an exhaustive analysis of the literature...
-
PTD4 Peptide Increases Neural Viability in an In Vitro Model of Acute Ischemic Stroke
PublicationIschemic stroke is a disturbance in cerebral blood flow caused by brain tissue ischemia and hypoxia. We optimized a multifactorial in vitro model of acute ischemic stroke using rat primary neural cultures. This model was exploited to investigate the pro-viable activity of cell-penetrating peptides: arginine-rich Tat(49–57)-NH2 (R49KKRRQRRR57-amide) and its less basic analogue, PTD4 (Y47ARAAARQARA57-amide). Our model included glucose...
-
Combination of therapy with 5-fluorouracil and cisplatin with electroporation in human ovarian carcinoma model in vitro
Publication -
Chaotic modes of oscillation of a vibro-impact system
Publication -
Static in vitro digestion model adapted to the general older adult population: an INFOGEST international consensus
PublicationUnderstanding the mechanisms of food digestion is of paramount importance to determine the effect foods have on human health. Significant knowledge on the fate of food during digestion has been generated in healthy adults due to the development of physiologically-relevant in vitro digestion models. However, it appears that the performance of the oro-gastrointestinal tract is affected by ageing and that a model simulating the digestive...
-
Flavonoids as tyrosinase inhibitors in in silico and in vitro models: basic framework of SAR using a statistical modelling approach
Publication -
Potential Use of Silica Nanoparticles for the Microbial Stabilisation of Wine: An In Vitro Study Using Oenococcus oeni as a Model
Publication -
Retrofitted vibro-pressed pavement bricks and their impregnation in modern architecture.
PublicationRecent construction projects require new properties of concrete building materials. The paper describes the technological methods of retrofitting of vibro-pressed concrete pavement brick and shows the results of improving physical properties of concrete by application of different impregnation agents.
-
Novel Nystatin A1 derivatives exhibiting low host cell toxicity and antifungal activity in an in vitro model of oral candidosis
PublicationOpportunistic oral infections caused by Candida albicans are frequent problems in immunocompromised patients. Management of such infections is limited due to the low number of antifungal drugs available, their relatively high toxicity and the emergence of antifungal resistance. Given these issues, our investigations have focused on novel derivatives of the antifungal antibiotic Nystatin A1, generated by modifications at the amino...
-
Usability of Mobile Applications: A Consolidated Model
PublicationMobile devices have become an integral part of the digital ecosystem, connecting people, businesses, and information around the world in ways never before possible. In particular, smartphones, tablets and other handheld devices equipped with mobile applications have changed every aspect of our lives. Today, a user can choose from nearly five million applications available for both Android and iOS operating systems. However, only...
-
Effect of oxidation and in vitro intestinal hydrolysis on phospholipid toxicity towards HT29 cell line serving as a model of human intestinal epithelium
PublicationOxidation of food-derived phospholipids (PLs) can influence nutrient digestion and induce oxidative stress in gastrointestinal epithelium. In this study, hen egg yolk PL fraction was used to evaluate the effect of lipoxygenase (LOX)-induced PL oxidation on the rate of PL hydrolysis catalyzed by pancreatic phospholipase A2 (PLA2) in the presence of bile salts (BSs). Then, PL/BS solutions containing native or oxidized PLs were used...
-
Uniform Model Interface for Assurance Case Integration with System Models
PublicationAssurance cases are developed and maintained in parallel with corresponding system models and therefore need to reference each other. Managing the correctness and consistency of interrelated safety argument and system models is essential for system dependability and is a nontrivial task. The model interface presented in this paper enables a uniform process of establishing and managing assurance case references to various types...
-
Shape-Depended Biological Properties of Ag3PO4 Microparticles: Evaluation of Antimicrobial Properties and Cytotoxicity in In Vitro Model—Safety Assessment of Potential Clinical Usage
Publication -
In Vitro Dissolution of Na-Ca-P-Oxynitrides
Publication: Sodium-calcium-phosphate based oxynitride glasses and glass-ceramics doped with Mg, Si, and Nb were studied in vitro in simulated body fluid (SBF) under static conditions. The release of ions and pH changes up to 7 days of immersion were investigated. The nitrogen incorporation into phosphate glass matrix was found to notably influence in vitro dissolution only of homogenous glasses. Increasing the nitrogen content in the samples...
-
In vitro toxicity studies of biodegradable, polyelectrolyte nanocapsules
Publication -
In vitro screening of 65 mycotoxins for insecticidal potential
Publication -
Comparative in vitro research of the Human Aortic Bioprosthesis
PublicationE valuate of the usefulness and reliability of structures based on the analysis of recorded parameters determining the flow through the Human Aortic Bioprosthesis (HAB) have been dealt with. By flow parameters changes determining the performance environment of prosthesis analyzed change of the motion dynamics of the valve leaflets as a function of pressure, thereby determining the degree of alignment of the prosthesis to the performance...
-
Degradation of implantable materials – in vivo and in vitro research
PublicationThe article concerns the biological and electrochemical degradation of metallic implants in vivo and in vitro studies. The in vivo research dealt with degradation of plates used to join bones, as well as endoprostheses. The most common damages were: metalosis, breaking in the microstructure changes, breaking in area of holes, as well as plastic deformation throughout the length of an implant. The material used for the research...
-
Modified polycarbonate urethane: synthesis, properties and biological investigation in vitro
PublicationNowy poliweglano uretan (PCU-I) otrzymano z alifatycznych monomerów: poliwęglanu heksanodiolu, 4,4'diizocyjanianu dicykloheksanometanu, mieszaniny małocząsteczkowych dioli i oleju rycynowego (zawierającego głównie trigliceryd kwasu 12-hydroksyoleinowego). PCU-II otrzymano analogicznie ale bez udziału oleju rycynowego. Obydwa PCU charakteryzowały się dobrą wytrzymałością na rozciąganie. PCU-I miał niższą temperaturę zeszklenia a...
-
Aktywne modele kształtu i ich biometryczne zastosowania = Active shape models and their biometric applications
PublicationAktywne modele kształtu zostały zaproponowane w latach 90 XX wieku jako uniwersalna metoda lokalizowania i rozpoznawania obiektów. Koncepcje teoretyczne, na których metoda ta została oparta, wydają się obiecujące, jednak ich praktyczna wartość nie została jeszcze do końca zweryfikowana. Autorzy niniejszej pracy przeprowadzili testy aktywnych modeli kształtu za pomocą własnego systemu lokalizacji obiektów, szczególną uwagę zwracając...
-
Use of Cytokine Mix-, Imiquimod-, and Serum-Induced Monoculture and Lipopolysaccharide- and Interferon Gamma-Treated Co-Culture to Establish In Vitro Psoriasis-like Inflammation Models
Publication -
Bile conjugation and its effect on in vitro lipolysis of emulsions
PublicationBile Salts (BS) are responsible for stimulating lipid digestion in our organism. Gut microbiota are responsible for the deconjugation process of primary conjugated to secondary unconjugated BS. We use two structurally distinct BS and characterize the rate of lipolysis as a compound parameter. A static in-vitro digestion model as well as meta-analysis of literature data has been performed to determine the most influential factors...
-
In Vitro Measurement of Conformational Stability of Fibrinogen Adsorbed on Siloxane
Publication -
In-vitro controlled release of doxorubicin from silica xerogels
Publication -
Impact of isoflavone genistein on psoriasis in in vivo and in vitro investigations
Publication -
Potential applications of plant in vitro cultures in phytoremediation studies
Publication -
The effectiveness of chemotherapy and electrochemotherapy on ovarian cell lines in vitro
Publication -
Nanocrystallization as a tool for controlling in vitro dissolution of borophosphate glass
PublicationThe controlled nanocrystallization of sodium-calcium-borophosphate glass (Na16.6Ca5.1B10.5Al0.8P10.5 O56.5 in at %) was conducted to investigate its influence on in vitro dissolution. Three temperatures (570 ◦C, 590 ◦C, and 610 ◦C) were selected based on thermal analysis and investigation of the morphology, structure, and in vitro dissolution of glass and glass-ceramics was conducted. The results of X-ray diffraction confirmed...
-
In Vitro Biological Evaluation of Aprepitant Based 177Lu-Radioconjugates
Publication -
In vitro anticariogenic effects of polyphenolics from Potentilla recta
Publication -
In vitro evaluation of novel lipopeptides with potential therapeutic application
PublicationThe synthesis of derivatives of Gly-His-Lys was elaborated followed by their antimicrobial activity investigation.
-
INFOGEST static in vitro simulation of gastrointestinal food digestion
PublicationDeveloping a mechanistic understanding of the impact of food structure and composition on human health has increasingly involved simulating digestion in the upper gastrointestinal tract. These simulations have used a wide range of different conditions that often have very little physiological relevance, and this impedes the meaningful comparison of results. The standardized protocol presented here is based on an international consensus...
-
Antibacterial activity of the secondary metabolites from in vitro cultures of Drosera aliciae
PublicationRośliny owadożerne (D. aliciae) metabolity wtórne farmakologicznie czynne substancje. Na wzrost akumulacji tychże substancji w tkankach roślin owadożernych ma wpływ dodatek elicytora. Końcowego oznaczenia zawartości metabolitów w ekstraktach roślinnych dokonano techniką chromatografii cieczowej.
-
Derivation of Executable Test Models From Embedded System Models using Model Driven Architecture Artefacts - Automotive Domain
PublicationThe approach towards system engineering compliant to Model-Driven Architecture (MDA) implies an increased need for research on the automation of the model-based test generation. This applies especially to embedded real-time system development where safety critical requirements must be met by a system. The following paper presents a methodology to derive basic Simulink test models from Simulink system models so as to execute them...
-
Efficacy and safety of phage therapy against Salmonella enterica serovars Typhimurium and Enteritidis estimated by using a battery of in vitro tests and the Galleria mellonella animal model
Publication -
Cancer stem cells and escape from drug-induced premature senescence in human lung tumor cells: implications for drug resistance and in vitro drug screening models
PublicationBadania z użyciem modelu komórek nowotworu płuc A549 wykazały, że komórki te po traktowaniu lekami uszkadzającymi DNA zatrzymują proliferację i wchodzą w stan starzenia komórkowego. Jednak post-inkubacja tych komórek prowadzi do powrotu do stanu proliferacji małej frakcji komórek. Wykazaliśy, że frakcja ta związana jest z obecnością komórek pierwotnych nowotworu w populacji komórek A549. Powrót do stanu proliferacji komóek A549...
-
Sensitivity of binomial N‐mixture models to overdispersion: The importance of assessing model fit
Publication -
The role and concept of sub-models in the smart fuzzy model of the internet mortgage market
PublicationThe paper introduces some challenges of the fast growing mortgage market in Poland. One of these challenges is the need for a model development that could be used for various predictions related to this market. At the current stage of the model evelopment process our main goal is to propose and introduce sub-models the role of which would be to describe three different economic environments: stable, fast growing, and recession....
-
A compact smart sensor based on a neural classifier for objects modeled by Beaunier's model
PublicationA new solution of a smart microcontroller sensor based on a simple direct sensor-microcontroller interface for technical objects modeled by two-terminal networks and by the Beaunier’s model of anticorrosion coating is proposed. The tested object is stimulated by a square pulse and its time voltage response is sampled four times by the internal ADC of microcontroller. A neural classifier based on measurement data classifies the...
-
Systemy ekspresyjne białek cytochromu P450 w badaniach in vitro metabolizmu leków = Expression systems of cytochrome P450 proteins in studies of drug metabolism in vitro
PublicationBiałka cytochromu P450 to najważniejsze enzymy biorące udział w metabolizmie większości stosowanych w klinice leków, odpowiedzialne za ich aktywację lub detoksykację. Niektóre z dróg metabolizmu leku mogą być jednak odpowiedzialne za jego podwyższoną toksyczność. Nowe systemy ekspresyjne białek cytochromu P450 w komórkach ssaków, w tym człowieka, projektowane są w celu poznania roli metabolizmu w mechanizmie działania potencjalnych,...
-
Integracja modeli ocenowych rozwoju organizacji IT w modelu pozyskiwania i przetwarzania wiedzy
PublicationCelem rozdziału jest prezentacja Modelu Pozyskiwania i Przetwarzania wiedzy (MPPW) wspomagającego rozwój organizacji IT oraz pokazanie możliwości wprowadzenia do opracowanego rozwiązania różnych modeli ocenowych.
-
Cytotoxicity of doxorubicin conjugated with C60 fullerene. Structural and in vitro studies
Publication -
Nanoparticles Influence Lytic Phage T4-like Performance In Vitro
Publication -
Antiglycoxidative properties of amantadine – a systematic review and comprehensive in vitro study
Publication -
Calophyllum inophyllum in vaginitis treatment: Stimulated by electroporation with an in vitro approach
Publication -
The in vitro culture supplements and selected aspects of canine oocytes maturation
Publication -
In Vitro Study of a Stentless Aortic Bioprosthesis Made of Bacterial Cellulose
Publication -
In vitro and in silico assessment of anti-inflammatory activity of cocoa powders
PublicationPlants are considered the major sources of biologically active compounds, which provide unlimited opportunities for their use either as medical treatments or as novel drug formulations. Cocoa powder is frequently used in nutrition and is known to have many benefits thanks to its wide range of biological activities. The presented study was focused on th evaluation of the anti-inflammatory potential of extracts obtained from cocoa...