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Search results for: BIOLOGICAL THREATS
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Meldrum’s acid assisted formation of tetrahydroquinolin‑2‑one derivatives a short synthetic pathway to the biologically useful scaffold
PublicationA new method for the preparation of tetrahydroquinolin-2-one derivatives is presented. This approach involves a two-step reaction between enaminones and acylating agents, immediately followed by electrophilic cyclization, all within a single synthesis procedure, eliminating the need to isolate intermediates. The entire process is facilitated by the use of acyl Meldrum’s acids which not only shortens the preparation time of the...
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Investigation of ecological parameters of a gas turbine combustion chamber with steam injection for the floating production, storage, and offloading vessel
PublicationThe article is dedicated to the investigation of the possibility of using the contact type gas turbine cycle with steam injection into the combustion chamber for the floating production, storage, and offloading vessel in order to increase the specific power and efficiency and reduce emissions of toxic components. A new approach is proposed, associated with the use of the two-stage injection of superheated steam into a gas turbine...
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Combined cold supply system for ship application based on low GWP refrigerants - Thermo-economic and ecological analyses
PublicationThe withdrawal of popular high-GWP refrigerants will significantly affect maritime industry. Refrigeration and air conditioning systems currently used on ships are not ready to fulfil future limitations. Therefore, there is a need for system, which will operate with low-GWP refrigerants and at the same time will be efficient and reliable in difficult environmental conditions. This paper explains the concept of a cold supply system,...
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Comparative Analysis of Carbon, Ecological, and Water Footprints of Polypropylene-Based Composites Filled with Cotton, Jute and Kenaf Fibers
PublicationComposites containing natural fibers are considered environmentally friendly materials which is related to the reduced use of fossil fuels and the emission of carbon dioxide compared to petroleum-based polymers. Nevertheless, a complete evaluation of their environmental impact requires a broader view. This paper presents a carbon, ecological, and water footprints assessment of polypropylene-based composites filled with cotton,...
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Determining and visualizing safe motion parameters of a ship navigating in severe weather conditions
PublicationThe paper presents a method of determining, organizing and displaying ship collision avoidance information, which is based on the Collision Threat Parameters Area (CTPA) technique. The method makes it possible to visualize navigational threats as well as possible collision avoidance manoeuvres. The solution is focused on supporting navigation in severe weather conditions. Normally collision avoidance decisions are made taking into...
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Cathodic Activation of Titania-Fly Ash Cenospheres for Efficient Electrochemical Hydrogen Production: A Proposed Solution to Treat Fly Ash Waste
PublicationFly ash (FA) is a waste product generated in huge amounts by coal-fired electric and steam-generating plants. As a result, the use of FA alone or in conjunction with other materials is an intriguing study topic worth exploring. Herein, we used FA waste in conjunction with titanium oxide (TiO2) to create (FA-TiO2) nanocomposites. For the first time, a cathodic polarization pre-treatment regime was applied to such nanocomposites...
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REVISTA DE BIOLOGIA MARINA Y OCEANOGRAFIA
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ECOLOGICAL ECONOMICS
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ECOLOGICAL ENTOMOLOGY
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Kulak burun bogaz ihtisas dergisi : KBB = Journal of ear, nose, and throat
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New “one‐pot” Pd(II) and Zn(II) complexes of Schiff bases, derivatives of 1‐amino‐1‐deoxy‐d‐sorbitol: Spectroscopic studies and biological and catalytic activities
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2,7-Dihydro-3H-pyridazino[5,4,3-kl]acridin-3-one derivatives, novel type of cytotoxic agents active on multidrug-resistant cell lines. Synthesis and biological evaluation.
PublicationOtrzymano serię pirydazyno akrydyn-3-onów w reakcji 9-okso-9,10-dihydroakrydyno-1-karboksylanu etylu z POCl3, następnie dodanie odpowiedniej alkiloaminoalkilohydrazyny. Badane związki wykazują w porównaniu z referencyjnymi cytostatykami DX, MIT niższe wartości indeksu RI, a także niższe aktywności cytotoksyczne.
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In vitro biological evaluation of a novel folic acid-targeted receptor quantum dot−β−cyclodextrin carrier for C-2028 unsymmetrical bisacridine in the treatment of human lung and prostate cancers
PublicationTraditional small-molecule chemotherapeutics usually do not distinguish tumors from healthy tissues. However, nanotechnology creates nanocarriers that selectively deliver drugs to their site of action. This work is the next step in the development of the quantum dot−β−cyclodextrin−folic acid (QD−β−CD−FA) platform for targeted and selected delivery of C−2028 unsymmetrical bisacridine in cancer therapy.Herein, we report an initial...
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Synthesis and biological activity of novel ester derivatives of N3-(4-metoxyfumaroyl)-(S)-2,3-diaminopropanoic acid containing amide and keto function as inhibitors of glucosamine-6-phosphate synthase
PublicationA short series of novel ester derivatives of N3-4-methoxyfumaroyl-(S)-2,3-diaminopropanoic acid (FMDP) containing amido or keto functions have been designed and synthesized. Their antifungal activity and inhibitory properties toward fungal glucosamine-6-phosphate synthase has also been evaluated. The obtained compounds 11-13 and 15-17 demonstrated good antifunga activity against Candida albicans. Compounds 11-13 displayed also...
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A Target Information Display for Visualising Collision Avoidance Manoeuvres in Various Visibility Conditions
PublicationThe paper introduces a new approach to displaying information on targets. The proposed display visualises three types of information: targets’ motion parameters (typical for target tracking), combinations of own course and speed which collide with those targets (typical for Collision Threat Parameters Area display by Lenart (1983)) and combinations of own course and speed which are not compliant with COLREGS in this case (based...
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Janusz Górski prof. dr hab. inż.
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The intertexteme as an instrument in the past — present — future dialogical space of urbanism practices: an intersemiotic analysis of graffiti and inscriptions in Gdansk and Kaliningrad
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Heavy metals in lake surface sediments in protected areas in Poland: concentration, pollution, ecological risk, sources and spatial distribution
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Ecological bearing systems for water turbines - two research programs aimed at making water turbines more "eco-friendly".
PublicationW pracy opisano próby wyeliminowania ropopochodnych środków smarowych z układów łożyskowania turbin wodnych. Próby dotyczą zastosowania bezsmarowych łożysk kierownic i smarowanych wodą łożysk wałów turbin. Wprowadzanie bezsmarowych łożysk kierownic wymaga stworzenia metod prognozowania ich trwałości w warunkach małych oscylacji. Do stosowania w łożyskach wałów zaproponowano smarowane wodą łożyska ceramiczne o oryginalnej konstrukcji,...
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Comparative Study on Assisted Solvent Extraction Techniques for the Extraction of Biologically Active Compounds from Sideritis raeseri and Sideritis scardica
PublicationThe plants in the Sideritis genus are postulated to exhibit several important medicinal properties due to their unique chemical composition. To isolate the targeted phytochemical compounds, the selection of a suitable extraction method is of primary importance. In this work, a comparative study on the phytochemical profiles of various Sideritis raeseri and Sideritis scardica extracts has been carried out. An untargeted metabolomics...
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RE-SHAPING THE LAND AND WATER CONNECTIONS AND ITS ROLE IN ACHIEVING LANDSCAPE AND ECOLOGICAL SYSTEMS’ CONTINUITY ON THE POST-INDUSTRIAL TERRITORIES
PublicationThis paper delves into recently applied strategies of creating new water areas and modifying the existing ones as a part of the transformation processes of post-industrial territories. It proves that while the pursuit for unique architectural and urban space values remains an important factor contributing to such modifications, they may also play an important role in reclaiming ecological systems continuity. On the basis of theoretical...
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Ecological Chemistry and Engineering A - Chemia i Inżynieria Ekologiczna A
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Journal of Experimental Zoology Part A-Ecological and Integrative Physiology
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Journal of Experimental Zoology Part A-Ecological Genetics and Physiology
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Machine Learning-Based Wetland Vulnerability Assessment in the Sindh Province Ramsar Site Using Remote Sensing Data
PublicationWetlands provide vital ecological and socioeconomic services but face escalating pressures worldwide. This study undertakes an integrated spatiotemporal assessment of the multifaceted vulnerabilities shaping Khinjhir Lake, an ecologically significant wetland ecosystem in Pakistan, using advanced geospatial and machine learning techniques. Multi-temporal optical remote sensing data from 2000 to 2020 was analyzed through spectral...
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WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
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MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING
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Synthesis and biological evaluation of novel analogues of batracylin with synthetic amino acids and adenosine: an unexpected effect on centromere segregation in tumor cells through a dual inhibition of topoisomerase IIa and Aurora B
PublicationIn the search for new anticancer agents we designed and synthesized batracylin derivatives with linking synthetic amino acid side chains of different lengths and adenosine. Unexpectedly, we have found that in water and the culture media adenosine–amino acid–BAT conjugates form supramolecular structures and this prevents these compounds from entering cells. Consequently, these compounds exerted no biological activity when tested...
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Synthesis and biological evaluation of 2,7-Dihydro-3H-dibenzo[de,h]cinnoli- ne-3,7-done derivatives a novel group of anticancer agents active on a multidrug resistance cell line.
PublicationZsyntezowano serię pochodnych pirydazonu z jednym lub dwoma łańcuchami bocznymi w różnych pozycjach chromoforu tetracyklicznego. Związki wykazały aktywność cytoksyczną na mysią białaczkę L1210 i ludzką k562 oraz na linii komórkowej oporności krzyżowej MDR (k562/DX). Dwa najbardziej aktywne związki przetestowano in vivo na mysiej białaczce P388. Wykazały one aktywność przeciwnowotworową porównywalną z aktywnością Mitoxantronu.
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Effect of modification of 6-[(aminoalkyl)amino]-7H-benzo[e]-perimidin-7-ones on their cytotoxic activity toward sensitive and multidrug resistant tumor cell lines. Synthesis and biological evaluation
PublicationPrzeprowadzono syntezę szeregu nowych pochodnych benzoperimidynowych, a mianowicie: monohydroksybenzoperimidyny i 2-aminobenzoperimidyny. Oznaczono aktywność przeciwnowotworową in vitro powyższych związków względem komórek nowotworowych bez oporności oraz z wykształconą opornością wielolekową. Wyznaczono również powinowactwo pochodnych do błony komórkowej, na kolumnie HPLC z odpowiednim wypełnieniem.
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Civilization Threats and Sustainable Development
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LIDAR data from a cliff measurement conducted in the vicinity of the town of Jastrzębia Góra on the Baltic Sea coast
Open Research DataMeasurement data were obtained during research related to the use of LiDAR observations to assess the stability of a coastal cliff. The collected information comes from measurements conducted in the vicinity of the town of Jastrzębia Góra on the Baltic Sea coast. The acquired point cloud constitutes a comprehensive set of data regarding the geometry...
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Spatial distribution and correlations among elements in smaller than 75 μm street dust: ecological and probabilistic health risk assessment
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Proteomic Profiling of Ectosomes Derived from Paired Urothelial Bladder Cancer and Normal Cells Reveals the Presence of Biologically-Relevant Molecules
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IFIP Conference on Biologically Inspired Collaborative Computing
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What should we know when choosing feather, blood, egg or preen oil as biological samples for contaminants detection? A non-lethal approach to bird sampling for PCBs, OCPs, PBDEs and PFASs
PublicationBirds are considered as good bio-monitors and they can provide highly valuable data about the level of contamination in their habitat. During the design of biomonitoring studies one of the first issues after choosing species is the choice of biological material. Non-lethally collected samples have recently been gaining greater attention as they offer several ethical and practical advantages. However, not all sample matrices are...
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Identification of novel psychoactive substances 25B-NBOMe and 4-CMC in biological material using HPLC-Q-TOF-MS and their quantification in blood using UPLC–MS/MS in case of severe intoxications
PublicationThis paper describes cases of poisoning caused by new psychoactive substances such as: 25BNBOMe (2-(4-bromo-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine) and 4-CMC (1-(4-chlorophenyl)-2-(methylamino)-1-propanone). The analytical procedure includes rapid and selective method for the extraction and determination of 4-CMC and 25B-NBOMe in blood samples using UPLC–MS/MS technique. To the best of our knowledge,this is...
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Data regarding a new, vector-enzymatic DNA fragment amplification-expression technology for the construction of artificial, concatemeric DNA, RNA and proteins, as well as biological effects of selected polypeptides obtained using this method
PublicationApplications of bioactive peptides and polypeptides are emerging in areas such as drug development and drug delivery systems. These compounds are bioactive, biocompatible and represent a wide range of chemical properties, enabling further adjustments of obtained biomaterials. However, delivering large quantities of peptide derivatives is still challenging. Several methods have been developed for the production of concatemers –...
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Therapeutic Potential of Multifunctional Tacrine Analogues
PublicationTacrine is a potent inhibitor of cholinesterases (acetylcholinesterase and butyrylcholinesterase) that shows limiting clinical application by liver toxicity. In spite of this, analogues of tacrine are considered as a model inhibitor of cholinesterases in the therapy of Alzheimer’s disease. The interest in these compounds is mainly related to a high variety of their structure and biological properties. In the present review, we...
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Phylogenetic analysis of Oncidieae subtribe - ITS1-5,8S-ITS2
Open Research DataThe dataset contains alignment and consensus matrix files, and results of phylogenetic analysis of ITS1- 5,8S-ITS2 region from 186 orchid species considered to belong Oncidieae subtribe. Sequences were assessed from NCBI GeneBank (list of all records with identifiers in the separate file)
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Phylogenetic analysis of Oncidieae subtribe - matK plastid region
Open Research DataThe dataset contains alignment and consensus matrix files, and results of phylogenetic analysis of plastid matK region from 186 orchid species considered to belong Oncidieae subtribe. Sequences were assessed from NCBI GeneBank (list of all records with identifiers in the separate file)
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Piotr Szczuko dr hab. inż.
PeoplePiotr Szczuko received his M.Sc. degree in 2002. His thesis was dedicated to examination of correlation phenomena between perception of sound and vision for surround sound and digital image. He finished Ph.D. studies in 2007 and one year later completed a dissertation "Application of Fuzzy Rules in Computer Character Animation" that received award of Prime Minister of Poland. His interests include: processing of audio and video, computer...
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Rafał Leszczyna dr hab. inż.
PeopleDr hab. Rafal Leszczyna is an associate professor at Gdansk University of Technology, Faculty of Management and Economics. He holds the M.Sc. degrees of Computer Science and Business Management. In December, 2006 he earned a Ph.D. in Computer Science, specialisation - Computer Security at the Faculty of Electronics, Telecommunications and Informatics of Gdansk University of Technology. Between 2004 and 2008 he worked in the European...
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Trends in In Silico Approaches to the Prediction of Biologically Active Peptides in Meat and Meat Products as an Important Factor for Preventing Food-Related Chronic Diseases
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EU Project of Life Programme “Algae Service for Life” Creates Tools for Ecological Service to Mitigate Cyanobacteria and Macroalgae Blooms in Freshwater Ecosystems
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Probing the binding selected metal ions and biologically active substances to the antimicrobial peptide LL-37 using DSC, ITC measurements and calculations
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The concept of research on ecological, energy and reliability effects of modified marine fuel oils application to supply compression-ignition engines in real conditions
PublicationWithin the article, basic assumptions of the research project financed by Regional Fund for Environmental Protection and Water in Gdansk were described. The project concerns the experimental investigations carried out on laboratory compression-ignition engine in conditions of its supply with a non-standard marine fuel oil. Configuration and measuring capability of laboratory test bed presently being constructed were introduced....
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The effect of lyophilization on selected biologically active components (vitamin c, catalase, lysozyme), total antioxidant capacity and lipid oxidation in human milk
PublicationHuman milk is rich in polyunsaturated fatty acids, as well as lysozyme, vitamin C and other bioactive compounds. The effect of lyophilization on the content of antioxidants (vitamin C and catalase CAT), bactericidal compounds (lysozyme), total antioxidant capacity (TAC) and lipid peroxidation in human milk was investigated in this study. Samples of mature human milk were collected from five healthy women who gave birth on the scheduled...
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Revista de Biologia Neotropical / Journal of Neotropical Biology
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Recent Issues and Challenges in the Study of Inland Waters
PublicationThis paper addresses several important problems and methods related to studies of inland waters based on the existing scientific literature. The use of UAVs in freshwater monitoring is described, including recent contact and non-contact solutions. Due to a decline in biological diversity in many parts of the globe, the main threats are described together with a modern method for algae and cyanobacteria monitoring utilizing chlorophyll...