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Search results for: in vitro metabolizm
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Studies of the effects of antifungal cationic derivatives of amphotericin B on human erythrocytes.
PublicationBadano nową grupę kationowych pochodnych amfoterycyny B pod kątem zależności pomiędzy ich zdolnością do asocjacji i selektywną toksycznością. We wszystkich przypadkach stosowano amfoterycynę B jako związek odniesienia. Jako miarę efektu toksycznego in vitro badanych związków stosowano wypływ wewnątrzkomórkowego potasu oraz hemolizę. Miarą aktywności przeciwgrzybowej był MIC i utrata potasu wewnatrzkomórkowego. Do oceny stopnia...
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Molecular Umbrella as A Nanocarrier for Antifungals
PublicationA molecular umbrella composed of two O‐sulfated cholic acid residues was applied for the construction of conjugates with cispentacin, containing a “trimethyl lock” (TML) or o‐dithiobenzylcarbamoyl moiety as a cleavable linker. Three out of five conjugates demonstrated antifungal in vitro activity against C. albicans and C. glabrata but not against C. krusei, with MIC90 values in the 0.22–0.99 mM range and were not hemolytic. Antifungal...
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Structural factors affecting affinity of cytotoxic oxathiole-fused chalcones toward tubulin
PublicationSynthesis, in vitro cytotoxic activity, and interaction with tubulin of (E)-1-(6-alkoxybenzo[d][1,3]oxathiol- 5-yl)-3-phenylprop-2-en-1-one derivatives (2) are described. Some of the compounds demonstrated cytotoxic activity at submicromolar concentrations, and the activity could be related to interaction with tubulin at the colchicine binding site. Interaction of selected derivatives with tubulinwas evaluated using molecular modeling,...
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Antimicrobial Activity of Chimera Peptides Composed of Human Neutrophil Peptide 1 (HNP-1) Truncated Analogues and Bovine Lactoferrampin
PublicationThree chimera peptides composed of bovine lactoferrampin and the analogue of truncated human neutrophil peptide 1 were synthesized by the solid-phase method. In two compounds peptide chains were connected via isopeptide bond, whereas in the third one disulfide bridge served as a linker. All three chimeras displayed significantly higher antimicrobial activity than the constituent peptides as well as their equimolar mixtures. The...
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Smart acoustic band structures
PublicationSmart acoustic band structures exhibit very interesting and non-standard physical properties due to the periodic nature of their certain characteristic on different scale levels. They manifest mostly in their frequency spectra as socalled frequency band-gaps or stop-bands, what has a great impact on the behaviour of these structures in relation to the propagation of vibro-acoustic signals that can be transmitted through the structures...
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Białka prokariotycznego systemu MMR: rola oraz interakcje
PublicationUszkodzenia komórkowego DNA w postaci błędnie sparowanych lub niesparowanych zasad azotowych są wynikiem niewłaściwie zachodzących procesów metabolizmu DNA, takich jak replikacja, rekombinacja oraz naprawa DNA. Utrwalenie tego rodzaju zmian prowadzi do powstania mutacji. System MMR (ang. DNA mismatch repair) usuwa te uszkodzenia przyczyniając się do zwiększenia wierności replikacji DNA oraz utrzymania stabilności genomu komórki....
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Fast-SEC coupled to ICP-MS for selected metal determination and its stability over time in polish wine
PublicationMetal ions contribute to the wine browning (as reaction catalysts), turbidity (in complexes), and astringency (due to inter- action with tannins). Being aware that bioavailability and metabolism of metal ions in the human body are strictly related with their concentration and the form they occur it is important to monitor not only the total content of metals but also their speciation. Thus, we can obtain more information about...
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The occurence and diagnosis of biomarkers of ethyl alcohol consumption
PublicationEthyl alcohol is a legal and a widely available psychoactive drug. However, its excessive consumption causes addiction. This leads to aggressive behaviors, family battery, difficulties in interpersonal relations, legal offences, suicides, car accidents and deterioration in labor productivity, what causes financial problems. Despite many social actions against alcohol consumption, this problem is still unresolved. Therefore, fast...
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Ce site dilution effects in the antiferromagnetic heavy fermion CeIn3
PublicationLa-doped intermetallic single crystals of Ce1−xLaxIn3 were synthesized via an In self-flux method throughout the entire range (x = 0–1). The prototypical heavy-fermion compound CeIn3 shows an antiferromagnetic phase transition at 10.1 K and becomes superconducting near a critical pressure where TN is completely suppressed. As the La concentration increases, Ce moments are diluted, and the lattice constant increases linearly, satisfying Vegard’s...
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Generation of biodiesel and glycerol from waste of rice industries in Brazil
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Determination of the bearing capacity of pile foundations based on CPT test results
PublicationAnalityczne określanie pełnej krzywej obciążenie - osiadanie na podstawie parametrów geotechnicznych wciąż stanowi bardzo trudne zadanie naukowe i inżynierskie. W pracy przedstawiono metodę bezpośredniego wykorzystania oporów na stożku sondy statycznej do określania pełnej krzywej osiadania dla pali Vibro-Fundex. W sumie jako materiał weryfikacyjny wykorzystano 94 próbne obciążenia statyczne pali.
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Prime-Boost Vaccination with Toxoplasma Lysate Antigen, but Not with a Mixture of Recombinant Protein Antigens, Leads to Reduction of Brain Cyst Formation in BALB/c Mice
PublicationIntroduction Infection with the ubiquitous parasite Toxoplasma gondii is a threat for immunocompro- mised patients and pregnant women and effective immune-prophylaxis is still lacking. Methods Here we tested a mixture of recombinant T . gondii antigens expressed in different develop- mental stages, i.e., SAG1, MAG1 and GRA7 (SMG), and a lysate derived from T . gondii tachyzoites (TLA) for prophylactic vaccination against cyst formation....
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Bioactive Ingredients with Health-Promoting Properties of Strawberry Fruit (Fragaria x ananassa Duchesne)
PublicationStrawberries (Fragaria x ananassa Duchesne) belong to the berry group and are characterized primarily by delightful sensory properties. Due to their chemical composition, these fruits are a rich source of bioactive compounds that can modify the metabolic and physiological functions of the body. The aim of this work is to present the current state of research on bioactive ingredients found in these fruits in the context of their...
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Adipokine and cytokine levels in patients with adrenocortical cancer, subclinical Cushing's syndrome and healthy controls
PublicationIntroduction In recent years researchers have focused at hormonal activity in Cushing’s syndrome (CS) in connection with metabolic disorders and the role of adipokines and cytokines secreted by the adipose tissue. The aim of the study was to investigate levels of adipokines and cytokines in patients with: subclinical CS (SCS) – in relation to hormonal parameters of hypercortisolemia, and, adrenocortical cancer (ACC). Materials...
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Bioactive core material for porous load-bearing implants
PublicationSo far state of knowledge on biodegradable materials is reviewed. Among a variety of investigated materials, those composed of polymers and ceramics may be considered as only candidates for a core material in porous titanium alloy. The collagen and chitosan among natural polymers, polyhydroxy acids among synthetic polymers, and hydroxyapatite and tricalcium phosphate among ceramics are proposed for further research. Three essential...
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Therapeutic Potential of Multifunctional Derivatives of Cholinesterase Inhibitors
PublicationThe aim of this work is review of tacrine analogues from the last three years, which were not included in the latest review work, donepezil and galantamine hybrids from 2015 and rivastigmine derivatives from 2014. In this account we summarize the efforts toward the development and characterization of non-toxic inhibitors of cholinesterases based on mentioned drugs with various interesting additional properties such as antioxidant,...
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Synthesis and biological evaluation of novel 3,6- amide and thioamide substituted- 2,3,4,9-tetrahydro-1H-carbazoles for anti-cancer activity
PublicationHerein, we report the synthesis of new compounds with demonstrated anticancer properties based on the 2,3,4,9- tetrahydro-1H-carbazole scaffold. The Fischer indolization method was used to close the heterocyclic motif. The synthesis method’s scope and limitations were thoroughly assessed through a series of experiments. Biological assays revealed that two thioamide compounds exhibited significant anticancer activity against MCF-7,...
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Quest for the Molecular Basis of Improved Selective Toxicity of All-Trans Isomers of Aromatic Heptaene Macrolide Antifungal Antibiotics
PublicationThree aromatic heptaene macrolide antifungal antibiotics, Candicidin D, Partricin A (Gedamycin) and Partricin B (Vacidin) were subjected to controlled cis-trans to all trans photochemical isomerization. The obtained all-trans isomers demonstrated substantially improved in vitro selective toxicity in the Candida albicans cells: human erythrocytes model. This effect was mainly due to the diminished hemotoxicity. The molecular modeling...
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Natural Products Counteracting Cardiotoxicity during Cancer Chemotherapy: The Special Case of Doxorubicin, a Comprehensive Review
PublicationCardiotoxicity is a frequent undesirable phenomenon observed during oncological treatment that limits the therapeutic dose of antitumor drugs and thus may decrease the effec-‐‑ tiveness of cancer eradication. Almost all antitumor drugs exhibit toxic properties towards cardiac muscle. One of the underlying causes of cardiotoxicity is stimulation of oxidative...
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Inhibition of amyloid fibril formation of hen egg white lysozyme by trimethylamine N-oxide at low pH
PublicationIn vitro inhibition of the formation of fibrous aggregates of proteins (amyloids) has gained increasing attention due to the number of diseases associated with protein misfolding and fibrillation. An interesting group of compounds for which pronounced activity against this phenomenon can be expected consists of low molecular weight substances (osmolytes) which have the ability to change protein stability. Here we investigate the...
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Inhibitors of amino acids biosynthesis as antifungal agents
PublicationFungal microorganisms, including the human pathogenic yeast and filamentous fungi, are able to synthesize all proteinogenic amino acids, including nine that are essential for humans. A number of enzymes catalyzing particular steps of human-essential amino acid biosynthesis are fungi specific. Numerous studies have shown that auxotrophic mutants of human pathogenic fungi impaired in biosynthesis of particular amino acids exhibit...
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Influence of the ionic strength on the amyloid fibrillogenesis of hen egg white lysozyme
PublicationThe study investigates the role of the electrostatic interactions in the fibrillation of the hen egg white lysozyme (HEWL). In order to achieve this aim the influence of the cations Na+, Mg2+ and Al3+ on the amyloid fibril formation and amorphous aggregation was tested. The amyloids are formed in the solution without added salt but the Thioflavin T fluorescence gives the false-negative result. In these conditions, the HEWL fibrils...
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Investigation of an elutable N-propylphosphonic acid chitosan derivative composition with a chitosan matrix prepared from carbonic acid solution
PublicationPorous chitosan composites using CO2 dissolution procedure and including water soluble N-propylphosphonic chitosan derivative (p-CHI) were obtained and characterized. In contrast to the control material, composites containing modified chitosan distinguished by a rapid moisture absorption and good adhesion to the skin. The FTIR analysis confirmed the presence of propylphosphonic group in the structure of the polymer. The porosity...
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Influence of different cultivation systems on bioactivity of asparagus
PublicationEvaluation of functional and bioactive compounds of Asparagus officinalis L. growing in conventional and organic greenhouse and conventional open –field farming was the aim of this research. Polyphenols in cladodes grown conventionally were higher than organic. Flavonoids and carotenoids were the highest in cladodes in open field. Organic spears were richer in total phenolics (+6.9% and +19.1%) and flavonoids (+4.7% and 16.8%)...
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Process of convergence in EU
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Process Engineering in Circular Economy
e-Learning CoursesKurs jest przeznaczony dla doktorantów szkoły doktorskiej w dyscyplnach: inżynieria lądowa i transport (SzD), III stopnia, stacjonarne inżynieria środowiska, górnictwo i energetyka (SzD), III stopnia, stacjonarne The course is addressed to PhD students of the doctoral school in disciplines: civil engineering and transport environmental engineering, mining and power engineering Course type: lecture Total hours of...
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Change Detection in Signals 2023
e-Learning CoursesChange Detection in Signals - files for students.
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Spectroscopy Methods in Nanotechnology 2023
e-Learning CoursesCourse for 2nd degree Students of Nanotechnology, specialization Nanostructures and computer simulations in materials science, sem. 2. The aim of the course is to discuss the basic theoretical and practical issues of spectroscopy and presentation of the various types of spectroscopic methods and ways to interpret spectra, with particular attention paid to the possibility of their use in the study of nanostructured systems.
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[ZiJ] Empirical research in Management
e-Learning CoursesDyscyplina: nauki o zarządzaniu i jakości Zajęcia obowiązkowe dla doktorantów I i II roku Prowadzący: dr inż. Wioleta Kucharska Liczba godzin: 30 Forma zajęć: laboratoria Discipline: management and quality Obligatory course for 1st and 2nd-year PhD students Academic teacher: dr inż. Wioleta Kucharska Total hours of training: 30 teaching hours Course type: laboratories
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Passive Methods in Heat Transport
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Law and Ethics in Science
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ICT in Management, Spring 2022
e-Learning Courses„ ICT w zarządzaniu licencjami” dla studentów studiów z zarządzania, edycja 2022 „ ICT w sklepie ” dla studentów BiM edycja 2022
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IT project management in business
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Corrosion in Theory and Practice
e-Learning Coursesstopień: II, semestr: II
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Spectroscopy Methods in Nanotechnology 2022
e-Learning CoursesCourse for 2nd degree Students of Nanotechnology, specialization Nanostructures and computer simulations in materials science, sem. 2. The aim of the course is to discuss the basic theoretical and practical issues of spectroscopy and presentation of the various types of spectroscopic methods and ways to interpret spectra, with particular attention paid to the possibility of their use in the study of nanostructured systems.
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Forecasting and optimalization in logistics
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Management in space industry WiMiO
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Surrogate methods in system engineering
e-Learning Courses{mlang pl} Dyscyplina: Automatyka, Elektronika i Elektrotechnika Zajęcia fakultatywne dla doktorantów II roku Prowadzący: dr hab. inż. Adrian Bekasiewicz Liczba godzin: 15 h Forma zajęć: wykład {mlang} {mlang en} Discipline: control, electronic and electrical engineering Facultative course for 2nd year PhD students Academic teacher: dr hab. inż. Adrian Bekasiewicz Total hours of training: 15 teaching hours Course...
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[EiF] Empirical research in Economics
e-Learning Courses{mlang pl} Dyscyplina: EiF Zajęcia obowiązkowe dla doktorantów I roku Prowadzący: A. Parteka / J. Wolszczak - Derlacz, F. Venturini Liczba godzin: 30 Forma zajęć: laboratoria {mlang} {mlang en} Discipline: EiF Obligatory course for 1st-year PhD students Academic teacher: A. Parteka / J. Wolszczak - Derlacz, F. Venturini Total hours of training: 30 teaching hours Course type: Laboratories {mlang}
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Ecological solutions in contemporary architecture
e-Learning CoursesThis lecture aims to equip you with a comprehensive understanding of ecological architecture and inspire you to integrate these principles into your future projects.
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HR management - Bachelor in management
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Process engineering in circular economy
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Advances in Functional Materials 2024
e-Learning CoursesOur summer school on Advances in Functional Materials 2024 aims to bring together young scientists (Ph.D. and MSc students) with specialists in materials engineering. You will be able to follow our lectures, and laboratory classes so you can practice what you have learned. This course consists of 40 hours of direct contact classes - 30 hours of lectures and 10 hours of laboratory classes delivered by our specialists from the Advanced...
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ICT in Management - Spring 2024
e-Learning CoursesICT in Management course for Bachelor in Management students (Spring 2024 edition)
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2024 Microscopy in Environmental Monitoring
e-Learning CoursesThe online repository will be used to teach students by presenting them lectures about variable aspects of microscopy techniques used in environmental monitoring.
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Daylight in Architecture 2022/23
e-Learning CoursesTutor: Professor Claudia Naves David Amorim (University of Brasilia) Project: 60 h (lectures + online platform + individual consultations) With a support of e-platform NLITED educational content; http://lms.nlited.eu/, Students will become familiar with the different methods of daylight assessment within the built environment. Innovative daylight design is understood as a better user-centred and energy-efficient design strategy. The...
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Spectroscopy Methods in Nanotechnology 2024
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Process engineering in circular economy
e-Learning CoursesDefinition and principles of the circular economy (CE). The transition from a linear model to a circular model. Business models for the CE. Circular design and innovation. CE assessment carbon footprint, life cycle assessment. Case studies of the cities implementing the CE concept. CE policy and legislation (EU and Poland). Wastewater treatment plants as an element of the CE. Energy and nutrient recovery technologies in wastewater...
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Advances in chemical technology II
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Recent advances in transcription regulation
e-Learning CoursesRecent advances in transcription regulation