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Search results for: IN VITRO METABOLIZM
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Modelling in machine design (PG_00057377)
e-Learning Coursesgoal of the subject is to show how simple enginnering models reflect the reality and how contemporary FEM calulations can illustrate the operation of machine elements
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L23_24 Artificial Intelligence in Healthcare
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Synthesis and Biological Evaluation of Acridine/Acridone Analogs as Potential Anticancer Agents
PublicationAcridine and acridone analogues were prepared by Ullmann condensation and then cyclization reaction. As a result of nucleophilic substitution reaction 1-nitro-9-phenoxyacridine or 1-chloro-4-nitro-9(10H)-acridone with the corresponding peptides, the planned acridine derivatives (10a-c, 12, 17-a-d, 19) have been obtained. The cytotoxic activity of the newly obtained analogs were evaluated against melanotic (Ma) and amelanotic (Ab)...
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Impact of obesity on cardiovascular health
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The antitumor compound triazoloacridinone C-1305 inhibits FLT3 kinase activity and potentiates apoptosis in mutant FLT3-ITD leukemia cells.
PublicationAim: FMS-like receptor tyrosine kinase (FLT3) is expressed in some normal hematopoietic cell types and plays an important role in the pathogenesis of acute myeloid leukemia (AML). In this study, we examined the effects of triazoloacridinone C-1305, an antitumor compound, on AML cells with different FLT3 status in vitro. Methods: A panel of human leukemic cell lines with different FLT3 status was used, including FLT3 internal tandem...
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The impact of lipophilicity on environmental processes, drug delivery and bioavailability of food components
PublicationLipophilic properties of the compound allow to predict its fate in living organisms and to propose the models of chemicals transport and accumulation in the ecosystem. Lipophilicity is also useful as the characteristic of chemicals in respect to their optimal attributes for specific biological and non-biological tasks. The lipophilicity descriptors define the potency of endo- and xenobiotics to metabolic transformations and their...
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Real-Time Volatilomics: A Novel Approach for Analyzing Biological Samples
PublicationThe use of the ‘omics techniques in environmental research has become common-place. The most widely implemented of these include metabolomics, proteomics, genomics, and transcriptomics. In recent years, a similar approach has also been taken with the analysis of volatiles from biological samples, giving rise to the so-called ‘volatilomics’ in plant analysis. Developments in direct infusion mass spectrometry (DI-MS) techniques have...
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Fungal L-Methionine Biosynthesis Pathway Enzymes and Their Applications in Various Scientific and Commercial Fields
PublicationL-methionine (L-Met) is one of the nine proteinogenic amino acids essential for humans since, in human cells, there are no complete pathways for its biosynthesis from simple precursors. L-Met plays a crucial role in cellular function as it is required for proper protein synthesis, acting as an initiator. Additionally, this amino acid participates in various metabolic processes and serves as a precursor for the synthesis of S-adenosylmethionine...
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Highly effective degradation of selected groups of organic compounds by cavitation based AOPs under basic pH conditions
PublicationCavitation has become on the most often applied methods in a number of industrial technologies. In the case of oxidation of organic pollutants occurring in the aqueous medium, cavitation forms the basis of numerous advanced oxidation processes (AOPs). This paper presents the results of investigations on the efficiency of oxidation of the following groups of organic compounds: organosulfur, nitro derivatives of benzene, BTEX, and...
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Rozdział 10.2 Metody oznaczania właściwości przeciwutleniających próbek żywności
PublicationWystępowanie większości chorób cywilizacyjnych może być rezultatem stresu oksydacyjnego prowadzącego do różnorodnych zmian w ludzkim organizmie, wywołanych działaniem tzw. reaktywnych form tlenu. Z tego też powodu pojawiło się olbrzymie zapotrzebowanie na szybkie testy umożliwiające pomiar całkowitej zawartości przeciwutleniaczy czy też ogólnej siły przeciwutleniającej produktów żywnościowych a w szczególności świeżych warzyw...
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Influence of mussels (Mytilus galloprovincials) from polluted and non-polluted areas on some atherosclerosis indices in rats fed cholesterol
PublicationBadano wpływ diety z dodatkiem małży z obszarów zanieczyszczonych i obszarów czystych ekologicznie na niektóre objawy arteriosklerozy u szczurów.Na podstawie wyników badań in vitro, małże pochodzące z obszarów zanieczyszczonych charakteryzują sie większą zawartością protein, metali ciężkich oraz przeciwutleniaczy.Badania przeprowadzono na 28 szczurach podzielonych na 4 grupy. Szczury z grupy kontrolnej otrzymywały podstawową diete...
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Biofilm formation and its regulation in Staphylococcus aureus
PublicationInfections caused by the major human and animal pathogen, Staphylococcus aureus are becoming an important problem due to its emerging resistance mechanisms and variety of virulence factors. Biofilm formation is considered to be one of the most important factor attributed to high pathogenicity of S. aureus. Described in the literature methods used in identification of biofilm forming abilities of bacteria consist of phenotypic and...
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Towards β-selectivity in functional estrogen receptor antagonists
PublicationBased on the benzo[b]naphtho[1,2-d]furan and benzo[b]naphtho[1,2-d]thiophene frameworks, a series of ligands with different basic side chains (BSCs) has been synthesized and pharmacologically evaluated. Also, their binding modes have been modelled using docking techniques. It was found that the introduction of a BSC in these systems brings about a decrease of affinity for both estrogen receptors α and β in an in vitro competitive...
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Hybrid analogues of SFTI-1 modified in P1 position by β- and γ-amino acids and N-substituted β-alanines
PublicationA series of compounds containing either non-proteinogenic beta-/gamma-amino acids or N-substituted beta-alanine residues (beta-peptoid units) in P-1 specificity position were synthesized based on the structure of sunflower trypsin inhibitor 1 (SFTI-1). The compounds were synthesized on a solid support; the N-substituted beta-alanines (beta Nhlys and beta Nhphe) were introduced into a peptidomimetic chain via a two-step approach...
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Haemocompatibility Of Non-Functionalized And Plasmachemical Functionalized Detonation Nanodiamond Particles
PublicationThe purpose of this paper is to present the innovative design of microwave plasma system for modification of detonation nanodiamond particles (DNP) using a special rotating drum placed inside the reactor. Nanodiamond particles manufactured by detonation method reveal the biological activity depending on surface functionalization. Plasmachemical modification of detonation nanodiamond particles gives the possibility of controlling...
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Biosynthetic and synthetic access to amino sugars.
PublicationAmino sugars are important constituents of a number of biomacromolecules and products of mi crobial secondary metabolism, including antibiotics. For most of them, the amino group is located at the positions C1, C2 or C3 of the hexose or pentose ring. In biological systems, amino sugars are formed due to the catalytic activity of specific aminotransferases or amidotransferases by introducing an amino functionality derived from L-glutamate...
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Removal of cyclohexane and ethanol from air in biotrickling filters inoculated with Candida albicans and Candida subhashii
PublicationThis paper presents investigations on the removal of cyclohexane and ethanol from air in polyurethane- -packed biotrickling filters, inoculated with Candida albicans and Candida subhashii fungal species. Results on process performance together with flow cytometry analyses of the biofilm formed over packing elements are presented and discussed. The results indicate that the presence of ethanol enhances the removal efficiency of cyclohexane...
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Characterization of metabolites in different kiwifruit varieties by NMR and fluorescence spectroscopy
PublicationIt is known from our previous studies that kiwifruits, which are used in common human diet, have preventive properties of coronary artery disease. This study describes a combination of 1H NMR spectroscopy, multivariate data analyses and fluorescence measurements in differentiating of some kiwifruit varieties, their quenching and antioxidant properties. A total of 41 metabolites were identified by comparing with literature data...
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Synthetic strategies in construction of organic low molecular-weight carrier-drug conjugates
PublicationInefficient transportation of polar metabolic inhibitors through cell membranes of eukaryotic and prokaryotic cells precludes their direct use as drug candidates in chemotherapy. One of the possible solutions to this problem is application of the ‘Trojan horse’ strategy, i.e. conjugation of an active substance with a molecular carrier of organic or inorganic nature, facilitating membrane penetration. In this work, the synthetic...
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Advances In Clinical And Medical Research
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imPlatelet classifier: image‐converted RNA biomarker profiles enable blood‐based cancer diagnostics
PublicationLiquid biopsies offer a minimally invasive sample collection, outperforming traditional biopsies employed for cancer evaluation. The widely used material is blood, which is the source of tumor-educated platelets. Here, we developed the imPlatelet classifier, which converts RNA-sequenced platelet data into images in which each pixel corresponds to the expression level of a certain gene. Biological knowledge from the Kyoto Encyclopedia...
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Characterization of the fate of lipids in activated sludge
PublicationPrzeprowadzono doświadczenie wykazujące transformację lipidów w aerobowych warunkach osadu czynnego. Wykazano, że całkowitej, początkowej zawartości lipidów (2000 mg/l) nie udało się obniżyć do wartości niższej niż 300 mg/l. Jednakże, zawartość poszczególnych kwasów tłuszczowych uległa drastycznym zmianom, zarówno spadkowi, jak i wzrostowi podczas wszystkich faz wzrostu mikrobiologicznego. Obserwowane zmiany zawartości indywidualnych...
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KONSTRUKCJA AUKSOTROFICZNEGO WZGLĘDEM L-LIZYNY SZCZEPU CANDIDA ALBICANS
PublicationEnzymy szlaku kwasu L-α-aminoadypinowego biosyntezy L-lizyny z Candida albicans są potencjalnymi celami molekularnymi w terapii przeciwgrzybowej. Niektóre grupy badawcze wykazały, że auksotrofia wobec L-lizyny u pewnych gatunków grzybów powoduje zmniejszenie ich zjadliwości i może mieć wpływ na wzrost in vivo [Liebmann i in. 2004]. Oznacza to, że można się spodziewać zahamowania wzrostu komórek grzybowych w wyniku działania selektywnych...
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Impact of emerging pollutants mixtures on marine and brackish phytoplankton: diatom Phaeodactylum tricornutum and cyanobacterium Microcystis aeruginosa
PublicationPharmaceuticals and ionic liquids (ILs) are emerging as significant micropollutants with environmental presence and potential ecological impacts. The possible simultaneous occurrence of these two groups of pollutants in aquatic environments raises complex challenges due to their diverse chemical properties and potential for interactive effects. Given the documented widespread presence of pharmaceuticals and the emerging concerns about...
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IT project management in business 2023
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Applications of AI methods in enterprise
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[IMe] Advanced numerical methods in mechanics
e-Learning Courses{mlang pl} Dyscyplina: IMe Zajęcia obowiązkowe dla doktorantów I roku Prowadzący: K. Tesch, A. Żak Liczba godzin: 45 Forma zajęć: wykład/laboratorium {mlang} {mlang en} Discipline: IMe Obligatory course for 1st year PhD students Academic teacher: K. Tesch, A. Żak Total hours of training: 45 teaching hours Course type: lecture/Laboratories {mlang}
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Spectroscopy Methods in Nanotechnology - laboratory 2022
e-Learning CoursesCourse for 2nd degree Students of Nanotechnology, specialization Nanostructures and computer simulations in materials science, sem. 2.
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FINANCIAL MANAGEMENT IN ENTERPRISE [2021/22]
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[ILiT, IŚGiE] Mathematical methods in engineering
e-Learning Courses{mlang pl} Dyscyplina: ILiT, IŚGiE Zajęcia obowiązkowe dla doktorantów I roku Prowadzący: P. Kłosowski Liczba godzin: 15 Forma zajęć: wykład {mlang} {mlang en} Discipline: ILiT, IŚGiE Obligatory course for 1st-year PhD students Academic teacher: P. Kłosowski Total hours of training: 15 teaching hours Course type: lecture {mlang}
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Internet Technology in Infosystems - Laboratory 2022
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[IMe] Advanced numerical methods in mechanics
e-Learning Courses{mlang pl} Dyscyplina: IMe Zajęcia obowiązkowe dla doktorantów I roku Prowadzący: K. Tesch, A. Żak Liczba godzin: 45 Forma zajęć: wykład/laboratorium {mlang} {mlang en} Discipline: IMe Obligatory course for 1st year PhD students Academic teacher: K. Tesch, A. Żak Total hours of training: 45 teaching hours Course type: lecture/Laboratories {mlang}
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Spectroscopy Methods in Nanotechnology - laboratory 2023
e-Learning CoursesCourse for 2nd degree Students of Nanotechnology, specialization Nanostructures and computer simulations in materials science, sem. 2.
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22/23_winter_ Legislative technique in planning
e-Learning CoursesThe objective of the module is for students to understand the principles of legislative technique and to be able to apply them correctly in the planning documents they draw up.
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Image Processing in Robotics (2021/2022)
e-Learning CoursesFor ISD M.Sc. (II degr.) 2 sem. Participants are to learn image processing algorithms related to transformation, filtration, feature detection (image descriptors), image processing algorithms in robotic industrial systems.
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[ILiT, IŚGiE] Mathematical methods in engineering
e-Learning Courses{mlang pl} Dyscyplina: inżynieria lądowa i transport; inżynieria środowiska, górnictwo i energetyka Zajęcia obowiązkowe dla doktorantów I i II roku Prowadzący: dr inż. Roger Sauer, prof. PG Liczba godzin: 15 Forma zajęć: wykład {mlang} {mlang en} Discipline: civil engineering and transport; environmental engineering, mining and power engineering Obligatory course for 1st and 2nd-year PhD students Academic teacher: dr...
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Nutrient removal in municipal wastewater treatment
e-Learning CoursesThis series of lectures and interactive teaching sessions will cover all the important aspects of nutrient removal in municipal wastewater treatment. There will be five sessions. The topics of the sessions are: 1) Nutrient removal – why, how and what has been achieved?; 2) Biological treatment processes and conventional nitrogen removal; 3) Shortcut nitrogen removal processes and climate implication of nitrogen removal; 4) Biological...
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ICT in management (summer 2022/2023)
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[IMe] Advanced numerical methods in mechanics
e-Learning Courses{mlang pl} Dyscyplina: IMe Zajęcia obowiązkowe dla doktorantów I roku Prowadzący: K. Tesch, A. Żak Liczba godzin: 45 Forma zajęć: wykład/laboratorium {mlang} {mlang en} Discipline: IMe Obligatory course for 1st year PhD students Academic teacher: K. Tesch, A. Żak Total hours of training: 45 teaching hours Course type: lecture/Laboratories {mlang}
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[Soft Skills] Workshop in research ethics
e-Learning Courses{mlang pl} Dyscyplina: Wszystkie dyscypliny Zajęcia obowiązkowe dla doktorantów III roku Prowadzący: Liczba godzin: 5 Forma zajęć: warsztaty {mlang} {mlang en} Discipline: All disciplines Obligatory course for 3rd year PhD students Academic teacher: Total hours of training: 5 teaching hours Course type: workshops {mlang}
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IT project management in business 2022
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Modelling methods in design (CAD, FEM)
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Models in spatial development 2024/25
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FINANCIAL MANAGEMENT IN ENTERPRISE [2023/24]
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FINANCIAL MANAGEMENT IN ENTERPRISE [2020/21]
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Advances in biomedical engineering (2023/2024)
e-Learning Courses{mlang pl} Dyscyplina: Inżynieria biomedyczna Zajęcia obowiązkowe dla doktorantów I i II roku Prowadzący: prof. dr hab. Piotr Szweda Liczba godzin: 30 {mlang} {mlang en} Discipline: Biomedical Engineering Obligatory course for 1st and 2-nd year PhD students Academic teacher: prof. dr hab. inż. Piotr Szweda Total hours of training: 30 teaching hours {mlang}
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Course restoration in progress copy 1
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Identification of Changes in Signals - 2023
e-Learning CoursesIdentification of Changes in Signals (practice) Identyfikacja Zmian w Sygnałach (ćw.)
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Spectroscopy Methods in Nanotechnology - laboratory 2024
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Mathematical Methods in Engineering 2023/2024
e-Learning CoursesJest to pomocnicza formatka do tworzenia kursów wspomagających nauczanie stacjonarne na WILiŚ. Formatka została utworzona i udostępniona przez CNE. Uwaga: W celu wykorzystania i modyfikacji należy: 1) skopiować kurs wzorcowy 2) dopiero w kopii nanosić zmiany.