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Search results for: BIOLOGICAL THREATS
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Influence of the Addition of Selected Spices on Sensory Quality and Biological Activity of Honey
PublicationBee honey is nutritious and has numerous health benefits, but its taste is for many people too bland. Honey with addition of spices could be important to the food industry as a functional product with positive health image and interesting taste. Such product would definitely meet health-driven consumers’ expectations. Therefore, the aim of this study was to evaluate the effect of addition of selected spices on sensory, antimicrobial,...
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Synthesis and Biological Evaluation of Acridine/Acridone Analogs as Potential Anticancer Agents
PublicationAcridine and acridone analogues were prepared by Ullmann condensation and then cyclization reaction. As a result of nucleophilic substitution reaction 1-nitro-9-phenoxyacridine or 1-chloro-4-nitro-9(10H)-acridone with the corresponding peptides, the planned acridine derivatives (10a-c, 12, 17-a-d, 19) have been obtained. The cytotoxic activity of the newly obtained analogs were evaluated against melanotic (Ma) and amelanotic (Ab)...
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Biological and mechanical properties of bone cement with nanoparticles - in vivo and in vitro research
PublicationDespite antibiotics preventive treatment, before and after an implant implementation, risk of infection are real. These infections at the implant surface develop in a few months after applying them into the body. To prevent the development of bacteria and to reduce the risk of infection, implants coated with nanoparticles come into use. The Mechanical Department of the Technical University of Gdańsk carried out a research with...
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Voltammetric and biological studies of folate-targeted non-lamellar lipid mesophases
PublicationFolate-targeted lipid nanostructures are promising strategies for the development of biocompatible drug delivery systems. The objective of this study was to evaluate the efficacy of drug delivery to cancer cells by folate-targeted lipid mesophases, cubosomes (CUB) and hexosomes (HEX), loaded with doxorubicin (DOX). Three cancer-derived cell lines (KB, HeLa, T98G) exhibiting different expressional levels of folate receptor protein...
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Chemical Aspects of Biological Activity of Isothiocyanates and Indoles, the Products of Glucosinolate Decomposition
PublicationThere is growing evidence that cancer chemoprevention employing natural, bioactive compounds may halt or at least slow down the different stages of carcinogenesis. A particularly advantageous effect is attributed to derivatives of sulfur-organic phytochemicals, such as glucosinolates (GLs) synthesized mainly in Brassicaceae plant family. GLs are hydrolysed enzymatically to bioactive isothiocyanates (ITC) and indoles, which exhibit strong...
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Biological and mechanical properties of bone cement with nanoarticles - in vitro and in vivo research
PublicationDespite antibiotic preventive treatment both before and after implant implementation, the risks of infection are real. These infections develop at the implant surface a few months after inserting them into the body. To prevent the development of bacteria and reduce the risk of infection, implants coated with nanoparticles are used. The Mechanical Department of the Technical University of Gdansk carries out research into using bone...
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In Vitro Biological Characterization of Silver-Doped Anodic Oxide Coating on Titanium
PublicationDespite the high biocompatibility and clinical effectiveness of Ti-based implants, surface functionalization (with complex osteointegrative/antibacterial strategies) is still required. To enhance the dental implant surface and to provide additional osteoinductive and antibacterial properties, plasma electrolytic oxidation of a pure Ti was performed using a nitrilotriacetic acid (NTA)-based Ag nanoparticles (AgNP)-loaded calcium–phosphate...
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Comprehensive Evaluation of the Biological Properties of Surface-Modified Titanium Alloy Implants
PublicationAn increasing interest in the fabrication of implants made of titanium and its alloys results from their capacity to be integrated into the bone system. This integration is facilitated by different modifications of the implant surface. Here, we assessed the bioactivity of amorphous titania nanoporous and nanotubular coatings (TNTs), produced by electrochemical oxidation of Ti6Al4V orthopedic implants’ surface. The chemical composition...
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Accumulation and fate of selected heavy metals in biological wastewater treatment system
PublicationBadano akumulację oraz stopień usuwania metali ciężkich (Cd, Cu, Pb, Zn) w systemie biologicznego oczyszczania ścieków. Porównano zawartość wybranych metali w ściekach surowych i oczyszczonych, a także ich stężenie w osadzie czynnym przed i po beztlenowej stabilizacji.
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Zagrożenia starych budynków w sąsiedztwie nowej zabudowy = The threat of old buildings security in neighbourhood of new buildings
PublicationNa przykładzie jednego z budynków mieszkalnych, przedstawiono zagrożenia na jakie są narażone stare obiekty w zwartej zabudowie śródmiejskiej, podczas prowadzenia w ich sąsiedztwie prac budowlanych, którym często towarzyszą głębokie wykopy. Powoduje to powstawanie licznych uszkodzeń, uniemozliwiających ich prawidłową eksploatację lub stanowiących nawet zagrożenie bezpieczeństwa.
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Mercury in the Diatoms of Various Ecological Formations
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Phosphate tricyclic coumarin analogs as steroid sulfatase inhibitors: synthesis and biological activity.
PublicationIn the present work, we report convenient methods for the synthesis and biological evaluation of phosphate tricyclic coumarin derivatives as potential steroid sulfatase inhibitors. The described synthesis includes the straightforward preparation of 7-hydroxy-2,3-dihydro-1H-cyclopenta[c]chromen-4-one, 3-hydroxy-7,8,9,10-tetrahydro-6H-benzo[c]chromen-6-one and 3-hydroxy-8,9,10,11-tetrahydro-7H-cyclohepta[c]chromen-6-one modified...
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The influence of pre- and postharvest treatments on selected biological and epigenetic activities of Brassica sprouts
PublicationIntroduction The Brassica vegetables are rich in glucosinolates (GLs), which are enzymatically hydrolysed to bioactive isothiocynates (ITC) and indoles, regarded as the most promising chemopreventing agents. However, in the majority of brassica sprouts the GL conversion into these beneficial derivatives occurs at the level of about 1 %, while in cabbage leaves exceeds 70%. Since sprouts represent plant material, which is frequently...
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Developments in the synthesis and biological activity of Glycyl-L-Histydyl-L-Lysine derivatives
PublicationWe emphasize on the methods of the synthesis described in the literature and present the aspects of Gly-His-Lys structure modifications that played a key role in scientific research.
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Symmetry-Breaking Bifurcation for Free Elastic Shell of Biological Cluster, Part 2
PublicationWe will be concerned with a two-dimensional mathematical model for a free elastic shell of biological cluster. The cluster boundary is connected with its kernel by elastic links. The inside part is filled with compressed gas or fluid. Equilibrium forms of the shell of biological cluster may be found as solutions of a certain nonlinear functional-differential equation with several physical parameters. For each multiparameter this...
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Biological Activity of Compounds Exhibiting Local Anesthetics's Properties Evaluated by QSAR Approach
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Nutritional Value and Biological Activity of Gluten-Free Bread Enriched with Cricket Powder
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Comparison of the Toxicity of Pristine Graphene and Graphene Oxide, Using Four Biological Models
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Gallic Acid-Functionalized, TiO2-Based Nanomaterial—Preparation, Physicochemical and Biological Properties
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Membrane Filtration-Assisted Enzymatic Hydrolysis Affects the Biological Activity of Potato Juice
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Thymus serpyllum Essential Oil and Its Biological Activity as a Modern Food Preserver
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The role of particulate and colloidal substrate in biological nutrient removal activated sludge systems
PublicationThe authors investigated COD fractionation according to the physical state (soluble/colloidal/particulate) in four wastewater treatment plants (WWTPs) in northern Poland. It was found that particulate and colloidal organic compounds constituted up to 70% of total COD. On the other hand, according to literature data, municipal wastewater contains readily and slowly biodegradable substrates in the amount of approximately 10-30% and...
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Optical, colloidal and biological properties of up-converting nanoparticles embedded in polyester nanocarriers
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CRF1 receptor splicing in epidermal keratinocytes: Potential biological role and environmental regulations
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Significant Down-Regulation of “Biological Adhesion” Genes in Porcine Oocytes after IVM
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Analysis of Potential Exposure to Components of Municipal Solid Waste in a Mechanical Biological Treatment
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Synthesis and biological evaluation of thiophosphate tricyclic coumarin derivatives as steroid sulfatase inhibitors
PublicationSteroid sulfatase (STS) enzyme inhibition is an important approach to the management of hormone-dependent breast cancer. In this paper, we report convenient methods for the synthesis and biological evaluation of thiophosphate tricyclic coumarin analogs exhibiting STS activity. The described methods are based on the straightforward preparation of 7-hydroxy-2,3-dihydro-1H-cyclopenta[c]chromen-2-one, 3-hydroxy- 7,8,9,10-tetrahydro-6H-benzo[c]chromen-6-one,...
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Impact of enhanced pretreatment on biological nutrient removal in municipal wastewater treatment plants
PublicationThe aim of this study was to determine the effect of enhanced primary treatment on: increasing primary sludge production for increased biogas production; reducing the organic load on downstream biological treatment processes and thereby reducing energy consumption for aeration; denitrification and enhanced biological phosphorus removal (EBPR) rates in the activated sludge system. For this purpose, three commercial organic polymers...
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The SARS-CoV-2 and mental health: From biological mechanisms to social consequences
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Properties of PEEK-supported films of biological substances prepared by the Langmuir-Blodgett technique
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Synthesis, biological activity and molecular modelling studies of tricyclic alkylimidazo-, pyrimido- and diazepinopurinediones
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Scaffolds Loaded with Dialdehyde Chitosan and Collagen—Their Physico-Chemical Properties and Biological Assessment
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Natural and synthetic acridines/acridones as antitumor agents: their biological activities and methods of synthesis.
PublicationPraca stanowi przegląd opisanych w literaturze chemicznej modyfikacji struktur naturalnych i syntetycznych pochodnych akrydyny i akrydonu. Artykuł obejmuje swym zakresem metody syntezy, a także wpływ budowy cząsteczek tych związków na ich aktywność przeciwnowotworową oraz mechanizm działania.
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Application of pH measurements for the following the course of biological treatment of wastewater and its control
PublicationZaprezentowano wyniki badań przeprowadzonych w skali laboratoryjnej w reaktorze imitującym działanie reaktora SBR. Oczyszczaniu poddano ścieki syntetyczne z dodatkiem glukozy. W trakcie oczyszczania ścieków monitorowano zmiany pH, redox, przewodności oraz stężenia azotu amonowego, azotanów i fosforanów. Stwierdzono korelację między pH i zmianami stężenia fosoranów oraz brak podobnej zależności dla związków azotowych.
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Solid phase synthesis and biological activity of linear tuftsin and retro-tuftsin derivatives
PublicationPrzedstawiono syntezę na fazie stałej nowych pochodnych tuftsyny i retro-tuftsyny i ich mikrobiologiczne właściwości. Otrzymane pochodne zawierały wiązanie izopeptydowe między epsilon-aminową grupą lizyny a takimi aminokwasami jak: Ala, beta-Ala, Val, Ile, Gly.
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The influence of selenium addition during seeds' germination on the biological properties of obtained sprouts
PublicationSelenium plays a vital role in human body, because in the form of aminoacids (Se-methionine, Se-cysteine) it is found in the active centres of over 25 enzymes, including those regarded as 'cytoprotective'. Unfortunatelly, its daily intake in Poland and other European countries is lower than predicted by dietary recommendations. The consequences of selenium deficiency in diet might be severe, including higher susceptibility to cardio-vascular...
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LC-ESI-MS profiling of Potentilla norvegica and evaluation of its biological activities
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Physical, Chemical and Biological Changes in the Gulf of Gdańsk Ecosystem (Southern Baltic Sea).
PublicationPrzedstawiono fizyczne, chemiczne i biologiczne zmiany zachodzące w ekosystemie Zatoki Gdańskiej (Południowy Bałtyk. Opisano klimat (temp. wody, opady poziom morza, zasolenie), fluktuację stężeń związków biogennych (azotany,fosforany, krzemiany), poziom organicznych zanieczyszczeń (POP´s, PcB´, pestycydy, WWA) oraz zmiany w biologicznym życiu morza.
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Rational design, synthesis and biological evaluation of thiadiazinoacridines: a new class of antitumor agents.
PublicationZsyntetyzowano serię związków o potencjalnej zdolności do wiązania się z DNA z grupy tiadiazinoakrydyn poprzez cyklizację odpowiednich pochodnych 9-imino-4-nitro-9,10-dihydroakrydyny. Zbadano ich zdolność do wiązania się z DNA oraz cytotoksyczność względem kilku linii komórek nowotworwych. Badania aktywności przeciwnowotworowej wobec białaczki P388 wskazały na zgodność tych wyników z wynikami cytotoksyczności in vitro. Wykazano,...
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Preliminary investigations on biological treatment of aqueous phase separated from cutting fluids
PublicationZaprezentowano wyniki fizykochemicznego podczyszczania przepracowanych cieczy obróbkowych pochodzących z różnych źródeł. Emulsje przepracowanych cieczy obróbkowych zostały rozdzielone na fazę organiczną i wodną z wykorzystaniem różnych koagulantów. Wydzielona faza wodna została następnie poddana biologicznemu oczyszczaniu z wykorzystaniem osadu czynnego. W wyniku oczyszczania ścieków uzyskano 59-88% obniżenie wartości ChZT.
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Phytochemical screening and biological evaluation of Greek sage (Salvia fruticosa Mill.) extracts
PublicationThis study explores the influence of extraction solvents on the composition and bioactivity of Salvia fruticosa extracts. Ultrasound-assisted extraction with water, ethanol and their mixtures in variable proportions was used to produce four different extracts. An untargeted UPLC/MS‑based metabolomics was performed to discover metabolites profile variation between the extracts. In the analyzed samples, 2704 features had been detected,...
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BIOLOGICAL AGE ASSESSMENT ALGORITHMS BASED ON X-RAY IMAGES OF BONE TISSUE
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Few-Layered Hexagonal Boron Nitride: Functionalization, Nanocomposites, and Physicochemical and Biological Properties
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Hexagonal Boron Nitride Functionalized with Au Nanoparticles—Properties and Potential Biological Applications
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Novel therapeutic compound acridine–retrotuftsin action on biological forms of melanoma and neuroblastoma
PublicationPURPOSE: As a continuation of our search for anticancer agents, we have synthesized a new acridine-retrotuftsin analog HClx9-[Arg(NO2)-Pro-Lys-Thr-OCH3]-1-nitroacridine (named ART) and have evaluated its activity against melanoma and neuroblastoma lines. Both tumors develop from cells (melanocytes, neurons) of neuroectodermal origin, and both are tumors with high heterogeneity and unsatisfactory susceptibility to chemotherapies....
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Mixed integer nonlinear optimization of biological processes in wastewater sequencing batch reactor
PublicationWastewater treatment plays a key role for humanity. The waste entering lakes, rivers, and seas deteriorates daily quality of life. Therefore, it is very important to improve the efficiency of wastewater treatment. From a control point of view, a biological wastewater treatment plant is a complex, non-linear, multidimensional, hybrid control system. The paper presents the design of the optimizing hierarchical control system applied...
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Influence of Different Nanometals Implemented in PMMA Bone Cement on Biological and Mechanical Properties
PublicationCemented arthroplasty is a common process to fix prostheses when a patient becomes older and his/her bone quality deteriorates. The applied cements are biocompatible, can transfer loads, and dampen vibrations, but do not provide antibacterial protection. The present work is aimed at the development of cement with antibacterial effectivity achieved with the implementation of nanoparticles of different metals. The powders of Ag,...
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Model of aeration system at biological wastewater treatment plant for control design purposes
PublicationThe wastewater treatment plant (WWTP) is a dynamic, very complex system, in which the most important control parameter is the dissolved oxygen (DO) con-centration. The air is supplied to biological WWTP by the aeration system. Aera-tion is an important and expensive activity in WWTP. The aeration of sewage ful-fils a twofold role. Firstly, oxygen is provided as the main component for biolog-ical processes. Secondly, it supports...
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Supervisory fuzzy control system for biological processes in sequencing wastewater batch reactor
PublicationThe paper proposes the design of the supervisory heuristic fuzzy control system applied to a Sequencing Batch Reactor (SBR) in the Wastewater Treatment Plant (WWTP). Based on real data records and the biological process and aeration system models, a control system for biological processes has been designed. The supervisory control system performs management of the reactor work cycle, determines the phase length, controls the sludge...
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