Filtry
wszystkich: 2093
wybranych: 1172
-
Katalog
- Publikacje 1172 wyników po odfiltrowaniu
- Czasopisma 1 wyników po odfiltrowaniu
- Osoby 101 wyników po odfiltrowaniu
- Wynalazki 9 wyników po odfiltrowaniu
- Projekty 41 wyników po odfiltrowaniu
- Laboratoria 1 wyników po odfiltrowaniu
- Zespoły Badawcze 9 wyników po odfiltrowaniu
- Kursy Online 745 wyników po odfiltrowaniu
- Dane Badawcze 14 wyników po odfiltrowaniu
Filtry wybranego katalogu
wyświetlamy 1000 najlepszych wyników Pomoc
Wyniki wyszukiwania dla: KOŃ
-
Oral and Maxillofacial Infections—A Bacterial and Clinical Cross-Section
Publikacja -
Phosphate and Thiophosphate Biphenyl Analogs as Steroid Sulfatase Inhibitors
PublikacjaIn the present work, we report convenient methods for the synthesis and biological evaluation of phosphate and thiophosphate biphenyl derivatives exhibiting steroid sulfatase (STS) activity. The described synthesis is based on straightforward preparation of biphenyl-4-ol and 40-hydroxybiphenyl- 4-carboxylic acid ethyl ester modified with various phosphate or thiophosphate moieties. The inhibitory effects of these compounds were...
-
Steroid Sulfatase Inhibitors Based on Phosphate and Thiophosphate Flavone Analogs
PublikacjaA series of phosphate and thiophosphate flavone derivatives were synthesized and biologically evaluated in vitro for inhibition of steroid sulfatase (STS) activity. The described synthesis includes the straightforward preparation of 7-hydroxy-2-phenyl-4H-chromen-4-one 3a, 2-(4-fluorophenyl)-7-hydroxy-4H-chromen-4-one 3b, 7-hydroxy-2-(4-(trifluoromethyl)phenyl)-4H-chromen-4-one 3c, 7-hydroxy-2-(p-tolyl)-4H-chromen-4-one 3d modified...
-
Changes in Epigenetic Patterns Related to DNA Replication in Vicia faba Root Meristem Cells under Cadmium-Induced Stress Conditions
PublikacjaExperiments on Vicia faba root meristem cells exposed to 150 µM cadmium chloride (CdCl2) were undertaken to analyse epigenetic changes, mainly with respect to DNA replication stress. Histone modifications examined by means of immunofluorescence labeling included: (1) acetylation of histone H3 on lysine 56 (H3K56Ac), involved in transcription, S phase, and response to DNA damage during DNA biosynthesis; (2) dimethylation of histone...
-
Novel 1,2,4-Oxadiazole Derivatives in Drug Discovery
PublikacjaAbstract: Five-membered 1,2,4-oxadiazole heterocyclic ring has received considerable attention because of its unique bioisosteric properties and an unusually wide spectrum of biological activities. Thus, it is a perfect framework for the novel drug development. After a century since the 1,2,4-oxadiazole have been discovered, the uncommon potential attracted medicinal chemists’ attention, leading to the discovery of a few presently...
-
Controlling crystallites orientation and facet exposure for enhanced electrochemical properties of polycrystalline MoO3 films
PublikacjaThis study focuses on the development and optimization of MoO3 films on commercially available FTO substrates using the pulsed laser deposition (PLD) technique. By carefully selecting deposition conditions and implementing post-treatment procedures, precise control over crystallite orientation relative to the substrate is achieved. Deposition at 450 °C in O2 atmosphere results in random crystallite arrangement, while introducing...
-
Instalacje fotowoltaiczne w budownictwie wielorodzinnym
PublikacjaArtykuł opisuje wpływ instalacji fotowoltaicznych na bezpieczeństwo eksploatacji budynków wielorodzinnych. W oparciu o projekty rzeczywistych obiektów przeprowadzono analizę zwiększenia ryzyka strat odgromowych, zmiany obciążenia konstrukcji dachu i wzrostu zagrożenia pożarowego na skutek montażu systemu fotowoltaicznego. Przeprowadzone obliczenia wskazują na konieczność kompleksowego podejścia do projektowania instalacji fotowoltaicznych....
-
Poly(hydroxybutyrate-co-hydroxyvalerate) as a biodegradable binder in a negative electrode material for lithium-ion batteries
PublikacjaIn this work, graphite-based negative electrode for lithium-ion battery consisting a novel and biodegradable binder poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV) is compared with standard graphite electrode with polyvinylidene fluoride (PVDF) as a binder. The rate and cycling performance of lithium ion insertion/extraction of electrodes with PHBV in a half-cell configuration are evaluated. Moreover, on the basis of the electrochemical...
-
Improving the Performance of a Graphite Foil/Polyaniline Electrode Material by a Thin PEDOT:PSS Layer for Application in Flexible, High Power Supercapacitors
PublikacjaIn this study, we present a novel strategy for enhancing polyaniline stability and thus obtaining an electrode material with practical application in supercapacitors. A promising (graphite foil/polyaniline/poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) GF/PANI/PEDOT:PSS) electrode material was characterized and used in the construction of a symmetric supercapacitor that provides an outstanding high power density. For this...
-
Influence of alkali metal cations on the photoactivity of crystalline and exfoliated amorphous WO3 – photointercalation phenomenon
PublikacjaIn order to investigate the effect of photointercalation on photoelectrochemical properties, two types of WO3-based photoanodes, bulk and exfoliated have been prepared and investigated. An aqueous exfoliation method is introduced for the simple fabrication of amorphous and hydrated WO3 nanomaterial using commercial bulk WO3 precursor. The comparison of obtained material with bulk WO3 was performed using Raman, UV–vis, and XPS as...
-
Modulation of dielectric properties in low-loss polypropylene-based composites at GHz frequencies: theory and experiment
PublikacjaPolymer composites with high dielectric constant and low loss tangent are highly regarded as substrates for modern high-speed electronics. In this work, we analyze the high-frequency dielectric properties of two types of composites based on polypropylene infused with high-dielectric-constant microparticles. Two types of fillers are used: commercial ceramics or titanium oxide ( TiO2) with different concentrations. The key observation...
-
Synthesis and steroid sulfatase inhibitory activities of N-phosphorylated 3-(4-aminophenyl)-coumarin-7-O-sulfamates
PublikacjaIn the present work, we report convenient methods for the synthesis and biological evaluation of N-phosphorylated derivatives of 3-(4-aminophenyl)-coumarin-7-O-sulfamate as potential steroid sulfatase (STS) inhibitors. Their binding modes were modeled using docking techniques. The inhibitory effects of the synthesized compounds were tested on STS isolated from human placenta. All of the newly synthesised coumarin derivatives were...
-
Ipertrofan Revisited—The Proposal of the Complete Stereochemistry of Mepartricin A and B
PublikacjaBeing a methyl ester of partricin, the mepartricin complex is the active substance of a drug called Ipertrofan (Tricandil), which was proven to be useful in treatment of benign prostatic hyperplasia and chronic nonbacterial prostatitis/chronic pelvic pain syndrome. Nevertheless, no direct structural evidence on the stereochemistry of its components has been presented to date. In this contribution, we have conducted detailed, NMR-driven...
-
Determination of free tyrosine in equestrian supplements by LC–MS/MS and comparison of its quantity with total free amino acids content in view of doping control
PublikacjaThe reports on the probable beneficial impact of tyrosine (TYR) supplementation on performance enhancement have contributed to the growth of interest in TYR in equestrian sports field and related industries, such as the manufacture of dietary and nutritional supplements. In this study, the first attempt to the assessment of horses exposure to TYR during nutritional supplementation was demonstrated by quantification of unbound TYR...
-
Widening of the electroactivity potential range by composite formation – capacitive properties of TiO2/BiVO4/PEDOT:PSS electrodes in contact with an aqueous electrolyte
PublikacjaComposites based on the titania nanotubes were tested in aqueous electrolyte as a potential electrode material for energy storage devices. The nanotubular morphology of TiO2 was obtained by Ti anodization. TiO2 nanotubes were covered by a thin layer of bismuth vanadate using pulsed laser deposition. The formation of the TiO2/BiVO4 junction leads to enhancement of pseudocapacitance in the cathodic potential range. The third component,...
-
A New Rehabilitation Device for Balance Impaired Individuals
PublikacjaIn the paper authors present a device designed to improve the rehabilitation process of people with balance impairment. The discussed device (JStep) utilizes a commercially available static standing frame (stander) modified in order to fit force sensing units under the feet and in the pillows around the hips of a patient. While executing rehabilitation tasks, the patient may compensate his balance deficiency by leaning on the pillows...
-
Does the low optical band gap of yellow Bi3YO6 guarantee the photocatalytical activity under visible light illumination?
PublikacjaBi3YO6, which is known as an ionic conductor, was tested here as an electrode and photoanode in contact with aqueous electrolytes. Bi3YO6 was deposited onto the Pt substrate and the such prepared electrode was polarized in various aqueous electrolytes. The optical energy band gap of the material equal to 1.89 eV was determined using the Kubelka-Munk function resulting from the UV-Vis spectrum (allowed indirect transition) and also...
-
Ti-Fe2O3/In2O3 as photoactive material: The role of the substrate in photoelectrochemical water oxidation
PublikacjaThe layers of Ti-Fe2O3/In2O3 were prepared on the different substrates using hydrothermal method: Ti/TiO2 nanotubes, Ti foil, FTO and FTO/TiO2. Materials were characterized using scanning electron microscopy, XRD, Raman, UV-Vis, and X-ray photoelectron spectroscopy and tested as photoanodes for water oxidation under illumination. The formation of heterojunction on the TiO2 nanotubes increases photocurrent of water oxidation at...
-
Diminshed toxicity of C-1748, 4-methyl-9-hydroxyethylamino-1-nitroacridine, compared with its demethyl analog, C-857, corresponds to its resistance to metabolism in HepG2 cells
PublikacjaThe narrow "therapeutic window" of anti-tumour therapy may be the result of drug metabolism leading to the activation or detoxification of antitumour agents. The aim of this work is to examine (i) whether the diminished toxicity of a potent antitumour drug, C-1748, 9-(2'-hydroxyethylamino)-4-methyl-1-nitroacridine, compared with its 4-demethyl analogue, C-857, results from the differences between the metabolic pathways for the...
-
Synthesis, biological activity and molecular modelling studies of tricyclic alkylimidazo-, pyrimido- and diazepinopurinediones
Publikacja -
Aging and Hypertension – Independent or Intertwined White Matter Impairing Factors? Insights From the Quantitative Diffusion Tensor Imaging
Publikacja -
Plasma Amino Acids May Improve Prediction Accuracy of Cerebral Vasospasm after Aneurysmal Subarachnoid Haemorrhage
Publikacja -
New Chalcones Derivatives With Potent Antitumor Activity And Their Metabolism In Vitro
PublikacjaChalcone derivatives exhibit a broad range of biological activities, with antioxidant and cytotoxic properties among the most studied. Despite numerous reports on chalcones as cytotoxic, and potentially anticancer agents, very little is know on their actual mechanism of activity. Generally, chalcones are considered as antimitotic agents, which interfere with tubulin assembly.We have recently developed a new class of chalcones with...
-
New matrix-free reference materials of volatile compounds - application of glass fibres as support materials for surface compounds
PublikacjaTechnika termicznego rozkładu związków powierzchniowych, znana od ponad dziesięciu lat, ulega ciągłym udoskonaleniom w celu otrzymywania coraz szerszej gamy wzorców analitycznych występujących na coraz niższych poziomach stężeń. Początkowo w roli nośnika stosowano żel krzemionkowy, który w trakcie dalszych faz rozwoju tej techniki zastąpiono kolejno szkłem porowatym, a następnie włóknem szklanym. W ostatnim czasie uproszczono układ...
-
Możliwości wykorzystania roślin kapustowatych na potrzeby rolnictwa zrównoważonego na przykładzie kapusty białej
PublikacjaRośliny kapustowate (Brassicaceae) stanowią najważniejszą grupę roślin o potencjalnym zastosowaniu na dużą skalę w ochronie środowiska. Wynika to głównie z dwóch własności ich fitokompleksu: zdolności wiązania zanieczyszczeń środowiskowych oraz wytwarzania substancji o aktywności skierowanej przeciwko agrofagom. Te cechy spowodowały, że proponuje się rolnicze wykorzystanie roślin kapustowatych w rewitalizacji terenów zdegradowanych...
-
Mercury concentrations in marine biota with special focus on grey and ringed seals
PublikacjaMarine organisms are exposed and sensitive to effects of environmental contamination by heavy metals including different forms of mercury. Baltic seals as the top predators of the marine ecosystem are even more endangered due to (considerable) longevity as well as a long biological half-time of toxin elimination. The concentrations of mercury in seals from the Baltic is poorly known, thus the aim of this work is to determine and...
-
Methylmercury and total mercury content in soft tissues of two bird species wintering in the Baltic Sea near Gdansk, Poland
PublikacjaOf the various forms of Hg occurring in nature, (mono) methylmercury (MeHg) is an especially toxic form and practically all forms of Hg can be converted into MeHg as a result of natural processes. Total mercury (THg) and MeHg were determined in tissues of two piscivorous birds: razorbill Alca torda and black-throated loon Gavia arctica to provide baseline data on current mercury concentrations for liver, kidneys and pectoral muscle...
-
Synthesis and SAR-study for novel arylpiperazine derivatives of 5-arylidenehydantoin with α1-adrenoceptor antagonistic properties
Publikacja -
NADPH-Cytochrome P-450 reductase in strongly involved in activating metabolic transformatios of 9-amino-1-nitroacridine antitumor agents
PublikacjaCelem pracy było wyjaśnienie roli reduktazy cytochromu P-450 jaką odgrywa ten enzym w przemianach metabolicznych dwóch związków przeciwnowotworowych z grupy pochodnych 1-nitroakrydyny. Zastosowano metodę HPLC do rozdziału metabolitów, a badania struktur przeprowadzono stosując metodę ESI-MS. Wykazano, że badana reduktaza jest zaangażowana bardziej w metabolizm aktywacyjny 1-nitroakrydyn niż metabolizm detoksykacyjny.
-
Multiple-Criteria-Based Electric Vehicle Charging Infrastructure Design Problem
Publikacja -
Wettability of plasma modified glass surface with bioglass layer in polysaccharide solution
Publikacja -
Volumetric staging in radiotherapy for oropharyngeal cancers
Publikacja -
Dual-Energy Computed Tomography in Loosening of Revision Hip Prosthesis
Publikacja -
The clinician’s guide to radiotherapy complications
Publikacja -
The effect of morphology and crystalline structure of Mo/MoO3 layers on photocatalytic degradation of water organic pollutants
PublikacjaMolybdenum oxide layers were formed by anodization of the Mo metallic foil in a water/ethylene glycol-based electrolyte containing fluoride ions. The as-prepared, amorphous samples were annealed in air at different temperatures in a range from 100 �C to 700 �C. The crystal phase and morphology of anodized and annealed MoO3 layers were investigated using X-ray diffraction, Raman spectroscopy, and scanning electron microscopy. The...
-
The phenomenon of increasing capacitance induced by 1T/2H-MoS2 surface modification with Pt particles – Influence on composition and energy storage mechanism
PublikacjaIn this paper, several approaches to the synthesis of molybdenum-based electrode materials for supercapacitors are presented, including anodization, hydrothermal process and annealing. For the material prepared via anodization of a molybdenum plate, followed by a hydrothermal process in thiourea aqueous solution, a thorough study of the Pt-surface modification through repetitive cycling in 1 M sulfuric acid with Pt acting as a...
-
Scaling Up the Process of Titanium Dioxide Nanotube Synthesis and Its Effect on Photoelectrochemical Properties
PublikacjaIn this work, for the first time, the influence of scaling up the process of titanium dioxide nanotube (TiO2NT) synthesis on the photoelectrochemical properties of TiO2 nanotubes is presented. Titanium dioxide nanotubes were obtained on substrates of various sizes: 2 × 2, 4 × 4, 5 × 5, 6 × 6, and 8 × 8 cm2. The electrode material was characterized using scanning electron microscopy as well as Raman and UV–vis spectroscopy in order...
-
A negative effect of carbon phase on specific capacity of electrode material consisted of nanosized bismuth vanadate embedded in carbonaceous matrix
PublikacjaLithium-ion batteries (LIBs) are widely used all over the world. The LIBs belong to a renewable energy source and energy storage devices. The increase in energy demand causes that new materials of higher energy and higher power densities are still under investigation. Herein, we compare electrochemical properties of bismuth vanadate (BiVO4) embedded and not embedded into carbonaceous matrix as an anode material along with structural...
-
Electrodes consisting of PEDOT modified by Prussian Blue analogues deposited onto titania nanotubes – Their highly improved capacitance
PublikacjaIn this work we present the outstanding energy storage of prepared inorganic-organic heterojunction where hydrogenated ordered titania nanotubes (H-TiO2NT) were modified by the hybrid made of poly(3,4-ethylenedioxythiophene) (pEDOT) and iron hexacyanoferrate centres (Fehcf, Prussian Blue). The material TiO2NT/pEDOT:Fechf was obtained electrochemically by means of: anodization, hydrogenation and finally, electropolymerization of...
-
2-Methoxyestradiol and Hydrogen Peroxide as Promising Biomarkers in Parkinson’s Disease
PublikacjaEstrogens function in numerous physiological processes including controlling brain cell growth and differentiation. 2-Meth- oxestradiol (2-ME2), a 17β-estradiol (E2) metabolite, is known for its anticancer effects as observed both in vivo and in vitro. 2-ME2 affects all actively dividing cells, including neurons. The study aimed to determine whether 2-ME2 is a potentially cancer-protective or rather neurodegenerative agent in a...
-
Efflux Pump Blockers in Gram-Negative Bacteria: The New Generation of Hydantoin Based-Modulators to Improve Antibiotic Activity
Publikacja -
Possibilities of production of new reference material - preparation of gaseous standard mixtures using thermal decomposition of immobilized compounds - the effect of selected parameters on the amount of released analyte.
PublikacjaW pracy opisano wyniki badań dotyczących wytwarzania nowego typu bezmatrycowych materiałów odniesienia lotnych związków organicznych. Do otrzymywania lotnych analitów wykorzystano technikę termicznego rozkładu związków powierzchniowych. Badano wpływ parametrów prowadzenia reakcji modyfikacji i termicznego rozkładu otrzymanych związków powierzchniowych na ilość otrzymanego analitu. Wyznaczono powtarzalność i oszacowano niepewność...
-
[Rozdział] 6. Materiały odniesienia
PublikacjaPrzedstawiono charakterystykę poszczególnych typów materiałów odniesienia. Opisano sposoby ich wytwarzania oraz cechy jakie powinny spełniać wraz z metodami ich wyznaczania. Podano przykłady materiałów odniesienia ze szczególnym uwzględnieniem substancji gazowych. Opisano i scharakteryzowano sposoby kalibracji.
-
Diminished toxicity of C-1748, 4-methyl-9-hydroxyethylamino-1-nitroacridine, compared with its demethyl analog, C-857, corresponds to its resistance to metabolism in HepG2 cells
Publikacja -
Regulation of the switch from early to late bacteriophage λ DNA replication
Publikacja -
Structure, thermal and mechanical properties of copoly(ester amide)s based on 2,5‐furandicarboxylic acid
Publikacja -
Circulating microRNAs as Biomarkers of Radiation Exposure: A Systematic Review and Meta-Analysis
Publikacja -
Towards classification of patients based on surface EMG data of temporomandibular joint muscles using self-organising maps
Publikacja -
Evaluation of La0.3Sr0.7Ti1−xCoxO3 as a potential cathode material for solid oxide fuel cells
Publikacja -
A review on the critical challenges and progress of SiOx-based anodes for lithium-ion batteries
Publikacja