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Wyniki wyszukiwania dla: controlled drug delivery
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CURRENT CONTROLLED TRIALS IN CARDIOVASCULAR MEDICINE
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Speech synthesis controlled by eye gazing
PublikacjaA method of communication based on eye gaze controlling is presented. Investigations of using gaze tracking have been carried out in various context applications. The solution proposed in the paper could be referred to as ''talking by eyes'' providing an innovative approach in the domain of speech synthesis. The application proposed is dedicated to disabled people, especially to persons in a so-called locked-in syndrome who cannot...
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Spontaneous unilateral exophthalmos after a vaginal delivery
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Emerging anticancer activity of candidal glucoseamine-6-phosphate synthase inhibitors upon nanoparticle-mediated delivery
PublikacjaNumerous glutamine analogues have been reported as irreversible inhibitors of the glucosamine-6-phosphate (GlcN-6-P) synthase in pathogenic Candida albicans in the last 3.5 decades. Among the reported inhibitors, the most effective N3-(4-methoxyfumaroyl)-L-2,3- diaminopropanoic acid (FMDP) has been extensively studied in order to develop its more active analogues. Several peptide−FMDP conjugates were tested to deliver FMDP to its...
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The Influence of the Co-Dopant Dexamethasone Phosphate on the Electrodeposition Process and Drug-Release Properties of Polypyrrole-Salicylate on Iron
PublikacjaIn this work, the influence of incorporation of two anti-inflammatory drugs dexamethasone phosphate and sodium salicylate on the electrodeposition process of polypyrrole (PPy) film on iron has been studied. The incorporation of the agents into PPy has been carried out in a one-step electropolymerization process on oxidizable iron. The role of each drug agent during the deposition process has been discussed. The morphological and...
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Representativity of ISO test track surface based on controlled pass-by measurements
PublikacjaWithin the Polish-Norwegian research project ELANORE, a limited Round Robin Test has been performed on four ISO tracks in Northern Europe. The basic objective of the project is to improve the EU directive on labelling of tyres for noise and rolling resistance. This directive is based on the measurement procedures proscribed in the UNECE Reg.117. Measurements on 3 ISO tracks were performed in 2021 and presented at InterNoise 2022....
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Cancer stem cells and escape from drug-induced premature senescence in human lung tumor cells: implications for drug resistance and in vitro drug screening models
PublikacjaBadania z użyciem modelu komórek nowotworu płuc A549 wykazały, że komórki te po traktowaniu lekami uszkadzającymi DNA zatrzymują proliferację i wchodzą w stan starzenia komórkowego. Jednak post-inkubacja tych komórek prowadzi do powrotu do stanu proliferacji małej frakcji komórek. Wykazaliśy, że frakcja ta związana jest z obecnością komórek pierwotnych nowotworu w populacji komórek A549. Powrót do stanu proliferacji komóek A549...
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Modeling Object Oriented Systems via Controlled English Verbalization of Description Logic
PublikacjaThe need for formal methods for Object Oriented (OO) systems resulted in methods like UML and Lepus3 that are de-facto graphical languages equipped with formal tools that are able to handle the design of OO systems. However, they lack precise semantics which might lead to problems, such as inconsistencies or redundancies. On the other hand, to our knowledge, there is no approach that allows one to understand and follow the requirements...
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A method of self-testing of an analog circuit terminated by an ADC in electronic embedded systems controlled by microcontrollers
PublikacjaA new self-testing method of analog parts terminated by an ADC in electronic embedded systems controlled by microcontrollers is presented. It is based on a new fault diagnosis method based on on-line (i.e. during measurement), transformations of voltage samples of the time response of a tested part to a square pulse - onto localization curves placed in the measurement space. The method can be used for fault detection and single...
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Nanosize effect of clay mineral nanoparticles on the drug diffusion processes in polyurethane nanocomposite hydrogels
PublikacjaStudies of swelling and release of naproxen sodium (NAP) solution by polyurethane nanocomposite hydrogels containing Cloisite® 30B (organically modified montmorillonite (OMMT)) have been performed. Polyurethane nanocomposite hydrogels are hybrid, nontoxic biomaterials with unique swelling and release properties in comparison with unmodified hydrogels. These features enable to use nanocomposite hydrogels as a modern wound dressing....
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Exposure to non-opioid analgesics during pregnancy and the risk of adverse drug reactions
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JOURNAL OF CONTROLLED RELEASE
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Magnetic field effects in dye-sensitized solar cells controlled by different cell architecture
PublikacjaThe charge recombination and exciton dissociation are generally recognized as the basic electronic processes limiting the efficiency of photovoltaic devices. In this work, we propose a detailed mechanism of photocurrent generation in dye-sensitized solar cells (DSSCs) examined by magnetic field effect (MFE) technique. Here we demonstrate that the magnitude of the MFE on photocurrent in DSSCs can be controlled by the radius and...
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Construction of a simulation model of goods delivery in international road transportation taking into account the functioning efficiency of logistics supply chain
PublikacjaThe object of this study is the process of goods delivery in international road transport using various types of logistics chains. The problem being solved is due to the need to develop recommendations for exporters of goods to reformat or design new supply chains during wartime. The expediency of organizing foreign trade operations by the cargo owners' own forces or with the involvement of enterprises providing logistics consulting...
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Low-Barrier Hydrogen Bond Determines Target-Binding Affinity and Specificity of the Antitubercular Drug Bedaquiline
PublikacjaThe role of short strong hydrogen bonds (SSHB) in ligand-target binding remains largely unexplored, thereby hin- dering a potentially important avenue in the rational drug de- sign. Here, we investigate the interaction between bedaquiline (Bq), a potent anti-tuberculosis drug, and the mycobacterial ATP synthase, to unravel the role of a specific hydrogen bond to a conserved acidic residue in the target affinity and specificity....
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Enhancing electrical properties through in-situ controlled nanocrystallization of V2O5–TeO2 glass
PublikacjaV2O5–TeO2 glass–ceramics (VTGC) were prepared by controlled annealing of the V2O5–TeO2 glass (VTG), which illustrates a parent glass matrix with a single charge carrier. The annealing proceeded at six temperatures selected between the glass transition and the maximum of the frst crystallization process to obtain various nanocrystallite sizes. Heat treatment caused an increase in DC conductivity by 2.5–3.5 (250–285 °C) order of...
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Injectable poloxamer/graphene oxide hydrogels with well‐controlled mechanical and rheological properties
PublikacjaAlthough significant progress has been made in the design and application of injectable hydrogels for biomedical applications, concurrent control of rheological and mechanical properties of injectable hydrogels has remained as an open challenge to the researchers. In this work, we introduce and put into practice a photo‐curable poloxamer (also known as Pluronic)/graphene oxide (Plu/GO) injectable hydrogel with well‐controlled rheological...
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Finding the right balance in oxygen delivery after resuscitation
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Internet as a new platform for delivery of microwave CAD services.
PublikacjaZaprezentowano aplikację przeznaczoną do syntezy filtrów rezonatorowych, która jest realizacją nowego sposobu myślenia związanego z rewolucją usług internetowych, które charakteryzują się niskim kosztem tworzenia oraz szybką i bezpieczną dystrybucją. Opisano stworzoną wielowarstwową aplikację, która gwarantuje łatwy, bezpieczny oraz ograniczony dostęp do aplikacji dla szerokiego kręgu osób. Zawarto w niej algorytm szybkiej syntezy...
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Experimental evaluation of the PLC-controlled drives properties.
PublikacjaPrzedstawiono strukturę stanowiska laboratoryjnego do testów oprogramowania PLC do sterowania napędami oraz do prowadzenia eksperymentalnych prób takich napędów. Omówiono zasady prowadzenia testów oprogramowania przed i w trakcie uruchamiania napędu. Przedstawiono przykładowe rezultaty doświadczeń.
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Recent progress in controlled carbonization of (waste) polymers
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Music Mixing Process Controlled by Hand Gestures
PublikacjaW referacie przedstawiono system umożliwiający sterowanie procesami miksowania śladów nagrania muzycznego za pomocą gestów rąk. Przybliżono podstawy wielomodalnej percepcji argumentujące potrzebę powstania tego typu systemu oraz założenia przyjęte w trakcie jego tworzenia. Część sprzętowa systemu składa się z rzutnika multimedialnego, kamery internetowej, komputera klasy PC z zainstalowanym oprogramowaniem systemu oraz ekranu dla...
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Preparation of silver nanoparticles with controlled particle size
PublikacjaNanocząstki srebra wykazują zdolność absorpcji promieniowania widzialnego, która jest efektem istnienia powierzchniowego plazmonu. W zależności od kształtu i wielkości cząstek obserwuje się różną barwę koloidów srebra. W wyniku przeprowadzonych badań otrzymano nanocząstki srebra metodą chemicznej redukcji. Zaobserwowano wpływ rodzaju reduktora (kwas askorbinowy, borowodorek sodu), stabilizatora (PVP, PVA) oraz prekursora srebra...
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Characterization of carbon deposit with controlled carburization degree
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Few-Layer Black Phosphorus/Chitosan Nanocomposite Electrodes via Controlled Electrodeposition for Enhanced Electrochemical Kinetic Performance
PublikacjaThis study presents the preparation and characterization of few-layer black phosphorus (FLBP) chitosan electrodes by controlled electrochemical deposition of chitosan nanoparticles on FLBP-modified glassy carbon electrodes. FLBP was prepared by solvent-assisted exfoliation of bulk BP and was further modified with chitosan forming together a nanocomposite, including easy cross-linking with nanomaterials and film-forming properties....
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Development of Local IDF-formula Using Controlled Random Search Method for Global Optimization
PublikacjaThe aim of the study is to present the effective and relatively simple empirical approach to rainfall Intensity-Duration-Frequency-formulas development, based on Controlled Random Search (CRS) for global optimization. The approach is mainly dedicated to the cases in which the commonly used IDF-relationships do not provide satisfactory fit between simulations and observations, and more complex formulas with higher number of parameters...
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Drug-resistant and hospital-associated Enterococcus faecium from wastewater, riverine estuary and anthropogenically impacted marine catchment basin.
PublikacjaEnterococci, ubiquitous colonizers of humans and other animals, play an increasingly important role in health-care associated infections (HAIs). Acquisition of resistance determinants not only seriously limits available therapeutic options but also increases available gene pool for other species. It is believed that the recent evolution of two clinically relevant species, Enterococcus faecalis and Enterococcus faecium occurred...
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Drug-Eluting Biopsy Needle as a Novel Strategy for Antimicrobial Prophylaxis in Transrectal Prostate Biopsy
PublikacjaOBJECTIVES: To preclinically evaluate drug-eluting biopsy needles (patent pending WO2016118026) as a new potential way of antimicrobial prophylaxis for transrectal prostate biopsy. METHODS: Twenty steel biopsy needles have been coated with polyvinyl alcohol, ciprofloxacin, and amikacin. Modified biopsy needles have been randomly divided into 3 groups (1:2:1 ratio). Needles from group I were immersed for 30 minutes in dedicated...
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Adapting new tools of urban freight management based on Gdynia’s dedicated delivery bays example – an analysis of the process
PublikacjaThe article presents an analysis of a process which ultimately helped Gdynia to designate pilot delivery sites in its downtown area using international experience. A verification was conducted of policy transfer theory and its practical implementation based on an URBACT Freight Tails project. While the choice of the solution was based on critical analysis of existing practical examples, it needed to be adapted to the local conditions...
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ENCAPSULATION OF ROXITHROMYCIN INTO GELLAN GUM MATRICES AND THE IMPACT OF OTHER NATURAL POLYMERS ON DRUG RELEASE
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A five-year retrospective study shows increasing rates of antimicrobial drug resistance in Cabo Verde for both Staphylococcus aureus and Escherichia coli
PublikacjaObjectives Data on baseline drug resistance is important in informing future antimicrobial stewardship programs. So far, no data on the antimicrobial drug resistance of clinical isolates was available for the African archipelago of Cabo Verde. Methods We have performed a retrospective analysis over five-years (2013-17) of the antimicrombial drug susceptibility profiles of clinical isolates in the two main hospitals of Cabo Verde....
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Pore Water Pressure Development in Soft Soil due to Installation and Loading of Controlled Modulus Columns
PublikacjaExcess pore water pressure (EPWP) development and decay due to the installation and static loading tests of controlled modulus columns (CMC) in soft soil was measured with piezometers equipped with low air entry (LAE) filters and a piezocone (CPTU) equipped with a high air entry (HAE) filter. The HAE filter allows for detailed detection of EPWP in short time intervals during construction of CMC. The influence zone due to the installation...
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Glutathione-mediated conjugation of anticancer drugs: an overview of reaction mechanisms and biological significance for drug detoxification and bioactivation.
PublikacjaThe effectiveness of many anticancer drugs depends on the creation of specific metabolites that may alter their therapeutic or toxic properties. One significant route of biotransformation is a conjugation of electrophilic compounds with reduced glutathione, which can be non-enzymatic and/or catalyzed by glutathione-dependent enzymes. Glutathione usually combines with anticancer drugs and/or their metabolites to form more polar...
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Size-Controlled Synthesis of Pt Particles on TiO2 Surface: Physicochemical Characteristic and Photocatalytic Activity
PublikacjaDifferent TiO2 photocatalysts, i.e., commercial samples (ST‐01 and P25 with minority of rutile phase), nanotubes, well‐crystallized faceted particles of decahedral shape and mesoporous spheres, were used as supports for deposition of Pt nanoparticles (NPs). Size‐controlled Pt NPs embedded in TiO2 were successfully prepared by microemulsion and wet‐impregnation methods. Obtained photocatalysts were characterized using XRD, TEM,...
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IEEE TRANSACTIONS ON POWER DELIVERY
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Chitosan as Valuable Excipient for Oral and Topical Carvedilol Delivery Systems
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Antibiotic loaded microspheres as antimicrobial delivery systems for medical applications
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Wettability and Stability of Naproxen, Ibuprofen and/or Cyclosporine A/Silica Delivery Systems
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Fluent Editor and Controlled Natural Language in Ontology Development
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Design and construction of an industrial robot controlled by the ROS environment
PublikacjaThis engineering thesis focuses on the recognition of modern budgetary solutions of roboticarms and on the design and implementation of one of them. Historical solutions are discussedusing the example of the IRB6 robot and the modern approach - the Omron Viper 850. Thepaper includes a description of the design thought of the different parts. Mechanical, electrical andsoftware aspects are presented. In...
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Quasi-controlled Experimentations on the Impact of AOP on Software Comprehensibility
PublikacjaAspect-oriented programming (AOP) emerged as a paradigm to modularize the concerns that lead to interwoven code if implemented using traditional programming techniques. Unfortunately, the new constructs introduced by aspect-oriented (AO) languages result in both: (1) obstacles in modular reasoning, and (2) high coupling between aspects and the augmented modules. There have been numerous attempts to tackle these issues, but none...
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In-vitro controlled release of doxorubicin from silica xerogels
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Review of Autonomous and Remotely Controlled Ships in Maritime Sector
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Digital Implementation of a Novel Controlled Rectifier Synchronization Method
PublikacjaZ uwagi na zakłócenia spotykane w przebiegach napięćia zasilającego prostowniki sterowane, tradycyjna metoda synchronizacji wykrywająca przejście naopięcia przez zero nie zapewnia prawidłowego działania prostownika. W artykule przedstawiono nową metodę synchronizacji prostowników sterowanych tyrystorowych i tranzystorowych z siecią zasilającą. W artykule przedstawiono zależności teoretyczne oraz wyniki badań symulacyjnych i eksperymentalnych.
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Practical realisation of new method of synchronization for controlled rectifier.
PublikacjaW artykule zaprezentowano nową metodę synchronizacji sygnałów sterujących prostownika z siecią. W prezentowanej metodzie nie ma potrzeby wykrywania chwili przejścia napięcia zasilającego przez zero. Przedstawiono zależności teoretyczne oraz wyniki badań symulacyjnych i eksperymentalnych uzyskanych w systemie z procesorem sygnałowym.
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Gesture-controlled Sound Mixing System With a Sonified Interface
PublikacjaIn this paper the Authors present a novel approach to sound mixing. It is materialized in a system that enables to mix sound with hand gestures recognized in a video stream. The system has been developed in such a way that mixing operations can be performed both with or without visual support. To check the hypothesis that the mixing process needs only an auditory display, the influence of audio information visualization on sound...
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Thin layer chromatography in drug discovery process
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Drug Research
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DRUG SAFETY
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Drug Topics
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