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Wyniki wyszukiwania dla: AGENT%20UBEZPIECZENIOWY
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Designing optimal operational-point trajectories using an intelligent sub-strategy agent-based approach
PublikacjaW rozdziale opisuje się metodę projektowania optymalnej i bezpiecznego sterowania nieliniowymi procesami dynamicznymi. Poszukiwane sterowanie jest wynikiem zastosowania elementarnej strategii poszczególnych agentów, realizujących zadanie minimalizacji wspólnej miary kosztu sterowania. Zagadnienie projektowania optymalnego sterowania traktowane jest jako proces decyzyjny, w którym decyzje podejmowane są w kolejnych regionach przestrzeni...
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The studies of imidazoacridinone antitumor agent, C-1311, in the field of metabolic transformations with cytochrome P450 isoenzymes
PublikacjaPraca zawiera wyniki badań metabolicznej transformacji przeciwnowotworowej pochodnej imidazoakrydonu C-1311 wobec rekombinantowych ludzkich izoenzymów P450. Związek nie ulegał transformacji w badanych warunkach, natomiast wykazano, że ma zdolność hamowania aktywności izoezymów CYP1A2 i CYP3A4.
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Phenylalanine-Based AMPA Receptor Antagonist as the Anticonvulsant Agent with Neuroprotective Activity—In Vitro and In Vivo Studies
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Metabolism of antitumour agent 1-nitroacridine derivative, C-1748 in pancreatic cancer cell lines
PublikacjaPancreatic cancer has the highest mortality rate of all major cancers because of limited treatment options. Surgical removal of the tumour is possible only in its early stage, nevertheless the asymptomatic development very often makes unable an accurate diagnose. In the case of metastatic pancreatic cancer only chemotherapy, mainly with gemcitabine, can be offered to patients. However, common resistance towards gemcitabine imposes...
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Application of agent-based simulated annealing and tabu search procedures to solving the data reduction problem
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SELECTING A REPRESENTATIVE DATA SET OF THE REQUIRED SIZE USING THE AGENT-BASED POPULATION LEARNING ALGORITHM
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Designing optimal operational-point trajectories using an intelligent sub-strategy agent-based approach
PublikacjaW rozdziale opisuje się metodę projektowania optymalnej i bezpiecznego sterowania nieliniowymi procesami dynamicznymi. Poszukiwane sterowanie jest wynikiem zastosowania elementarnej strategii poszczególnych agentów, realizujšcych zadanie minimalizacji wspólnej miary kosztu sterowania. Zagadnienie projektowania optymalnego sterowania traktowane jest jako proces decyzyjny, w którym decyzje podejmowane sš w kolejnych regionach przestrzeni...
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Photosensitive and pH-dependent activity of pyrazine-functionalized carbazole derivative as promising antifungal and imaging agent
PublikacjaCarbazole skeleton plays a significant role as a structural scaffold of many pharmacologically active compounds. Pyrazine-functionalized carbazole derivative was constructed by coupling 2-amino-5-bromo-3-methylaminepyrazine (ABMAP) into 3 and 6 positions of the carbazole ring. Multi-experimental methods were used, e.g., potentiometric, spectroscopic (ATR, UV, XRD powder,1H and13C NMR), electrochemical (cyclic voltammetry), and...
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From tryptophan to novel mitochondria-disruptive agent, synthesis and biological evaluation of 1,2,3,6-tetrasubstituted carbazoles
PublikacjaMitochondrial targeting plays an important role in anticancer therapy. The Mn(III)-promoted cyclization of 5- (1H-indol-3-yl)-3-oxopentanoic acid allow to obtain novel substituted carbazole derivatives that can act as mitochondria-disruptive agents. The starting materials used for the synthesis of these new aminocarbazoles are oxopentanoate derivatives of tryptophan. The scope and limitation of this method of synthesis are determined...
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World Research Journal of Antimicrobial Agents
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Cardiovascular and Hematological Agents in Medicinal Chemistry
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Rendezvous of Heterogeneous Mobile Agents in Edge-Weighted Networks
PublikacjaWe introduce a variant of the deterministic rendezvous problem for a pair of heterogeneous agents operating in an undirected graph, which differ in the time they require to traverse particular edges of the graph. Each agent knows the complete topology of the graph and the initial positions of both agents. The agent also knows its own traversal times for all of the edges of the graph, but is unaware of the corresponding traversal...
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Arsenic-Based Warfare Agents: Production, Use, and Destruction
PublikacjaSince the beginning of time, civilizations have looked for more creative ways to dominate and defeat their enemies. The rapid development of the chemical industry just before the Second World War started the era of modern chemical weapon production based on poisons, including toxic arsenic compounds. This paper provides a detailed overview of the production, usage and destruction of this dangerous chemical weapon. Milestones include:...
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Leader election for anonymous asynchronous agents in arbitrary networks
PublikacjaWe consider the problem of leader election among mobile agents operating in an arbitrary network modeled as an undirected graph. Nodes of the network are unlabeled and all agents are identical. Hence the only way to elect a leader among agents is by exploiting asymmetries in their initial positions in the graph. Agents do not know the graph or their positions in it, hence they must gain this knowledge by navigating in the graph...
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Agents in Simulation of Cyberattacks to Evaluate Security of Critical Infrastructures
PublikacjaIn the last years critical infrastructures have become highly dependent on the information technologies and exposed to cyberattacks. Because the effects of the attacks can be detrimental, it is crucial to comprehensively asses the security of the infrastructures' information systems. This chapter describes MAlSim - the simulator of malicious software based on software agents, developed for the needs of a testbed for critical infrastructures...
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The role and construction of educational agents in distance learning environments
PublikacjaArtykuł przedstawia definicję oraz klasyfikację agentów edukacyjnych. Wskazuje typowe cele i zadania agentów, a także omawia schemat ich budowy i funkcjonowania. Wskazano także różnorodność możliwości, jakie stwarzają różne rodzaje agentów w procesie nauczania. W artykule opisano także wytworzony w ramach badań prototyp agenta WAS, którego zadaniem jest wspomaganie uczniów w zakresie pracy z materiałami edukacyjnymi.
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Rendezvous of Distance-Aware Mobile Agents in Unknown Graphs
PublikacjaWe study the problem of rendezvous of two mobile agents starting at distinct locations in an unknown graph. The agents have distinct labels and walk in synchronous steps. However the graph is unlabelled and the agents have no means of marking the nodes of the graph and cannot communicate with or see each other until they meet at a node. When the graph is very large we want the time to rendezvous to be independent of the graph size...
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Rendezvous of heterogeneous mobile agents in edge-weighted networks
PublikacjaWe introduce a variant of the deterministic rendezvous problem for a pair of heterogeneous agents operating in an undirected graph, which differ in the time they require to traverse particular edges of the graph. Each agent knows the complete topology of the graph and the initial positions of both agents. The agent also knows its own traversal times for all of the edges of the graph, but is unaware of the corresponding traversal...
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Integracja inteligentnego agenta diagnostycznego z systemami CRM.
PublikacjaW artykule zawarto propozycję integracji inteligentnych agentów diagnostycznych z systemami CRM zarządzania przedsiębiorstwem, w szczególności z podsystemem zarządzania zasobami informatycznymi.
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Synthesis of S-thioacyl dithiophosphates, efficient and chemoselectivethioacylating agents
PublikacjaŁatwo dostępne ditiofosforany acylu izomeryzują do monotiofosforanów O- iS-tioacylu. Reakcja jest odwracalna, więc ogrzewanie ditiofosforanów acylu prowadzi zazwyczaj do powstania mieszaniny izomerycznych bezwodników, która nie może być wykorzystana do wydajnego tioacylowania. Jednak działaniem kwasu ditiofosforowego na mieszaninę izomerycznych bezwodników można wydajnie otrzymać ditiofosforany tioacylu. Związki te to doskonałe...
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Neuronowo Sterowane Agenty w Procesie Zespołowego Zaganiania
PublikacjaPrzedstawiono rozwiązanie problemu zaganiania na drodze uczenia algorytmami ewolucyjnymi. Neuronowe agenty aktywne na podstawie informacji o położeniach pozostałych agentów aktywnych i biernych poprzez odpowiednie poruszanie się skupiają agenty bierne na możliwie małej powierzchni.
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Gossiping by energy-constrained mobile agents in tree networks
PublikacjaEvery node of an edge-weighted tree network contains a data packet. At some nodes are placed mobile agents, each one possessing an amount of energy (not necessarily the same for all agents). While walking along the network, the agents spend the energy proportionally to the distance traveled and collect copies of the data packets present at the visited network nodes. An agent visiting a node deposits there copies of all currently...
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Mobile chromatographs and spectrometers for the analysis of chemical warfare agents
PublikacjaThis article describes the technological state of readiness regarding mobile chromatographs and spectrometers and their appiicability for the analysis of chemical warfare agents (CWAs), degradation products, simulants, and precursors.
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Amino Acid Based Antimicrobial Agents – Synthesis and Properties
PublikacjaStructures of several dozen of known antibacterial, antifungal or antiprotozoal agents are based on the amino acid scaffold. In most of them, the amino acid skeleton is of a crucial importance for their antimicrobial activity, since very often they are structural analogs of amino acid intermediates of different microbial biosynthetic pathways. Particularly, some aminophosphonate or aminoboronate analogs of protein amino acids are...
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Application of Intelligent Conversational Agents in E-learing Environments
PublikacjaThe paper concerns intelligent tutoring systems and concentrates on apliaction of virtual mentors in distance learning environments. Different educational agent types are described. The prototype of an agent developed at Gdansk University of Technology is also presented, as well as its internal representation and construction. Benefits of virtual mentors applied in distance learning are also pointed out.
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Synthesis of 2-amino-2,6-dideoxy-D-glucitol-6-sulfonic acid as a potential antifungal agent.
PublikacjaGlucosamine-6P (GlcN-6P) synthase catalyzes the first committed step in the biosynthetic pathway leading to the formation of UDP-GlcNAc, a sugar nucleotide precursor providing D-glucosamine for the formation of chitin and manoproteins. 2-Amino-2,6-dideoxy-D-glucitol-6-sulfonic acid is an analog of 2-amino-2-deoxy-D-glucitol 6-phosphate (GlcN-ol-6-P), a known inhibitor of GlcN-6-P synthase, in which the phosphate group of the latter...
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Institution of the health care agent in Polish legislation: position of the Polish Working Group on End-of-Life Ethics
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BeesyBees: A mobile agent-based middleware for a reliable and secure execution of service-based workflow applications in BeesyCluster
PublikacjaIntegrating distributed services into workflows comes with its own set of challenges, including security, coordination, fault tolerance and optimisation of execution time. This paper presents an architecture and implementation - nicknamed BeesyBees - that allows distributed execution of workflow applications in BeesyCluster using agents. BeesyCluster is a middleware that allows users to access distributed resources as well as publish...
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Isoform-specific inhibition of DNA topoisomerase II as the mechanism of action of novel anticancer agent C-1305
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Whole genome sequencing of Fowl aviadenovirus A - a causative agent of gizzard erosion and ulceration, in adult laying hens
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Ionic liquid as morphology-directing agent of two-dimensional Bi2WO6: New insight into photocatalytic and antibacterial activity
PublikacjaAn efficient and durable utilization of light to drive photocatalytic reactions still requires the overcoming of barriers. Herein, two-dimensional (2D) ultrathin IL_Bi2WO6 (IL_BWO) photocatalysts were prepared for the first time via ionic liquid-assisted hydrothermal route by adjusting the amount of tetrabutylammonium chloride [TBA][Cl], synthesis temperature and duration. IL played the role of morphology-directing agent given...
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Fecal indicators resistance to antimicrobial agents present in municipal wastewater
PublikacjaIn this study removal rate of six antimicrobial compounds (belonging to folate pathway inhibitors and macrolides class) was analyzed in processes of local wastewater treatment plant (WWTP) together with susceptibility patterns of erythromycin (E) resistant Enterococcus spp. and trimethoprim/sulfamethoxazole (SXT) resistant Escherichia coli. According to the obtained data, six of tested antimicrobial agents, namely erythromycin,...
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GROUP COMPOSER - System for Modeling Agents’ Team Building for Tasks
PublikacjaMulti-agent systems consist of many autonomous units, called agents, that can interact when trying to achieve their goals. The selection of interaction partners is called team formation. Three basic approaches can be considered to match multi-agent system resources to the problem at hand. To research the properties of different approaches, a software for modeling team formation in multi-agent systems has been created and is presented...
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Deterministic rendezvous of asynchronous bounded-memory agents in polygonal terrains
PublikacjaWe consider two versions of the rendezvous problem: exact RV, when the points representing agents have to coincide at some time, and e-RV, when these points have to get at distance less than e in the terrain. In any terrain, each agent chooses its trajectory, but the movements of the agent on this trajectory are controlled by an adversary that may, e.g. speed up or slow down the agent.
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Vitamin D and its analogs as anticancer and anti-inflammatory agents
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Deterministic rendezvous of asynchronous bounded-memory agents in polygonal terrains
PublikacjaTwo mobile agents, modeled as points starting at differentlocations of an unknown terrain, have to meet. The terrain is a polygon with polygonal holes. We consider two versions of this rendezvous problem: exact RV, when the points representing the agents have to coincide at some time, and epsilon-RV, when these points have to get at distance less than epsilon in the terrain. In any terrain, each agent chooses its trajectory, but...
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Big Data Processing by Volunteer Computing Supported by Intelligent Agents
PublikacjaIn this paper, volunteer computing systems have been proposed for big data processing. Moreover, intelligent agents have been developed to efficiency improvement of a grid middleware layer. In consequence, an intelligent volunteer grid has been equipped with agents that belong to five sets. The first one consists of some user tasks. Furthermore, two kinds of semi-intelligent tasks have been introduced to implement a middleware...
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Harmful biological agents in municipal waste thermal treatment plants
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An untraceability protocol for mobile agents and its enhanced security study
PublikacjaArtykuł przedstawia rozszerzoną analizę bezpieczeństwa zaproponowanego przez nas protokołu ochrony przed tropieniem (ang. untraceability protocol) dla agentów mobilnych. Jak dotąd, tak systematyczna analiza bezpieczeństwa nie została przeprowadzona. Co więcej, istniejące znane analizy bezpieczeństwa koncentrują się wyłącznie na atakujących wewnętrznych. Uważamy, że stworzona przez nas lista kontrolna ataków może posłużyć jako...
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The Usefulness of Cyclic Diamidines with Different Core-substituents as Antitumor Agents
PublikacjaA series of related polycationic compds. has been screened for potential antitumor activity by the NCI's in vitro testing (one dose primary anticancer assay and the NCI-60 full panel screening). The GI50 values of triazines 3 and 4 are on av. 1.9 μM and 2.4 μM, resp. Furan 8 deserves mention too (1.9 μM). The biol. test results showed that carbazole 10 possessed cytotoxic activity in the nanomolar range, much better than...
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The Influence of Binding Agents on Stiffness of Mineral-cement-emulsion Mixtures
PublikacjaThis paper attempts to determine the behavior of mineral-cement-emulsion mixture (MCE) under load, whether is it similar to asphalt mixtures (viscoelastic behavior) or to cement treated materials (elastic behavior). To answer this question nine mineral- cement-emulsion mixtures with different combinations of cement and emulsion content were tested in laboratory using Simple Performance Test (SPT). For each mixture stiffness moduli...
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Selection of derivatisation agents for chlorophenols determination with multicriteria decision analysis
PublikacjaThe paper shows very systematic method of selection of derivatisation agents for a given group of analytes. In this study 8 derivatisation agents are assessed for their capability to derivatise 8 chlorophenols. Multicriteria decision analysis is used to combine many objectives of derivatisation agents selection into single, easy to be interpreted numerical value. Three basic analyses were performed to obtain rankings with the aims...
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Quantum strategies for rendezvous and domination tasks on graphs with mobile agents
PublikacjaThis paper explores the application of quantum nonlocality, a renowned and unique phenomenon acknowledged as a valuable resource. Focusing on an alternative application, we demonstrate its quantum advantage for mobile agents engaged in specific distributed tasks without communication. The research addresses the significant challenge of rendezvous on graphs and introduces a distributed task for mobile agents grounded in the graph...
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Constructing autonomous agents using the cognitive-emotional architecture of the mind
PublikacjaThe article discusses an important issue regarding the humanoid aspects of modern science related to the autonomy of systems and robotization. Particular attention is paid to the basic aspects of cognitive architecture. After a short introduction, the Intelligent Decision Making System, developed at the ETI Faculty of the Gdańsk University of Technology, is described.
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Concept of the mobile monitoring system for chemical agents control in the air
PublikacjaW artykule przedstawiono koncepcję mobilnego systemu monitoringu związków chemicznych zanieczyszczających powietrze. Nowością w przedstawionej koncepcji monitoringu jest pomiar zanieczyszczeń powietrza wzdłuż ciągów komunikacyjnych, co do tej pory nie jest realizowane. W tym celu przedstawiono propozycję rozwiązania stosunkowo małego, bezobsługowego modułu do pomiarów związków chemicznych, który z łatwością będzie montowany na...
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A Review of Traffic Analysis Attacks and Countermeasures in Mobile Agents' Networks
PublikacjaFor traditional, message-based communication, traffic analysis has been already studied for over three decades and during that time various attacks have been recognised. As far as mobile agents’ networks are concerned only a few, specific-scope studies have been conducted. This leaves a gap that needs to be addressed as nowadays, in the era of Big Data, the Internet of Things, Smart Infrastructures and growing concerns for privacy,...
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Dimethyl(3,3,3-trifluoropropyl)silyldiethylamine—A new silylating agent for the derivatization of β-blockers and β-agonists in environmental samples
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Interactive information and decision support system for urban and industrial air quality management based on multi-agent system
PublikacjaThis article presents conception of interactive information and decision support system for urban and industrial air quality management. The emphasis of the project is on real-time analysis and multi-media information, and the support of distributed and mobile clients through the Internet. The approach integrates meteorological data and forecasts, air quality and emission monitoring, dynamic 3D simulation modelling and forecasting,...
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Imidazoacridinone antitumor agent, c-1311, as a selective mechanism-based inactivator of human recombinant cytochrome P450 1A2
PublikacjaPrzedmiotem badań była przeciwnowotworowa pochodna imidazoakrydonu, C-1311, która pod nazwą Symadex R, znajduje się aktualnie w II fazie badań klinicznych. Wcześniejsze wyniki pozwoliły stwierdzić, że związek ten jest selektywnym inhibitorem niektórych enzymów cytochromowych. Podjęto zatem próbę wyjaśnienia mechanizmu inhibicji izoenzymów cytochromu P450 przez C-1311. Wykazano, że utrata aktywności katalitycznej obu izoenzymów...
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An Approach to Data Reduction for Learning from Big Datasets: Integrating Stacking, Rotation, and Agent Population Learning Techniques
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