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Assestment of the anti-cancer activity of the copper complexes with imidazole and pivalato ligands
PublikacjaDespite the development of science and technology progress so far there have not been found effective drugs for cancer. Many coordination compounds were investigated due to their antitumor potential. The most known cis-diamminedichloroplatinum(II) is used as anti-cancer therapeutic agent. The copper complexes are the coordination compounds possessing anti-tumour properties. Their capability to kill cancer cells is mainly linked...
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Predictions of cervical cancer identification by photonic method combined with machine learning
PublikacjaCervical cancer is one of the most commonly appearing cancers, which early diagnosis is of greatest importance. Unfortunately, many diagnoses are based on subjective opinions of doctors—to date, there is no general measurement method with a calibrated standard. The problem can be solved with the measurement system being a fusion of an optoelectronic sensor and machine learning algorithm to provide reliable assistance for doctors...
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The Influence of Antitumor Unsymmetrical Bisacridines on 3D Cancer Spheroids Growth and Viability
PublikacjaThe culture of 3D spheroids is a promising tool in drug development and testing. Recently, we synthesized a new group of compounds, unsymmetrical bisacridines (UAs), which exhibit high cytotoxicity against various human cell lines and antitumor potency against several xenografts. Here, we describe the ability of four UAs—C-2028, C-2041, C-2045, and C-2053—to influence the growth of HCT116 and H460 spheres and the viability of HCT116...
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Growth inhibition of cultured cancer cells by Ribes nigrum leaf extract
PublikacjaThe present article includes data on the possible selective cytotoxic effect of extract of Ribes nigrum L. growing at high Armenian landscape. For this purpose, different non-cancer (microglial BV-2 wild type (Wt), acyl-CoA oxidase 1 (ACOX1) deficient (Acox1-/-) and cancer (human colon adenocarcinoma HT29 and human breast cancer MCF7) cell lines were applied. R. nigrum leaf ethanol extract showed a growth inhibition effect towards...
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Deep eutectic solvents – Ideal solution for clean air or hidden danger?
PublikacjaThe industrial sector is one of the fastest-growing sources of greenhouse gases, due to its excessive energy consumption to meet the rapidly growing demand for energy-intensive products. The use of deep eutectic solvents (DESs) has been studied extensively in order to cope with these harmful gases, but their usage can be an issue in respect to ecological reasons. Do deep eutectic solvents harm the atmosphere? Yes, these solvents...
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RAGE as a Novel Biomarker for Prostate Cancer: A Systematic Review and Meta-Analysis
PublikacjaThe receptor for advanced glycation end-products (RAGE) has been implicated in driving prostate cancer (PCa) growth, aggression, and metastasis through the fueling of chronic inflammation in the tumor microenvironment. This systematic review and meta-analysis summarizes and analyzes the current clinical and preclinical data to provide insight into the relationships among RAGE levels and PCa, cancer grade, and molecular effects....
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Insights into oral microbiome and colorectal cancer – on the way of searching new perspectives
PublikacjaMicrobiome is a keystone polymicrobial community that coexist with human body in a beneficial relationship. These microorganisms enable the human body to maintain homeostasis and take part in mechanisms of defense against infection and in the absorption of nutrients. Even though microbiome is involved in physiologic processes that are beneficial to host health, it may also cause serious detrimental issues. Additionally, it has been...
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Tribological and nanoscale research on model friction couples intended for hip joint prostheses
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Experimental measurements of artificial hip joint surfaces and applications for the preassure and capacity distributions
PublikacjaZe względu na wzrastającą potrzebę wszczepiania człowiekowi endoprotez stawu biodrowego, niniejsza praca przedstawia badania geometrycznej struktury ich powierzchni, które mają znaczący wpływ na proces smarowania, eksploatacji oraz funkcjonowanie narządów ruchu.
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Preoperative Ultrasonographic Assessment of the Anterior Pelvic Plane for Personalized Total Hip Replacement
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THE DETERMINATION OF ABRASION RESISTANCE OF SELECTED BIOMATERIALS FOR THE FRICTION PAIRS IN THE HIP JOINT ENDOPROSTHESIS
PublikacjaThe key requirement for the modern endoprosthesis is high durability of the friction components, which results in long and trouble-free operation in the human body. The durability of currently used endoprosthesis is often limited by tribological wear processes of friction components (e.g. between the head and the acetabular component in a hip joint endoprosthesis) [8, 19, 23, 24]. In order to compare the tribological wear, tribological...
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Implementation of failover and load balancing algorithms in SIP PBX High Availability system
PublikacjaGoal of the project was to design a High Availability SIP VoIP system that guarantees access to additional services like auto-attendent and automatic call distribution. The realization of the project required system to have load balancing and failover algorithms implemented. From the end users’ point of view the whole system had to figure as a single element. After taking under consideration the known methods of implementations...
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Comparisson between impulsive and periodic non-newtonian lubrication of human hip joint
PublikacjaOpis smarowania powierzchni sferycznych stawu biodrowego człowieka przedstawiono w aspektach hydromechaniki, przy pomocy równań zachowania pędu i ciągłości strugi dla osiowo niesymetrycznego przepływu cieczy lepkosprężystej z wykorzystaniem związków konstytutywnych Rivlina Ericksena we współrzędnych sferycznych.
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A proposition of the computational model for the dynamic analysis of stress and strain distribution in the hip joint
PublikacjaCelem pracy jest sformułowanie zadania modelowania dynamiki odkształceń i rozkładu naprężeń stawu biodrowego, a w szczególności kości udowej, pod wpływem sił mięśniowych oraz zadanych sił zewnętrznych. Rozwiązanie tego zadania pozwoli wyjaśnić niektóre zjawiska np. jakie ruchy kości udowej oraz jakie materiały użyte do jej alloplastyki są przyczyną urazów i poważnych uszkodzeń. Omówiono problemy związane z zastosowaniem metody...
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Differential Response of MDA-MB-231 and MCF-7 Breast Cancer Cells to In Vitro Inhibition with CTLA-4 and PD-1 through Cancer-Immune Cells Modified Interactions
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A tool for designing water tanks for measuring hydroacoustic transducers
PublikacjaSpecial water tanks are commonly used to measure the parameters of underwater acoustic systems. They must meet specific requirements, the fulfilment of which ensures very small but acceptable measurement errors. These requirements define the size of the tank and its shape as well as the strong attenuation of reflected waves. At the design stage, it is necessary to determine the impact of the tank structure on the measurement errors...
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Tracking of the broadband source of the underwater noise in the very shallow water conditions
PublikacjaThe paper contains the result s, both theoretical and experimental , connected with the tracking of the underwater noise source as small ships, pontoon , diver and so on. The pro blem of security in the shallow water area is the challenge for underwater acousticians. In this paper there is take n into account the detection of the sources that move on the surface of the sea or underwater in shallow...
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Uwagi o problemach w nauczaniu projektowania i eksploatacji siłowni okrętowych (referat dyskusyjny) = Remarks on problems in teaching about designing and operating in ship power plant (discursive study).
PublikacjaW referacie uzasadniono celowość uwzględniania wybranych zagadnień projektowania siłowni w kształceniu studentów wydziałów mechanicznych akademii morskich i zagadnień eksploatacji siłowni w kształceniu studentów odpowiednich wydziałów politechnik.
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Damage Control in Warships
PublikacjaAs a result of dynamic quantitative and qualitative developments in the maritime industry its participants face harder and harder challenges pertaining to safety of ships and navigation. Practice has shown that even very well organised fleets are harassed by emergencies and accidents that can be neither predicted nor absolutely avoided. In order to counter the occuring emergencies and accidents, and to minimize their effects damage...
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Nanoconjugates of graphene oxide derivatives and meso-tetraphenylporphyrin: a new avenue for anticancer photodynamic therapies – Cell-on-a-Chip analysis
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Microfluidic Method of Pig Oocyte Quality Assessment in relation to Different Follicular Size Based on Lab-on-Chip Technology
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Estimation of Minimum Uncut Chip Thickness during Precision and Micro-Machining Processes of Various Materials—A Critical Review
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Analysis of possible application of high-temperature nuclear reactors to contemporary large-output steam power plants on ships
PublikacjaThis paper is aimed at analysis of possible application of helium to cooling high-temperature nuclear reactor to be used for generating steam in contemporary ship steam-turbine power plants of a large output with taking into account in particular variable operational parameters. In the first part of the paper types of contemporary ship power plants are presented. Features of today applied PWR reactors and proposed HTR reactors...
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Modeling and simulation of blood flow under the influence of radioactive materials having slip with MHD and nonlinear mixed convection
PublikacjaRadioactive materials are widely in industry, nuclear plants and medical treatments. Scientists and workers in these fields are mostly exposed to such materials, and adverse effects on blood and temperature profiles are observed. In this regard, objective of the current study is to model and simulate blood based nanofluid with three very important radioactive materials, named as Uranium dioxide (UO2), Thorium dioxide (ThO2) and...
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Magnetic signature reproduction of ferromagnetic ships at arbitrary geographical position, direction and depth using a multi-dipole model
PublikacjaThe reproduction of magnetic signatures is an important issue concerning the safety of ship traffic, as well as the identification and classification of vessels. Moreover, military applications of magnetic signatures and their reproduction refer to the activation or protection against activation of magnetic naval mines. Previous works on this subject focused on recording and replicating the signatures under the same conditions...
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Application of Navigated Ultrasound for Assessment of the Anterior Pelvic Plane in Patients With Degenerative Hip Diseases
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Badania wytrzymałościowe na zginanie i ściskanie nowoczesnych budowlanych paneli kompozytowych SIP.
PublikacjaW pracy przedstawiono wyniki badań wytrzymałościowych na zginanie i ściskanie nowych na polskim rynku budowlanym paneli kompozytowych SIP. Panele składają się z 2 sztywnych okładzin cementowo-magnezjowych zbrojonych włóknem szklanym oraz miękkiego rdzenia ze styropianu. Panele charakteryzują się m.in. niskim ciężarem, szybkim i łatwym montażem oraz wysoką wytrzymałością, ognioodpornością, odpornością na korozję i izolacyjnością...
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Vimentin immunoexpression and its prognostic activity in colon cancer among Caucasian patients
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Near-Infrared Fluorescence Image-Guided Surgery in Esophageal and Gastric Cancer Operations
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Caffeine Inhibits Differentiation Of Lung Cancer Stem Cells By Modulating Their Respiratory Metabolism
PublikacjaIt is ell established that many tumor types contain a fraction of cells, with stem cell-like properties, called cancer stem cells (CSCs), that are resistant to apoptosis induced by therapeutic agents. The presence of CSCs may explain why a standard anticancer treatment, that eliminates only differentiated cancer cells, does not lead to cancer cure.We previously showed the existence of caffeine-sensitive mechanism that controls...
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Serum MicroRNAs as Xerostomia Biomarkers in Patients With Oropharyngeal Cancer Undergoing Radiation Therapy
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Bayesian multilevel model of micro RNA levels in ovarian-cancer and healthy subjects
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Myeloid-derived suppressor cells (MDSCs) in brain cancer: challenges and therapeutic strategies
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Determination of amino acids in urine of patients with prostate cancer and benign prostate growth
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The Occurrence of Cancer and of Adenomae in the Large Bowel and the Concentration of N -Nitrosamines in the Gastric Juice
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Advanced Assessment of the Endogenous Hormone Level as a Potential Biomarker of the Urogenital Tract Cancer
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The Relationship of Purpose in Life and Hope in Shaping Happiness Among Patients with Cancer in Poland
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Can popular films instil carcinophobia? Images of cancer in popular Polish cinema
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NEEDS AND CHALLENGES IN DISPATCHING EMERGENCY MEDICAL SERVICES IN SITUATIONS OF POTENTIAL MILITARY DANGER
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From chemoresistance to cancer stem cells: the case of BRCP/ABCG2 half transporter
PublikacjaLudzkie białko ABCG2 jest pompą typu ABC tworzącą homodimery i aktywnie transportującą leki i inne substraty naturalne i syntetyczne. Nadekspresja tego białko prowadzi do oporności na leki przeciwnowotworowe. Białko ABCG2 występuje w wielu formach zmutowanych, różniących się własnościami substratowymi, stąd istotne dla oporności na leki jest jaka forma genu i białka ABCG2 ulega nadekspresji w komórce. Ostatnie badania wskazują,...
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Optimised expression cassettes of hpt marker gene for biolistic transformation of Miscanthus sacchariflorus
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Saliva as a first-line diagnostic tool: A spectral challenge for identification of cancer biomarkers
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Application of a three‑dimensional (3D) breast cancer model to study macrophage polarization
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Tissue Rheology as a Possible Complementary Procedure to Advance Histological Diagnosis of Colon Cancer
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Altered circadian genes expression in breast cancer tissue according to the clinical characteristics
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The impact of the Polish mass breast cancer screening program on prognosis in the Pomeranian Province
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Prognostic Significance of TOP2A Gene Dosage in HER-2-Negative Breast Cancer
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CDKN2A common variant and multi-organ cancer risk—a population-based study
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Therapy with CD4+CD25+ T regulatory cells – should we be afraid of cancer?
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Germline mutations in theCHEK2 kinase gene are associated with an increased risk of bladder cancer
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