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Wyniki wyszukiwania dla: ROUTES OF INFECTION
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Epitope Mapping of BmpA and BBK32 Borrelia burgdorferi Sensu Stricto Antigens for the Design of Chimeric Proteins with Potential Diagnostic Value
PublikacjaLyme disease is a tick-borne zoonosis caused by Gramnegative bacteria belonging to the Borrelia burgdorferi sensu lato (s.l.) group. In this study, IgM- and IgG-specific linear epitopes of two B. burgdorferi sensu stricto (s.s.) antigens BmpA and BBK32 were mapped using a polypeptide array. Subsequently, two chimeric proteins BmpABBK32-M and BmpA-BBK32-G were designed to validate the construction of chimeras using the identified...
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Dissecting gamma frequency activities during human memory processing
PublikacjaGamma frequency activity (30-150 Hz) is induced in cognitive tasks and is thought to reflect underlying neural processes. Gamma frequency activity can be recorded directly from the human brain using intracranial electrodes implanted in patients undergoing treatment for drug-resistant epilepsy. Previous studies have independently explored narrowband oscillations in the local field potential and broadband power increases. It is not...
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Heat tint colours on stainless steel and welded joints
PublikacjaSurface layer condition of stainless steels and welded joints influences strongly their corrosion resistance. This problem seems to be underestimated. This current study explains the phenomenon of heat tint forming on welds, the methods of its removal, inspection procedures after heat tint removing and post weld finishing
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Linezolid-resistant Enterococcus faecium strains isolated from one hospital in Poland –commensals or hospital-adapted pathogens?
PublikacjaOne of the most pressing problems of enterococci infections is occurring resistance to linezolid, which is an antibiotic used in the treatment of infections caused by vancomycin-resistant strains (VRE). The main objective of our research was to investigate the relationship of 19 linezolid-resistant E. faecium isolates from 18 patients hospitalized at Clinical Hospital in Gdansk (Poland). One of the LZDREF was isolated in 2003...
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Does the chemical modification of Nystatin A1 affect the drug's ability to overcome the multidrug resistance of fungi?
PublikacjaAlthough the contemporary medicine keeps moving forward, disseminated infections caused by fungal pathogens are an emerging challenge. The dramatic rise of fungal diseases, especially the most life-threatening systemic mycoses is associated with a permanently growing number of immunodeficient patients. Undoubted difficulties in the treatment of fungal infections are caused by lack of highly effective and selective antifungal drugs,...
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Activation of N2O and SO2 by the P–B Bond System. Reversible Binding of SO2 by the P–O–B Geminal Frustrated Lewis Pair
PublikacjaHerein, we present the first transformation of borylphosphine into borylphosphinite using nitrous oxide. Borylphosphine reacts with N2O via insertion of a single oxygen atom into the P−B bond and formation of a P−O−B bond system. Borylphosphine and borylphosphinite capture SO2 and activate it in an irreversible and reversible manner, respectively.
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Tuftsin-Properties and Analogs
PublikacjaImmunomodulation is one of the significant therapeutic strategies. It includes both stimulation or suppression of the immune system by a variety of substances called immunomodulators, designed to regulate the immune response of the organism to infections of varying etiology. An example of such a substance is tuftsin (TKPA) 3 (Fig. (1)). Tuftsin is an endogenous immunomodulator of a wide spectrum of biological activity. Tetrapeptide...
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Enhancement of the Brayton cycle efficiency by water or steam utilization
PublikacjaIn the paper, thermodynamic analysis of two modifications of a Brayton cycle into enhancement cycles with water/steam injection are discussed. The first one deals with a STIG modified system with both interstage compressed air cooling and air heating (heat regeneration) before combustion chamber. The second one, mainly devoted to higher steam/air ratio, is connected with separate steam production in a HRSG. The analysis has been...
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Molecular detection of Candida krusei
PublikacjaThe species identification of fungi belonging to genus Candida is an important issue as this genus becomes the emerging problem of nosocomial infections. As Candida krusei presents intrinsicresistance to the fluconazole that is the drug of the first choice in case of invasive candidiasis the PCR identifying the DNA of C. krusei was elaborated. The analytical sensitivity of the assay on spiked blood samples was estimated at 3-5...
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EXHAUST TEMPERATURE MEASUREMENTS OF THE MARINE TURBOCHARGED DIESEL ENGINES IN OPERATION
PublikacjaThe article presents the selected metrology issues concerning the exhaust temperature of the turbocharged marine engines during operation. The special concern has been paid on existing disturbances as well as thermodynamical interpretation of the recorded measurement signal. A diagnostic informativeness of the standard exhaust temperature’s measurements has worked out while the engine runs in steady states has been also considered...
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Budesonide treatment of professional athletes and anti-doping testing- case studies
PublikacjaAccording to the World Anti-Doping Agency (WADA) Prohibited List, glucocorticosteroids are prohibited in competition and only when administered by oral, intravenous, intramuscular or rectal routes. Up to now, in order to differentiate whether glucocorticosteroids were administered by one of the prohibited routes or not, a specific reporting limit for urinary concentrations of parent compounds and their metabolites was established...
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Low frequency of itraconazole resistance found among avian Aspergillus fumigatus isolates
PublikacjaAspergillus fumigatus is the most frequent etiological factor of invasive aspergillosis in human as well as animals, including birds. Aspergillosis caused by drug-resistant strains poses a significant therapeutic issue, especially if resistance pattern includes insensitivity to triazoles, i.e. drugs recommended for the primary therapy purposes. Majority of resistant isolates hold the TR34/L98H...
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Mitigation of Fake Data Content Poisoning Attacks in NDN via Blockchain
PublikacjaAbstract—Information-centric networks struggle with content poisoning attacks (CPAs), especially their stronger form called Fake Data CPA, in which an intruder publisher uploads content signed with stolen credentials. Following an existing graphinfection based approach leveraging the constrained time when stolen credentials are useful, we design a blockchain-based mitigation scheme for Named Data Networking architectures. We postulate...
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The method of tribotesting of PVD coated elements in oscillation motion at high temperature
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Numerical Study of the Impinging Jets Formed by an Injector with Different Nozzle Diameters
PublikacjaThe collision of two or more liquid jets may provide considerable atomisation and efficient mixing of injected substances at the same time. This phenomenon is used, among others, in rocket engines, where the fuel and oxidiser are introduced separately and almost immediately mixed through self-impingement. Depending on the injection and operating conditions, diverse configurations of impinging jets are used, such as doublets,...
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pH-dependent composite coatings for controlled drug delivery system - Review
PublikacjaNowadays in case of long-term implants, the most common postoperative complications are bacterial infections, which in consequence may provoke loos- ening of the implants in the primary phase of stabilization. Bacterial infections are currently the most frequent cause of revision surgery of the implants such as hip joint endoprosthesis, knee joint endoprosthesis and dental implants. In order to provide the local and long-term antibacterial...
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Nanodiamonds Doped with Manganese for Applications in Magnetic Resonance Imaging
PublikacjaNanodiamonds (NDs) are emerging with great potential in biomedical applications like biomarking through fluorescence and magnetic resonance imaging (MRI), targeted drug delivery, and cancer therapy. The magnetic and optical properties of NDs could be tuned by selective doping. Therefore, we report multifunctional manganese-incorporated NDs (Mn-NDs) fabricated by Mn ion implantation. The fluorescent properties of Mn-NDs were tuned...
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A Concept for Safe and Less Expensive Acceleration of a Marine Steam Turbine Start-up
PublikacjaThis paper analyses the issue of accelerated start-up of a marine steam turbine, which is an important problem because the start-up of a steam machine involves the combustion of fuel that is not transformed into useful energy. To find novel technologies that offer improvements in this aspect is essential due to restrictions on reducing ship emissions. Thus, the shorter the start-up time, the better for the environment and economy....
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Application of road map of operating condition for estimation of fuel and electric energy consumption from city transport
PublikacjaThe paper presents procedure of data collecting and generation of road map of operating condition in the selected urban area. This map allows forecasting the selected vehicle operating parameters for the assumed road. The main parameters calculated using the road maps of operating conditions are: total energy spent to drive the selected vehicle, consumed fuel, travel time, average speed of travel, CO2 emissions. Presented example...
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Laxer Clinical Criteria for Gaming Disorder May Hinder Future Efforts to Devise an Efficient Diagnostic Approach: A Tree-Based Model Study
PublikacjaInternet Gaming Disorder (IGD) has been recognized in May 2013 and can be evaluated using the criteria developed by American Psychiatric Association (APA). The present study investigated the role each IGD criteria plays in diagnosing disordered gaming. A total of 3,377 participants (mean age 20 years, SD = 4.3 years) participated in the study. The data collected was scrutinized to detect patterns...
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The Response of Selected Domestic Capital Markets on the Development of COVID-19 Pandemic – a Broader View
PublikacjaObjective: The study examines how the record of the first, hundredth, thousandth, ten-thousandth, one-hundred-thousandth, and millionth cases of COVID-19 affected investor behaviour in capital markets. It also looks at whether the month in which the first case was recorded in a given market affected the direction and strength of investor reactions. Lastly, it verifies whether the two announcements made by the WHO related to COVID-19...
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Photoelectric properties of a novel MEH-PPV/F16ZnPc heterojunction
PublikacjaPhotoelectric properties of a novel poly[2-methoxy-5-(2-ethylhexyloxy-p-phenylenevinylen)] (MEH-PPV)/perfluorozincphthalocyanine (F16ZnPc) planar heterojunction provided with BCP and MoO3 buffer layers sandwiched between indium tin oxide (ITO) and Ag are shown. Efficient photogeneration of charge carriers at this junction is observed. Effect of bathocuproine (BCP) and MoO3 buffer layers on the performance of cells is analysed....
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Biofilm bakteryjny uropatogennych szczepów E. coli Dr+ jako czynnik indukujący przewlekłość zakażeń dróg moczowych ograniczający ich leczenie
PublikacjaZakażenia dróg moczowych (ZUM) stanowią jedne z najczęściej występujących infekcji bakteryjnych, dotykających każdego roku miliony osób na świecie. Problematyka tych zakażeń wynika z ich przewlekłości i nawrotów, pomimo stosowania terapii antybiotykowej oraz ciągle wzrastającej lekooporności uropatogenów je wywołujących. Dominującym czynnikiem etiologicznym ZUM są uropatogenne szczepy E. coli (UPECs), wykazujące zdolność do adhezji,...
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Ergonomics in Polish outpatient clinics
PublikacjaOutpatient clinics are structures In which ergonomics play a key role. This fact is associated with an often occurring risk of developing hospital-acquired infection. The risk increases with mistakes made in wrong planning the functional and spatial lay-out is subordinated to high utilitarian requirements, including hygienic and sanitary, and technological requirements. A properly planned structure allows to reduce dangers more...
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MutS3: a MutS homologue of unknown biological function
PublikacjaThe homologues of MutS proteins are widespread among both Prokaryotes and Eukaryotes. MutS designated as MutS1 is a part of MMR (mismatch repair) system which is responsible for removal of mispaired bases and small insertion/deletion loops in DNA. Initially, the only MutS homologues known were those engaged in mismatch repair and these were later designated as MutS1. Subsequently, the MutS2 homologue was distinguished. MutS2 does...
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Przekształtnik prądu jako sterownik w układach napędowych z silnikami indukcyjnymi
PublikacjaThe circuits used for power conversion applied in drives with electric machines are classified into two groups: voltage source inverters (VSI) and current source inverters (CSI). Application of the current source inverter results in better properties of drive than application of voltage source inverter because there is no output filter. The development of power electronics and especially the IGBTs, in which on/off-times are very...
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Reducing common mode voltage and bearing currents in quasi - resonant DC - link inverter
PublikacjaIn the paper, a concept of separation of an inverter-fed induction motor drive from its mains supply by two transistor switches inserted in the dc-link circuit is reexamined based on the proposed parallel quasi-resonant dc-link inverter (PQRDCLI). The objective of the paper is to show an advantage of the proposed topology in limiting high frequency common mode voltage and bearing currents. In the laboratory setup, an induction...
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The work-family interface: Job demands, work engagement and turnover intentions of Polish nurses
PublikacjaA conflict between one's professional life and one's family life may lead to lower well-being both at work and home. Most nurses are women who have traditionally reconciled their professional life with family life. One aim of this study was to examine the relationships between the work-family conflict (WFC),the family-work conflict (FWC), and the perception of job demands (quantitative workload and interpersonal conflicts at work)....
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Application of method of differential magnetometric system for detection of sunken objects
PublikacjaThis paper presents a magnetometric system with scalar sensors mounted on two independent platforms, which is used to detect sunken shipwrecks. Increasing the distance between the sensors allows for more precise measurement of the difference in the magnetic induction module than in the case of sensors mounted e.g. on the aeroplane’s wings. This type of system makes it possible to enlarge detection range of the sunken wrecks.
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LABOUR SHARE IN THE DOMESTIC INCOME COMPARED TO DIFFERENT LABOUR MARKETS
PublikacjaThe purpose of this paper is to examine the changes in the share of labour in the domestic income in the years 1995-2010 in the Visegrád Group states, taking into account the level of development of the domestic labour markets. The study involves a review of the literature relating to the labour market issues, collecting sources and their use in the empirical part. The study used the induction method, the elements of descriptive...
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Wearable system supporting navigation of the blind
PublikacjaImproving blind people comfort of life is a problem ofgreat importance. Fortunately, new technolgies provide us withadditional methods to improve everyday life of the blind and visuallyimpaired. The paper presents experimental system made byresearchers from Department of Geoinformatics of Gdansk Universityof Technology, which is capable of finding the route from theindicated source to chosen destination, using dedicated digital...
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A new approach to cross-bonding in medium voltage cable lines
PublikacjaThe medium voltage underground cable sheaths are usually bonded and earthed in every substation on the cable route. This results in additional power losses in the sheaths. The paper presents an idea of reducing power losses caused by sheaths cross-bonding. The idea of sheaths cross-connecting only in selected MV/LV substations is given instead of a typical solution, where sheaths cross-bonding requires installing additional joints...
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Metal-Organic Frameworks in Green Analytical Chemistry
PublikacjaTaking into consideration the rapid expansion of MOFs applications in the analytical chemistry area, it is important to evaluate the existing and future analytical MOF-based methods according to GAC principles. From this point of view, eco-friendly MOFs-based methods should include features such as: green design and synthesis of MOF, evaluation of toxicity issues of MOFs, and incorporation of MOFs in GAC methods. This Chapter will...
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Latest Achievements in Concrete Structures Three-Dimensional Printing
PublikacjaWe can hear about three-dimensional printed concrete structures for several years, up to date solutions in this technology allow entire printing settlements of tiny concrete houses. Due to technical limitations, these houses are still small and not very durable, but undoubtedly, this technology is developing. Home printed in three-dimensional technology can be an alternative to modular container buildings implemented in areas affected...
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Recurrent bowel-blood translocations of Escherichia coli with the unique virulence characteristics over three-year period in the patient with acute myeloid leukaemia – case report
PublikacjaIn patients with haematological malignancies, the bowel remains the main source of Escherichia coli bloodstream infections. We present the clinical example of recurrent bowel-blood translocations of E. coli with the unique virulence characteristics in a 55-year-old male with the diagnosis of acute myeloid leukaemia. The virulent factors profile of examined strains confirmed that the co-existence of genes papC, sfa, usp and cnf1,...
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Compensation of magnetic disturbances caused by sensors in a differential magnetometric system
PublikacjaStudy of low magnetic fields necessitates the use of precision magnetometers working in a differential system. Minimization of this error is a substantial issue in the case of magnetometers working in a differential system on a mobile platform. The compensation method of heading error consists in taking measurements of changes in magnetic induction with the use of the tested magnetometer for various locations of the sensor in relation...
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Report no WOiO/II/67/2015 - Expertise about load capacity of twistlock foundation and sliding foundation
PublikacjaCustomer delivered to Laboratory 17 elements - twist lock foundations and sliding lock foundations (ship equipment for container lashing). Elements were selected from production series. Each element was loaded for braking load. After test visual inspection had been performed. The expertise contains: description of tested elements, test assumptions, test stand, results and conclusions
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Aproksymacja przebiegu trasy kolejowej na przykładzie krzywoliniowego odcinka połączenia Somonino-Gdańsk Osowa
PublikacjaW artykule zaprezentowano wyniki wyznaczenia współrzędnych przebiegu trasy kolejowej metodami aproksymacji wielomianowej i interpolacji krzywą kubiczną w oparciu o pomiary czasu rzeczywistego GPS zrealizowane z wykorzystanie polskiej aktywnej sieci geodezyjnej ASG-EUPOS. Rozważania teoretyczne poparte zostały praktycznym przykładem aplikacyjnym opartym o zrealizowane pomiary inwentaryzacyjne zmodernizowanego odcinka toru kolejowego...
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Voice Maps - portable, dedicated GIS for supporting street navigtion and self-dependent movement of the blind
PublikacjaThe concept and the prototype application of the system supporting the street navigation and independent, outdoor movement of the blind is presented. The system utilises the GIS database of geometric network of the pedestrian paths in the city and is capable of finding the route from the indicated source to destination. Subsequently, the system supports the movement of the blind along the found route. The information on the user's...
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The Efficacious Benefit of 25-Hydroxy Vitamin D to Prevent COVID-19: An In-Silico Study Targeting SARS-CoV-2 Spike Protein
PublikacjaThe environment has rapidly looked at proven specialist task forces in the aftermath of the COVID-19 pandemic to build public health policies and measures to mitigate the effects of emerging coronaviruses. According to the researchers, taking 10 μg of 25-hydroxy vitamin D daily is recommended to keep us safe. There have been several studies recently indicating that there is a reduced risk of contracting Coronavirus by 25-hydroxy...
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Mechanisms of azole resistance among clinical isolates of Candida glabrata in Poland
PublikacjaCandida glabrata is currently ranked as the second most frequently isolated aetiological agent of human fungal infections, next only to Candida albicans. In comparison with C. albicans, C. glabrata shows lower susceptibility to azoles, the most common agents used in treatment of fungal infections. Interestingly, the mechanisms of resistance to azole agents in C. albicans have been much better investigated than those in C. glabrata....
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Enzymes of the lysine biosynthetic pathway as targets for antifungals ?
PublikacjaSystemic infections caused by human pathogenic fungi in immunocompromized patients continue to be one of the important clinical problems. Limited availability of safe and efficacious antifungal chemotherapeutics and emerging resistance to existing drugs stimulates search for novel molecular targets for antifungals. The α-aminoadipate pathway (AAP) of L-lysine biosynthesis is unique in fungi and thus has been so far considered...
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The Effect of AgInS2, SnS, CuS2, Bi2S3 Quantum Dots on the Surface Properties and Photocatalytic Activity of QDs-Sensitized TiO2 Composite
PublikacjaThe eect of type (AgInS2, SnS, CuS2, Bi2S3) and amount (5, 10, 15 wt%) of quantum dots (QDs) on the surface properties and photocatalytic activity of QDs-sensitized TiO2 composite, was investigated. AgInS2, SnS, CuS2, Bi2S3 QDs were obtained by hot-injection, sonochemical, microwave, and hot-injection method, respectively. To characterize of as-prepared samples high-resolution transmission electron microscopy (HRTEM), scanning...
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Miniaturized Metal-Mountable U-shaped Inductive-Coupling-Fed UHF RFID Tag Antenna with Defected Microstrip Surface
PublikacjaThis study presents a novel miniature ultra-high frequency (UHF) radio frequency identification (RFID) tag for metallic objects. Its arrangement includes a U-shaped feeder, which is inductively coupled to two E-type connected patches. Size reduction is achieved by means of utilizing the U-shaped feeder, and introducing a defection in the connection between the two E-type patches. The defection in the connection area between the...
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Magneto-thermal convection of low concentration nanofluids
PublikacjaThe main aim of this paper was to analyze possible utilization of the low concentration nanofluids and the magnetic field to enhance heat transfer. The studied fluids were based on water with an addition of copper particles (40-60 nm diameter). They belonged to the diamagnetic group of materials. As a first attempt to stated target the analysis of enclosure placed in the maximal value of square magnetic induction gradient was carried...
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Proposal of a mobile medical waste incinerator with automatic waste feeder and heat recovery system
PublikacjaThe paper presents and discusses the issue of medical waste (including hazardous ones) and their proper management. Inappropriate handling of infectious medical waste directly endangers the human being health and the environment. Infectious waste must therefore be properly disposed of – one of the most commonly used methods is the thermal treatment in the incinerators tailored for this purpose. During designing an incinerator unit,...
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Pomiary skuteczności hamowania w stacjach kontroli pojazdów
PublikacjaPrzeprowadzono pomiary skuteczności hamowania w warunkach różnych stacji kontroli pojazdów. Celem przedsięwzięcia było porównanie wyników z uzyskanych pomiarów. Na tej podstawie pozyskano dane umożliwiające opracowanie założeń do koncepcji metodyki badań technicznych pojazdów zabytkowych w stacjach kontroli pojazdów.
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A systematic retrieval of international competitiveness literature: a bibliometric study
PublikacjaOver the last three decades there has been growing interest in international competitiveness research. However, as evidenced by the academic literature, there is a lack of systematic chronological studies synthesizing how this field has evolved over time. The main aim of this paper is to consolidate the state of the art of academic research on international competitiveness in the discipline of economics by using a new method: a...
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Silver complexes stabilized by large silanethiolate ligands – crystal structures and luminescence properties
PublikacjaBulky silanethiolate and disiladithiolate ligands were applied to synthesize one mononuclear and three trinuclear silver complexes including two cyclic “microclusters” and a linear tri-nuclear silanethiolate complex. All obtained compounds are characterized by X-ray diffraction and FT-IR. NMR and emission spectroscopies were used where possible. The first trinuclear anionic silver thiolate is structurally characterized. The influence...
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Constant vs. Variable Efficiency of Electric Drive in Train Run Simulations
PublikacjaTrain run simulations, which focus on various power- and energy-oriented aspects, should reflect the losses in the electric powertrain. In general, the powertrain efficiency varies with respect to load and speed. Including this relation in simulation requires knowledge about detailed drivetrain parameters, which are often unavailable. This paper verifies the possibility to approximate the drivetrain efficiency in train run simulations...