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Wyniki wyszukiwania dla: LIVER CANCER
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Late subclinical hemolysis and long-term outcomes after aortic valve replacement with On-X mechanical prostheses – a preliminary single-center report
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Dosimetry study of Re-188 liquid balloon for intravascular brachytherapy using polymer gel dosimeters and laser-beam optical CT scanner
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Analysis of pharmacotherapy regimen and costs in patients with drug-resistant epilepsy following vagus nerve stimulation therapy: a single-center study (Poland)
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Integracja narzędzi do zarządzania wymaganiami oraz zarządzania projektem na przykładzie IBM Rational Requirements Composer i Team Concert
PublikacjaInżynieria wymagań jest jednym z najistotniejszych elementów przedsięwzięcia informatycznego, w szczególności programistycznego.
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Effect of Impoundment on Physico-chemical Properties of Water in the Flowing through stream, the Case of the Turawa Reservoir
PublikacjaThe Turawa reservoir is one of the most important storage reservoirs in Poland. Quite many physico-chemical parameters of water in the reservoir itself and also in the Mała Panew, the river flowing through the reservoir were measured at various periods of the year. Measuring and sampling points were situated at the river inflow, over the reservoir, and at the river outflow. The parameters included temperature, electrical conductivity,...
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Falling accident risk in Poland.
PublikacjaFor the last few years we observe optimistic tendencies in traffic risk development in Poland - the number of fatalities decreases about 10% per year, bringing Poland closer to European Union standards. Nevertheless in 2001 we observed the unexpected, and bigger than forecasted, fatality reduction. The reason was the economic downturn suffered across the country, resulting in reduced demand for transportation. The danger lies in...
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Falling accident risk in Poland.
PublikacjaFor the last few years we observe optimistic tendencies in traffic risk development in Poland the number of fatalities decreases about 10% per year, bringing Poland closer to European Union standards. Nevertheless in 2001 we observed the unexpected, and bigger than forecasted, casualty reduction. The reason was the economic downturn suffered across the country, resulting in reduced demand for transportation. The danger lies in...
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Attention-Based Deep Learning System for Classification of Breast Lesions—Multimodal, Weakly Supervised Approach
PublikacjaBreast cancer is the most frequent female cancer, with a considerable disease burden and high mortality. Early diagnosis with screening mammography might be facilitated by automated systems supported by deep learning artificial intelligence. We propose a model based on a weakly supervised Clustering-constrained Attention Multiple Instance Learning (CLAM) classifier able to train under data scarcity effectively. We used a private...
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Rewitalizacja dróg wodnych delty Wisły jako podstawa nowej perspektywy osiedleńczej
PublikacjaW artykule opisano badania dotyczące rewitalizacji dróg wodnych Delty Wisły. Problematyka badawcza dotyczy rozwoju obszaru na styku lądu i wody. Wpływ lokalizacji nadmorskiej, i związana z nią problematyka wynikająca z położenia poniżej poziomu morza są dostrzegalne nawet do stu kilometrów od wybrzeża. Dodatkowym aspektem, który ujemnie wpływa na rozwój obszaru delty po II wojnie światowej jest utrata tożsamości regionalnej. Dlatego...
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Roll respose of ship fitted with passive stabilizing tank.
PublikacjaPrzedstawiono fizyczny i matematyczny model kołysań statku z biernym zbiornikiem stabilizacyjnym. Wyprowadzono równania ruchu i podano ich rozwiązania. Określono najistotniejsze zalecenia projektowe w oparciu o uzyskane rozwiązania. Wskazano kierunek poszukiwania optymalnych rozwiązań dla układu statek-bierny zbiornik stabilizacyjny.
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Location of ship rolling axis.
PublikacjaPodano definicję osi kołysań statku i metodę określania jej położenia. Położenie osi zależy nie tylko od rozkładu mas statku ale równiez od tzw. ''mas towarzyszących'', które są reprezentacją sił hydrodynamicznych działających na statek w czasie kołysania. Podano proste formuły pozwalajace obliczyć poprawne położenie osi kołysań statku.
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Model-Based Testing of Embedded Systems in the Automotive Domain
PublikacjaPhD
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From Functional Requirements through Test Evaluation Design to Automatic Test Data Retrieval – a Concept for Testing of Software Dedicated for Hybrid Embedded Systems
PublikacjaFrom Functional Requirements through Test Evaluation Design to Automatic Test Data Retrieval – a Concept for Testing of Software Dedicated for Hybrid Embedded Systems
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Quality of Test Specification by Application of Patterns
PublikacjaEmbedded system and software testing requires sophisticated methods, which are nowadays frequently supported by application of test patterns. This eases the test development process and contributes to the reusability and maintainability of the test specification. However, it does not guarantee the proper level of quality and test coverage in d ifferent dimensions of the test specification. In this paper the quality of the test...
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Model-based testing for execution algorithms in the simulation of cyber-physical systems
PublikacjaThe understanding of simulation semantics of a hybrid system is a challenge for computational engineers as it requires expertise in computer science, engineering, numerical methods, and mathematics at once. The testing methods for the execution of a simulation are being researched but not yet applied on the industrial level. Consequently, the semantics of the simulation becomes a critical artifact in the system development process....
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Chemometric modeling of aquatic toxicity of contaminants of emerging concern (CECs) in Dugesia japonica and its interspecies correlation with daphnia and fish: QSTR and QSTTR approaches
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Splice variants of mitofusin 2 shape the endoplasmic reticulum and tether it to mitochondria
PublikacjaIn eukaryotic cells, different organelles interact at membrane contact sites stabilized by tethers. Mitochondrial mitofusin 2 (MFN2) acts as a membrane tether that interacts with an unknown partner on the endoplasmic reticulum (ER). In this work, we identified the MFN2 splice variant ERMIT2 as the ER tethering partner of MFN2. Splicing of MFN2 produced ERMIT2 and ERMIN2, two ER-specific variants. ERMIN2 regulated ER morphology,...
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Selective Cytostatic and Cytotoxic Anticancer Effects of Bisfunctional Agents: A Strategy for the Design of DNA Binding Agents
PublikacjaVarious agents have been synthesized and proved useful for the National Cancer Institute's anticancer testing as potential new drugs, but most agents suffer side effects from their limited selectivity against cancer cells over healthy ones. Therefore, this paper attempts to describe drugs in terms of the level of tumor cell selectivity which they possess to define the features of mols. that are essential for useful cytotoxicity....
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Novel fused pyran derivatives induce apoptosis and target cell cycle progression in anticancer efficacy against multiple cell lines.
PublikacjaNitrogen-based heterocycles such as pyrazole, imidazole, 1,2,4-triazole, benzimidazole, and benzotriazole substituted fused pyran derivatives (6a–e, 8a–e, 10a–e, 12a–e,&14a–e) have been synthesized and tested for their in vitro anticancer efficacies against MCF7, A549, and HCT116 cancer cell lines. Among the compounds, 6e, 14b, and 8c were identified as the most potent against MCF7, A549, and HCT116, with IC50 values of 12.46 2.72...
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Biocompatibility and potential functionality of lanthanum-substituted cobalt ferrite spinels
PublikacjaBulk and nanostructurized lanthanum-cobalt spinels have attracted a lot of interest from researchers, due to their unique physical and chemical properties as well as functionalities, which are interesting for biomedical and electronic industries. In this manuscript we show that introducing small lanthanum (La3+) content can tune magnetic, electronic and cytotoxic properties of the CoFe2− xLaxO4 system (x ≤ 0.1). The mechanisms...
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Modulation of UDP-glucuronidation by acridinone antitumor agents C-1305 and C-1311 in HepG2 and HT29 cell lines, despite slight impact in noncellular systems.
PublikacjaBackground Among the studied antitumor acridinone derivatives developed in our laboratory, 5-dimethylaminopropylamino-8-hydroxytriazoloacridinone (C-1305) and 5-diethylaminoethylamino-8-hydroxyimidazoacridinone (C-1311) exhibited cytotoxic and antitumor properties against several cancer types and were selected to be evaluated in preclinical and early-phase clinical trials. In the present work, we investigated the impact of C-1305...
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Transformation of the countryside into an open-air museum as a way to rescure its spatial layout and to improve the quality of live = Przekształcenie wsi w muzeum na wolnym powietrzu jako sposób ratowania jej układu przestrzennego i poprawy jakości życia mieszkańców
PublikacjaSince the first open-air museums until today, the exposition subject-matter has been specialized (ethnographic, archeological, industrial and technical skansens). But idea of the existence of such objects remains unchanged. Still, the goal is to show the collection of wooden buildings in the environment as close to their origin as possible or in the home environment. These distinguish the skansens and make them different then municipal...
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Vanadium toxicity in chickpea (Cicer arietinum L.) grown in red soil: Effects on cell death, ROS and antioxidative systems
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Novel 2-(2-alkylthiobenzenesulfonyl)-3-(phenylprop-2-ynylideneamino)guanidine derivatives as potent anticancer agents – Synthesis, molecular structure, QSAR studies and metabolic stability
PublikacjaA series of new 2-(2-alkylthiobenzenesulfonyl)-3-(phenylprop-2-ynylideneamino)guanidine derivatives have been synthesized and evaluated in vitro by MTT assays for their antiproliferative activity against cell lines of colon cancer HCT-116, cervical cancer HeLa and breast cancer MCF-7. The obtained results indicated that these compounds display prominent cytotoxic effect. The best anticancer properties have been observed for derivatives...
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Assessment of the ice jam potential on regulated rivers and reservoirs with the use of numerical model results
PublikacjaThis study presents an attempt at estimating the jam potential on rivers with significant anthropogenic intervention in the course or flow characteristics of the river. The DynaRiCE model was used for forecasting both the place and time of an ice jam occurrence. In this modified method, two ice parameters are subjected to analysis, namely the relative ice-to-water velocity (vi/vw),and the ice thickness to single floe thickness...
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Zarządzanie dokumentami cyfrowymi i metody ich prezentacji w systemie SETI-1
PublikacjaW artykule zostały zaprezentowane zagadnienia związane z zarządzaniem dokumentami cyfrowymi oraz rozwiązanie, jakie przyjęto w systemie SETI-1. System ten - aktualnie będący w fazie opracowywania - jest przeznaczony do wspomagania administrowania Wydziałem Elektroniki, Telekomunikacji i Informatyki PG [3]. Przedstawiono, jak rozumiany jest w systemie dokument cyfrowy, a następnie opisano mechanizmy, jakie wybrano w celu jego tworzenia,...
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Bioactive and bioavailability of minerals in rats loaded with cholesterol and kiwi fruit
PublikacjaThe aim of this study was to compare the content of polyphenols (TP), minerals, ascorbic acid (AA) and total antioxidant capacities (TAC) of conventional and organic kiwifruit ‘Hayward’ treated with ethylene after harvest and to determine their influence on plasma TAC, mineral content in the liver and bioavailability (RBV — relative bioavailability value) in rats fed diet containing cholesterol. Organic and conventionally grown...
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From tryptophan to novel mitochondria-disruptive agent, synthesis and biological evaluation of 1,2,3,6-tetrasubstituted carbazoles
PublikacjaMitochondrial targeting plays an important role in anticancer therapy. The Mn(III)-promoted cyclization of 5- (1H-indol-3-yl)-3-oxopentanoic acid allow to obtain novel substituted carbazole derivatives that can act as mitochondria-disruptive agents. The starting materials used for the synthesis of these new aminocarbazoles are oxopentanoate derivatives of tryptophan. The scope and limitation of this method of synthesis are determined...
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Novel N-(aryl/heteroaryl)-2-chlorobenzenesulfonamide derivatives: synthesis and anticancer activity evaluation
PublikacjaA new series of N-(aryl/heteroaryl)-2-chlorobenzenesulfonamide derivatives 4-21 have been synthesized, and evaluated at the National Cancer Institute (USA) for their in vitro activities against a panel of 60 different human cancer cell lines. Among them, compounds 16, 20 and 21 exhibited remarkable cytotoxic activity against numerous human cancer cell lines. We found that sulfonamide derivative 21 appeared to be more selective...
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Reduced colonic microbial diversity is associated with colitis in NHE3-deficient mice
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Numerical Modeling of Water and Ice Dynamics for Analysis of Flow Around the Kiezmark Bridge Piers
PublikacjaThis paper presents the results of a numerical model study on the effect of ice on the proposed bridge piers in the Vistula River outlet and its effect on flow conditions in the river. The model DynaRICE is used in this study, which is a two-dimensional hydro-ice dynamic numerical model developed for dynamic ice transport and jamming in rivers. To simulate river hydrodynamics in the vicinity of the bridge piers, 2-dimensional numerical...
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Concentrations of heavy metals and PCBs in the tissues of European beavers (Castor fiber) captured in northeastern Poland
PublikacjaEuropean beavers (Castor fiber) from two regions were examined to identify exposure to persistent environmental contaminants. A reference group was comprised of six animals from the Forest Division of Srokowo, and an exposed group was comprised of five animals from the vicinity of a former military airport operated in 1918–1986—both from Warmia land in Poland. 137 Cs in beavers' muscles was considered negligible for the overall...
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Geographic Information System for Flood Hazard Analysis and Early Warning Using Numerical Weather Predictions
PublikacjaFloods are a phenomenon which causes significant losses of lives as well as property damage, which in turn severely impact the local economy. The nature of a flooding has been well researched, and several methods of flood hazard simulation have been established over the last decades. The current legislation in the European Union requires the Member States to create, maintain and update flood risk and hazard maps, as well as identify...
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ARRIERE-GARDE IN ARCHITECTURE, AS A RESPONSE TO POST-POSTMODERN REALITY
PublikacjaThe article presents a general discussion on the direction of contemporary architecture. We can freely speak that postmodernity, understood in its philosophical core as a search for meaning in architecture, as a strategy of building our environment is over. What comes next? Some say, from lack of better naming, that we live in post-postmodern times. Term post-postmodernity is a call for new strategy of shaping our societies and...
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SU-FF-T-192: Complete 3D QA for Rapid Arc Using BANG Polymer Gel and OCTOPUS-IQ Fast Laser CT Scanner
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Zarządzanie procesem innowacyjnym w polskich małych i średnich przedsiębiorstwach
PublikacjaZarządzanie procesem innowacyjnym stanowi wyzwanie dla menedżerów, nie tylko dużych przedsiębiorstw. Przedsiębiorcy stają przed problemem czy i jakie działania przed-sięwziąć, aby efektywnie konkurować na rynku. Poziom innowacyjności polskich małych i średnich przedsiębiorstw nie świadczy dobrze o sposobie zarządzania procesem innowacyjnym. Jednak w nowym okresie programowania pojawią się środki przeznaczone na wdrożenia w firmach....
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Wykorzystanie narzędzi pracy zdalnej w działaniach Koła Naukowego Konstruktorów Pojazdów
PublikacjaNiniejszy artykuł stanowi opis działalności Koła Naukowego Konstruktorów Pojazdów, w którego działaniach wykorzystywane są nowoczesne narzędzia pracy zdalnej. Dzięki takiemu podejściu, możliwe staje się wyeliminowanie niedogodnień, z którymi borykano się stosując standardowe, starsze podejście do realizacji zadań projektowych w jednostkach badawczo-rozwojowych. Podane przykłady ilustrują, w jaki sposób powszechny obecnie dostęp...
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Minun seikkailuni Turun Kiikurit Laulu- ja Tanssiyhtyeen kanssa… [My adventure with the folk group of song and dance Turun Kiikurit…]
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Aktualność "Sporu o istnienie świata" Romana Ingardena w świetle współczesnych mu stanowisk filozoficznych
PublikacjaParadoksalnie Ingarden nie jest w stanie wykazać, że świat realny istnieje w pewnym zasadniczym sensie „istnienia”, bo przyjmuje taki sam jak Husserl egologiczny, przeżyciowy model czystej świadomości i sam podążając za Husserlem przyjmuje istnienie dwóch dziedzin przedmiotów indywidualnych: dziedzinę czystej świadomości (rozumianej po husserlowsku jako strumień przeżyć) i dziedzinę świata realnego za punkt wyjścia swoich rozważań....
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Greencoin: prototype of a mobile application facilitating and evidencing pro-environmental behavior of citizens
PublikacjaAmong many global challenges, climate change is one of the biggest challenges of our times. While it is one of the most devastating problems humanity has ever faced, one question naturally arises: can individuals make a difference? We believe that everyone can contribute and make a difference to the community and lives of others. However, there is still a lack of effective strategies to promote and facilitate pro-environmental...
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Three Principles for Healthy Living with Light and Lighting
PublikacjaThe lockdown measures applied to cities and towns during the worldwide Covid-19 pandemic have had a widespread impact on people’s lives. Some have found themselves confined to their homes, with limited social contact and a reduced quality of life. Others have found that the lockdown improved their wellbeing, as more time was spent outside, instead of commuting and working in an office building, plus the benefits of spending increased...
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Mercury concentration and the absolute and relative sizes of the internal organs in cormorants Phalacrocorax carbo (L. 1758) from the breeding colony by the Vistula Lagoon (Poland)
PublikacjaThis work analyses the effect of mercury on the condition of cormorants (Phalacrocorax carbo) from an extensive breeding colony in northern Poland, the largest in Europe. A total of 55 birds (44 adults and 11 immature) were obtained. Total mercury (Hg) concentrations were measured in the liver, kidneys, breast muscles, heart, gullet (oesophagus), stomach, intestines, trachea, lungs and eyeballs. The total body mass (TBM) and empty...
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Novel insights into conjugation of antitumor-active unsymmetrical bisacridine C-2028 with glutathione: characteristics of non-enzymatic and glutathione S-transferase-mediated reactions
PublikacjaUnsymmetrical bisacridines (UAs) are a novel potent class of antitumor-active therapeutics. A significant route of phase II drug metabolism is conjugation with glutathione (GSH), which can be non-enzymatic and/or catalyzed by GSH-dependent enzymes. The aim of this work was to investigate the GSH-mediated metabolic pathway of a representative UA, C 2028. GSH supplemented incubations of C-2028 with rat, but not with human, liver...
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Detection of circulating tumor cells by means of machine learning using Smart-Seq2 sequencing
PublikacjaCirculating tumor cells (CTCs) are tumor cells that separate from the solid tumor and enter the bloodstream, which can cause metastasis. Detection and enumeration of CTCs show promising potential as a predictor for prognosis in cancer patients. Furthermore, single-cells sequencing is a technique that provides genetic information from individual cells and allows to classify them precisely and reliably. Sequencing data typically...
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Molecularly imprinted polymers for the detection of volatile biomarkers
PublikacjaIn the field of cancer detection, the development of affordable, quick, and user-friendly sensors capable of detecting various cancer biomarkers, including those for lung cancer (LC), holds utmost significance. Sensors are expected to play a crucial role in the early-stage diagnosis of various diseases. Among the range of options, sensors emerge as particularly appealing for the diagnosis of various diseases, owing to their cost-effectiveness,...
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Novel molecules containing structural features of NSAIDs and 1,2,3-triazole ring: Design, synthesis and evaluation as potential cytotoxic agents
PublikacjaFor the first time the template containing structural features of more than one NSAIDs and the 1,2,3-triazole ring was explored for the identification of potential cytotoxic agents. These new and complex molecules were predicted to be effective inhibitors of PDE4B by molecular modelling studies in silico. The multi-step synthesis of these compounds were carried out starting from the well-known drug nimesulide and involved the use...
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Biochemical, Structural Analysis, and Docking Studies of Spiropyrazoline Derivatives
PublikacjaIn this study, we evaluated the antiproliferative potential, DNA damage, crystal struc‐ tures, and docking calculation of two spiropyrazoline derivatives. The main focus of the research was to evaluate the antiproliferative potential of synthesized compounds towards eight cancer cell lines. Compound I demonstrated promising antiproliferative properties, especially toward the HL60 cell line, for which IC50 was equal to 9.4 μM/L....
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Attitudes of oncology patients’ towards biospecimen donation for biobank research
PublikacjaBackground Since the biological material that remains after diagnostic and therapeutic procedures plays crucial role in biobank research, this study aims to explore cancer patients’ views on the donation of biospecimens for research purposes. Methods 548 oncology patients from two hospitals with oncology treatment units in Poznan, Poland,...
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Inhibition of phthalocyanine-sensitized photohemolysis of human erythrocytes by polyphenolic antioxidants: description of quantitative structure–activity relationships
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Expression-based decision tree model reveals distinct microRNA expression pattern in pediatric neuronal and mixed neuronal-glial tumors
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