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Wyniki wyszukiwania dla: clinical psychology
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Virulence, antifungal susceptibility and molecular mechanisms of echinocandin resistance among Candida isolates recovered from clinical specimens
PublikacjaFungi of the genus Candida belong to the natural microflora of healthy individuals. However, they can also be a cause of opportunistic infections especially among patients with an impaired immune system. The first line therapy of Candida infections is based on triazoles. However, in recent years there an increase of azole resistant Candida spp., in particular C. glabrata and C. krusei, has been observed. For this reason, echinocandin...
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Distinct clinical phenotypes in paediatric cancer patients with sepsis are associated with different outcomes—an international multicentre retrospective study
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Applying agiile practices to the development of safety-critical software
PublikacjaDevelopment of safety critical software is subjected to numerous restrictions and recommendations. To meet these requirements classical software development models (e.g. V-model) are usually applied. Agile methodologies, although rapidly increasing their popularity, were generally regarded as unsuitable for such projects. However, they offer potential benefits which provide a strong incentive to incorporate them into safety-critical...
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Approach to security assessment of critical infrastructures' information systems
PublikacjaThis study presents an approach to the security assessment of the information systems of critical infrastructures. The approach is based on the faithful reconstruction of the evaluated information system in a computer security laboratory followed by simulations of possible threats against the system. The evidence collected during the experiments, stored and organised using a proprietary system InSAW, may later be used for the creation...
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Safety and security governance problems of critical systems and infrastructures
PublikacjaW artykule przedstawiono kilka problemów związanych z zarządzaniem bezpieczeństwem i ochroną informacji w systemach i infrastrukturach krytycznych.Bardzo ważne jest zidentyfikowanie i scharakteryzowanie infrastruktury krytycznej. Przedstawiono nowe wyzwania związane z łączeniem podejścia bezpieczeństwa i ochrony informacji w procesie podejmowania decyzji
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Wireless Networks as an Infrastructure for Mission-Critical Business Applications
PublikacjaDespite the dynamic growth of wireless network systems, their pres-ence in business-support infrastructure has been limited. In the article we provide an overview of generic corporate network architecture and examine usefulness of available wireless network solutions in such systems. Following this overview we analyze new wireless network architecture which currently undergoes standardization process - wireless mesh. It can result...
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Managing the security vulnerabilities of critical systems and hazardous plants
PublikacjaRozdział poświęcono aktualnym problemom zarządzania ochroną obiektów podwyższonego ryzyka jako ważnych systemów infrastruktury krytycznej. Zarządzanie odpornością na ataki takich obiektów jest oparte na ocenach ryzyka. Podkreśla się, że występują ważne instalacje i systemy wymagające specjalnej uwagi i zabezpieczeń, szczególnie systemy kontroli dostępu do sterowni i urządzeń komunikacji. Opisuje się przykładowe technologie ochrony....
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Critical Reappraisal of Casagrande and Taylor Methods for Coefficient of Consolidation
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The critical factors of landfill fire impact on air quality
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Integrated monitoring, control and security of Critical Infrastructure Systems
PublikacjaModern societies have reached a point where everyday life relies heavily on desired operation of critical infrastructures, in spite of accidental failures and/or deliberate attacks. The issue of desired performance operation of CIS at high security level receives considerable attention worldwide. The pioneering generic methodologies and methods are presented in the paper project for designing systems capable of achieving these...
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Agents in Simulation of Cyberattacks to Evaluate Security of Critical Infrastructures
PublikacjaIn the last years critical infrastructures have become highly dependent on the information technologies and exposed to cyberattacks. Because the effects of the attacks can be detrimental, it is crucial to comprehensively asses the security of the infrastructures' information systems. This chapter describes MAlSim - the simulator of malicious software based on software agents, developed for the needs of a testbed for critical infrastructures...
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Security Evaluation of IT Systems Underlying Critical Networked Infrastructures
PublikacjaCritical infrastructures have become highly dependent on information and communication technology (ICT). The drawback of this situation is that the consequences of disturbances of the underlying ICT networks may be serious as cascading effects can occur. This raises a high demand for security assurance, with a high importance assigned to security evaluations. In this paper we present an experiment-centric approach for the characterisation...
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Algorithms and Tools for Intelligent Control of Critical Infrastructure Systems
PublikacjaCritical Infrastructure Systems (CIS) are spatially distributed and of a network structure. The dynamics are nonlinear, uncertain and with several time scales. There is a variety of different objectives to be reliably met under a wide range of operational conditions. The operational conditions are influenced by the disturbance inputs, operating ranges of the CIS, faults in the sensors and actuators and abnormalities occurring in...
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Uniform Expansivity Outside a Critical Neighborhood in the Quadratic Family
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Searching for Critical Conditions During Lifeboat Launching – Simulations
PublikacjaThe article describes numerical simulations of the process of lifeboat launching at the ship’s side. The research is aimed at finding the values of ship motion parameters which appear to be most dangerous for people in the lowered lifeboat due to the generated accelerations. The simplified model of ship hull motion adopted at this research stage bases on a superposition of harmonic motions with given amplitudes and periods in six...
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Heat and mass exchange in the process of condensation on critical droplets.
PublikacjaSformułowano model wzrostu kropli krytycznej podając równania zmiany masy i temperatury kropli. Pokazano formę zlinearyzowaną tych równań dobrze aproksymującą wzrost kropli w poblizu wymiaru krytycznego. Podano rozwiązanie układu zlinearyzowanego uzależniając zmianę temperatury od zmiany masy kropli i czasu charakterystycznego.
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Sensitivity analysis of critical forces of trusses with side bracing
PublikacjaThe present research is devoted to the study of out-of-plane buckling of trusses with elastic side bracing. Inthis paper, a sensitivity analysis of critical buckling loads of a truss due to bracing stiffness is carried out. A method based on the sensitivity analysis for the determination of the threshold bracing stiffness conditionfor full bracing of a truss is proposed. The influence lines of the unit change of the bracing stiffness...
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Approach to evaluation of time to the critical degradation of ship pipelines
PublikacjaIn the article an approach to the problem of estimating time to the critical degradation of ship pipelines is considered. Such an assessment would consist of six stages. The fundamental idea is to include to the estimation of time to failure of pipelines such elements like: materials that the pipelines are made, destructive physical phenomena taking place in them and applied means of protection. The result of that evaluation should...
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Polysaccharide-based Nanocomposites for Biomedical Applications: A Critical Review
PublikacjaPolysaccharides (PSA) are taking specific position among biomaterials for advanced applications in medicine. Nevertheless, poor mechanical properties is known as the main drawback of PSA, which highlights need for PSA modification. Nanocomposites PSA (NPSA) are a class of biomaterials widely used as biomedical platforms, but despite their importance and worldwide use have not been reviewed. Herein we critically reviewed application...
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Neutralising Responsibility: A Critical Analysis of an Airline’s Climate Disclosures
PublikacjaSustainability reporting provides companies with a medium through which they can communicate their non-financial impacts to stakeholders. The airline industry has been much at the centre of the climate change debate in recent years, which is why it is hardly surprising that airlines seek to take a proactive stance in such reporting. This study critically assesses how an airline based in the Scandinavian region constructs sustainability...
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Challenges in security and safety management of critical systems and infrastructures
PublikacjaReferat poświęcono aktualnym problemom zarządzania bezpieczeństwem systemów i infrastruktur krytycznych. Infrastruktury krytyczne szereguje się z uwzględnieniem kilku kryteriów. Zarysowuje się problematykę zarządzania podatnością obiektów podwyższonego ryzyka na działania z zewnątrz oraz zagadnienie analizy ryzyka na przykładzie systemu elektroenergetycznego. W końcowej części referatu opisuje się nowe wyzwania związane z zarządzaniem...
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Polycyclic aromatic hydrocarbons in smoked fish - a critical review
PublikacjaDym wędzarniczy zawiera wśród setek składników co najmniej 100 wielopierścieniowych węglowodorów aromatycznych (WWA). Benzo{a}piren (BaP) jest uważany za wskaźnikowy, rakotwórczy WWA w wędzonych rybach. Współczesne procedury analityczne obejmujące ekstrakcję węglowodorów z matrycy, oczyszczenie, rozdzielenie metodą GC lub HPLC przy użyciu, odpowiednio, detektora MS albo FLD, umożliwiają oznaczenie indywidualnych WWA w wędzonych...
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Pre-clinical evaluation of 1-nitroacridine derived chemotherapeutic agent that has preferential cytotoxic activity towards prostate cancer
PublikacjaPraca zawiera wyniki badań przedklinicznych pochodnej 1-nitroakrydyny C-1748 wobec komórek ludzkiego raka prostaty CaP in vitro, jak i przeszczepialnego na zwierzęta. W oparciu o fosforylację histonu H2AX jako markera podwójnych cięć DNA wykazano, że C-1748 jest bardziej aktywny w komórkach CaP niż HL60. Zidentyfikowano poza tym receptor androgenny (AR) jako cel molekularny badanego związku. W doświadczeniach na zwierzętach stwierdzono...
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Surgeons’ perspectives on artificial intelligence to support clinical decision-making in trauma and emergency contexts: results from an international survey
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Transplantable Melanomas in Hamsters and Gerbils as Models for Human Melanoma. Sensitization in Melanoma Radiotherapy—From Animal Models to Clinical Trials
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Eligible-and-enrolled vs. eligible-but-not-enrolled patients with chronic ischaemic heart failure in randomized clinical trials of myocardial regeneration
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The New 3D Printed Left Atrial Appendage Closure with a Novel Holdfast Device: A Pre-Clinical Feasibility Animal Study
PublikacjaMany patients undergoing cardiac surgery have risk factors for both atrial fibrillation and stroke. The left atrial appendage (LAA) is the primary site for thrombi formation. Therefore LAA occlusion devices should be tested for their ability to reduce future cerebral ischemic events in patients with high-risk of haemorrhage. The aim of this study was to evaluate the safety and feasibility of a novel left atrial appendage exclusion...
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FIMA, the questionnaire for health-related resource use in the elderly population: validity, reliability, and usage of the Polish version in clinical practice
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Improvement in clinical symptoms in patients with the first episode of psychosis is associated with a decrease in systemic nitric oxide availability. A pilot study
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Clinical effectiveness of primary prevention implantable cardioverter-defibrillators: results of the EU-CERT-ICD controlled multicentre cohort study
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Personalized prediction of the secondary oocytes number after ovarian stimulation: A machine learning model based on clinical and genetic data
PublikacjaControlled ovarian stimulation is tailored to the patient based on clinical parameters but estimating the number of retrieved metaphase II (MII) oocytes is a challenge. Here, we have developed a model that takes advantage of the patient’s genetic and clinical characteristics simultaneously for predicting the stimulation outcome. Sequence variants in reproduction-related genes identified by next-generation sequencing were matched...
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Update on the molecular pathogenesis and clinical treatment of Mantle Cell Lymphoma (MCL): minutes of the 9th European MCL Network conference
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Visual method for detecting critical damage in railway contact strips
PublikacjaEnsuring an uninterrupted supply of power in the electric traction is vital for the safety of this important transport system. For this purpose, monitoring and diagnostics of the technical condition of the vehicle's power supply elements are becoming increasingly common. This paper presents a new visual method for detecting contact strip damage, based on measurement and analysis of the movement of the overhead contact line (OCL)...
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Assessment of a critical area for a give-way ship in a collision encounter
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Potentiometric detection of organic ionics in separation methods: a critical evaluation
PublikacjaCzujniki potencjometryczne są w tej chwili stosowane głównie w połączeniu ze wstrzykową analizą przepływową. Badano membranowe czujniki potencjometryczne pod względem zastosowania w połączeniu z wysokosprawną chromatografią cieczową i elektroforezą kapilarną. Stosowano anality takie jak środki powierzchniowo czynne i proste leki. Zauważono, że czujniki potencjometryczne dają dobre odpowiedzi na małe i duże jony z ładunkiem wielokrotnym...
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Dedicated Geographical Information System in the context of Critical Infrastructure Protection
PublikacjaNowe zaawansowane narzędzia Technologii Informacyjnych i Komunikacyjnych mogą stanowić bardzo użyteczną pomoc podczas przewidywania różnego rodzaju zagrożeń jak również minimalizacji związanego z nimi ryzyka. Artykuł prezentuje Sieciowy System Informacji Przestrzennej dla Szacowania i Wizualizacji Infrastruktur Krytycznych i ich Zagrożeń, stworzony dla Urzędu Miejskiego w Gdańsku przez Politechnikę Gdańską. System ten jest przeznaczony...
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Information and Konowledge management: advances, approaches, challenges and critical issues
PublikacjaPrzedstawiono zarys najnowszych osiągnięć w zakresie zarządzania wiedza i informacja wraz z ich krytyczna ocena.
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A Typology of Small Business Growth Modelling: A Critical Literature Review
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Electronic Cigarette Use and Metabolic Syndrome Development: A Critical Review
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Revealing the anisotropy effects on the critical magnetic field in CaC6 superconductor
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Comparative conformance cases for monitoring multiple implementations of critical requirements
PublikacjaThe paper presents the concept and the mechanism of comparative conformance cases which support conformance monitoring in situations where a standard or other set of requirements are being implemented at multiple sites. The mechanism is enabled by NOR-STA services which implement the TRUST-IT methodology and are deployed in the cloud in accordance with the SaaS model. In the paper we introduce the concept of comparative conformance...
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Research Platform for Monitoring, Control and Security of Critical Infrastructure Systems
PublikacjaSustainable operation of Critical Infrastructure Systems (CISs) is of a major concern to modern societies. Monitoring, control and security of such systems plays a key role in guaranteeing continuous, reliable and above all secure access to the resources provided by these systems. Development of adequate software and hardware structures, as well as algorithms to perform such functions cannot be done apart from the operational conditions...
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Modeling the Influence of Salts on the Critical Micelle Concentration of Ionic Surfactants
PublikacjaWe show for the first time that a phenomenological, augmented volume-based thermodynamics (aVBT) model is capable to predict the critical micelle concentrations of ionic surfactants, including ionic liquids, with added salts. The model also adjusts for the type of salt added by including its molecular volume, which might form a connection to the Hofmeister effect. The other physico-chemically relevant quantities included in the...
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Molecular Strategy for Survival at a Critical High Temperature in Eschierichia coli
PublikacjaThe molecular mechanism supporting survival at a critical high temperature (CHT) in Escherichia coli was investigated. Genome-wide screening with a single-gene knockout library provided a list of genes indispensable for growth at 47°C, called thermotolerant genes. Genes for which expression was affected by exposure to CHT were identified by DNA chip analysis. Unexpectedly, the former contents did not overlap with the latter except...
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Knowledge Management Critical Success Factors and the Innovativeness of KIBS Companies
PublikacjaThe purpose of this paper is to examine the influence of two critical success factors for knowledge management (i.e. leadership and support by the management, motivational practices) on the innovativeness of knowledge-intensive business service (KIBS) companies in the SMEs sector. A sample of 400 companies (KIBS SMEs) located in the Pomeranian District in Poland was selected. The questionnaire was designed to measure knowledge...
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Critical Success Factors for Knowledge Management in SMEs in the KIBS Sector
PublikacjaThe purpose of this paper is to examine knowledge management practices and critical success factors (CSFs) for their introduction in small and medium-sized enterprises (SMEs) in the knowledge-intensive business services (KIBS) sector. Methodology: The paper is based on the results of an exploratory qualitative survey involving owners and managers of small and medium-sized companies operating in the KIBS sector. In the survey, eight...
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Evaluating Security and Resilience of Critical Networked Infrastructures after Stuxnet
PublikacjaThe chapter presents the current configuration of the simulation environment for the evaluations of the security and resilience of critical networked infrastructures, which enables simulations of Stuxnet-like attacks. The configuration includes new features added to the MAlSim - Mobile Agent Malware Simulator after the advent of Stuxnet in reference to the experiments aiming at the security evaluation of a power plant which we...
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Critical conditions of hydrogen-air detonation in partially confined geometry
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Assessment of the level of reliability of power supplies of the objects of critical infrastructure
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A direct method for risk assessment when ship is in critical conditions
PublikacjaPrzedstawiono metodę oceny bezpieczeństwa statku w warunkach krytycznych. Zdefiniowano warunki krytyczne. Podano praktyczne sposoby oceny ryzyka przetrwania statku w warunkach krytycznych. Opisano bezpośrednią metodę oceny ryzyka w warunkach krytycznych. Podano przykłady oceny ryzyka.