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Wyniki wyszukiwania dla: QSAR STUDIES
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Studies on the behaviour of titanium activation foils during long-term exposure at the JET tokamak
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Comparative studies of Rhodamine B decolorization in the combined process Na2S2O8/visible light/ultrasound
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Low Field NMR Studies of Wheat Bread Enriched with Potato Juice During Staling
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Forced degradation studies of ivabradine and in silico toxicology predictions for its new designated impurities
PublikacjaAll activities should aim to eliminate genotoxic impurities and/or protect the API againstdegradation. There is a necessity to monitor impurities from all classification groups,hence ivabradine forced degradation studies were performed. Ivabradine was provedto be quite durable active substance, but still new and with insufficient stability data.Increased temperature, acid, base, oxidation reagents and...
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Studies on Aryl-Substituted Phenylalanines: Synthesis, Activity, and Different Binding Modes at AMPA Receptors
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Cuprous Oxide Thin Films Implanted with Chromium Ions - Optical and Physical Properties Studies
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Case studies of resonance phenomena in high voltage overhead power lines with shunt reactors
PublikacjaMisguided design of the towers of power transmission lines can lead to serious problems such as voltage asymmetry, overvoltages, electric arc extinction difficulties or resonance – in case of double circuit line with shunt reactors. The paper points out those threats on example of 400 kV double circuit overhead transmission line with shunt reactors.
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Thermophysical properties of the phase change material mixtures – preliminary studies on macromolecular hydrocarbons example.
PublikacjaThe aim of this work is a theoretical and experimental analysis of the macromolecular hydrocarbon mixtures composition and the impact on thermophysical parameters of the phase change materials (PCM) made from these mixtures. The analysis of the current state of knowledge extended by the author’s own studies have been presented. Thermophysical characteristics of the hydrocarbons and their mixtures have been specified, in such a...
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Modification of microporous polyurethane elastomers with different types of ash—morphological, mechanical, and thermal studies
PublikacjaIncorporation of wood ash particles from wood gasification into microporous polyurethane elastomers has been investigated and compared to addition of commercially available microspheres resulting from coal burning. Samples were modified with 3 and 6 wt% of fillers. Structure, mechanical, and thermal properties of obtained elastomers were investigated. Incorporation of both types of ash particles decreased the density of polyurethanes...
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Numerical studies on size effects in concrete beams. Architecture Civil Engineering Environment ACEE
PublikacjaW artykule przedstawiony wyniki obliczeń efektów skali w belkach betonowych podczas zginania. Zastosowano model sprężysto-plastyczny z nielokalnym osłabieniem. Rozkład wytrzymałości na rozciąganie był stochastyczny - przestrzennie skorelowany. Belki były geometrycznie podobne. Wyniki porównano z modelem efektu skali Bazanta.
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Studies of the Modelling Accuracy of Steam Turbine Control Systems for Diagnostic Tests of Automatic Synchronizers
PublikacjaOne of the important factors that affect the reliable operation of the power system and the rapid restitution after disaster is a quick and effective combining synchronous electric power facilities to operate in parallel. Hence, diagnostics of automatic synchronizers at every stage of their life, from building a prototype, through the whole life, until removing such devices from the operation, is an extremely important and responsible...
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Studies on applicability of new solid-phase microextraction and determination of short - chain monocarboxylic acids
PublikacjaA convenient approach to monitor the short-chain monocaroboksylic acids (SCAMs) in different samples is gas chromatography (GC) preceded by sample preparation based on solid-phase microextraction (SPME). The fiber with polar coatings were used to extract the SCAMs from headspace of liquid and solid samples. Recently polimeric ionic liquid (PIL) fiber coatings have been proposed to extract volatile organic compounds, minly polar...
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DNA restriction analysis as a supportive tool in mechanistic studies carried out by 32P-postlabelling
PublikacjaNumerous antitumor and carcinogenic compounds are able to modify DNA by forming covalent bonds with its constituents, while some anticarcinogenic compounds are known to prevent such a modification. All these processes are of vital biological import_ance, though deeper inside into factors influencing formation of DNA adducts is difficult due to the low level of their occurrence. 32P-Postlabelling approach ensures very sensitive...
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Structural Studies of Thyroid Peroxidase Show the Monomer Interacting With Autoantibodies in Thyroid Autoimmune Disease
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Mechanistic studies of the hydrolysis of p-nitrophenyl sulfate catalyzed by arylsulfatase from Helix pomatia
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Structural studies on radiopharmaceutical DOTA-minigastrin analogue (CP04) complexes and their interaction with CCK2 receptor
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Synthesis, Pharmacological Evaluation, and Computational Studies of Cyclic Opioid Peptidomimetics Containing β3-Lysine
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Akebia quinata and Akebia trifoliata - a review of phytochemical composition, ethnopharmacological approaches and biological studies
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Structural studies of methyl brevifolincarboxylate in solid state by means of NMR spectroscopy and DFT calculations
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Tocopheryl Succinate-Induced Structural Changes in DPPC Liposomes: DSC and ANS Fluorescence Studies
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Comparative studies of manufacturing strategies within multi-machine production systems using simulation
PublikacjaZaprezentowano metodykę budowy struktur przestrzennych systemów produkcji typu gniazdowego wg zasad technologii grupowej, wykorzystując zaproponowane modele i algorytmy analizy zbiorów/relacji rozmytych. Generowane, z wykorzystaniem tych algorytmów, przebiegi procesów porównywano z przebiegami procesów w strukturach przestrzennych typu hybrydowego, tj. o wspólnych zasobach. Odnosząc się do zdefiniowanego studium przypadku, wykazano...
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Passive layer cracking studies performed on A95056 Aluminum Alloy by DEIS and acoustic emission
PublikacjaZbadano proces pękania warstwy pasywnej na stopie aluminium A95056 w warunkach zmiennych naprężeń rozciągających i polaryzacji anodowej z wykorzystaniem techniki DEIS oraz emisji akustycznej (AE), jako metody porównawczej. Określono elektrochemiczne i mechaniczne przyczyny badanego procesu. Wyznaczono progową (krytyczną) wartość naprężeń, przy których zarejestrowano proces pękania warstwy pasywnej na badanym stopie aluminium. Badanemu...
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Glucosamine-6-phosphate synthase,a novel target for antifungalagents.Molecular modelling studies in drug design
PublikacjaPraca dotyczy modelowania zarówno samych inhibitorów syntazy glukozamino-6-fosforanu jak i ich oddziaływania z obydwiema domenami tego enzymu. Enzym syntaza glukozamino-6-fosforanu został zaproponowany jako nowy cel molekularny w chemoterapii infekcji grzybowych. Zaprojektowano i zsyntezowano szereg inhibitorów tego enzymu - potencjalnych nowych leków przeciwgrzybowych. Dzięki modelowaniu molekularnemu udało się wyjaśnić mechanizm...
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Complementary studies of residual stress distribution of repaired power plant steam turbine casing
PublikacjaRozkład i poziom naprężeń własnych w korpusach turbin badano za pomocą efektu Barkhausena oraz metodą nawiercania otworów. Badano również twardość. Korpusy były reperowane metodą zaspawania. Wykazano, iż zastosowana technologia nie wprowadza naprężeń o poziomie zagrażającym dalszej ekploatacji korpusu.
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The Polish perspective on adopting EU standards nitrogen removal at large WWTPs - case studies
PublikacjaW związku z przyjęciem nowych regulacji prawnych w zakresie usuwania azotu w dużych oczyszczalniach ścieków (>100 000 RM), potrzebne są wiarygodne i dokładne informacje na temat wymiarowania stref anoksycznych w komorach osadu czynnego. Badania zostały przeprowadzone w oczyszczalniach Gdańsk-Wschód oraz Gdynia-Dębogórze. Ich celem było porównanie szybkości denitryfikacji określonej w warunkach laboratoryjnych oraz obliczonej na...
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Studies on 16-membered azothia-and azoxythiacrown ethers as ion carriers in ion selective membranes.
Publikacja16-członowe azo iazoksy korony zawierające w makropierścieniu atomy siarki były badane jako nośniki jonów w jonoselektywnych elektrodach membranowych. Związki te badane były pod kątem kompleksowania metali I i II grupy układu okresowego oraz metali ciężkich i przejściowych. Wyznaczone zostały stałe trwałości kompleksów azokoron z wybranymi kationami za pomocą metody sandwiczowej. W wyniku badań potwierdzono tworzenie się silnych...
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Molecular aspects of the interaction between amphotericin B and a phospholipid bilayer: molecular dynamics studies.
PublikacjaAmfoterycyna B jest antybiotykiem z grupy polienów makrolidowych. Stosowany jest on w leczeniu układowych infekcji grzybowych. Wiadomo że związek ten oddziałuje ze składnikami błon lipidowych i tworzy kanały. W przedstawianej pracy prezentowane są wyniki symulacji przeprowadzonej dynamiką molekularną układu składającego się z 200 cząsteczek lipidów DMPC i jednej cząsteczki amfoterycyny ułożonej na powierzchni błony. Z przeprowadzonej...
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Solubility enhancement of metronidazole using natural deep eutectic solvents: Physicochemical and thermodynamic studies
PublikacjaThis research aimed to explore the utility of natural deep eutectic solvents (NADES) as the co-solvents for slightly water-soluble metronidazole (MNZ). After testing 70 wt% (percentage by weight) aqueous mixtures of seven NADESs, it was found that MNZ had the highest solubility in water solutions of NADES composed of choline chloride (ChCl) and citric acid (CA). The solubility of MNZ (expressed as 103 mol fraction) increased with...
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Effect of underwater friction stir welding parameters on AA5754 alloy joints: experimental studies
PublikacjaThe water as a welding environment may generate serious technological and metallurgical problems but in certain cases, the physicochemical properties of water can be used effectively, e.g., to impart the specific properties of welded materials. The purpose of the work was verification of effectiveness of the water cooling of aluminium alloy AA5754 for various sets of technological parameters of underwater friction stir welding...
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Modified GAPI (MoGAPI) Tool and Software for the Assessment of Method Greenness: Case Studies and Applications
PublikacjaThe green analytical procedure index (GAPI) has been widely used to assess the greenness of different steps in analytical methodology. In the GAPI index, the different stages of the chemical analysis process are depicted using five pentagrams divided in subsections, labeled green, yellow, or red according to the degree of greenness. This GAPI tool provides a quick overview of the environmental impact and safety of the procedure....
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Experimental and numerical studies on the mechanical response of a piezoelectric nanocomposite-based functionally graded materials
PublikacjaThis work presents an experimental study of piezoelectric structures reinforced by graphene platelets, based on the concept of the functionally graded materials (FGMs). The assumed model is a rectangular beam/plate and the composition is due to the Halpin-Tsai rule. The model is also simulated in the Abaqus software which is the first time that such a structure has been modelled in an FEM package. In addition, a mathematical model...
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Toxoplasma gondii recombinant antigens as tools for serodiagnosis of human toxoplasmosis: current status of studies
PublikacjaToxoplasma gondii is a parasitic protozoan which is the cause of toxoplasmosis. Although human toxoplasmosis in healthy adults is usually asymptomatic, serious disease can occur in the case of congenital infections and immunocompromised individuals. Furthermore, despite the exact recognition of its etiology, it still presents a diagnostic problem. Diagnosis of toxoplasmosis is mainly based on the results of serological tests detecting...
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A new approach to β-decays studies impacting nuclear physics and astrophysics: The PANDORA setup
PublikacjaTheory predicts that lifetimes of β-radionuclides can change dramatically as a function of their ionization state. Experiments performed in Storage Rings on highly ionized atom have proven nuclei can change their beta decay lifetime up to several orders of magnitude. The PANDORA (Plasmas for Astrophysics, Nuclear Decay Observation and Radiation for Archaeometry) experiment is now conceived to measure, for the first time, nuclear...
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Indole-Acrylonitrile Derivatives as Potential Antitumor and Antimicrobial Agents—Synthesis, In Vitro and In Silico Studies
PublikacjaA series of 2-(1H-indol-2-yl)-3-acrylonitrile derivatives, 2a–x, 3, 4a–b, 5a–d, 6a–b, and 7, were synthesized as potential antitumor and antimicrobial agents. The structures of the prepared compounds were evaluated based on elemental analysis, IR, 1H- and 13NMR, as well as MS spectra. X-ray crystal analysis of the representative 2-(1H-indol-2-yl)-3-acrylonitrile 2l showed that the acrylonitrile double bond was Z-configured. All...
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The Application of Dynamic Electrochemical Impedance Spectroscopy (DEIS) Technique in Corrosion and Corrosion Inhibition Studies
Publikacjaorrosion studies have attracted considerable interest in the areas of materials chemistry and industrial chemistry, as it affects the direct and indirect costs of industry, leading to huge economic setbacks due to the need for repair, maintenance, and even shutdowns due corrosion damage. This new volume is a comprehensive resource that presents new and up-to-date, theoretical, and experimental corrosion inhibition studies.
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Anisotropic mechanical behavior and auxeticity of penta-graphene: Molecular statics/molecular dynamics studies
PublikacjaWe investigate the mechanical properties of penta-graphene (PG), a recently proposed two-dimensional carbon allotrope using atomistic simulation techniques combined with the empirical description of interatomic interactions. We report on the dependence of its three in-plane mechanical moduli (i.e. Young's modulus, Poisson's ratio and shear modulus) on the deformation direction, strain and temperature. We show that PG displays a...
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Heat recovery from the hybrid photovoltaic tile – experimental studies with the solar light simulator
PublikacjaConsidering the current development of micro-cogeneration energy sources, supported by the national prosumer policy and the act on the renewable energy sources, there is a great demand for the effective solar technologies. In this area, the photovoltaic cells with a combined conversion of the solar radiation energy into the electrical and thermal energy (PV/T cells) seem to be attractive. They are already widely available and treated...
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Cooperation in Creating Innovation in Polish Small and Medium-Sized Enterprises in the Light of Empirical Studies
PublikacjaNowadays, sources of competitive advantage and economic development are sought in the sphere of innovation. They are at the centre of interest of representatives of the world of politics, science, and business. Moreover, they have been incorporated into governmental and international strategic development programmes. This article attempts to characterize and evaluate cooperation in creating innovation in small and medium-sized...
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Photoresponsive Amide-Based Derivatives of Azobenzene-4,4′-Dicarboxylic Acid—Experimental and Theoretical Studies
PublikacjaAzobenzene derivatives are one of the most important molecular switches for biological and material science applications. Although these systems represent a well-known group of compounds, there remains a need to identify the factors influencing their photochemical properties in order to design azobenzene-based technologies in a rational way. In this contribution, we describe the synthesis and characterization of two novel amides...
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X-Ray Diffraction, Mössbauer Spectroscopy and Magnetoelectric Effect Studies of Multiferroic Bi5Ti3FeO15 Ceramics
PublikacjaBi5Ti3FeO15 ceramics belongs to multiferroic class of materials. In this work it was prepared by solid-state sintering method and investigated by X-ray diffraction, Mössbauer spectroscopy, and magnetoelectric effect measurements. As it was proved by X-ray diffraction studies the single-phase Bi5Ti3FeO15 compound was obtained. The Mössbauer investigations revealed paramagnetic character of the compound at room temperature as well...
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Aqueous solutions of NMA, Na2HPO4 , and NaH2PO4 as models for interaction studies in phosphate–protein systems
PublikacjaPhosphate buffers are essential for many areas of studies. However, their influence on buffered systems is often ignored. The phosphate salts can interact with biologically important macromolecules (e.g. proteins) and stabilize or destabilize them. With our research, we want to answer question what kind of interactions, if any, occur between phosphate ions and a protein backbone model — N-methylacetamide (NMA). ATR-FTIR spectroscopy...
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Effect of osmolytes of different type on DNA behavior in aqueous solution. Experimental and theoretical studies
PublikacjaOsmolytes, the small organic molecules accumulated in cells under environmental stress, can modulate the stability of biopolymers such as proteins and DNA. In spite of many years of research, there is no established molecular mechanism of the influence of osmolytes on DNA structure. Here, we used two model osmolytes that denature (urea) or stabilize (trimethylglycine, TMG) proteins to study their effect on DNA in aqueous solutions...
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FE studies of quasi-static mass flow in bins: the polar elasto-plastic approach
PublikacjaPrzedstawiono wyniki numerycznej analizy zachowania się materiału sypkiego w silosie podczas przepływu quasi-statycznego. Obliczenia wykonano metodą elementów skończonych na bazie mikropolarnego sprężysto-plastycznego prawa materiałowego.
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Studium Wykonalności projektu informatycznego.
PublikacjaRozdział przedstawia przedmiot, cele i zakres Studium Wykrywalności oraz jego usytuowanie w cyklu życia projektu informatycznego. Omawiane są obszary dokonywanej oceny - wykrywalność techniczna, organizacyjna, zestawienia nakładów i oczekiwanych korzyści, elementy ryzyka i aspekty prawne. Proponowany jest zakres i kształt Raportu Wykrywalności, stanowiącego dokument kończący Studium. Prezentację kończy omówienie zawartości...
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KASZUBY bionicznie. Studium formy
PublikacjaWystawa towarzysząca Szkole Letniej “Dom&Ziemia” prezentuje studium form bionicznych i kulturowych osadzonych w realiach przyrodniczych Kaszub. Celem była prezentacja określonej metody twórczego działania jako preludium przeprowadzanych warsztatów, ale także ukazanie potencjału regionu.
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New 2-[(4-Amino-6-N-substituted-1,3,5-triazin-2-yl)methylthio]-N-(imidazolidin-2-ylidene)-4-chloro-5-methylbenzenesulfonamide Derivatives, Design, Synthesis and Anticancer Evaluation
PublikacjaIn the search for new compounds with antitumor activity, new potential anticancer agents were designed as molecular hybrids containing the structures of a triazine ring and a sulfonamide fragment. Applying the synthesis in solution, a base of new sulfonamide derivatives 20–162 was obtained by the reaction of the corresponding esters 11–19 with appropriate biguanide hydrochlorides. The structures of the compounds were confirmed...
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Noturnos, etudes, scherzi...
Publikacjakatalog wystawy malarstwa i rzeźby grupy polskich artystów mieszkajacych w Portugalii, która miała miejsce w Casa Santa Maria, Cascais w Portugali. Twórczość inspirowana muzyka Fryderyka Chopina z okazji 200 rocznicy urodzin kompozytora. Format 16,5x24cm, 4 strony w języku portugalskim. Na stronach 3 i 4 przedstawiona jest nota o autorze i jego twórczosci oraz reprodukcja jednego z 5 obrazów prezentowanych na wystawie.
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Timing properties of LuAP:Ce studied with large-area avalanche photodiodes
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Polymerization and Structure of Opposing Polymer Brushes Studied by Computer Simulations
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Hydration of aprotic donor solvents studied by means of FTIR spectroscopy
PublikacjaThe paper attempts to explain the mutual influence of nonpolar and electron-donor groups on solute hydration,the problem of big importance for biological aqueous systems. Aprotic organic solvents have been used asmodel solutes, differing in electron-donating power. Hydration of acetonitrile, acetone, 2-butanone, andtriethylamine has been studied by HDO and (partially) H2O spectra. The quantitative version of...