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Insights into the Effects of Cancer Associated Mutations at the UPF2 and ATP-Binding Sites of NMD Master Regulator: UPF1
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Highly Conserved Homotrimer Cavity Formed by the SARS-CoV-2 Spike Glycoprotein: A Novel Binding Site
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Synthesis and SAR Studies of Antibacterial Peptidyl Derivatives Based upon the Binding Site of Human Cystatin C
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Energy-Saving Mechatronic System for Fatigue Tests of Materials under Variable-Amplitude Proportional Bending and Torsion
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Molecular dynamics study of a gelsolin-derived peptide binding to a lipid bilayer containing phosphatidylinositol 4,5-bisphosphate
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Energy-based fatigue failure characteristics of materials under random bending loading in elastic-plastic range
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Novel single-stranded DNA-binding proteins from extreme psychrophilic bacterium Psychromonas ingrahamii 37
PublikacjaWe report the identification and characterization of the single-stranded DNA binding protein (SSB) from extreme psychrophilic bacterium Psychromonas ingrahamii 37 (PinSSB) that grows expotentially at -12°C and may well grow at even lower temperatures. PinSSB is one of the largest known bacterial SSB protein consisting 222 amino acid residues with a calculated molecular mass of 25.1 kDa. The analysis by gel filtration chromatography...
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Characterization of exceptionally thermostable single-stranded DNA-binding proteins from Thermotoga maritima and Thermotoga neapolitana
PublikacjaBACKGROUND: In recent years, there has been an increasing interest in SSBs because they find numerous applications in diverse molecular biology and analytical methods.RESULTS: We report the characterization of single-stranded DNA binding proteins (SSBs) from the thermophilic bacteria Thermotoga maritima (TmaSSB) and Thermotoga neapolitana (TneSSB). They are the smallest known bacterial SSB proteins, consisting of 141 and 142 amino...
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Comovements between heavily shorted stocks during a market squeeze: Lessons from the GameStop trading frenzy
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Fibronectin-, vitronectin- and laminin-binding proteins at the cell walls of Candida parapsilosis and Candida tropicalis pathogenic yeasts
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Molecular simulations study of ligand-release mechanism in an odorant-binding protein from the southern house mosquito
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A new anisotropic bending model for nonlinear shells: Comparison with existing models and isogeometric finite element implementation
PublikacjaA new nonlinear hyperelastic bending model for shells formulated directly in surface form is presented, and compared to four existing prominent bending models. Through an essential set of elementary nonlinear bending test cases, the membrane and bending stresses of each model are examined analytically. Only the proposed bending model passes all the test cases, while the other bending models either fail or only pass the test cases for...
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Correlation between Fractal Dimension and Areal Surface Parameters for Fracture Analysis after Bending-Torsion Fatigue
PublikacjaThis paper investigates the fracture surface topography of two steel and aluminum alloys subject to bending-torsion fatigue loadings, as well as their susceptibility to fatigue performance and failure mechanisms. Using fracture surface topography data analysis, elements with different geometries were elaborated. A correlation between the fractal dimension, other selected parameters of surface topography such as areal Sx, and...
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The impact of surface slope and calculation resolution on the fractal dimension for fractures of steels after bending-torsion fatigue
PublikacjaThe article presents the results of the fractal dimension measurements on the fatigue fracture surfaces of 10HNAP and S355J2 steels specimens after combined bending-torsion fatigue. For smooth and ring-notched specimens, three loading conditions were analyzed: (1) bending; (2) bending-torsion; and (3) torsion fatigue. Post-failure surface topography measurements were carried out on the entire fracture surfaces using an optical...
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NON-LOCAL VOLUMETRIC APPROACH TO ANALYSIS DEFECT'S SHAPE INFLUENCE ON SPECIMENS DURABILITY SUBJECTED TO BENDING AND TORSION
PublikacjaThe influence of defect features on fatigue behaviour is a complex trivial issue. Although the important advances over the last decades, the dialectical relationship between the defect orientation and durability is not clearly understood. The paper aims at studying the influence of the orientation of elliptical defects on the durability of samples made of C45 steel. Three types of samples with elliptical defects were subjected...
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Structure-activity relationship study of tetrapeptide inhibitors of the Vascular Endothelial Growth Factor A binding to Neuropilin-1
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Paternal Postpartum Bonding and Its Predictors in the Early Postpartum Period: Cross-Sectional Study in a Polish Cohort
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Membrane Sterols Modulate the Binding Mode of Amphotericin B without Affecting Its Affinity for a Lipid Bilayer
PublikacjaMembrane-active antibiotics are known to selectively target certain pathogens based on cell membrane properties, such as fluidity, lipid ordering, and phase behavior. These are in turn modulated by the composition of a lipid bilayer and in particular by the presence and type of membrane sterols. Amphotericin B (AmB), the golden standard of antifungal treatment, exhibits higher activity toward ergosterol-rich fungal membranes, which...
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Exploratory analysis and ranking of analytical procedures for short-chain chlorinated paraffins determination in environmental solid samples
PublikacjaShort-chain chlorinated paraffins are ones of the most recent chemical compounds that have been classified as persistent organic pollutants. They have various applications and are emitted to the environment. Despite the fact, that the content levels of these compounds in the environmental compartments should be monitored, there is still a lack of well-defined and validated analytical procedures, proposed or suggested by the national...
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Highly Conserved Homotrimer Cavity Formed by the SARS-CoV-2 Spike Glycoprotein: A Novel Binding Site
PublikacjaAn important stage in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) life cycle is the binding of the spike (S) protein to the angiotensin converting enzyme-2 (ACE2) host cell receptor. Therefore, to explore conserved features in spike protein dynamics and to identify potentially novel regions for drugging, we measured spike protein variability derived from 791 viral genomes and studied its properties by molecular...
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Mapping the Structural and Dynamic Determinants of pH-Sensitive Heparin Binding to Granulocyte Macrophage Colony Stimulating Factor
PublikacjaGranulocyte macrophage colony stimulating factor (GMCSF) is an immunomodulatory cytokine that is harnessed as a therapeutic. GMCSF is known to interact with other clinically important molecules, such as heparin, suggesting that endogenous and administered GMCSF has the potential to modulate orthogonal treatment outcomes. Thus, molecular level characterization of GMCSF and its interactions with biologically active compounds is critical...
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Green`s function methods for Mathematical modeling of unidirectional diffusion process in isothermal metals bonding process
PublikacjaPodano wykorzystanie funkcji Greena w rozwiązaniu matematycznego modelu dyfuzji jednowymiarowej podczas izotermicznego łączenia metali.
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Taq DNA polymerase fused with DNA binding protein with increased resistance to inhibitors from clinical samples
PublikacjaNowadays PCR method is commonly used in molecular diagnostic. However, in many cases PCR is limited, by the presence of inhibitory substances in biological, soil or food samples Efficiency and fidelity of amplification is strongly connected with DNA polymerase and reaction conditions. To meet the requirements of modern diagnostic methods it is essential to seeking for new DNA polymerases with better properties useful in these field....
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Bending and buckling formulation of graphene sheets based on nonlocal simple first-order shear deformation theory
PublikacjaThis paper presents a formulation based on simple first-order shear deformation theory (S-FSDT) for large deflection and buckling of orthotropic single-layered graphene sheets (SLGSs). The S-FSDT has many advantages compared to the classical plate theory (CPT) and conventional FSDT such as needless of shear correction factor, containing less number of unknowns than the existing FSDT and strong similarities with the CPT. Governing...
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Textile reinforced concrete members subjected to tension, bending, and in-plane loads: Experimental study and numerical analyses
PublikacjaTextile reinforced concrete has raised increasing research interest during the last years, mainly due to its potential to be used for freeform shell structures involving complex load situations. Yet, most experimental work has focused on test setups with primarily uniaxial loading. In the current work, such setups are complemented with a novel test setup of deep beams, including in-plane bending and shear. Further, nonlinear finite...
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Topography measurement methods evaluation for entire bending-fatigued fracture surfaces of specimens obtained by explosive welding
PublikacjaIn this paper, the methods of compensation of differences in the results of entire bending-fatigued fracture surface topographies were presented. The roughness evaluation was performed with a focus variation microscope and confocal surface topography measurement techniques. The differences in the ISO 25178 roughness parameters were investigated and procedures for their compensation were studied. It was found that various types...
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Parametric FE studies on a coupled energetic-statistical size effect in plain concrete beams under bending
PublikacjaW artykule omówiono wyniki połączonego deterministyczno-statystycznego efektu skali w betonowych belkach podczas zginania. Obliczenia wykonano stosując MES w zakresie sprężysto-plastyczności z nielokalnym osłabieniem. Obliczenia wykonano dla różnych długości korelacji i współczynnika zmienności.
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Calculations of fracture process zones on meso-scale in notched concrete beams subjected to three-point bending.
PublikacjaW artykule przedstawiono wyniki numeryczne MES modelowanie belek betonowych z nacięciem na poziomie skali mezo. Beton został opisany na poziomie skali mezo jako stochastyczny materiał 3-składnikowy złożony z kruszywa, zaczynu cementowego oraz stref kontaktu. Obliczenia wykonano przy wykorzystaniu modelu degradacji sztywności z nielokalnym osłabieniem. Zbadano wpływ stochastycznego rozkładu kruszywa, średnicy, kształtu oraz zagęszczenia...
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Investigations on fracture in reinforced concrete beams in 3-point bending using continuous micro-CT scanning
PublikacjaThis study explores a fracture process in rectangular reinforced concrete (RC) beams subjected to quasi-static three-point bending. RC beams were short and long with included longitudinal reinforcement in the form of a steel or basalt bar. The ratio of the shear span to the effective depth was 1.5 and 0.75. The focus was on the load–deflection diagram and crack formation. Three-dimensional (3D) analyses of the size and distribution...
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Finite element analysis on failure of reinforced concrete corner in sewage tank under opening bending moment
PublikacjaW artykule omówiono mechanizm uszkodzenia żelbetowego zbiornika ściekowego w narożniku ściany, który uległ uszkodzeniu podczas próby wypełnienia na skutek nadmiernych przemieszczeń poziomych ścian pod wpływem otwierającego momentu zginającego. Aby wyjaśnić przyczyny awarii, przeprowadzono kompleksowe obliczenia metodą elementów skończonych (MES) żelbetowego zbiornika w warunkach odkształcenia płaskiego. Beton zamodelowano za pomocą...
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Potencjał strategii slow city dla rozwoju miast kształtujących się metropolii polskich. Na przykładzie Pucka i Kartuz miast Obszaru Metropolitalnego Gdańsk-Sopot-Gdynia
PublikacjaW artykule wskazano możliwości wykorzystania filozofii ruchu Slow, do wykształcenia nowego modelu Metropolitalnych Slow City (MSC). Odniesiono się do założeń ruchu Cittaslow, pokazując potencjały dla alternatywnego kierunku strategii rozwojowej w duchu „miast dobrego życia” dla ośrodków w granicach obszarów metropolitalnych. W podsumowaniu założenia teoretyczne zilustrowano przykładem innowacyjnego modelu projektu rewitalizacji...
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Impact of Large-scale urban interventions on contemporary city centers. Gdansk case study. Wpływ przedsiewzięć urbanistycznych dużej skali na centra miast. Studium przypadku Gdańska
PublikacjaLarge scale urban interventions have become a common development practice in cotemporary cities, allowing achieving rapid changes in their urban structure. They can be analyzed taking into account various perspectives. Some of them include planning and development models, transformation of brownfields and other types of distressed urban areas, as well as consequences and results of their implementation in existing urban structures....
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Elektryczne zespoły zasobnikowe jako alternatywa dla elektryfikacji nowych linii w Trójmieście = Electric Multiple Units With Energy Storage – Alternative to Electrification of New Lines in Three City
PublikacjaRozważono zastosowanie nowoczesnych zespołów trakcyjnych na liniach pasażerskich Trójmiasta. Zaproponowano budowę linii Gdańsk Śródmieście - Orunia Górna oraz odtworzenie komunikacji do północnych dzielnic Gdyni. Przeanalizowano trójmiejski układ komunikacyjny dla ruchu pociągów z zasobnikami energii. Zaproponowano trasę Orunia Górna - Wrzeszcz - Osowa - Chylonia - Port Oksywie z naprzemiennie występującymi odcinkami zelektryfikowanymi...
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Metropolie ery cyfrowej- wpływ nowych technologii informacyjnych i komunikacyjnych na kształt współczesnego miasta = Digital metropolis - the impact of new information and communication technologies on contemporary city
PublikacjaDynamiczny rozwój technologii informacyjnych i cyfrowych zapoczątkowany w drugiej połowie XX wieku wpłynął na zmianę wizerunku współczesnego miasta. Coraz bardziej wyraźną rolę w jego tworzeniu zaczęły odgrywać fasady, powłoki budynków oraz fragmenty przestrzeni publicznych, w obrębie których zaczęto integrować pojawiające się innowacyjne technologie, potocznie zwane medialnymi. Powierzchnie architektoniczne wyposażone w nie...
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Costs of privatization of the banking sector in Poland in 1997-2000
Dane BadawczeOn June 14, 1996, a special law was passed on the merger and grouping of certain banks in the form of joint-stock companies. Pursuant to these regulations, the PeKaO S.A. banking group was established, which was the only entity of this type established in this way. Additionally, by the end of 1996, four out of nine regional banks were sold, i.e. Wielkopolski...
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An investigation on the role of GMA grafting degree on the efficiency of PET/PP-g-GMA reactive blending: morphology and mechanical properties
PublikacjaGlycidyl methacrylate (GMA) has been grafted on polypropylene (PP) with the aid of styrene (St) comonomer, by changing dicumyl peroxide initiator content, GMA level, and St concentration. The performance of the resulting PP-g-GMA reactive material towards static and dynamic mechanical properties of poly (ethylene terephthalate) (PET) was monitored in terms of grafting reaction variables and compatibilizer content. Fourier transform...
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Determination of API content in a pilot-scale blending by near-infrared spectroscopy as a first step method to process line implementation
PublikacjaNear infrared (NIR) spectroscopy was used for estimation of powder blend homogeneity and manufacturing control of a medicinal product powder mixture containing active pharmaceutical ingredient (API). Aiming at initiating a Process Analytical Technology (PAT) activity, the first step was a stationary mode atline evaluation. In this, the content of pharmaceutical active compound in the powder mixtures intended to the direct tabletting...
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Exposure of a small Arctic seabird, the little auk (Alle alle) breeding in Svalbard, to selected elements throughout the course of a year
PublikacjaThe Arctic marine ecosystem can be altered by processes of natural and anthropogenic origin. Spatio-temporal variation in species exposure to contamination is still poorly understood. Here, we studied elemental concentrations in the non-lethally collected samples from the most numerous seabird in European Arctic, the little auk (Alle alle) nesting in one breeding colony in Svalbard. This seabird spent the breeding season in the...
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Towards Compact City – Gdańsk-Osowa district case study, proposal no 2, January 2021
Dane BadawczeThe data presents results of work within the participatory planning process: Towards Compact City – Gdańsk-Osowa district case study, proposal no 2, from January 2021. The goal of the process was to present the new, innovative design visions for the area located in Gdańsk-Osowa district in the context of “Compact city” and “Walkable city” ideas. The...
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Towards Compact City – Gdańsk-Osowa district case study, proposal no 3, January 2021
Dane BadawczeThe data presents results of work within the participatory planning process: Towards Compact City – Gdańsk-Osowa district case study, proposal no 3, from January 2021. The goal of the process was to present the new, innovative design visions for the area located in Gdańsk-Osowa district in the context of “Compact city” and “Walkable city” ideas. The...
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Towards Compact City – Gdańsk-Osowa district case study, proposal no 7, January 2021
Dane BadawczeThe data presents results of work within the participatory planning process: Towards Compact City – Gdańsk-Osowa district case study, proposal no 7, from January 2021. The goal of the process was to present the new, innovative design visions for the area located in Gdańsk-Osowa district in the context of “Compact city” and “Walkable city” ideas. The...
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Towards Compact City – Gdańsk-Osowa district case study, proposal no 6, January 2021
Dane BadawczeThe data presents results of work within the participatory planning process: Towards Compact City – Gdańsk-Osowa district case study, proposal no 6, from January 2021. The goal of the process was to present the new, innovative design visions for the area located in Gdańsk-Osowa district in the context of “Compact city” and “Walkable city” ideas. The...
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Towards Compact City – Gdańsk-Osowa district case study, proposal no 5, January 2021
Dane BadawczeThe data presents results of work within the participatory planning process: Towards Compact City – Gdańsk-Osowa district case study, proposal no 5, from January 2021. The goal of the process was to present the new, innovative design visions for the area located in Gdańsk-Osowa district in the context of “Compact city” and “Walkable city” ideas. The...
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Towards Compact City – Gdańsk-Osowa district case study, proposal no 1, January 2021
Dane BadawczeThe data presents results of work within the participatory planning process: Towards Compact City – Gdańsk-Osowa district case study, proposal no 1, from January 2021. The goal of the process was to present the new, innovative design visions for the area located in Gdańsk-Osowa district in the context of “Compact city” and “Walkable city” ideas. The...
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Towards Compact City – Gdańsk-Osowa district case study, proposal no 4, January 2021
Dane BadawczeThe data presents results of work within the participatory planning process: Towards Compact City – Gdańsk-Osowa district case study, proposal no 4, from January 2021. The goal of the process was to present the new, innovative design visions for the area located in Gdańsk-Osowa district in the context of “Compact city” and “Walkable city” ideas. The...
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Towards Compact City – Gdańsk-Osowa district case study, proposal no 8, January 2021
Dane BadawczeThe data presents results of work within the participatory planning process: Towards Compact City – Gdańsk-Osowa district case study, proposal no 8, from January 2021. The goal of the process was to present the new, innovative design visions for the area located in Gdańsk-Osowa district in the context of “Compact city” and “Walkable city” ideas. The...
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Towards Compact City – Gdańsk-Osowa district case study, proposal no 9, January 2021
Dane BadawczeThe data presents results of work within the participatory planning process: Towards Compact City – Gdańsk-Osowa district case study, proposal no 9, from January 2021. The goal of the process was to present the new, innovative design visions for the area located in Gdańsk-Osowa district in the context of “Compact city” and “Walkable city” ideas. The...
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Bacteriological and physicochemical monitoring of inland surface waters within the administrative boundaries of Gdańsk city in 2010
Dane BadawczeThe dataset containst the results of a bacteriological and physico-chemical study of inland surface waters within the administrative boundaries of Gdańsk city in 2010.The examined material consisted of water samples collected from four lakes located within the administrative boundaries of Gdańsk, Poland.
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Bacteriological and physicochemical monitoring of inland surface waters within the administrative boundaries of Gdańsk City in 2008
Dane BadawczeThe dataset containst the results of a bacteriological and physico-chemical study of inland surface waters within the administrative boundaries of Gdańsk city in 2008. The examined material consisted of water samples collected from four lakes located within the administrative boundaries of Gdańsk, Poland.
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Bacteriological and physicochemical monitoring of inland surface waters within the administrative boundaries of Gdańsk City in 2009
Dane BadawczeThe dataset containst the results of a bacteriological and physico-chemical study of inland surface waters within the administrative boundaries of Gdańsk city in 2009. The examined material consisted of water samples collected from four lakes located within the administrative boundaries of Gdańsk, Poland.