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Wyniki wyszukiwania dla: therapeutic landscapes
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Poszukiwanie układów obiektów architektonicznych zgodnych z uwarunkowaniami przyrodniczymi Pojezierza Kaszubskiego. Studium autorskie
PublikacjaStudium docelowych form zamieszkiwania oparto o obserwacje przyrodnicze i próbę ich kulturowej transpozycji poprzez działania artystyczne. Metaforyczne wyobrażenia form zamieszkiwania prezentowane w wielu wariantach ukazują jej adaptowalność do różnorodnych, unikalnych uwarunkowań przyrodniczych. Kontekst stanowi zarówno inspirację jak i zadanie problemowe, na które odpowiedzią jest konkretna forma układu, spasowana do swojego...
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Peptidoglycan hydrolases - potential weapons against Staphylococcus aureus
PublikacjaBacteria of the genus Staphylococcus are common pathogens responsible for a broad spectrum of human and animal infections and belong to most important etiological factors causing food poisoning. Because of rapid increase in prevalence of isolation of staphylococci resistant to many antibiotics, there is an urgent need for development of new alternative chemotherapeutics. A number of studies have recently demonstrated the strong...
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Epigenetic inhibitor zebularine activates ear pinna wound closure in the mouse
PublikacjaBackground:Most studies on regenerative medicine focus on cell-based therapies and transplantations.Small-molecule therapeutics, though proved effective in different medical conditions, have not been extensivelyinvestigated in regenerative research. It is known that healing potential decreases with development and devel-opmental changes are driven by epigenetic mechanisms, which suggests epigenetic repression of regenerativecapacity.Methods:We...
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The Role of Greenery and Traffic Calming Measures in Planning of Road Infrastracture
PublikacjaThe role of greenery and traffi c calming measures in road infrastructure planning. The “life” of a town is connected with its infrastructure. So it is that, apart from serving their principal function, motorways, roads, airports and other facilities which make transport possible largely determine contemporary urban design. To achieve balanced forms of urban infrastructure that ensure comfort, safety and spatial order, it is necessary when...
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Reshaping financial systems: The role of ICT in the diffusion of financial innovations – Recent evidence from European countries
PublikacjaExchange-traded funds (ETFs) are among the fastest-growing types of innovative financial products. The emergence and spread of these instruments have been facilitated by the digital revolution. Information and communication technology (ICT) is profoundly reshaping the global economic landscape, laying solid foundations for unrestricted and unbounded flows of information and knowledge, eliminating information asymmetries, and furthering...
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Microbial and chemical quality assessment of the small rivers entering the South Baltic. Part II: Case study on the watercourses in the Puck Bay catchment area
PublikacjaDue to its location, Puck Bay is an area particularly vulnerable to pollution of anthropogenic origin. The aim of the study was to assess the water quality of small watercourses entering the inner part of Puck Bay. The paper presents the results of chemical and microbiological analyses of 10 rivers and canals at their estuaries located on the western shore of the internal Puck Bay. The following environmental parameters were analyzed:...
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Architecture in the field of art on the example of author’s realizations
PublikacjaThe aim of the article was to show the place of architecture in the space of art on the example of original projects. In the author's opinion, architecture, using an artistic object as a means of expression, influences the process of living by showing the recipient, who is an inhabitant, important values from the point of view of creating a house that ensures a good quality of life and strengthening the understanding of both various...
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On the Possibility of the Amphotericin B-Sterol Complex Formation in Cholesterol- and Ergosterol-Containing Lipid Bilayers: A Molecular Dynamics Study
PublikacjaAmphotericin B (AmB) is a well-known membrane-active antibiotic that has been used to treat systemicfungal infections for more than 45 years. Therapeutic application of AmB is based on the fact that it is moreactive against ergosterol-containing membranes of fungal cells than against mammalian membranes withcholesterol. In this paper, we examine the hypothesis according to which the selectivity of the AmB's membraneaction originates...
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Longitudinal drug synergy assessment using convolutional neural network image-decoding of glioblastoma single-spheroid cultures
PublikacjaAbstract Background In recent years, drug combinations have become increasingly popular to improve therapeutic outcomes in various diseases, including difficult to cure cancers such as the brain cancer glioblastoma. Assessing the interaction between drugs over time is critical for predicting drug combination effectiveness and minimizing the risk of therapy resistance. However, as viability readouts of drug combination experiments...
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Essential Oils, Silver Nanoparticles and Propolis as Alternative Agents Against Fluconazole Resistant Candida albicans, Candida glabrata and Candida krusei Clinical Isolates
PublikacjaDevelopment of effective and safe therapeutic treatment of fungal infections remains one of the major challenge for modern medicine. The aim of presented investigation was to analyze the in vitro antifungal activity of selected essential oils, ethanolic extracts of propolis and silver nanoparticles dropped on TiO2 against azole-resistant C. albicans (n = 20), C. glabrata (n = 14) and C. krusei (n = 10) clinical isolates. Among...
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Diminshed toxicity of C-1748, 4-methyl-9-hydroxyethylamino-1-nitroacridine, compared with its demethyl analog, C-857, corresponds to its resistance to metabolism in HepG2 cells
PublikacjaThe narrow "therapeutic window" of anti-tumour therapy may be the result of drug metabolism leading to the activation or detoxification of antitumour agents. The aim of this work is to examine (i) whether the diminished toxicity of a potent antitumour drug, C-1748, 9-(2'-hydroxyethylamino)-4-methyl-1-nitroacridine, compared with its 4-demethyl analogue, C-857, results from the differences between the metabolic pathways for the...
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Phytoecdysteroid containing plants – a source of bioactive compounds with potential anticarcinogenic effects
PublikacjaEcdysteroids are a group of steroids synthesized in inver- tebrates as molting hormones and also in some plants as secondary metabolites acting as a defense against parasites. These compounds do not naturally occur in mammals and are not structurally related to mammalian steroid hor- mones, consequently do not activate mammalian hormone receptors. Ecdysteroids exhibit very low toxicity to mam- mals and to date no serious side effects...
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Edible dragonflies and damselflies (order Odonata) as human food – A comprehensive review
PublikacjaThe rapid growth of the human population leads to a big concern about the food y and demand worldwide. However, due to the reduction in global arable land area, humans need to find alternative food sources to fulfil their needs. Consequently, edible insects have been identified as a promising solution to ameliorate food security and increase global nutrition. Among more than 2,100 identified edible insect species, dragonflies and...
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Dual-Activity Fluoroquinolone-Transportan 10 Conjugates offer alternative Leukemia therapy during Hematopoietic Cell Transplantation
PublikacjaHematopoietic cell transplantation (HCT) is often considered a last resort leukemia treatment, fraught with limited success due to microbial infections, a leading cause of mortality in leukemia patients. To address this critical issue, we explored a novel approach by synthesizing antileukemic agents containing antibacterial substances. This innovative strategy involves conjugating fluoroquinolone antibiotics, such as ciprofloxacin...
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Efficacy of intralesional bleomycin in treatment resistant viral warts
PublikacjaIntroduction Optimal management of treatment-refractory viral warts caused by human papillomavirus is unknown. One of the treatment methods is intralesional bleomycin solution. Objective To determine risk factors for resistant viral warts (not responding to conventional treatments for ≥ 6 months), to determine the effectiveness and safety of intralesional bleomycin in a group of patients with viral warts resistant to conventional...
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Emerging anticancer activity of candidal glucoseamine-6-phosphate synthase inhibitors upon nanoparticle-mediated delivery
PublikacjaNumerous glutamine analogues have been reported as irreversible inhibitors of the glucosamine-6-phosphate (GlcN-6-P) synthase in pathogenic Candida albicans in the last 3.5 decades. Among the reported inhibitors, the most effective N3-(4-methoxyfumaroyl)-L-2,3- diaminopropanoic acid (FMDP) has been extensively studied in order to develop its more active analogues. Several peptide−FMDP conjugates were tested to deliver FMDP to its...
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The Distribution of Glucosinolates in Different Phenotypes of Lepidium peruvianum and Their Role as Acetyl- and Butyrylcholinesterase Inhibitors—In Silico and In Vitro Studies
PublikacjaThe aim of the study was to present the fingerprint of different Lepidium peruvianum tu- ber extracts showing glucosinolates-containing substances possibly playing an important role in preventinting dementia and other memory disorders. Different phenotypes of Lepidium peruvianum (Brassicaceae) tubers were analysed for their glucosinolate profile using a liquid chromatograph coupled with mass spectrometer (HPLC-ESI-QTOF-MS/MS platform)....
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Hotspot of human verbal memory encoding in the left anterior prefrontal cortex
PublikacjaBackground: Treating memory and cognitive deficits requires knowledge about anatomical sites and neural activities to be targeted with particular therapies. Emerging technologies for local brain stimulation offer attractive therapeutic options but need to be applied to target specific neural activities, at distinct times, and in specific brain regions that are critical for memory formation. Methods: The areas that are critical...
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Tomasz Szymański dr inż. arch.
OsobyTomasz Szymański (dr inż. arch.) jest architektem i adiunktem na Wydziale Architektury Politechniki Gdańskiej. Absolwent Wydziału Architektury Politechniki Gdańskiej. Studia zakończone dyplomem z wyróżnieniem. Zainteresowania badawcze dr. Tomasza Szymańskiego skoncentrowane są wokół kwestii dziedzictwa przemysłowego, re-use, adaptacji i rewitalizacji obiektów poprzemysłowych, obiektów poportowych i postoczniowych na nowe funkcje...
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A Systematic Review for Establishing Relevant Environmental Parameters for Urban Lighting: Translating Research into Practice
PublikacjaThe application of lighting technologies developed in the 20th century has increased the brightness and changed the spectral composition of nocturnal night-time habitats and night skies across urban, peri-urban, rural, and pristine landscapes, and subsequently, researchers have observed the disturbance of biological rhythms of flora and fauna. To reduce these impacts, it is essential to translate relevant knowledge about the potential...
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Koncepcja metropolitalnego slow-przedmieścia jako narzędzie poprawy jakości życia w międzymieście
PublikacjaPowstałe wskutek suburbanizacji struktury uznawane są za nową formę krajobrazu zurbanizowanego. Poprawa ich jakości wymaga stworzenia nowych narzędzi planowania międzymiasta (niem. die Zwischenstadt). Należą do nich innowacyjne wizje przestrzenne, kreujące alternatywę dla globalnych trendów homogenizujących kulturę życia społecznego w strefi e podmiejskiej. Inspirowana modelem agri-hood autorska koncepcja slow-przedmieścia wykorzystuje doświadczenie...
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A Vision of Sustainable Design Concepts for Upgrading Vulnerable Coastal Areas in Light of Climate Change Impacts: A Case Study from Beirut, Lebanon
PublikacjaRapid urbanization combined with the effects of climate change has increased the vulnerability of poor urban communities to natural hazards, particularly to informal settlements located in coastal areas. Apart from socio-economic challenges, the effects of climate change threaten the very existence of these settlements. They are particularly vulnerable due to their poor structural quality and lack of adequate infrastructure to...
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MEDIA ARCHITECTURE AND INTERACTIVE ART INSTALLATIONS STIMULATING HUMAN INVOLVEMENT AND ACTIVITIES IN PUBLIC SPACES
PublikacjaThis paper examines the potential for media architecture and interactive art installations to stimulate human involvement and activities in public spaces. On the basis of theoretical approaches, case studies and interdisciplinary surveys, the paper provides insight into how screens projecting media and interactive installations in city spaces can inspire people to become active on many levels. The research is focused, both on temporary...
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Planning the City Against Barriers. Enhancing the Role of Public Spaces
PublikacjaContemporary cities are being fragmented by growing number of technical barriers like roads, railways, infrastructural objects, that generate variety of problems of different nature. The aim of the research is to present the issues connected with such barriers in the city and the ways of solving them. Main problems are e.g.: the destruction of the complexity of urban fabric, functional disadvantages, environmental and landscape...
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Impact of Innovative Financial Products on Financial Systems: Exchange Traded Products and the Polish Financial System
PublikacjaExchange Traded Products (ETPs) are one of the most recent and most rapidly developing financial products. As their assets grow they have an increasing impact on financial systems in many countries, including USA, UK or Japan. Development of ETPs is linked with many opportunities and threats for the local financial systems. Their correct assessment is becoming more difficult due to the growing complexity of the available products,...
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(Re)Shaping Open Access Policy to Scientific Resources at Polish Technical Universities: Gdańsk University of Technology Perspective
PublikacjaDeveloping European Open Access policy to scientific resources is one of the most important issues undertaken during the public debate about future scholarly communication trends. The Open Access landscape is determined by several factors (e.g. mandates). The open mandate: voluntary or mandatory, can be implemented at the institutional, national or international level. It requires scholars to use open repository to deposit results...
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Public art in the era of urban transformations. A case study of Eduardo Paolozzi’s artistic output in Edinburgh and in London
PublikacjaUrban space dedicated to cultural life, entertainment or business is currently exposed to dynamic urbanistic transformations. Monumental works of art within the boundaries of cities, for years embedded in the urban landscape and awareness of viewers, are moved to other places or even destroyed. Decisions about a change of their location and context, which are fundamental aspects for the impression made by a given work of art, cause...
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The effect of the wood temperature upon specific cutting resistance during machining with narrow-kerf saws
PublikacjaW pracy przedstawiono wyniki badań eksperymentalnych właściwego powierzchniowego oporu skrawania drewna sosny w funkcji wilgotności drewna, temperatury drewna oraz prędkości posuwu podczas przecinania cienkimi piłami. Proces cięcia prowadzono na pilarce ramowej wielopiłowej PRW15M. Sosnowe próbki przed badaniami mrożono w komorze klimatycznej - temperatura drewna -5 C deg., -20 C deg., +20 C deg. Czas wymrażania przed próbami określano...
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Axsial run-out circular saws
PublikacjaW pracy przedstawiono podstawowe przyczyny i efekty bicia osiowego ostrzy pił w układzie przecinania na pilarkach tarczowych.
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The system for identification of the band saw wheel cross profile
PublikacjaPrzedstawiono system do identyfikacji zarysu poprzecznego koła pilarki taśmowej, dzięki któremu producent pił taśmowych ma możliwość naprężenia brzeszczotu piły w sposób zapewniający jej poprawną pracę. Opisano budowę i zasadę działania systemu. Uzyskane dane mogą być wprowadzane do układów sterowania automatycznych urządzeń ze sterowaniem CNC (naprężających piły taśmowe). Dane systemu: szerokość sprawdzanych kół do 300 mm, dokładność...
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Precision of cutting system in circular sawing machine
PublikacjaW pracy przedstawiono analizę dokładności układu przecinania pilarki tarczowej, w której uwzglednoino dokładność struktury geometryczno- ruchowej przecinarki.
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Modulation of CYP3A4 activity and induction of apoptosis, necrosis and senescence by the antitumor imidazoacridinone C-1311 in human hepatoma cells
PublikacjaThere is increasing evidence that the expression level of drug metabolic enzymes affects the final cellular response following drug treatment. Moreover, anti-tumour agents may modulate enzymatic activity and/or cellular expression of metabolic enzymes in tumour cells. We investigated the influence of CYP3A4 overexpression on the cellular response induced by the anti-tumour agent C-1311 in hepatoma cells. C-1311-mediated CYP3A4...
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Art and Healthcare - Healing Potential of Artistic Interventions in Medical Settings
PublikacjaThe stereotype of a machine for healing seems to be well rooted in common thinking and social perception of hospital buildings. The technological aspect of healthcare architecture has been influenced for several years by three major factors. The first is linked to the necessity of providing safety and security in the environment of elevated epidemiological risk. The second concerns the need for incorporating advanced technology...
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Voltammetric and biological studies of folate-targeted non-lamellar lipid mesophases
PublikacjaFolate-targeted lipid nanostructures are promising strategies for the development of biocompatible drug delivery systems. The objective of this study was to evaluate the efficacy of drug delivery to cancer cells by folate-targeted lipid mesophases, cubosomes (CUB) and hexosomes (HEX), loaded with doxorubicin (DOX). Three cancer-derived cell lines (KB, HeLa, T98G) exhibiting different expressional levels of folate receptor protein...
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Machine-Learning-Based Global Optimization of Microwave Passives with Variable-Fidelity EM Models and Response Features
PublikacjaMaximizing microwave passive component performance demands precise parameter tuning, particularly as modern circuits grow increasingly intricate. Yet, achieving this often requires a comprehensive approach due to their complex geometries and miniaturized structures. However, the computational burden of optimizing these components via full-wave electromagnetic (EM) simulations is substantial. EM analysis remains crucial for circuit...
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Healthier and Environmentally Responsible Sustainable Cities and Communities. A New Design Framework and Planning Approach for Urban Illumination
PublikacjaAlthough sustainability and sustainable development are both considered necessary practices in various fields today, a recent analysis showed that the Sustainable Development Goal SDG11: Sustainable Cities and Communities established by the United Nations does not address urban illumination and its impact. This oversight is of concern because research carried out in the last 20+ years indicates artificial light at night (ALAN)...
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How to teach architecture? – Remarks on the edge of Polish transformation processes after 1989
PublikacjaThe political changes in Poland after 1989 have resulted in a whole range of dynamic processes including the transformation of space. Until that time the established institutional framework for spatial, urban and architectural planning policy was based on uniform provisions of the so-called planned economy. The same applied to the training of architects, which was based on a unified profile of education provided at the state’s...
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OrphaGPT: An Adapted Large Language Model for Orphan Diseases Classification
PublikacjaOrphan diseases (OD) represent a category of rare conditions that affect only a relatively small number of individuals. These conditions are often neglected in research due to the challenges posed by their scarcity, making medical advancements difficult. Then, the ever-evolving medical research and diagnosis landscape calls for more attention and innovative approaches to address the complex challenges of rare diseases and OD. Pre-trained...
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Accelerated Parameter Tuning of Antenna Structures by Means of Response Features and Principal Directions
PublikacjaPopularity of numerical optimization has been steadily on the rise in the design of modern antenna systems. Resorting to mathematically rigorous parameter tuning methods is a matter of practical necessity as interactive techniques (e.g., parameter sweeping) are no longer adequate when handling several performance figures over multi-dimensional parameter spaces. The most common design scenarios involve local tuning since decent...
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Narratives on cutting down trees on private land. A comparison of urban and rural municipalities in Poland using the Q-deliberation method
PublikacjaIncreased development in rural and urban areas leads to a decrease in tree cover and reduces the ecosystem services that trees provide. Municipal authorities must consider managing trees on private land to ensure that residents have access to trees and green spaces. In doing so, they must frequently confront conflicting stakeholder views, which are driven by diverse public and private interests and impacted by the type of landscape...
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Using creative approaches for discovering biomorphic forms for appropriate human habitation in natural environments. Case study of Kashubian Lake District
PublikacjaThe research process consisted of studies of natural and cultural conditions of the Kashubian Lake District This is an area of exceptional natural conditions. For centuries, it has seen human habitation with respect to landscape values. Given its extensive forest cover and the lack of heterogeneity of natural conditions, the area has become an interesting inspiration for the author’s original project. The project is aimed at searching...
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The Bridge of Knowledge – defining and implementing national Open Access policy by Polish universities. Gdansk University of Technology perspective
PublikacjaThe European Commission states that Open Access to scientific resources funded by the European Union shall facilitate the use of research results financed from the public funds. Moreover, it will cause an increase in the innovative capacity of Europe. The Open Access landscape is determined by several factors such as mandates. The open mandate may be voluntary or mandatory and implemented at the institutional, national or international...
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Platform governance for sustainable development: Reshaping citizen-administration relationships in the digital age
PublikacjaChanging governance paradigms has been shaping and reshaping the landscape of citizen-administration relationships, from impartial application of rules and regulations by administration to exercise its authority over citizens (bureaucratic paradigm), through provision of public services by administration to fulfil the needs of citizens (consumerist paradigm), to responsibility-sharing between administration and citizens for policy...
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Improved-Efficacy Optimization of Compact Microwave Passives by Means of Frequency-Related Regularization
PublikacjaElectromagnetic (EM)-driven optimization is an important part of microwave design, especially for miniaturized components where the cross-coupling effects in tightly arranged layouts make traditional (e.g., equivalent network) representations grossly inaccurate. Efficient parameter tuning requires reasonably good initial designs, which are difficult to be rendered for newly developed structures or when re-design for different operating...
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Microbial and chemical quality assessment of the small rivers entering the South Baltic. Part I: Case study on the watercourses in the Baltic Sea catchment area
PublikacjaThe area of the Coastal Landscape Park (CLP) due to its location is extremely attractive touristic area. In the summer season, a significant increase in population density is observed, which influences surface water quality. Large numbers of tourists generate an increased amount of municipal wastewater, being treated in local treatment plants and discharged into rivers and streams. The paper presents preliminary research from summer...
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The Changing Nature of In‐Between Spaces in the Transformation Process of Cities
PublikacjaIn the in‐between spaces of cities, there are many problems of various nature and scale: functional, spatial, economic, environmental, visual, and social. There are also some hidden potentials that can be activated. The aim of the article is to explore the possibilities of solving existing problems and to show the possibilities of using the potentials of in‐between spaces with regard to the changing nature of a city. The article,...
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Methodology for Carrying Out Measurements of the Tombolo Geomorphic Landform Using Unmanned Aerial and Surface Vehicles near Sopot Pier, Poland
PublikacjaThe human impact on the ecosystem has been particularly evident in the last century; it transforms the Earth’s surface on an unprecedented scale and brings about irreversible changes. One example is an oceanographic phenomenon known as a tombolo, i.e., a narrow belt connecting the mainland with an island lying near the shore formed as a result of sand and gravel being deposited by sea currents. The phenomenon contributes to an...
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Ocena przekształceń piętrowego, ceglanego domu z dachem półpłaskim z przełomu XIX–XX wieku pod wpływem termomodernizacji na przykładzie gminy Puck, woj. pomorskie.
PublikacjaCeglane budynki mieszkalne z przełomu XIX i XX wieku, które stanowiły charakterystyczny element krajobrazu wsi pomorskiej, obecnie powszechnie poddawane są modernizacji w celu poprawy warunków cieplnych. Przedmiotem badania jest stan zachowania najmłodszego, historycznego typu domuw zagrodzie chłopskiej na Kaszubach – piętrowego, ceglanego domu z dachem półpłaskim. Badanie przeprowadzono na obszarze gminy Puck. Zidentyfikowano...
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Analiza wielokryterialna wariantów systemu zaopatrzenia w wodę zespołu padów
PublikacjaJednym z istotnych problemów decyzyjnych na etapie potencjalnej eksploatacji gazu z formacji łupkowych jest wybór sposobu zaopatrzenia w wodę kopalni gazu łupkowego. Z uwagi na duże zapotrzebowanie na wodę do procesu szczelinowania kolejno przekazywanych do eksploatacji odwiertów wydobywczych, należy poszukiwać systemu zaopatrzenia w wodę, który zagwarantuje wymaganą jej ilość, a jednocześnie nie będzie zbyt dużym obciążeniem dla...
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Novel insights into conjugation of antitumor-active unsymmetrical bisacridine C-2028 with glutathione: characteristics of non-enzymatic and glutathione S-transferase-mediated reactions
PublikacjaUnsymmetrical bisacridines (UAs) are a novel potent class of antitumor-active therapeutics. A significant route of phase II drug metabolism is conjugation with glutathione (GSH), which can be non-enzymatic and/or catalyzed by GSH-dependent enzymes. The aim of this work was to investigate the GSH-mediated metabolic pathway of a representative UA, C 2028. GSH supplemented incubations of C-2028 with rat, but not with human, liver...