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Wyniki wyszukiwania dla: MINING TREMOR
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Low-Barrier Hydrogen Bond Determines Target-Binding Affinity and Specificity of the Antitubercular Drug Bedaquiline
PublikacjaThe role of short strong hydrogen bonds (SSHB) in ligand-target binding remains largely unexplored, thereby hin- dering a potentially important avenue in the rational drug de- sign. Here, we investigate the interaction between bedaquiline (Bq), a potent anti-tuberculosis drug, and the mycobacterial ATP synthase, to unravel the role of a specific hydrogen bond to a conserved acidic residue in the target affinity and specificity....
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The clamping selection method to reduce the vibration of large-size workpieces during the face milling process
PublikacjaThe article introduces a method for selecting the best clamping conditions to obtain vibration reduction during milling of large-size workpiece. It is based on experimental modal analysis performed for a set of assumed, fixing conditions of a considered workpiece to identify Frequency Response Functions (FRFs) for each tightening torque of the mounting screws. Simulated plots of periodically changing nominal cutting forces are...
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Convenient and efficient N-methylation of secondary amines under solvent-free ball milling conditions
PublikacjaIn the present work, we report the development of a rapid, efcient, and solvent-free procedure for the N-methylation of secondary amines under mechanochemical conditions. After optimization of the milling parameters, a vibrational ball mill was used to synthesize 26 tertiary N-methylated amine derivatives in a short time of 20 min (30 Hz frequency) and high yields ranging from 78 to 95%. An exception was compounds having a hydroxyl...
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Planning Around Polarisation: Components of Finding Common Ground Based on Regeneration Projects in London and Gdańsk
PublikacjaVarious forms of public participation in urban design and planning—as presented and discussed in literature—have recently been challenged by the needs and expectations of different stakeholders, including those coming from the private sector. This comes with a redefinition of the public good and the roles and responsibilities of municipal authorities in post‐liberal times. As a result, contemporary participatory processes need...
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Monitoring Regenerative Heat Exchanger in Steam Power Plant by Making Use of the Recurrent Neural Network
PublikacjaArtificial Intelligence algorithms are being increasingly used in industrial applications. Their important function is to support operation of diagnostic systems. This paper pesents a new approach to the monitoring of a regenerative heat exchanger in a steam power plant, which is based on a specific use of the Recurrent Neural Network (RNN). The proposed approach was tested using real data. This approach can be easily adapted to...
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Low-Voltage Low-Power Filters with Independent ω0 and Q Tuning for Electronic Cochlea Applications
PublikacjaAn acoustic second-order low-pass filter is proposed for filter banks emulating the operation of a human cochlea. By using a special filter structure and an innovative quality (Q)-factor tuning technique, an independent change of the cutoff frequency (ω0) and the Q-factor with unchanged gain at low frequencies is achieved in this filter. The techniques applied result in a simple filter design with low Q-factor sensitivity to component...
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Adjusting the Stiffness of Supports during Milling of a Large-Size Workpiece Using the Salp Swarm Algorithm
PublikacjaThis paper concerns the problem of vibration reduction during milling. For this purpose, it is proposed that the standard supports of the workpiece be replaced with adjustable stiffness supports. This affects the modal parameters of the whole system, i.e., object and its supports, which is essential from the point of view of the relative tool–workpiece vibrations. To reduce the vibration level during milling, it is necessary to...
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The role of additives in improving the flammability and calorific value of leather shavings and the binding of chromium compounds in ash
PublikacjaLeather processing companies are struggling with the problem of increasing costs of post-production waste disposal. Therefore, the issue of thermal waste disposal at the plant and the use of generated heat in the production process is becoming more and more popular. Leather waste on its own does not allow for autothermal combustion despite the sufficient higher heating value (HHV). Therefore the Authors proposed to improve the...
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Tuning of microstructure in engineered poly (trimethylene terephthalate) based blends with nano inclusion as multifunctional additive
PublikacjaImmiscible blends and their composites are heterogeneous and have variable morphology due to variation in mesophase regions. Tuning, i.e. controlling the phase dimension is important, thereof we report a “super-combo” effect of multiwalled carbon nanotubes (MWCNTs) in poly (trimethylene terephthalate)/polypropylene (PTT/ PP) blend system. MWCNTs act as a good reinforcing agent and compatibilizer in the otherwise immiscible PTT/...
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A Highly Selective Biosensor Based on Peptide Directly Derived from the HarmOBP7 Aldehyde Binding Site
PublikacjaThis paper presents the results of research on determining the optimal length of a peptide chain to eectively bind octanal molecules. Peptides that map the aldehyde binding site in HarmOBP7 were immobilized on piezoelectric transducers. Based on computational studies, four Odorant Binding Protein-derived Peptides (OBPPs) with dierent sequences were selected. Molecular modelling results of ligand docking with selected peptides were...
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The Optimal Spindle Speed Map for Reduction of Chatter Vibration During Milling of Bow Thruster Blade
PublikacjaW artykule przedstwiono przykład wykorzystania procedury tworzenia mapy optymalnych prędkosci obrotowych w celu ograniczenia drgań samowzbudnych podczas frezowania płata śruby okrętowego steru strumieniowego.
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A Method for The Assessing of Reliability Characteristics Relevant to an Assumed Position-Fixing Accuracy in Navigational Positioning Systems
PublikacjaThis paper presents a method which makes it possible to determine reliability characteristics of navigational positioning systems, relevant to an assumed value of permissible error in position fixing. The method allows to calculate: availability , reliability as well as operation continuity of position fixing system for an assumed, determined on the basis of formal requirements - both worldwide and national, position-fixing accuracy....
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Reduction of vibration level by the spindle speed optimisation during ball end milling of flexible details
PublikacjaPraca dotyczy nadzorowania drgań podczas skrawania przedmiotów podatnych frezem kulistym. Przedsatwiono wspomaganą komputerowo procedurę nadzorowania z optymalizacją prędkości obrotowej narzędzia. Przy modelowaniu wykorzystano niestacjonarny model obliczeniowy. Rezultatem modelowania jest układ hybrydowy, w którym oddzielono podukłady: modalny, łączący i strukturalny. Metoda wymaga identyfikacji częstości własnych co może być wykonane...
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Ocena wybranych własności materiałowych polimerowej warstwy ślizgowej hydrodynamicznego łożyska wzdłużnego = An estimation of selected material properties of the hydrodynamic thrust bearing polymer lining
PublikacjaZaprezentowano metody pomiaru najważniejszych własności mechanicznych i cieplnych polimerowego pokrycia segmentowego łożyska wzdłużnego, do których zaliczyć należy moduł sprężystości wzdłużnej oraz współczynnik przewodności cieplnej materiału dodatkowym utrudnieniem planowanego zadania jest fakt, że próbka do badań dostępna będzie jedynie w formie wycinka z segmentu łożyskowego, z tego powodu nie jest możliwe zastosowanie ogólnie...
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Educational Data Mining
Konferencje -
Janusz Kozak prof. dr hab. inż.
OsobyDr hab. inż. Janusz Kozak Dziekan Wydziału Oceanotechniki i Okrętownictwa Politechniki Gdańskiej Urodzony: 04.07.1953 w Pucku Absolwent Technikum Budowy Okrętów „Conradinum” w Gdańsku, 1973. Absolwent Instytutu Okrętowego PG, 1978. Po ukończeniu studiów praca w Stoczni Gdynia, a od roku 1980 w Katedrze Technologii Okrętów Instytutu Okrętowego a później Wydziału Oceanotechniki i Okrętownictwa Politechniki Gdańskiej kolejno na...
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Metabolic Profiles of New Unsymmetrical Bisacridine Antitumor Agents in Electrochemical and Enzymatic Noncellular Systems and in Tumor Cells
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Circulating Tumor Cells as a Marker of Disseminated Disease in Patients with Newly Diagnosed High-Risk Prostate Cancer
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Immunoscore, circulating tumor cells and human-derived organoids as potential predictive tools in personalized cancer medicine
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Novel electrogravimetric biosensors for the ultrasensitive detection of plasma matrix metalloproteinase-2 considered a potential tumor biomarker
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CGB and GNRH1 expression analysis as a method of tumor cells metastatic spread detection in patients with gynecological malignances
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Nicotinamide phosphorybosiltransferase overexpression in thyroid malignancies and its correlation with tumor stage and with survivin/survivin DEx3 expression
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99mTc-Galacto-RGD2: A Novel 99mTc-Labeled Cyclic RGD Peptide Dimer Useful for Tumor Imaging
PublikacjaThis study sought to evaluate [99mTc(HYNIC-Galacto-RGD2)-(tricine)(TPPTS)] (99mTc-Galacto-RGD2: HYNIC = 6-hydrazinonicotinyl; Galacto-RGD2 = Glu[cyclo[Arg-Gly-Asp-D-Phe-Lys(SAA-PEG2-(1,2,3-triazole)-1-yl-4-ethylamide)]]2 (SAA = 7-amino-L-glycero-L-galacto-2,6-anhydro-7-eoxyheptanamide, and PEG2 = 3,6-dioxaoctanoic acid); and TPPTS = trisodium triphenylphosphine-3,3',3''-trisulfonate) as a new radiotracer for tumor imaging. Galacto-RGD2...
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Stable nanoconjugates of transferrin with alloyed quaternary nanocrystals Ag–In–Zn–S as a biological entity for tumor recognition
PublikacjaOne way to limit the negative effects of anti-tumor drugs on healthy cells is targeted therapy employing functionalized drug carriers. Here we present a biocompatible and stable nanoconjugate of transferrin anchored to Ag-In-Zn-S quantum dots modified with 11-mercaptoundecanoic acid (Tf-QD) as a drug carrier versus typical anticancer drug, doxorubicin. Detailed investigations of Tf-QD nanoconjugates without and with doxorubicin...
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The ability to overcome multidrug resistance of tumor cell lines by novel acridine cytostatics with condensed heterocyclic rings
PublikacjaZbadano aktywność cytotoksyczną, in vitzo dwóch nowych grup cytostatyków akrydynowych zawierających skondensowane pierścienie heterocykliczne w stosunku do komórek nowotworowych linii wrażliwych i opornych. Otrzymane wyniki potwierdziły naszą wcześniejszą hipotezę o istotnej roli pierścieni hetero-cyklicznych w pokonywaniu krzyżowej oporności wielolekowej.
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Metabolic Profiles of New Unsymmetrical Bisacridine Antitumor Agents in Electrochemical and Enzymatic Noncellular Systems and in Tumor Cells
PublikacjaNew unsymmetrical bisacridines (UAs) demonstrated high activity not only against a set of tumor cell lines but also against human tumor xenografts in nude mice. Representative UA compounds, named C-2028, C-2045 and C-2053, were characterized in respect to their physicochemical properties and the following studies aimed to elucidate the role of metabolic transformations in UAs action. We demonstrated with phase I and phase II enzymes...
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The impedance method of monitoring the degradation of rubber linings in applications where progressive deterioration is the predominant failure mechanism
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Linking habitat composition, local population densities and traffic characteristics to spatial patterns of ungulate‐train collisions
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Linking occurrence and changes in local abundance of farmland bird species to landscape composition and land-use changes
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Insights into the Effects of Cancer Associated Mutations at the UPF2 and ATP-Binding Sites of NMD Master Regulator: UPF1
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Interfaces with Structure Dynamics of the Workhorses from Cells Revealed through Cross-Linking Mass Spectrometry (CLMS)
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Highly Conserved Homotrimer Cavity Formed by the SARS-CoV-2 Spike Glycoprotein: A Novel Binding Site
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Synthesis and SAR Studies of Antibacterial Peptidyl Derivatives Based upon the Binding Site of Human Cystatin C
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Structure-activity relationship study of tetrapeptide inhibitors of the Vascular Endothelial Growth Factor A binding to Neuropilin-1
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Molecular dynamics study of a gelsolin-derived peptide binding to a lipid bilayer containing phosphatidylinositol 4,5-bisphosphate
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Control of Luminescence by Tuning of Crystal Symmetry and Local Structure in Mn4+ -Activated Narrow Band Fluoride Phosphors
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Indirect Relationship between Alcoholics Anonymous Spirituality and Their Hopelessness: The Role of Meaning in Life, Hope, and Abstinence Duration
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Correlation between type of alkali rinsing, cytotoxicity of bio-nanocellulose and presence of metabolites within cellulose membranes
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Electron Binding Capabilities of Some Silylenes Having Small Singlet−Triplet Splittings or Triplet Ground States
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Strength of the Lewis–Brønsted Superacids Containing In, Sn, and Sb and the Electron Binding Energies of Their Corresponding Superhalogen Anions
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Finding the Right Solvent: A Novel Screening Protocol for Identifying Environmentally Friendly and Cost-Effective Options for Benzenesulfonamide
PublikacjaThis study investigated the solubility of benzenesulfonamide (BSA) as a model compound using experimental and computational methods. New experimental solubility data were collected in the solvents DMSO, DMF, 4FM, and their binary mixtures with water. The predictive model was constructed based on the best-performing regression models trained on available experimental data, and their hyperparameters were optimized using a newly...
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Fibronectin-, vitronectin- and laminin-binding proteins at the cell walls of Candida parapsilosis and Candida tropicalis pathogenic yeasts
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Molecular simulations study of ligand-release mechanism in an odorant-binding protein from the southern house mosquito
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A qualitative 5-country comparison of the perceived impacts of COVID-19 on people living with dementia and unpaid carers
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Met and unmet care needs of older people with dementia living at home: Personal and informal carers’ perspectives
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Time for a paradigm shift in shared decision-making in trauma and emergency surgery? Results from an international survey
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The estimation of cutting forces and specific force coefficients during finishing ball end milling of inclined surfaces
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Liver fatty acid-binding protein might be a predictive marker of clinical response to systemic treatment in psoriasis
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Pharmacological characterization and binding modes of novel racemic and optically active phenylalanine-based antagonists of AMPA receptors
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Binding of anionic Pt(ii) complexes in a dedicated organic matrix: towards new binary crystalline composites
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