Filtry
wszystkich: 591
-
Katalog
- Publikacje 531 wyników po odfiltrowaniu
- Czasopisma 17 wyników po odfiltrowaniu
- Osoby 15 wyników po odfiltrowaniu
- Wynalazki 2 wyników po odfiltrowaniu
- Projekty 4 wyników po odfiltrowaniu
- Kursy Online 16 wyników po odfiltrowaniu
- Wydarzenia 3 wyników po odfiltrowaniu
- Dane Badawcze 3 wyników po odfiltrowaniu
Wyniki wyszukiwania dla: PEPTIDE TRANSPORTERS
-
Synthesis, Chemical Characterization and Multiscale Biological Evaluation of a dimericcRGD Peptide for Targeted Imaging of αVβ3 Integrin Activity
PublikacjaCyclic peptides containing the Arg-Gly-Asp (RGD) sequence have been shown to specifically bind the angiogenesis biomarker α V β3 integrin. We report the synthesis, chemical characterization, and biological evaluation of two novel dimeric cyclic RGD-based molecular probes for the targeted imaging of α V β3 activity (a radiolabeled version, 64Cu-NOTA-PEG4-cRGD2, for PET imaging, and a fluorescent version, FITC-PEG4-cRGD2, for in...
-
99mTc-Galacto-RGD2: A Novel 99mTc-Labeled Cyclic RGD Peptide Dimer Useful for Tumor Imaging
PublikacjaThis study sought to evaluate [99mTc(HYNIC-Galacto-RGD2)-(tricine)(TPPTS)] (99mTc-Galacto-RGD2: HYNIC = 6-hydrazinonicotinyl; Galacto-RGD2 = Glu[cyclo[Arg-Gly-Asp-D-Phe-Lys(SAA-PEG2-(1,2,3-triazole)-1-yl-4-ethylamide)]]2 (SAA = 7-amino-L-glycero-L-galacto-2,6-anhydro-7-eoxyheptanamide, and PEG2 = 3,6-dioxaoctanoic acid); and TPPTS = trisodium triphenylphosphine-3,3',3''-trisulfonate) as a new radiotracer for tumor imaging. Galacto-RGD2...
-
Prediction of Bioactive Peptides From Chicken Feather and Pig Hair Keratins Using In Silico Analysis Based on Fragmentomic Approach
PublikacjaBackground: Keratin is among the most abundant structural proteins of animal origin, however it remains broadly underutilized. Objective: Bioinformatic investigation was performed to evaluate selected keratins originating from mass-produced waste products, i.e., chicken feathers and pig hair, as potential sources of bioactive peptides. Methods: Pepsin, trypsin, chymotrypsin, papain, and subtilisin were used for in silico keratinolysis...
-
The Role of Hypoxia-Inducible Factor-1α, Glucose Transporter-1, (GLUT-1) and Carbon Anhydrase IX in Endometrial Cancer Patients
Publikacja -
Life-long norepinephrine transporter (NET) knock-out leads to the increase in the NET mRNA in brain regions rich in norepinephrine terminals
Publikacja -
Structural elucidation of transmembrane transporter protein bilitranslocase: Conformational analysis of the second transmembrane region TM2 by molecular dynamics and NMR spectroscopy
Publikacja -
TRANSPORTER Wydziałowe Targi Pracy
WydarzeniaBiuro Karier, Wydział OiO, studenci kierunku Transport oraz WRS OiO serdecznie zapraszają na Targi Pracy TRANSPORTER.
-
Release systems based on self-assembling RADA16-I hydrogels with a signal sequence which improves wound healing processes
PublikacjaSelf-assembling peptides can be used for the regeneration of severely damaged skin. They can act as scaffolds for skin cells and as a reservoir of active compounds, to accelerate scarless wound healing. To overcome repeated administration of peptides which accelerate healing, we report development of three new peptide biomaterials based on the RADA16-I hydrogel functionalized with a sequence (AAPV) cleaved by human neutrophil elastase...
-
Elastic multi-layer resilient IP-over-Flexgrid networking: Detailed cost analysis with bandwidth-variable transponders
Publikacja -
Efficient Gradient-Based Algorithm with Numerical Derivatives for Expedited Optimization of Multi-Parameter Miniaturized Impedance Matching Transformers
PublikacjaFull-wave electromagnetic (EM) simulation tools have become ubiquitous in the design of microwave components. In some cases, e.g., miniaturized microstrip components, EM analysis is mandatory due to considera¬ble cross-coupling effects that cannot be accounted for otherwise (e.g., by means of equivalent circuits). These effects are particularly pronounced in the structures in¬volving slow-wave compact cells and their numerical...
-
Multi-objective optimization of compact UWB impedance matching transformers using Pareto front exploration and adjoint sensitivities
PublikacjaIn this paper, a technique for fast multi-objective optimization of impedance matching transformers has been presented. In our approach, a set of alternative designs that represent the best possible trade-offs between conflicting objectives (here, the maximum reflection level within a frequency band of interest and the circuit size) is identified by directly exploring the Pareto front. More specifically, the subsequent Pareto-optimal...
-
Synthesis of conjugates of muramyl dipeptide and nor-muramyl dipeptide with retro-tuftsin (Arg-Pro-Lys-ThrOMe) as potential immunostimulants.
PublikacjaOpisano syntezę nowych koniugatów muramylodipeptydu i nor-muramylo-dipeptydu z estrem metylowym tuftsyny o odwróconej sekwencji (Arg-Pro-Lys-Thr-OMe)jako potencjalnych immunostymulantów. Synteza tych połączeń została przeprowadzona zgodnie z zasadami chemii peptydów.
-
Cis/trans conformational equilibrium across the N-methylphenylalanine2- N-methylphenylalanine3 peptide bond of arginine vasopressin analogs
Publikacja -
Understanding the interactions between protein stabilizers and the peptide bond through the analysis of the volumetric and compressibility properties for the model systems
PublikacjaThis work confirms our earlier supposition, that volumetric and acoustic parameters for simple model proposed by us are directly related to stabilizing/destabilizing effect of osmolytes on proteins structure. The apparent molar volumes, V and the apparent molar isentropic compressions, KS,, of glycine and N,N,N –trimethylglycine (betaine) were determined from densities and speed of sound measurements in aqueous solution of N-methylacetamide...
-
Structural changes of a simple peptide—Trpzip-1—in aqueous solutions and the corresponding hydration phenomena under the influence of temperature
PublikacjaTrpzip-1, a simple β-hairpin, is a rare example of peptide with stable secondary structure and can be a convenient model to study temperature-related processes that potential prion or amyloid proteins undergo. Although its sequence is simple, the exact processes which the peptide undergoes in aqueous solutions are quite complex and not well understood. The selection of well-established experimental (DSC, FTIR) and theoretical methods...
-
A Novel Delivery System for the Controlled Release~of Antimicrobial Peptides: Citropin 1.1 and Temporin A
Publikacja -
Antinociceptive and Cytotoxic Activity of Opioid Peptides with Hydrazone and Hydrazide Moieties at the C-Terminus
Publikacja -
Nanoparticles associated with antimicrobial peptides (AMPs) promising combination for biomedical and veterinary applications
Publikacja -
Molecular dynamics study of amyloid formation of two Abl-SH3 domain peptides
Publikacja -
New conjugates of muramyl dipeptide and nor-muramyl dipeptide linked to tuftsin and retro-tuftsin derivatives significantly influence their biological activity
PublikacjaOpisano syntezę nowych koniugatów MDP i nor-MDP z pochodnymi tuftsyny i retro-tuftsyny zawierającymi wiązanie izopeptydowe pomiędzy epsilon-aminową grupą lizyny, a karboksylową grupą Ala, Gly czy Val. Zbadano ich aktywność biologiczną, m.in. profil cytokinowy.
-
Inhibitory activity of double‐sequence analogues of trypsin inhibitor SFTI‐1 from sunflower seeds: an example of peptide splicing
Publikacja -
Development of a Peptide Derived from Platelet-Derived Growth Factor (PDGF-BB) into a Potential Drug Candidate for the Treatment of Wounds
PublikacjaObjective: This study evaluated the use of novel peptides derived from platelet-derived growth factor (PDGF-BB) as potential wound healing stimulants. One of the compounds (named PDGF2) was subjected for further research after cytotoxicity and proliferation assays on human skin cells. Further investigation included evaluation of: migration and chemotaxis of skin cells, immunological and allergic safety, the transcriptional analyses...
-
Influence of Dimerization of Lipopeptide Laur-Orn-Orn-Cys–NH2 and an N-terminal Peptide of Human Lactoferricin on Biological Activity
Publikacja -
Binding modes of a new epoxysuccinyl–peptide inhibitor of cysteine proteases. Where and how do cysteine proteases express their selectivity?
Publikacja -
Lipidated Analogs of the LL-37-Derived Peptide Fragment KR12—Structural Analysis, Surface-Active Properties and Antimicrobial Activity
Publikacja -
Relative quantification of pork and beef in meat products using global and species-specific peptide markers for the authentication of meat composition
PublikacjaWe used global and species-specific peptide markers for a relative quantitative determination of pork and beef in raw and processed meat products made of the two meat species. Four groups of products were prepared (i.e., minced raw meats, sausages, raw and fried burgers) in order to represent products with different extents of food processing. In each group, the products varied in the pork/beef proportions. All products were analysed...
-
Peptide bond modification. I. Simple and efficient method of Boc-Gly[CH(OH)CH2]Gly-OH synthesis.
PublikacjaZaprezentowano prostą i efektywną metodę syntezy obu enancjomerów t-butoksykarbonylo chronionego pseudo dipeptydu (R) oraz (S)-Boc-Gly[CH(OH)CH2]Gly-OH.
-
Measurements of no-load and short-circuit parameters of power transformers with taps
Dane Badawcze1) The Laboratory LINTE^2 is a large research infrastructure operated by the Faculty of Electrical and Control Engineering at Gdańsk University of Technology, to be found in Gdańsk, Poland (54.3690 N, 18.6130 E).
-
Current state of a dual behaviour of antimicrobial peptides-Therapeutic agents and promising delivery vectors
Publikacja -
Antimicrobial Activity of Selected Antimicrobial Peptides Against Planktonic Culture and Biofilm of Acinetobacter baumannii
Publikacja -
Sample Concentration of Charged Small Molecules and Peptides in Capillary Electrophoresis by Micelle to Cyclodextrin Stacking
Publikacja -
Bioactive peptides from beef products fermented by acid whey – in vitro and in silico study
Publikacja -
Effect of probiotic bacteria on antiradical activity of peptides isolated from dry-cured loins
Publikacja -
An animal model of the procognitive properties of cysteine protease inhibitor and immunomodulatory peptides based on colostrum.
Publikacja -
Efficient parallel algorithms in global optimization of potential energy functions for peptides, proteins, and crystals
Publikacja -
Molecular basis and quantitative assessment of TRF1 and TRF2 protein interactions with TIN2 and Apollo peptides
PublikacjaShelterin is a six-protein complex (TRF1, TRF2, POT1, RAP1, TIN2, and TPP1) that also functions in smaller subsets in regulation and protection of human telomeres. Two closely related proteins, TRF1 and TRF2, make high-affinity contact directly with double-stranded telomeric DNA and serve as a molecular platform. Protein TIN2 binds to TRF1 and TRF2 dimer-forming domains, whereas Apollo makes interaction only with TRF2. To elucidate...
-
Cyclic Peptidic Furin Inhibitors Developed by Combinatorial Chemistry
Publikacja -
Resistance of human prostate carcinoma cells to a new antitumor compound capridine beta is associated with changed drug metabolism combined with both inherent and drug-induced overexpression of ABC transporters
PublikacjaW pracy charakteryzujemy mechanizm oporności na nową pochodną 1-nitroakrydyny, związku capridine beta (C-1748) o wysokiej aktywności przeciwnowotworowej, znajdującego się w badaniach klinicznych. Nasze dane wskazują, że oporność na ten związek jest wynikiem zmienionego metabolizmu inaktywującego C-1748 oraz wzrostem ekspresji pompy błonowej ABCG2 a także innych białek transportowych typu ABC.
-
Design, synthesis and in vitro biological evaluation of a small cyclic peptide as inhibitor of vascular endothelial growth factor binding to neuropilin-1
Publikacja -
Osteoblast and bacterial cell response on RGD peptide‐functionalized chitosan coatings electrophoretically deposited from different suspensions on Ti13Nb13Zr alloy
PublikacjaMetallic materials for long-term load-bearing implants still do not provide high antimicrobial activity while maintaining strong compatibility with bone cells. This study aimed to modify the surface of Ti13Nb13Zr alloy by electrophoretic deposition of a chitosan coating with a covalently attached Arg-Gly-Asp (RGD) peptide. The suspensions for coating deposition were prepared in two different ways either using hydroxyacetic acid...
-
A study on the protection of methionine and the reduction of methionine sulfoxide in methionine-containing analogues of the growth-modeling factor Gly-His-Lys
PublikacjaThe protection of methionine and the reduction of methionine sulfoxide in methionine-containing analogues of Gly-His-Lys are described. The peptides were synthesized by a solid-phase method using the standard Fmoc procedure. Simultaneous deprotection of the peptide side chain and liberation from the resin were achieved using an appropriate TFA cocktail. The TFA cocktail was selected to minimize oxidation of the methionine residue....
-
Possible mechanisms for protecting NCα bonds in helical peptides from electron-capture (or transfer) dissociation
Publikacja -
Effect of Marination Time on the Antioxidant Properties of Peptides Extracted from Organic Dry-Fermented Beef
Publikacja -
Synergistic action of extracts from carnivorous plants and synthetic peptides against plant pathoghenic bacteria
Publikacjaw pracy przedstawiono rezultaty badań nad sprawdzeniem aktywności przeciwbakteryjnej ekstraktów z roślin Drosera capensis i Dionaea muscipula w połączeniu z dwoma syntetycznymi peptydami: CAMEL oraz pexiganan. Najwyższą aktywnością przeciwbakteryjną odznaczał się chloroformowy ekstrakt z D. muscipula z peptydem CAMEL.
-
Retro analog concept: comparative study on physico-chemical and biological properties of selected antimicrobial peptides
Publikacja -
Amides as models to study the hydration of proteins and peptides — spectroscopic and theoretical approach on hydration in various temperatures
PublikacjaInteractions with water are one of the key factors which determine protein stability and activity in aqueous solutions. However, the protein hydration is still insufficiently understood. N-methylacetamide (NMA) is regarded as a minimal part of the peptide backbone and the relative simplicity of its structure makes it a good model for studies on protein–water interactions. In this paper, the influence of NMA and N,N-dimethylacetamide...
-
Synthesis of novel, peptidic kinase inhibitors with cytostatic/cytotoxic activity
Publikacja -
Comparison of peptide cancer signatures identified by mass spectrometry in serum of patients with head and neck, lung and colorectal cancers: Association with tumor progression
Publikacja -
Probing the binding selected metal ions and biologically active substances to the antimicrobial peptide LL-37 using DSC, ITC measurements and calculations
Publikacja -
The influence of a synthetic growth hormone‐releasing hormone analogue G11 and opioid peptide biphalin on selected fibroblasts parameters relevant to wound healing
Publikacja