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Endometrial nitric oxide production and nitric oxide synthases in the equine endometrium: Relationship with microvascular density during the estrus cycle
PublikacjaNitric oxide (NO) plays an important role in angiogenesis and in the regulation of the blood flow. This study was carried out to investigate (i) the effects of endogenous estrogens and progestins and exogenous progesterone (P(4)) (5 ng/ml or 1 microg/ml) or estradiol 17beta (E(2)beta) (50 pg/ml or 1 microg/ml) on in vitro endometrial NO synthesis; (ii) the presence of different isoforms of NO synthase;...
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Tuning a Hybrid GPU-CPU V-Cycle Multilevel Preconditioner for Solving Large Real and Complex Systems of FEM Equations
PublikacjaThis letter presents techniques for tuning an accelerated preconditioned conjugate gradient solver with a multilevel preconditioner. The solver is optimized for a fast solution of sparse systems of equations arising in computational electromagnetics in a finite element method using higher-order elements. The goal of the tuning is to increase the throughput while at the same time reducing the memory requirements in order to allow...
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Managment of low grade waste heat from the supercritical power plant using the ORC cycle aided by bleed steam
PublikacjaW pracy przedstawiono oryginalną koncepcję dogrzewu obiegu ORC za pomocą pary upustowej z nadkrytycznego bloku energetycznego.
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Assessment, optimisation and working fluid comparison of organic rankine cycle combined with negative CO2 gas power plant system
PublikacjaThis study aims to investigate the application of the Organic Rankine Cycle (ORC) as an alternative to low-pressure expansion in the negative CO2 power plant (nCO2PP). The reason for this study is that a detailed analysis of nCO2PP indicates a certain amount of waste heat present in the exhaust gas from the high-to-intermediate pressure gas turbine. Some of this energy can be used by the application of the expansion in a low-pressure...
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Comparison of traditional district heating with low temperature district heating systems featuring organic Rankine cycle and heat pump
PublikacjaPaper presents a comparison between a traditional district heating system with conventional boilers as a source of heat and electricity purchases from power utilities and a low temperature DH system incorporating the CHP with organic Rankine Cycle providing electricity and local heat pump raising the temperature of the DH fluid to the required temperature in the dwelling, meaning that both heat and electricity are produced within...
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Comprehensive thermodynamic analysis of steam storage in a steam cycle in a different regime of work: A zero-dimensional and three-dimensional approach
PublikacjaDue to the current trends aiming to reduce carbon dioxide emissions by increasing the use of renewable energy sources, changes are required in the operation of coal-fired steam units. The unstable nature of renewable energy sources, depending on weather conditions, means that the amount of energy produced varies and is not always in line with peak demand. To ensure the security and stability of energy supplies in the energy system,...
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Increased susceptibility of PARP-1 KO cells to antitumor triazoloacridone C-1305 is associated with permanent G2 cell cycle arrest.
PublikacjaTriazoloakrydon C-1305 jest nowym inhibitorem topoizomerazy II wykazującym wysoką aktywność przeciwnowotworową. W tej pracy badaliśmy działanie cytotoksyczne pochodnej C-1305 i jej analogu strukturalnego C-1533 wobec komórek fibroblastów mysich i dwóch mutantów, w których uszkodzono gen PARP-1. Jak wykazaliśmy, komórki z uszkodzonym genem PARP-1 są nadwrażliwe na działanie związku C-1305 w porównaniu z komórkami PARP-1 +/+ podczas...
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The influence of 4-substituted and unsubstituted derivatives of 1-nitroacridine on the cell cycle and induction of apoptosis in human cancer HT29 and HeLa S3.
PublikacjaZbadano wpływ pochodnych 1-nitroakrydyny C-1748 i C-857, w stężeniach biologicznie istotnych, na cykl życiowy oraz indukcję apoptozy komórek raka jelita grubego HT29 oraz raka szyjki macicy HeLa S3. Metodą cytometrii przepływowej wykazano, że 4-metylo-1-nitroakrydyna C-1748 powoduje akumulację komórek HT29 w fazie S i komórek HeLa S3 w fazie G2 cyklu komórkowego zaś związek C-857 indukuje akumulację komórek HT29 i HeLa S3 w fazie...
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Novel fused pyran derivatives induce apoptosis and target cell cycle progression in anticancer efficacy against multiple cell lines.
PublikacjaNitrogen-based heterocycles such as pyrazole, imidazole, 1,2,4-triazole, benzimidazole, and benzotriazole substituted fused pyran derivatives (6a–e, 8a–e, 10a–e, 12a–e,&14a–e) have been synthesized and tested for their in vitro anticancer efficacies against MCF7, A549, and HCT116 cancer cell lines. Among the compounds, 6e, 14b, and 8c were identified as the most potent against MCF7, A549, and HCT116, with IC50 values of 12.46 2.72...
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A COMPREHENSIVE REVIEW OF LIFE CYCLE ASSESSMENT AND ENERGY EFFICIENCY IN 3D PRINTING FOR CONSTRUCTION: CURRENT STATE, BENEFITS, LIMITATIONS, AND FUTURE OUTLOOK
PublikacjaThe agenda of Industry 4.0 strongly affects design and construction at all its phases, and three-Dimensional Printing (3DP) is an essential part of it. The emerging technology has the potential to become a more valid and accepted form of construction. This research is based on a literature review regarding the relationships between the concepts of Life Cycle Assessment (LCA) and energy efficiency for 3DP in construction research...
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ProSIL Software for functional saferty management in life cycle = Aplikacja ProSIL do zarządzania bezpieczeństwem funkcjonalnym w cyklu życia
PublikacjaIn the paper the ProSIL software to aid the functional safety management is presented. The software consists of three modules to aid: determination of the required SIL level (ProSILen), veryfication of the SIL level (ProSILver). In the aplication the method of the calibrated risk graph to determine the required safety integrity level SIL for defined safety instrumented functions is applied. The methods concerning functional safety...
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The life cycle cost of a building from the point of view of environmental criteria of selecting the most beneficial offer in the area of competitive tendering
PublikacjaThe article analyses environmental and ecological criteria of selecting the most beneficial offer in the aspect of LCC. Construction works contracts and the potential method of defining the above criteria, among others, is pondered on (for example by the recommendation of a material, which is supposed to be used, a ban on substances that are harmful for human health as well for the environment). In the relation to the above, it...
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Assessment of immunomodulation and regulation of cell cycle in epithelium and stroma after Cidofovir injection in patients with recurrent respiratory papillomatosis—Pilot study
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On energy, exergy, and environmental aspects of a combined gas-steam cycle for heat and power generation undergoing a process of retrofitting by steam injection
PublikacjaThe paper presents a study of retrofitting of a combined heat and power (CHP) plant aimed to increase the electric to heating power ratio. The modification would involve diverting part of the steam to the gas turbine, instead of letting it go to the steam turbine, using injection technique into a combustion chamber. Therefore, two potential retrofitting approaches are analyzed: steam injection gas turbine (STIGT) and combined steam...
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Reduction of CO2 Emissions from Offshore Combined Cycle Diesel Engine-Steam Turbine Power Plant Powered by Alternative Fuels
PublikacjaDiverse forms of environmental pollution arise with the introduction of materials or energy that exert adverse effects on human health, climate patterns, ecosystems, and beyond. Rigorous emission regulations for gases resulting from fuel combustion are being enforced by the European Union and the International Maritime Organization (IMO), directed at maritime sectors to mitigate emissions of SOx, NOx, and CO2. The IMO envisions...
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HIERARCHICAL CYCLES IN MODERN POWER SYSTEMS – EXERGY ANALYSIS UNDER PART LOADS
PublikacjaThe aim of the paper is to investigate thermodynamic efficiency of advanced hierarchic power cyclesunder partial loads by using of exergy analyze. Advanced hierarchical power systems arecomposed of few energy conversion cycles, most common are steam and gas cycles in various configurations, but they may contain fuel cells, ORC, lithium bromide absorption chillers and others. Moreover hierarchical cycles can be powered by several...
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Human red blood cells targeted metabolome analysis of glycolysis cycle metabolites by capillary electrophoresis using an indirect photometric detection method
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Triazoloacridone C-1305 abrogates the restriction checkpoint in cells lacking functional p53 and promotes their accumulation in the G2/M phase of the cell cycle
PublikacjaTriazoloakrydon C-1305, nowy inhibitor topoizomerazy II, wykazuje wysoką aktywość cytotoksyczną wobec komórek wielu typów nowotworów. Komórki mysie pozbawione genu PARP-1 wykazywały nadwrażliwość na działanie tego związku. W pracy testowaliśmy działanie związku wobec dwóch różnych komóek nowotworowych różniących się statusem p53: komórkami białaczki myelocytarnej HL-60 i raka sutka MCF-7. Wykazaliśmy, że inkubacja ze związkiem...
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The ability of children aged 6 and 9 years, respectively, to detect errors in a narrative based on incorrect information about evaporation in the water cycle
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Evaluation of the influence of the opening pressure of a marine Diesel engine injector on the results of numerical simulation of the working cycle and their comparison with the results of the laboratory experiment
PublikacjaThe article presents the results of a numerical simulation of the working process carried out in a diesel engine. In the applied utility program DIESEL-RK, the laboratory engine Farymann Diesel type D10 was implemented. A selected inoperability of its functional fuel supply system - reduced opening pressure of the injector pinj - was introduced. The values of adequate diagnostic parameters were determined: working gas temperature...
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Comparison Analysis of Blade Life Cycles of Land-Based and Offshore Wind Power Plants
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The role of the combined nitrogen-sulfur-carbon cycles for efficient performance of anammox-based systems
PublikacjaThe combined anammox/mixotrophic denitrification process was conducted in two granular sequencing batch reactors (SBRs) during a 200-day operation. Both reactors were fed with synthetic medium, but SBR2 was enriched with additional sulfate (SO4 2 ) which influenced sulfate reduction ammonium oxidation (SRAO) and heterotrophic reduction of SO4 2 by sulfate reducing bacteria. It was hypothesized that the addition of SO4 2 could...
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Analiza cyklu życia modułu słonecznego i jego wpływ na środowisko = Life cycle analysis of a solar module and its ecological impact
PublikacjaSystemy fotowoltaiczne są odnawialnym źródłem energii elektrycznej, które w czasie eksploatacji nie emitują żadnych szkodliwych substancji, hałasu, nie zwiększają również efektu cieplarnianego. Wpływ każdego produktu na środowisko naturalne, w tym także systemów fotowoltaicznych, musi uwzględniać końcową fazę istnienia - okres po zakończeniu eksploatacji. Obecnie produkowane moduły ogniw fotowoltaicznych mają 25÷30-letnią gwarancję...
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f-Cycles - a new approach to providing fast service recovery at low backup capacity overhead
PublikacjaW artykule zaproponowano klasowy algorytm doboru tras przeżywalnych, wykorzystujący autorską koncepcję f-Cykli ochronnych. Celem podejścia było zminimializowanie wartości czasu odtwarzania uszkodzonych strumieni ruchu. Cel ten został osiągnięty poprzez dostosowanie wielkości obszaru ochrony w zależności od klasy usług. Badania symulacyjne pokazały, że wykorzystując autorką koncepcję f-Cykli ochronnych, możliwe jest również jednoczesne...
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Influence of Different Biofuels on the Efficiency of Gas Turbine Cycles for Prosumer and Distributed Energy Power Plants
PublikacjaThe efficiency of a gas turbine can be affected by the use of different biofuels usually with a relatively Lower Heating Value (LHV). The paper evaluates the impact of calorific value of fuel on turbine performance and analyzes the possibilities of optimizing turbine construction from the point of view of maximum efficiency for a particular fuel. The several variants of design of small power microturbines dedicated to various biofuels...
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Comparative study of a bottoming SRC and ORC for Joule–Brayton cycle cooling modular HTR exergy losses, fluid-flow machinery main dimensions, and partial loads
PublikacjaEnergy conversion efficiency increase in power plants with high-temperature gas-cooled reactors via implementation of the bottoming cycle was investigated under nominal and minimal thermal load of a high-temperature reactor (HTR). Heat transfer surface area and turbine outlet volumetric flow rate in bottoming cycles was also investigated. Water and two low-boiling point working fluids (ammonia and ethanol) were analyzed. Analyzed...
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Down-regulation of DNA topoisomerase IIalpha leads to prolonged cell cycle transit in G2 and early M phases and increased survival to microtubule-interacting agents
PublikacjaInhibitory polimeryzacji mikrotubul wykazują preferencyjną toksyczność wobec komórek mitotycznych. W ramach tego projektu badaliśmy czy oporność komórek ludzkich białaczek na inhibitor mikrotubul, winkrystynę, prowadzi do zmian w regulacji progresji cyklu komórkowego. Nasze wyniki wskazują, że oporności na winkrystynę towarzyszą zmiany w długości fazy G2 i M w nieobecności i obecności inhibitora wrzeciona mitotycznego, nokodazolu....
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Analysis of carboxylic acid metabolites from the tricarboxylic acid cycle in Bacillus subtilis cell extract by capillary electrophoresis using an indirect photometric detection method
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Functional safety and cyber security analysis for life cycle management of industrial control systems in hazardous plants and oil port critical infrastructure including insurance
PublikacjaThis report addresses selected methodological aspects of proactive reliability, functional safety and cyber security management in life cycle of industrial automation and control systems (IACS) in hazardous plants and oil port critical installations based on the analysis of relevant hazards / threats and evaluation of related risks. In addition the insurance company point of view has been also considered, because nowadays the insurer,...
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Energy, water detailed usage. Living lab testing for sustainable urban food-water-energy cycle.
Dane BadawczeData set contains detailed, continuous measurements of the usage of water and electrical energy (AC power) in an experimental facility set up in a scientific laboratory (Laboratorium im. B.Niemkiewicza) at the Faculty of Mechanical Engineering and Ocean Technology of the Gdansk University of Technology. The test bed was established in co-operation...
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Numerical Verification of Tests on the Influence of the Imposed Thermal Cycles on the Structure and Properties of the S700MC Heat-Affected Zone
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Calculation of the standard potentials of the dithiocarbamate/thiuram disulfide redox system via thermochemical cycles and computational electrochemistry .
Publikacja.
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High yield synthesis and preliminary spectroscopic study of mono-N-alkylated cyclen derivatives of salicylic acid
PublikacjaW artykule przedstawiono reakcję bezpośredniego alkilowania cyklenu bromopochodnymi kwasu salicylowego. Otrzymane związki wykorzystano do badań spektroskopowych. Stwierdzono, że tworzą one wybiórczo kompleksy z jonami metali grupy II. Wyznaczono stałe tworzących się kompleksów.
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Effectiveness of various types of coating materials applied in reinforced concrete exposed to freeze–thaw cycles and chlorides
PublikacjaThis study assesses the durability of coated and uncoated concrete surfaces protected with four different coating materials: water-soluble (BW), solvent-based (BR), mineral (MI), and epoxy (EP). The durability assessment includes evaluating the absorption rate of water, pull-off adhesion strength, and coating material thickness. Concrete samples were subjected to immersion in regular water and a 7% urea solution, followed by...
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Effectiveness of various types of coating materials applied in reinforced concrete exposed to freeze–thaw cycles and chlorides
PublikacjaThis study assesses the durability of coated and uncoated concrete surfaces protected with four Different coating materials: water-soluble (BW), solvent-based (BR), mineral (MI), and epoxy (EP). The durability assessment includes evaluating the absorption rate of water, pull-of adhesion strength, and coating material thickness. Concrete samples were subjected to immersion in regular water and a 7% urea solution, followed by cyclic...
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Spectral Analysis of Capital Markets
PublikacjaIn this paper the problem of cycles existence in capital markets is addressed. A spectral analysis algorithm, which reduces signal-to-noise ratio, is proposed to derive cycle periodograms for the yield function of DJIA, WIG~20, and NIKKEI 225 indices. Peaks of the the periodograms provide premises to postulate the existence of some possible cycles. The 3.5 year periodicity in all 3 indices, which can be related to Kitchin cycle...
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Comparative Study of Pavement Rehabilitation Using Hot in-Place Recycling and Hot-Mix Asphalt: Performance Evaluation, Pavement Life Prediction, and Life Cycle Cost Analysis
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Antitumor imidazoacridinone derivative C-1311 induces cell cycle arrest and cellular senescence-like phenotypic changes in human non-small lung A549 cancer cells
PublikacjaPrzeprowadzone badania miały na celu zbadanie rodzaju odpowiedzi komórkowej indukowanej przez pochodną C1311 w komórkach ludzkiego, niedrobnokomórkowego raka płuc A549, wyselekcjonowanych do badań ze względu na wysoką wrażliwość na działanie pochodnej C-1311. Wszystkie eksperymenty przeprowadzone zostały przy stężeniu hamującym proliferację komórek nowotworowych w 80%. Badania z wykorzystaniem techniki cytometrii przepływowej oraz...
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The most popular fields of study at full-time first-cycle studies and uniform master's studies in 2010/2011
Dane BadawczeUniversities try to adjust their didactic offer to the preferences of university candidates and the market situation. The socio-economic changes of the transformation period meant that specialists in the field of the market economy were in demand on the labor market. Subsequently, at universities, such fields as: "Management" or "Pedagogy" are ranked...
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Numerical Simulation and Experimental Analysis of Thermal Cycles and Phase Transformation Behavior of Laser-Welded Advanced Multiphase Steel
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Body fat, energy balance and estradiol levels: a study based on hormonal profiles from complete menstrual cycles
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Investigations into Exhaust Particulate Emissions from Multiple Vehicle Types Running on Two Chassis Dynamometer Driving Cycles
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The TPR reduction profile of CeO2/10wt.%Cu with BCD - 2 cycles
Dane BadawczeThe dataset includes the TPR reduction profiles of CeO2/10wt.%Cu. The samples of nanoCeO2 impregnated with BCD-assisted precursor solution (betacyclodextrin). The dataset includes two cycles of reduction (samples oxidized in between)
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The TPR reduction profile of CeO2/10wt.%Mn with BCD - 2 cycles
Dane BadawczeThe dataset includes the TPR reduction profiles of CeO2/10wt.%Mn. The samples of nanoCeO2 impregnated with BCD-assisted precursor solution (betacyclodextrin). The dataset includes two cycles of reduction (samples oxidized in between)
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The TPR reduction profile of CeO2/10wt.%Co with BCD - 2 cycles
Dane BadawczeThe dataset includes the TPR reduction profiles of CeO2/10wt.%Co. The samples of nanoCeO2 impregnated with BCD-assisted precursor solution (betacyclodextrin). The dataset includes two cycles of reduction (samples oxidized in between)
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The TPR reduction profile of CeO2/10wt.%Ni with BCD - 2 cycles
Dane BadawczeThe dataset includes the TPR reduction profiles of CeO2/10wt.%Ni. The samples of nanoCeO2 impregnated with BCD-assisted precursor solution (betacyclodextrin). The dataset includes two cycles of reduction (samples oxidized in between)
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The TPR reduction profile of CeO2/10wt.%Fe with BCD - 2 cycles
Dane BadawczeThe dataset includes the TPR reduction profiles of CeO2/10wt.%Fe. The samples of nanoCeO2 impregnated with BCD-assisted precursor solution (betacyclodextrin). The dataset includes two cycles of reduction (samples oxidized in between)
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<p>Mechano-signalling, induced by fullerene C<sub>60</sub> nanofilms, arrests the cell cycle in the G2/M phase and decreases proliferation of liver cancer cells</p>
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Life cycle assessment - a new approach to the question of environmental strain caused by analytical laboratories = Ocena cyklu życia - nowe podejście do zagadnienia uciążliwości środowiskowej laboratorów analitycznych
PublikacjaPraca przedstawia wyniki porównawczej oceny cyklu życia dla procesów pozyskiwania ekstraktów końcowych metodą ekstrakcji w układzie ciecz - ciecz i ekstrakcji do fazy stałej. Rozważano jedynie aspekt ekologiczny pozyskiwania wyników, nie bacząc na koszty ekologiczne i inne. Badania oparte są na informacjach uzyskanych w określonym laboratorium analitycznym oraz danych zawartych w bibliotece programu SimaPro. Techniką bardziej przyjazną...
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Jerzy Kowalski dr hab. inż.
Osoby