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Selected organophosphorus compounds with biological activity. Applications in medicine
PublicationThe purpose of this article is to provide an overview of the latest applications of organophosphorus compounds (OPs) that exhibit biological activity. A large family of OPs have become popular in recent years. The practical application of OPs in modern medicine has been attributed to their unique properties. In this article, the methods used to select these compounds will be emphasized. This paper will first outline the findings...
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Territorial Aspects of Entrepreneurial Activity in Polish Suburban Zones
PublicationGlobalization has led to an increased correlation and integration of various fields in modern civilization, including those connected with allocation of entrepreneurial functions. Connection, on a global scale, has shown an increased significance of worldwide corporations. Territorial allocation of the entrepreneurial function has become the subject of translocation and revaluation. Translocation can be understood as the change...
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Optimal placement of IMU sensor for the detection of children activity
PublicationIn this paper an investigation to determine the optimal placement of IMU sensors for the purpose of children characteristic activity detection is presented. The article compares four different placement of two IMU sensors on human body. Ten healthy volunteers participated within the study. Data were collected firstly from two wireless 9-axial IMU sensors placed at the left and right wrists, then sensors were placed at lower back...
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Biological Activity of Tea-Chokeberry and Chokeberry Fermented Beverages
PublicationFermented beverages, such as kombucha are gaining more and more popularity due to their beneficial effects on human health. These products are obtained by the fermentation of tea infusion using so called tea fungus. This microbial consortium can also be used to prepare fermented fruit beverages. Therefore, the aim of this study was to determine the changes in the antioxidant profile of tea-chokeberry and chokeberry beverages...
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Determination of Antioxidant Activity of Vitamin C by Voltammetric Methods
PublicationVoltammetric methods—cyclic (CV) and differential pulse voltammetry (DPV) are considered the most appropriate way to evaluate antioxidant activity of redox active compounds. They provide information about both mechanism and kinetics of electrochemical oxidation of antioxidants as well as their physical and chemical properties such as the redox potential or the number of electrons transferred. These methods are helpful for understanding...
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Meiothermus ruber cells as β-galactosidase activity biocatalyst
PublicationThe current study allowed to establish the possibility of using whole cells of thermophilic bacteria Meiothermus ruber as a biocatalyst with β-galactosidase activity. β-galactosidases are used for hydrolysis of lactose as well as for oligosaccharides synthesis. The advantages of using whole bacterial cells catalysis is not only elimination of tedious, expensive protein isolation and/or purification but also stabilization of enzymes...
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Inhibitors of angiogenesis in cancer therapy – synthesis and biological activity
PublicationAngiogenesis is the process of formation of new capillaries from preexisting blood vessels. Angiogenesis is involved in normal physiological processes, and plays an important role in tumor invasion and development of metastases. Vascular endothelial growth factor (VEGF) plays a key role in angiogenesis. VEGF is a mitogen for vascular endothelial cells and stimulates their proliferation. By inhibiting the biological activity of...
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new analogues of agmatine with higher activity to imidazoline receptors
PublicationOpracowano syntezę nowych pochodnych imidazoliny, będących kompilacją struktury agmatyny i imidazoliny w wyniku zaprojektowanej przez nas drogi syntezy. Kluczowymi substratami w syntezie były pochodne 1,2,4 -triaminobutanu, otrzymane z chronionego kwasu glutaminowego. Otrzymane nowe pochodne imidazoliny wykazywały zróżnicowane powinowactwo do receptorów imidazolinowych I1, I2 oraz do receptorów alfa -adrenergicznych.
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Effect of neoteric solvents on the activated sewage sludge activity
PublicationCiecze jonowe (ILs) cieszą sie rosnącym zainteresowaniem z uwagi na fakt, iż znajdują coraz więcej zastosowań jako alternatywa dla rozpuszczalników organicznych. W związku z zaistnieniem możliwości zastosowania ILs w nowych czystych technologiach nastała potrzeba zbadania ich toksyczności w stosunku do organizmów żywych i środowiska. Celem badań było oszacowanie wpływu cieczy jonowych na wyselekcjonowane mikroorganizmy osadu czynnego....
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Physical Activity and Cognitive Functioning of Children: A Systematic Review
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Chemical Composition and Antimicrobial Activity of New Honey Varietals
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Synthesis and biological activity of tricyclic aryloimidazo-, pyrimido-, and diazepinopurinediones
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Thioacetamide and thiourea impact on visible light activity of TiO2
PublicationAktywne w świetle widzialnym fotokatalizatory na bazie tlenku tytanu (IV) przygotowano w wyniku hydrolizy izopropylanu tytanu (IV) z tioacetamidem i tiomocznikiem oraz kalcynacji w temperaturze 450ºC. Wyniki badań wskazują, że fenol i 4-chlorofenol były efektywnie degradowane w obecności domieszkowanego TiO2 oraz światła widzialnego (λ>400 nm). Głównym celem badań było zbadanie wpływu ilość zastosowanego prekursora domieszki...
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Preparation and photocatalytic activity of B-doped titanium dioxide
PublicationOtrzymano TiO2 domieszkowany borem, aktywny w reakcjach fotodegradacji pod wpływem światła widzialnego (λ>400 nm). Fotokatalizatory otrzymano poprzez hydrolizę tytanianu(IV) izopropylu w obecności związków boru lub poprzez ucieranie ST-01 z prekursorami B i następnie kalcynację w temperaturze 450stC. Jako źródło boru zastosowano kwas borowy (0,5 i 10%wag.) lub trietylo ester kwasu borowego (0,5; 1; 5 i 10%wag.). Najwyższą aktywność...
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The biological activity of new tuftsin derivatives - induction of phagocytosis
PublicationFagocytoza odgrywa ważną rolę w ochronie organizmu przed różnymi mikroorganizmami. Proces ten może być indukowany przez różne czynniki np. endogenny immunomodulator jakim jest tuftsyna czy muramylo-dipeptyd (MDP), najmniejszy syntetyczny glikopeptyd bakteryjnej ściany komórkowej. Zsyntetyzowano nowe analogi MDP i nor-MDP z tuftsyną i retro-tuftsyną, które są zdolne do indukowania fagocytozy. Najbardziej obiecujące okazały się dwa...
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Improvement of photocatalytic activity of silicate paints by removal of K2SO4
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Hybridization of adsorptivity with photocatalytic activity—carbon-coated anatase
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Chemical reactivity and antimicrobial activity of N-substituted maleimides
PublicationZsyntezowano kilkanaście N-podstawionych maleimidów, zawierających w swojej strukturze podstawniki o różnej wielkości i polarności.Maleimidy o charakterze obojętnym wykazywały silny efekt przeciwgrzybowy; ich aktywność przeciwbakteryjna była zróżnicowana. Niską aktywność przeciwbakteryjną, ale wysoką aktywność cytostatyczną stwierdzono dla maleimidów o charakterze zasadowym. Reaktywność chemiczna i lipofilowość miały wpływ na aktywność...
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Synthetic analogues of cyanobacterial alkaloid cylindrospermopsin and their toxicological activity
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Selected biologic markers of inflammation and activity of Crohn’s disease
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Antitumor activity of opiorphin, sialorphin and their conjugates with a peptide klaklakklaklak
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Antimicrobal and ostheointegration activity of bone cement contains nanometals
PublicationPurpose: One of the major problems in bone surgery are infections – especially thoseoccurring in the course of the operating on the patients with lowered immunity system,because they carry the danger of complications. In the Mechanical Department of TechnicalUniversity of Gdansk, there has been carried the research with the use of bone cement andmetal nanoparticles.Design/methodology/approach: The bone cement was used without supplement...
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Identifying the impact of external environment on business angel activity
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Effect of psoriasis activity on serum adiponectin and leptin levels
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Thymus vulgaris Essential Oil and Its Biological Activity
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Assessment of risks connected with economic activity in the SME sector
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Antimycobacterial activity of 5-arylidene aromatic derivatives of hydantoin
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Structure-Activity Relationships in Two-Electron Reduction of Quinones
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Radionuclides activity and effective doses referred to geological formations
PublicationNaturally occurring radioactive materials (NORM) are present in Earth’s crust and they caused natural background radiation, variable in different regions. Liquid, gas and solid radionuclides emit three types of radiation – alpha, beta and gamma. Fluctuations of natural radioactivity in different geological formations in the world and in Poland were compared in relation to radiological hazard. Also drilling cuttings from boreholes...
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Biological activity of conjugates of muramyl dipeptides with batracylin derivatives
PublicationW artykule opisano aktywność biologiczną koniugatów muramylo-dipeptydów z batracyliną lub pochodnymi batracyliny. Badania przeprowadzone w Akademii Medycznej w Gdańsku miały na celu oznaczenie immunomodulacyjnych właściwości tych koniugatów wobec subpopulacji leukocytów krwi obwodowej hodowanych w obecności komórek nowotworowych (K562, WEHI164, Ab melanoma). Leukocyty izolowane były z krwi obwodowej uzyskanej od zdrowych ochotników....
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Lactoferrin Is an Allosteric Enhancer of the Proteolytic Activity of Cathepsin G
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Catalase activity in blood fractions of patients with sporadic ALS
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Matriptase-2: monitoring and inhibiting its proteolytic activity
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Preparation, characterization and photocatalytic activity of metal-loaded NaNbO3
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Biological activity of conjugates of muramyl dipeptides with batracylin derivatives
PublicationZaprezentowano immunomodulacyjne właściwości nowych koniugatów batracyliny (BAT) z pochodnymi muramylodipeptydów wobec subpopulacji leukocytów krwi obwodowej hodowanych w obecności komórek linii nowotworowych. Leukocyty izolowane były z krwi obwodowej uzyskanej od zdrowych ochotników. Zbadane koniugaty MDP lub nor-MDP z batracyliną wykazały silniejsze własności hamujące proliferację komórek wybranych linii nowotworowych (K562,...
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A.D.A.M. test (Antibiofilm Dressing's Activity Measurement) — Simple method for evaluating anti-biofilm activity of drug-saturated dressings against wound pathogens
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S09-4 The development of the Physical Activity Environment Policy Index (PA-EPI): a tool for monitoring and benchmarking government policies and actions to improve physical activity
PublicationBackground Insufficient physical activity (PA) is a global issue for health. A multifaceted response, including government action, is essential to improve population levels of PA. The purpose of this study was to develop the ‘Physical Activity Environment Policy Index’ (PA-EPI) monitoring framework to assess government policies and actions for creating a healthy PA environment. Methods An iterative process was undertaken. This...
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S09 Insights into the development of the physical activity environment policy index, a tool for benchmarking implementation of public policies to create healthy physical activity policy environments
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Influence of S-Oxidation on Cytotoxic Activity of Oxathiole-Fused Chalcones
PublicationSynthesis, in vitro cytotoxic activity, and interaction with tubulin of oxidized, isomeric 1-(5-alkoxybenzo[d] [1,3]oxathiol-6-yl)-3-phenylprop-2-en-1-ones and 1-(6- alkoxybenzo[d][1,3]oxathiol-5-yl)-3-phenylprop-2-en-1- ones are described. Most of the compounds demonstrated cytotoxic activity at submicromolar concentrations. It was found that oxidation of sulfur atom of the oxathiole-fused chalcones strongly influenced activity...
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Synthesis, Antimicrobial and Mutagenic Activity of a New Class of d-Xylopyranosides
PublicationEight N-[2-(2′,3′,4′-tri-O-acetyl-α/β-d-xylopyranosyloxy)ethyl]ammonium bromides, a new class of d-xylopyranosides containing a quaternary ammonium aglycone, were obtained. Their complete structure was confirmed using NMR spectroscopy (1H, 13C, COSY and HSQC) and high-resolution mass spectrometry (HRMS). An antimicrobial activity against fungi (Candida albicans, Candida glabrata) and bacteria (Staphylococcus aureus, Escherichia...
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The influence of food phytochemicals on cyclic phosphodiesterase 4 (PDE4) activity
PublicationCyclic phosphodiesterase 4 (PDE4) belongs to family of cyclic phosphodiesterases, which are expressed predominantly in inflammatory cells, airway smooth muscles, cardiovascular tissues and brain. Inhibitors of this family of enzymes found medicinal applications as antidepressants, antiinflamatory drugs (mainly in airway diseases) or antiasthmatics (Ibudilast). PDE4 inhibitors are also being tested for preventing the development...
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Elderly persons professional activity - substantive issues and methodical challenges
PublicationPopulation ageing and mass withdrawal of persons around retirement age from the labour market constitutes a serious threat for European Union economy, especially in the so-called new member states. The coming years are expected to bring a considerable increase in public spending on pensions and health care, as well as changes in the structure and size of consumer demand and an increase in the number of socially excluded individuals....
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Pr-doped TiO2: The effect of metal content on photocatalytic activity
PublicationThe Pr-TiO2 nanoparticles were prepared by using the sol-gel method. As-prepared samples were characterized by BET measurements, X-ray powder diffraction analysis (XRD) and UV-Vis spectra. Visible and ultraviolet light photocatalytic activity of the sample was studied by photodegradation of phenol while considering the influence of the dopant concentration. TiO2 doped with 0.25 mol% of praseodymium showed the highest photocatalytic...
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Accelerometer signal pre-processing influence on human activity recognition
PublicationA study of data pre-processing influence on accelerometer-based human activity recognition algorithms is presented. The frequency band used to filter-out the accelerometer signals and the number of accelerometers involved were considered in terms of their influence on the recognition accuracy.
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New Chalcones Derivatives With Potent Antitumor Activity And Their Metabolism In Vitro
PublicationChalcone derivatives exhibit a broad range of biological activities, with antioxidant and cytotoxic properties among the most studied. Despite numerous reports on chalcones as cytotoxic, and potentially anticancer agents, very little is know on their actual mechanism of activity. Generally, chalcones are considered as antimitotic agents, which interfere with tubulin assembly.We have recently developed a new class of chalcones with...
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Automatic Clustering of EEG-Based Data Associated with Brain Activity
PublicationThe aim of this paper is to present a system for automatic assigning electroencephalographic (EEG) signals to appropriate classes associated with brain activity. The EEG signals are acquired from a headset consisting of 14 electrodes placed on skull. Data gathered are first processed by the Independent Component Analysis algorithm to obtain estimates of signals generated by primary sources reflecting the activity of the brain....
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Mobile Activity Plan Applications for Behavioral Therapy of Autistic Children
PublicationThis paper concerns technological support for behavioral therapy of autistic children. A family of tools dedicated for mobile devices is presented, that allows to design and perform an activity schedule in behavioral therapy. The paper describes the main challenges, that were encountered, especially in meeting the non-functional requirements of the application: simplicity, repeatability, robustness, personalization, re-usability...
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Jaw biomechanics: Estimation of activity of muscles acting at the temporomandibular joint
PublicationThe aim of this study was to elaborate a method of estimation of activity of surface muscles acting at the temporomandibular joint of the healthy subjects by using a surface electromyography (EMG). The scope of this study involved testing chosen jaw motions (open, close, lateral deviation) and process of mastication occurring during eating food with different toughness (chewing gum, cereal and carrot) by using mixed sides, right...
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Characteristic and specificity of protease activity of thermophilic bacteria Meiothermus ruber
PublicationThe primary purpose of research was to establish the possibility of using thermophilic bacteria Meiothermus ruber as a source of proteolytic enzymes. The main reason of searching new proteases is their commercial value especially in production of detergents, food, pharmaceuticals, leather, diagnostics or waste management. The development of this type processes will be possible by utilization of enzymes which have unique characteristics...
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Synthesis and biological activity of mycophenolic acid-amino acid derivatives
PublicationIn search of new immunosuppressants, mycophenolic acid (MPA) was coupled with amino acid methyl esters followed by hydrolysis to analogs bearing free carboxylic groups. The obtained compunds were tested in vitro as growth inhibitors of lymphoid cell line (Jurkat) and human peripheral blood mononuclear cells (PBMC) from healthy donors. According to obtained results recovering of free carboxylic group increased their activity. Additionally,...