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Search results for: WOUND HEALING IN VIVO
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Expression of high affinity choline transporter during mouse development in vivo and its upregulation by NGF and BMP-4 in vitro
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Enhancement of Inhibition of the Pseudomonas sp. Biofilm Formation on Bacterial Cellulose-Based Wound Dressing by the Combined Action of Alginate Lyase and Gentamicin
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Bisphenol A exposure and healing effects of Adiantum capillus-veneris L. plant extract (APE) in bisphenol A-induced reproductive toxicity in albino rats
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Metabolic Profiling of Jasminum grandiflorum L. Flowers and Protective Role against Cisplatin-Induced Nephrotoxicity: Network Pharmacology and In Vivo Validation
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In vivo creation of plasmid pCRT01 and its use for the construction of carotenoid-producing Paracoccus spp. strains that grow efficiently on industrial wastes
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Gas chromatography-olfactometry (GC-O), electronic noses (e-noses) and electronic tongues (e-tongues) for in vivo food flavour measurement
PublicationThe capter revies two types of artificial olfaction instrumentation, i.e. gas-chromatography-olfactometry (GC-O) and chemical sensor technologies (electronic nose and tongue), combined with multivariate data processing methods as promising approaches for rapid analysis of food. The chapter also includes examples of specific applications for the detection of food flavour and volatile components.
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Mangiferin and Hesperidin Transdermal Distribution and Permeability through the Skin from Solutions and Honeybush Extracts (Cyclopia sp.)—A Comparison Ex Vivo Study
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A.D.A.M. test (Antibiofilm Dressing's Activity Measurement) — Simple method for evaluating anti-biofilm activity of drug-saturated dressings against wound pathogens
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In vivo evidence of ascorbate involvement in the generation of epigenetic DNA modifications in leukocytes from patients with colorectal carcinoma, benign adenoma and inflammatory bowel disease
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<p>In vivo Studies on Pharmacokinetics, Toxicity and Immunogenicity of Polyelectrolyte Nanocapsules Functionalized with Two Different Polymers: Poly-L-Glutamic Acid or PEG</p>
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Synthesis and characterization of novel aliphatic polyurethanes for tissue engineering applications
PublicationSummarizing, in this thesis was described the synthesis of novel PUR system, which was obtained by using aliphatic diisocyanate (HDI), amorphous macrodiol (PEBA) and chain extender (BDO). This PUR system was established as suitable for TE purpose and successfully modified with AA, which as expected improved its biocompatibility. According to this, AA-modified HDI-based PURs is the PUR system ready for further studies including...
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Protective Effect of Morus alba Leaf Extract on N-Nitrosodiethylamine-induced Hepatocarcinogenesis in Rats
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TH-D-BRB-06: Assessment of Proton Beam In-Vivo Dose Verification by Directly Comparing Doses Measured in Tissue-Equivalent Polymer Gels to Proton-Activated Positron-Emission Distributions in the Gels Post Irradiation
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A Prospective, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Study Evaluating Meniscal Healing, Clinical Outcomes, and Safety in Patients Undergoing Meniscal Repair of Unstable, Complete Vertical Meniscal Tears (Bucket Handle) Augmented with Platelet-Rich Plasma
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Nutraceutical value of persimmon (Diospyros kaki Thunb.) and its influence on some indices of atherosclerosis in an experiment on rats fed cholesterol-containing diet
PublicationThe nutraceutic value of persimmon (Diospyros kaki Thunb. cv. Triumph) and its influence on some indices of atherosclerosis were studied in vitro and in experiment on rats fed cholesterol-containing diet. It was found that persimmon possesses a high nutraceutical value: it contains soluble fibers, total polyphenols and phe - nolic acids. The content of dietary fiberwas 1.83 ± 0.11, 0.69 ± 0.07 and 1.14 ± 0.12 g/100 g fresh weight...
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Odczuwanie przestrzeni, czyli architektura jako lekarstwo
PublicationRecenzja książki, Esther M. Sternberg, Healing Spaces: The Science of Place and Well-Being , The Belknap press of Harvard University press, 2010, ISBN 978-0-674-05748-7
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Conception and design of a hybrid exciter for brushless synchronous generator. Application for autonomous electrical power systems = Koncepcja i projekt hybrydowej wzbudnicy bezszczotkowego generatora synchronicznego. Zastosowanie w autonomicznych systemach elektroenergetycznych.
PublicationThis paper covers a subject of a hybrid excitation system for a brushless synchronous generator working with variable speed in an autonomous energy generation system (e.g. airplane power grid). A hybrid excitation system (hybrid exciter) means a synchronous machine with wound-field and permanent magnet excitation. The hybrid exciter supply a dc field current to the synchronous generator field winding through a rotating rectifier....
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Polyurethanes modified with natural polymers for medical application. Part II. Polyurethane/gelatin, polyurethane/starch, polyurethane/cellulose
PublicationThis paper is a literature overview of biomedical PUR modifications with natural polymers such as starch, cellulose and gelatin. Properties like biodegradability and biocompatibility of modified PUR cause that these materials may be used as wound dressings, tissue scaffolds, tissue implants and also vascular grafts.
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Advances in electrical impedance methods in medical diagnostics
PublicationOmówiono elektroimpedancyjne metody diagnostyczne i aparaturę pomiarową opracowane w Politechnikach - Gdańskiej i Warszawskiej.Przedyskutowano właściwości elektryczne różnych tkanek biologicznych, omówiono konstrukcję celek i elektrod do pomiarów in vivo oraz in vitro. Opisano konstrukcję wybranych systemów pomiarowych - pletyzmografów, kardiografów i tomografów elektroimpedancyjnych a także stosownego oprogramowania, np. rekonstrukcji...
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Research, theories and practical experience of therapeutic landscapes as a tool for urban open space design
PublicationThis paper reviews the research on therapeutic landscapes and discusses the design of urban parks and open green space. Firstly, the most relevant research on therapeutic landscapes is reviewed. Secondly, the practical experience of healing and therapeutic gardens is discussed. Finally, the conclusions leading to future use of therapeutic landscape concept in urban open space design are presented.
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A probe for immittance spectroscopy based on the parallel electrode technique.
PublicationW pracy zaprezentowano konstrukcję sondy do spektroskopowych pomiarów immitancyjnych. Obliczono jej stałą, którą to wartość zweryfikowano eksperymentalnie. Pokazano przykładowe wyniki pomiarów in vivo.
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Numerical heat transfer model in skin burn depth simulations
PublicationW artykule przedstawiono numeryczny model wymiany ciepła zachodzącej w tkance skórnej . Wyniki symulacji na modelu zostały porównane z wynikami pomiarów In vivo na zwierzętach.
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Thermal imaging of skin burns. 9th European Congress of Thermology.
PublicationArtykuł przedstawia wyniki badań in-vivo diagnostyki oparzeń skóry z użyciem metod termograficznych. Wykazano iż na podstawie obrazu termograficznego możliwa jest klasyfikacja głębokości oparzenia.
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Linear Micropolar Elasticity Analysis of Stresses in Bones Under Static Loads
PublicationWe discuss the finite element modeling of porous materials such as bones using the linear micropolar elasticity. In order to solve static boundary-value problems, we developed new finite elements, which capture the micropolar behavior of the material. Developed elements were implemented in the commercial software ABAQUS. The modeling of a femur bone with and without implant under various stages of healing is discussed in details
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Tomografia elektroimpedancyjna
PublicationW opracowaniu przedstawiono podstawowe zagadnienia obrazowania elektroimpe-dancyjnego. Omówiono budowę aparatury i algorytmy rekonstrukcyjne. Przedsta-wiono przykładowe wyniki rekonstrukcji zarówno pomiarów eksperymentalnych iin vivo.
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Immunomodulation of macrophages activity in murine bacteremia model
PublicationZaprezentowano wyniki badań in vitro i in vivo połączeń muramylodipeptydu (MDP) z tetrapeptydem jakim jest tuftsyna. Otrzymane rezultaty pokazują, że badane związki modulują fagocytarne możliwości makrofagów w mysim modelu bakteryjnym.
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Thermal imaging and modelling of burned skin
PublicationW artykule przedstawiono wyniki eksperymentów in-vivo na zwierzętach w diagnostyce oparzeń z wykorzystaniem metod obrazowania termicznego w podczerwieni. Wyniki skorelowano z rezultatami otrzymanymi w symulacjach numerycznych tkanki skóry.
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Double layer adhesive silicone dressing as a potential dermal drug delivery film in scar treatment
PublicationThe present studies focused on the evaluation of design of an adhesive silicone film intended for scar treatment. Developed silicone double layer film was examined in terms of its future relevance to therapy and applicability on the human skin considering properties which included in vitro permeability of water vapor and oxygen. In order to adapt the patches for medical use in the future there were tested such properties as...
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Limitations of DSC-MRI for quantitative brain perfusion.
PublicationArtykuł przedstawia ograniczenia metody DSC-MRI w ilościowej ocenie przepływów mózgowych. W zakresie pięciu różnych grup zagadnień przeprowadzono testy symulacyjne oraz obliczenia na podstawie badań fantomowych i in-vivo. Pokazano i omówiono wyniki badań.
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Inhibitors of amino acids biosynthesis as antifungal agents
PublicationFungal microorganisms, including the human pathogenic yeast and filamentous fungi, are able to synthesize all proteinogenic amino acids, including nine that are essential for humans. A number of enzymes catalyzing particular steps of human-essential amino acid biosynthesis are fungi specific. Numerous studies have shown that auxotrophic mutants of human pathogenic fungi impaired in biosynthesis of particular amino acids exhibit...
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Combined anticancer therapy with imidazoacridinone analogue C‐1305 and paclitaxel in human lung and colon cancer xenografts—Modulation of tumour angiogenesis
PublicationThe acridanone derivative 5-dimethylaminopropylamino- 8- hydroxytriazoloacridinone (C-1305) has been described as a potent inhibitor of cancer cell growth. Its mechanism of action in in vitro conditions was attributed, among others, to its ability to bind and stabilize the microtubule network and subsequently exhibit its tumour- suppressive effects in synergy with paclitaxel (PTX). Therefore, the objective of the present study...
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Metal nanoparticles-assisted early diagnosis of diseases
PublicationEarly diagnosis is essential for the effective illness treatment, but traditional diagnostic approaches inevitably have major downsides. Recent advancements in nanoparticle-based biosensors have created new opportunities for accelerating diagnosis. High surface area, exceptional sensitivity, high specificity, and optical characteristics of metal and metal oxide nanoparticles have made it possible to detect a variety of health conditions...
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Non invasive optical cellular imaging in humans.
PublicationOne of the most appealing and still unsolved problems in biological and medical imaging is the possibility of noninvasive visualization of tissue in vivo with an accuracy of microscopic examination. A major difficulty to solve in biomedical imaging is a degradation of image quality caused by the presence of optical inhomogeneity of tissue. Is there any chance to develop a microscopic method that allows non-invasive observation...
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A six-ring probe for monitoring conductivity changes
Publicationstreszczenie: W pracy przedstawiono konstrukcję sondy szściopierścieniowej do monitorowania zmian immitancji. Zdefiniowano czułość sondy i przedstawiono jej rozkład dla przypadków izotropowych i anizotropowych. Teoretyczne symulacje za pomocą metody elementów skończonych zostały zweryfikowane eksperymentalnie, za pomocą specjalnie skonstruowanego zestawu pomiarowego. Zamieszczono przykładowe pomiary in vivo.
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Polyurethanes as a carrier of drugs for gentamicin
PublicationGentamicin is one of the most popular drug and is widely used due to its antibiotic properties. 3% of world production of polyurethanes (PU) is dedicated to biomedical applications, where they can serve are parts of orthopedic prosthesis or artificial organs, disposable medical devices, wound and burn dressing, contact lenses among others. In the study, to obtain drug carriers, a combination of these two materials were prepared...
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Preparation, characterization and antimicrobial activity of polyvinyl alcohol/gum arabic/chitosan composite films incorporated with black pepper essential oil and ginger essential oil
PublicationIn this study, biocomposite films based on polyvinyl alcohol (PVA), gum arabic (GA) and chitosan (CS) incorporated with BPEO and GEO were fabricated by solvent casting method. FTIR, XRD, SEM and DSC were performed with mechanical and antimicrobial properties of PVA/GA/CS films with and without BPEO and GEO. The BPEO and GEO incorporated PVA/GA/CS films were significantly inhibited the growth of Bacillus cereus, Staphylococcus aureus,...
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Cellulose Nanomaterials in Biomedical, Food, and Nutraceutical Applications: A Review
PublicationNanotechnology with bionanomaterials have tremendous potential to enhance and utilize for nutrient and bioactive absorption, drug delivery systems, pharmaceutical, and nutraceutical field through various applications. Cellulose nanomaterials are green materials that are obtained from renewable sources and possess exceptional mechanical strength and biocompatibility. The associated unique physical and chemical properties have made...
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Utilizing pulse dynamics for non-invasive Raman spectroscopy of blood analytes
PublicationNon-invasive measurement methods offer great benefits in the field of medical diagnostics with molecular-specific techniques such as Raman spectroscopy which is increasingly being used for quantitative measurements of tissue biochemistry in vivo. However, some important challenges still remain for label-free optical spectroscopy to be incorporated into the clinical laboratory for routine testing. In particular, non-analyte-specific...
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Receptor for advanced glycation end‐products: Biological significance and imaging applications
PublicationThe receptor for advanced glycation end-products (RAGE or AGER) is a transmembrane, immunoglobulin-like receptor that, due to its multiple isoform structures, binds to a diverse range of endo- and exogenous ligands. RAGE activation caused by the ligand binding initiates a cascade of complex pathways associated with producing free radicals, such as reactive nitric oxide and oxygen species, cell proliferation, and immunoinflammatory...
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Chitosan, Collagen and Gelatin in the design of novel materials with antimicrobial acticity
PublicationMedical devices containing and releasing antiinfective agents directly on the site of injury are a common group of materials available and widely used in treating difficult to heal wounds. Sustained contact of the active agent to the damaged tissue, needed to inhibit infection and preservation of microbiological purity of the wound, is provided by the immobilization antimicrobial agents on the surface of the matrix material or...
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Synthesis and biological evaluation of 2,7-Dihydro-3H-dibenzo[de,h]cinnoli- ne-3,7-done derivatives a novel group of anticancer agents active on a multidrug resistance cell line.
PublicationZsyntezowano serię pochodnych pirydazonu z jednym lub dwoma łańcuchami bocznymi w różnych pozycjach chromoforu tetracyklicznego. Związki wykazały aktywność cytoksyczną na mysią białaczkę L1210 i ludzką k562 oraz na linii komórkowej oporności krzyżowej MDR (k562/DX). Dwa najbardziej aktywne związki przetestowano in vivo na mysiej białaczce P388. Wykazały one aktywność przeciwnowotworową porównywalną z aktywnością Mitoxantronu.
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The Dynamic Model of Magnetic Hysteresis
PublicationThis paper presents the scalar dynamic magnetic hysteresis model based on the Preisach theory. The important role in this theory played hysteresis operator states. The changes of these operators` states are not immediate in the dynamic model but they are a function of time and parameter k representing the magnetic properties of the material. In this paper the transient state of the hysteresis operator is defined by the nonlinear...
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Solid Phase Microextraction: Apparatus, Sorbent Materials, and Application.
Publicationhe primary objective of this review article is to strategically screen and highlight the advancements in the area of solid phase microextraction (SPME). The plenty of review articles have been written on different aspects of SPME, this review is dedicated to provide the brief but clear overview of the research footprints so produced from SPME. Some of the key advancements in types and designs, coating materials, coating strategies,...
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Biomechanics of the front abdominal wall as a potential factorleading to recurrence with laparoscopic ventral hernia repair
PublicationThis study investigated the front abdominal wallto describe its elasticity in vivo and searched for elongationsthat possibly stretched an implanted mesh, therebycausing fixation failure and subsequent recurrence.To measure front abdominal wall elongations, amodel of fascia movements was created. Eight healthyvolunteers were measured during exercise to determine theextent of elongations in their front abdominal wall. Videoswere...
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Simulation of the Remanence Influence on the Transient States of the Single-Phase Transformer Including Feedback Preisach Model
PublicationThis paper presents the results of the experimental and simulation investigation concerning the influence of remanence in the core of a single-phase transformer at the no-load transient state. Experimental studies consisted of the discharge of the capacitor through the primary winding at several different values of the residual magnetic flux. The paper presents a model of the transformer test system, taking into account the magnetic...
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Quality prediction of foil capacitors by acoustic emission signals
PublicationJakość i trwałość kondensatorów foliowych jest zależna od ich warunków pracy (np. nadmiarowego napięcia pracy, temperatury, wilgotności) oraz od potencjalnych defektów wprowadzonych na różnych etapach wytwarzania kondensatorów. Nieustanny nacisk na wzrost jakości wytwarzanych elementów przy jednoczesnej redukcji kosztów wytwarzania oznacza, że nowe, tanie i szybkie metody predykcji jakości tych elementów są mocno poszukiwane. W...
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Active Dynamic Thermography in Medical Diagnostics
PublicationThis is an overview of active thermal imaging methods in medical diagnostics using external thermal stimulation. In this chapter, several clinical cases diagnosed using the active dynamic thermography method, ADT, are presented. Features of this technology are discussed and main advantages underlined. Applications in skin burn diagnostics and quantitative evaluation leading to modern classification of burned patients for further...
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The immunoregulatory effects of edeine analogues in mice
PublicationZbadano właściwości immunoregulatorowe kilku, otrzymanych na drodze syntezy, uproszczonych analogów peptydowego antybiotyku edeiny w testach in vivo i in vitro z wykorzystaniem modelu mysiego. Jako związek referencyjny zastosowano edeinę B. Otrzymane peptydy wykazywały efekt stymulacyny na proliferację splenocytów z użyciem konkawaliny, podczas gdy zastosowanie mitogenu powodowało hamowanie proliferacji splenocytów. Peptydy hamowały...
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Noninvasive glucose sensing in scattering media using OCT, PAS, and TOF techniques.
PublicationW pracy przedstawiono możliwości wykorzystania optycznej tomografii koherencyjnej (OCT), spektroskopii fotoakustycznej (PAS)i spektroskopii czasu przelotu (TOF) w pomiarach glukozy w ośrodku silnie rozpraszającym. Równolegle opracowano modele propagacji światła w tych ośrodkach wykorzystując metodę Monte Carlo. W pomiarach wykorzystano ''Intralipid'' jako fantom tkanki. W dalszych badaniach wykorzystano mięso wieprzowe i dokonano...
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Healthy financial system of local government on the example of Poland
Publicationhealthy local government financial system lays the foundation for the ability of local government units (LGUs) to carry out public tasks at the current qualitative and quantitative level and to meet their obligations in the short and long term. A healthy financial system of local government is a system that is adequate, stable, unified, consistent, transparent, diversified, counter-cyclical, guarantees the financial independence...