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Search results for: ACTIVE PHARMACEUTICAL INGREDIENTS
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Quantitative Active Dynamic Thermal IR-Imaging and Thermal Tomography in Medical Diagnostics
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Smart MV/LV distribution transformer for Smart Grid with active prosumer participation
PublicationWraz z rozwojem sieci dystrybucyjnych i ich stopniowym przekształcaniem w inteligentne sieci typu Smart Grid będzie rosłoznaczenie i udział sterowanych układów przekształtnikowych mocy stosowanych jako interfejsy pomiędzy źródłami energii a sieciąoraz pomiędzy siecią a odbiorcami. W artykule rozwinięto koncepcję wymiany konwencjonalnych transformatorów dystrybucyjnych50 Hz na inteligentne transformatory dystrybucyjne. Zaproponowano...
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Improving the accuracy of bearing in active sonar with cylindrical array using spectrum estimation.
PublicationThe articles presents a method for improving the accuracy of bearing in multibeam sonar with a cylindrical array. Based on a known spatial spectrum estimation technique, the method has been successfully used in linear array systems. Its accuracy of bearing is satisfactory and ensures a relatively low computational effort. The article discusses certain simplifications and assumptions to adapt the spatial spectrum estimation technique...
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Application of surface active amino acid ionic liquids as phase-transfer catalyst
PublicationFive structurally related morpholinium derived ionic liquids containing N-acetyl-glycinate anion were synthesized and their thermal stability, surface properties and activity as phase transfer catalysts investigated. The thermal properties were studied by differential scanning calorimetry, while the adsorption at the air/water interface and micellization behavior was analyzed by surface tension measurements, conductometry and isothermal...
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Voriconazole-Based Salts Are Active against Multidrug-Resistant Human Pathogenic Yeasts
PublicationVoriconazole (VOR) hydrochloride is unequivocally converted into VOR lactates and valinates upon reaction with silver salts of organic acids. This study found that the anticandidal in vitro activity of these compounds was comparable or slightly better than that of VOR. The Candida albicans clinical isolate overexpressing CaCDR1/CaCDR2 genes, highly resistant to VOR, was apparently more susceptible to VOR salts. On the other hand,...
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Probing the Magnetic Anisotropy of Co(II) Complexes Featuring Redox-Active Ligands
PublicationCoordination complexes that possess large magnetic anisotropy (otherwise known as zero-field splitting, ZFS) have possible applications in the field of magnetic materials, including single molecule magnets (SMMs). Previous studies have explored the role of coordination number and geometry in controlling the magnetic anisotropy and SMM behavior of high-spin (S = 3/2) Co(II) complexes. Building upon these efforts, the present work...
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Structure of solvation water around the active and inactive regions of a type III antifreeze protein and its mutants of lowered activity
PublicationWater molecules from the solvation shell of the ice-binding surface are considered important for the antifreeze proteins to perform their function properly. Herein, we discuss the problem whether the extent of changes of the mean properties of solvation water can be connected with the antifreeze activity of the protein. To this aim, the structure of solvation water of a type III antifreeze protein from Macrozoarces americanus (eel...
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Artemisia abrotanum L. (Southern Wormwood)—History, Current Knowledge on the Chemistry, Biological Activity, Traditional Use and Possible New Pharmaceutical and Cosmetological Applications
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A Novel Electrochemical Sensor Based on Graphene Oxide Nanosheets and Ionic Liquid Binder for Differential Pulse Voltammetric Determination of Droxidopa in Pharmaceutical and Urine Samples
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A novel cold-active β-D-galactosidase with transglycosylation activity from the Antarctic Arthrobacter sp. 32cB - gene cloning, purification and characterization
PublicationA gene encoding a novel β-D-galactosidase from the psychrotolerant Antarctic bacterium Arthrobacter sp. 32cB was isolated, cloned and expressed in Escherichia coli. The active form of recombinant β-D-galactosidase consists of two subunits with a combined molecular weight of approximately 257 kDa. The enzyme's maximum activity towards o-nitrophenyl-β-D-galactopyranoside was determined as occurring at 28 °C and pH 8.0. However, it...
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Comparative analysis of three‐phase dual active bridge converter with different transformer topology and modern universal control for DC microgrids
PublicationThe presented work discusses issues related to the use of modern multiphase topologies of Dual Active Bridge (DAB)-type converters. Converters of this type are widely used in most DC microgrid applications. The introduction emphasizes a comparative analysis between single-phase and multi-phase DAB topologies within high-power DC microgrids, delving into their respective advantages, drawbacks, design procedures, and considerations...
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Determination of mefenamic acid in urine and pharmaceutical samples by HPLC after pipette-tip solid phase microextraction using zinc sulfide modified carbon nanotubes
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Determination of pharmaceutical residues in drinking water in Poland using a new SPE-GC-MS(SIM) method based on Speedisk extraction disks and DIMETRIS derivatization
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Ecotoxicological equilibria of triclosan inMicrotox, XenoScreen YES/YAS, Caco2, HEPG2 and liposomal systems are affected by the occurrence of other pharmaceutical and personal care emerging contaminants
PublicationContaminants of emerging concernmay be considered as any chemicals or factorswhose unintended continuous release and persistence in the environmentmay lead to any observable undesirable response of living beings. Still not much is known on reciprocal toxicological impact of given chemicals when present in binary or more complex mixtures. In thiswork, an attemptwas thus undertaken to study the impact of butylparaben,methylparaben and...
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High power, zero ripples active filtering system with power modules operating in parallel
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A hybrid, coupled reactors based 18-pulse diode rectifier with active power filter
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New Insights into Dietary Supplements Used in Sport: Active Substances, Pharmacological and Side Effects
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Methods of decreasing the lasing thresholds of optical resonators with periodically structured active nano wires
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Burn depths evaluation based on active dynamic IR thermal imaging - A preliminary study
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Differentiating between Inactive and Active States of Rhodopsin by Atomic Force Microscopy in Native Membranes
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Post-Activation Performance Enhancement: Save Time With Active Intra-Complex Recovery Intervals
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A rapid, selective, and ultrasensitive voltammetric and gravimetric protocol for MMP-1 active form detection
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Effect of Active Mining Impact On Properties with Engineering Structures – Forecast and Final Result Discrepancies
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Selective monoprotection of 1,4,7,10-tetraazacyclododecane via direct reactions with 4-nitrophenyl active esters
Publication1,4,7,10-tetraazacyklododekan jest cykliczną tetraaminą. Z chemicznego punktu widzenia wszystkie atomy azotu posiadają takie same właściwości fizykochemiczne. Jedyną różnicę stanowią ich właściwości kwasowo-zasadowe. Cyklen posiada dwa atomy azotu o obniżonej zasadowości. Właściwość ta z powodzeniem wykorzystywana jest w reakcjach jednoczesnej selektywnej substytucji dwóch atomów w pozycji 1 i 7. W przypadku bezpośredniej reakcji...
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From Democratic (Citizenship) Education to Participative Democracy? Youth’s Difficult Way to Active Citizenship
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ALD thin ZnO layer as an active medium in a fiber-optic Fabry–Perot interferometer
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Edu Inspiracje WZiE: Active Learning, czyli o mocy aktywnego przetwarzania informacji
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The use of a static electrical energy meter as a transducer of active power to a pulse frequency signal
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Active Linear Tunable Resistance Element and Application to Feedforward Linearization of CMOS Transconductance Amplifier
PublicationW pracy przedstawiono koncepcję układową przestrajalnego rezystora liniowego MOS wykorzystującego tranzystory pracujące w zakresie triodowym. Opracowana struktura, jak wykazały symulacje komputerowe, charakteryzuje się dobrymi właściwościami zarówno jeżeli chodzi o zakres przestrajania jak i liniowość charakterystyk przejściowych. Pozwoliło to efektywnie wykorzystać prezentowany element do linearyzacji operacyjnego wzmacniacza...
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Higuchi fractal dimension analysis of surface EMG signals and determination of active electrode positions
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A new approach to active noise and vibration control - [Part I: the known frequency case]
PublicationThis paper presents a new approach to rejection of complex-valued sinusoidal disturbances acting at the output of a discrete-time stable linear plant with unknown dynamics. It is assumed that the frequency of the sinusoidal disturbance is known, and that the output signal is contaminated with wideband measurement noise. The disturbance rejection control rule is first derived and analyzed for a nominal plant model, different from...
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A new approach to active noise and vibration control - [Part II: unknown frequency case]
PublicationThis paper presents a new approach to rejection of complex-valued sinusoidal disturbances acting at the output of a discrete-time stable linear plant with unknown and possibly timevarying dynamics. It is assumed that both the instantaneous frequency of the sinusoidal disturbance and its amplitude may be slowly varying with time and that the output signal is contaminated with wideband measurement noise. It is not assumed that a...
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Treatment of high-quality groundwater by means of one-stage filtration on active filtration beds
PublicationPrzeprowadzone badania pilotowe uzdatniania wody podziemnej wysokiej jakości, wykazały, że wody o niewielkich stężeniach żelaza (< 0,6 mgl) i manganu (<0,1 mg/l) można uzdatniać stosując napowietrznie i jednostopniową filtrację, w układzie zamkniętym, przez aktywne złoża filtracyjne. Wszystkie przebadane złoża (jednowarstwowe z piasku kwarcowego; dwuwarstwowe z piasku kwarcowego i piroluzytu oraz trzywarstwowe z antracytu, piasku...
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ALD thin ZnO layer as an active medium in a fiber-optic Fabry-Perot interferometer
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Influence of Protonation State on the Excited State Dynamics of a Photobiologically Active Ru(II) Dyad
PublicationThe influence of ligand protonation on the photophysics of a ruthenium (Ru) dyad bearing the 2-(1-pyrenyl)-1H-imidazo[4,5-f][1,10]-phenanthroline (ippy) ligand was investigated by time-resolved transient absorption spectroscopy. It was found that changes in the protonation state of the imidazole group led to changes in the electronic configuration of the lowest lying excited state. Formation of the fully deprotonated imidazole...
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The effect of UV-C irradiation on lipids and selected biologically active compounds in human milk
PublicationThe effect of UV-C irradiation of human milk on lipid oxidation, content of antioxidants (vitamin C and catalase, CAT) and bactericidal compounds (lysozyme), as well as the total antioxidant capacity (TAC), of the breast milk was investigated. In parallel, the extent of inactivation of some bacteria was also determined. UV-C at doses from 85 to 740 J L−1 caused total inactivation of Escherichia coli and Staphylococcus aureus, but...
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DNA Methylation Changes Induced by Redox-Active Compounds—Choosing the Right PCR-Based Method
PublicationThe impact of catechins on the expression profile of redox-related genes in HT29 cell line has been studied recently by our group using Oxidative Stress RT2 Profiler PCR Array. Within the examined panel of 84 genes, the down-regulation of SRXN1 gene was unique among other up-regulated genes. We hypothesized that the observed down-regulation resulted from DNA methylation and have exploited this observation to choose the proper strategy...
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Studies on the orientation effect of crystallites and its application to cocrystal screening of selected pharmacologically active compounds
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Ammonium Enhances Food Waste Fermentation to High-Value Optically Active l-Lactic acid
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Supercritical fluid extraction of algae enhances levels of biologically active compounds promoting plant growth
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Identification of sustainable trypsin active‐site inhibitors from Nigrospora sphaerica strain AVA‐1
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Ce-modified zeolite BEA catalysts for the trichloroethylene oxidation. The role of the different and necessary active sites
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Influence of molecular organization of photo-active azo-phanes on thereactivity in monolayers at the air-water interface.
PublicationStwierdzono, że molekularna organizacja monowarstw na granicy powietrze-woda, otrzymanych z amfifilowego azofanu z nierozgałęzionym podstawnikiem n-dodecylowym różni się od tej uzyskanej dla analogu z objętościowym podstawnikiem ''tert''-oktylowym pod względem powierzchni zajmowanej przez cząsteczkę. Kompleksowanie jonów sodu z subfazy wodnej, jak wywnioskowano z pomiaru potencjału powierzchniowego, jest ułatwione w przypadku azofanu...
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3-phase medium frequency transformer for a 100kW 1.2kV 20kHz Dual Active Bridge converter
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Metabolism of 1α-hydroxyvitamin D3 by cytochrome P450scc to biologically active 1α,20-dihydroxyvitamin D3
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Investigation of active channels in multi-channel surface arm EMG recordings for 24 different movements
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The effect of cabbage juice and its active components on transcription factor Nrf2 in breast cell lines
PublicationObniżenie zagrożenia chorobami nowotworowymi w przypadku diety bogatej w kapustę wiąże się ze zdolnością bioaktywnych związków tego warzywa do indukowania enzymów ochronnych 2. fazy będacych pod kontrolą czynnika transkrypcyjnego Nrf2. Zbadano wpływ soków z kapusty na poziom Nrf2 w komórkach unieśmiertelnionych i nowotworowych linii odpowiednio MCF10A i MCF-7. W obu przypadkach obserwowano wzrost poziomu tego czynnika oraz jego...
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Aktywne modele kształtu i ich biometryczne zastosowania = Active shape models and their biometric applications
PublicationAktywne modele kształtu zostały zaproponowane w latach 90 XX wieku jako uniwersalna metoda lokalizowania i rozpoznawania obiektów. Koncepcje teoretyczne, na których metoda ta została oparta, wydają się obiecujące, jednak ich praktyczna wartość nie została jeszcze do końca zweryfikowana. Autorzy niniejszej pracy przeprowadzili testy aktywnych modeli kształtu za pomocą własnego systemu lokalizacji obiektów, szczególną uwagę zwracając...
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One-Step Synthesis of W/O and O/W Emulsifiers in the Presence of Surface Active Agents
PublicationThe main goal of this study was to describe the method of the synthesis of the dodecyl-, tetradecyl-, hexadecyl- and octadecyl-propylene glycol emulsifiers in the presence of selected anionic and nonionic surfactants. Acyl propylene glycol emulsifiers were produced by esterification of propane-1,2-diol (propylene glycol, PG) with C12:0-C18:0 fatty acids in the presence of anionic sodium dodecyl sulfate (SDS) and nonionic-poly(ethylene...
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Four Level Diode-Clamped Back-To-Back Converter with Active DC Link Voltage Control
PublicationThis article presents the design and control of 4L-DC back-to-back converter. To solve the DC link voltage balancing problem in four-level converter a new three-level double chopper topology based on PO-PWM modulation was designed and successfully tested. Also, the paper describes two phase space vector pulse width modulation 2P-SVPWM based on the shape function of finite elements. The control structure with modified Dead-Beat...